Details of the Drug

General Information of Drug (ID: DM0B7NO)

Drug Name

Isoarnebin 4

Synonyms

Shikonin; NSC 252844; Shikonin S; Shikonin,(S); Tokyo Violet

Indication

Disease Entry	ICD 11	Status	REF
Coronavirus Disease 2019 (COVID-19)	1D6Y	Investigative	[1]
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Therapeutic Class

Antiviral Agents

Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

#Ro5 Violations (Lipinski): 0

Molecular Weight (mw)

288.29

Logarithm of the Partition Coefficient (xlogp)

Rotatable Bond Count (rotbonds)

Hydrogen Bond Donor Count (hbonddonor)

Hydrogen Bond Acceptor Count (hbondacc)

Chemical Identifiers

Formula: C16H16O5
IUPAC Name: 5,8-dihydroxy-2-[(1R)-1-hydroxy-4-methylpent-3-enyl]naphthalene-1,4-dione
Canonical SMILES: CC(=CC[C@H](C1=CC(=O)C2=C(C=CC(=C2C1=O)O)O)O)C
InChI: InChI=1S/C16H16O5/c1-8(2)3-4-10(17)9-7-13(20)14-11(18)5-6-12(19)15(14)16(9)21/h3,5-7,10,17-19H,4H2,1-2H3/t10-/m1/s1
InChIKey: NEZONWMXZKDMKF-SNVBAGLBSA-N

Cross-matching ID

PubChem CID: 479503
ChEBI ID: CHEBI:81068
CAS Number: 517-89-5
TTD ID: D0QM4U

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
COVID-19 papain-like proteinase (PL-PRO)	TTNHMO8	R1AB_SARS2 (819-2763)	Inhibitor	[1]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
72 kDa type IV collagenase (MMP2)	OT5NIWA2	MMP2_HUMAN	Gene/Protein Processing	[2]
Actin, aortic smooth muscle (ACTA2)	OTEDLG8E	ACTA_HUMAN	Gene/Protein Processing	[3]
Amphiregulin (AREG)	OTJFOR67	AREG_HUMAN	Gene/Protein Processing	[2]
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Gene/Protein Processing	[3]
Cadherin-1 (CDH1)	OTFJMXPM	CADH1_HUMAN	Gene/Protein Processing	[2]
Cadherin-2 (CDH2)	OTH0Y56P	CADH2_HUMAN	Gene/Protein Processing	[2]
Caspase-3 (CASP3)	OTIJRBE7	CASP3_HUMAN	Protein Interaction/Cellular Processes	[3]
Cellular tumor antigen p53 (TP53)	OTIE1VH3	P53_HUMAN	Gene/Protein Processing	[4]
Collagen alpha-1(I) chain (COL1A1)	OTI31178	CO1A1_HUMAN	Gene/Protein Processing	[3]
Collagen alpha-1(III) chain (COL3A1)	OTT1EMLM	CO3A1_HUMAN	Gene/Protein Processing	[3]

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Molecular Interaction Atlas (MIA)

MIA Detail

Jump to Detail Molecular Interaction Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 36 Cell Line(s) in Bone Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
RPMI-3460/CS1	GDSC1	0.2217	1.2686	0.2214	47.2297
SK-PN-DW	GDSC1	-2.6904	-1.7003	-2.6904	83.3302
HOS	GDSC1	-2.3384	-1.1349	-2.3384	78.9078
EW-16	GDSC1	-2.3361	-1.0391	-2.3361	78.7733
EW-13	GDSC1	-1.3505	-0.288	-1.3505	66.8565
ES1	GDSC1	-1.0701	0.3583	-1.0706	63.2902
EW-3	GDSC1	-0.884	2.7458	-1.0475	59.1813
EW-18	GDSC1	-0.8665	0.4325	-0.8668	60.7961
ES7	GDSC1	-0.8207	0.8055	-0.8229	60.147
MHH-ES-1	GDSC1	-0.7474	0.809	-0.7491	59.2641
ES8	GDSC1	-0.7095	0.5249	-0.7097	58.8502
EW-11	GDSC1	-0.6614	0.7009	-0.6621	58.2367
MG-63	GDSC1	-0.4531	2.2787	-0.5204	55.2185
A-673	GDSC1	-0.4321	0.0212	-0.4321	55.4014
U2OS	GDSC1	-0.262	3.911	-0.6273	52.563
CAL-72	GDSC1	0.1008	4.6683	-0.455	49.0616
EW-7	GDSC1	0.2119	1.2442	0.2116	47.3529
EW-1	GDSC1	0.2136	1.6483	0.2097	47.3414
TC-71	GDSC1	0.2178	1.0349	0.2178	47.2775
SK-ES-1	GDSC1	0.2578	1.3321	0.2574	46.7792
ES4	GDSC1	0.303	2.5425	0.2502	46.3609
CHSA0108	GDSC1	0.3237	2.1476	0.3041	46.0205
NY	GDSC1	0.501	2.495	0.4634	43.8955
G-292 clone A141B1	GDSC1	0.5132	2.4911	0.4765	43.7422
HuO9	GDSC1	0.8735	2.3229	0.8621	39.1479
SaOS-2	GDSC1	1.1393	5.6766	0.3013	39.4654
ES6	GDSC1	1.4138	3.2815	1.3363	32.8042
ES5	GDSC1	1.4195	2.8961	1.3912	32.4326
CAL-78	GDSC1	1.452	7.0321	0.0551	38.2576
H-EMC-SS	GDSC1	1.8086	3.1471	1.7761	27.5982
HuO-3N1	GDSC1	2.1855	4.3454	1.9157	24.4598
SJSA-1	GDSC1	2.2056	4.4865	1.8902	24.5177
CHSA0011	GDSC1	2.206	3.563	2.1418	22.8368
CHSA8926	GDSC1	2.3446	15.163	-3.0147	40.4432
EW-24	GDSC1	2.6356	3.7344	2.5742	17.45
NOS-1 [Human HNSCC]	GDSC1	2.88	3.9346	2.7949	14.5558
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⏷ Show the Full List of 36 Cancer Drug Sensitivity Data of This Drug

Cancer Drug Sensitivity Data Curated from 149 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
JM1	GDSC1	-2.6909	-1.9707	-2.6909	83.5616
ST486	GDSC1	-3.7413	-2.355	-3.7413	92.7517
GA-10	GDSC1	-3.6882	-2.9477	-3.6882	94.6957
SU-DHL-10	GDSC1	-3.4056	-2.8869	-3.4056	92.3407
SU-DHL-5	GDSC1	-3.3116	-1.8929	-3.3117	89.0073
Ku812	GDSC1	-3.2925	-2.3044	-3.2925	90.0968
MOLP-8	GDSC1	-3.2383	-1.843	-3.2383	88.3877
NALM-6	GDSC1	-3.0323	-2.115	-3.0323	87.4135
Kasumi-1	GDSC1	-2.9629	-1.3288	-2.9631	84.978
Reh	GDSC1	-2.9187	-2.16	-2.9187	86.2998
QIMR-WIL	GDSC1	-2.9117	-1.9606	-2.9117	85.9751
SR	GDSC1	-2.7927	-1.21	-2.7928	83.3648
Farage	GDSC1	-2.7167	-1.7413	-2.7167	83.6589
NKM-1	GDSC1	-2.6958	-1.4144	-2.6958	82.9575
DEL	GDSC1	-2.6692	-1.4303	-2.6692	82.7293
HAL-01	GDSC1	-2.3363	-1.2035	-2.3363	78.9525
SIG-M5	GDSC1	-2.3313	-1.2256	-2.3313	78.9166
CA46	GDSC1	-2.2765	-0.7519	-2.2767	77.7624
NK-92MI	GDSC1	-2.2186	-1.2045	-2.2186	77.6124
GR-ST	GDSC1	-2.1901	-1.0052	-2.1902	77.1458
OCI-Ly19	GDSC1	-2.1591	-0.8209	-2.1591	76.627
NU-DUL-1	GDSC1	-2.1446	-1.2787	-2.1446	76.7627
P30/OHK	GDSC1	-2.1045	-1.1472	-2.1045	76.2362
U-698-M	GDSC1	-2.0988	0.2959	-2.1069	74.0914
A4/Fukuda	GDSC1	-1.9858	-0.8547	-1.9858	74.6951
OCI-AML-2	GDSC1	-1.9002	-0.9993	-1.9002	73.7215
EB2	GDSC1	-1.8818	-0.9483	-1.8818	73.4866
WSU-NHL	GDSC1	-1.8525	-0.3108	-1.8528	72.7565
Karpas-231	GDSC1	-1.8505	-0.9693	-1.8505	73.1075
ALL-PO	GDSC1	-1.7646	-0.4347	-1.7646	71.8715
OCI-AML-3	GDSC1	-1.7428	-1.0052	-1.7428	71.7805
KCL-22	GDSC1	-1.7185	-0.6735	-1.7185	71.4329
MV4-11	GDSC1	-1.6602	-0.1456	-1.6606	70.4706
KMS-12-BM	GDSC1	-1.6447	-0.3162	-1.6448	70.4076
Ramos.2G6.4C10	GDSC1	-1.6361	-0.7579	-1.6361	70.4384
H9	GDSC1	-1.6329	-0.9046	-1.6329	70.4082
EoL-1	GDSC1	-1.6269	-0.8545	-1.6269	70.3317
Mono-Mac-6	GDSC1	-1.6053	0.5603	-1.6119	69.0678
OPM-2	GDSC1	-1.5746	-0.5702	-1.5746	69.6539
Hs 445	GDSC1	-1.5551	-0.1603	-1.5553	69.2731
MLMA	GDSC1	-1.5245	-0.694	-1.5245	69.0498
MY-M12	GDSC1	-1.5163	-0.5843	-1.5163	68.9386
YT	GDSC1	-1.4485	0.026	-1.4489	67.9231
OCI-AML-5	GDSC1	-1.3874	0.1179	-1.388	67.1594
SU-DHL-8	GDSC1	-1.3452	-0.5652	-1.3452	66.8121
KOPN-8	GDSC1	-1.3431	0.3551	-1.3447	66.4932
KE-37	GDSC1	-1.3088	0.3929	-1.3104	66.0749
SCC-3	GDSC1	-1.2995	-0.841	-1.2995	66.2435
SU-DHL-16	GDSC1	-1.2741	-0.2566	-1.2741	65.9102
MN-60	GDSC1	-1.2592	-0.1791	-1.2592	65.7169
RS4;11	GDSC1	-1.217	0.06	-1.2172	65.1536
MEG-01	GDSC1	-1.1719	0.2891	-1.1724	64.5343
BV-173	GDSC1	-1.1623	-0.3129	-1.1623	64.5256
MOLT-4	GDSC1	-1.1166	-0.1694	-1.1166	63.9505
LC4-1	GDSC1	-1.0949	0.1438	-1.0951	63.6468
MHH-PREB-1	GDSC1	-1.0816	-0.1356	-1.0816	63.5143
ALL-SIL	GDSC1	-1.0703	0.4262	-1.0711	63.2692
JJN-3	GDSC1	-1.0579	-0.1273	-1.0579	63.2188
TUR	GDSC1	-1.0434	0.5955	-1.0452	62.8784
SK-MM-2	GDSC1	-1.0223	0.8369	-1.0268	62.498
Karpas-620	GDSC1	-1.009	0.1128	-1.009	62.5943
P32/ISH	GDSC1	-0.9988	0.2422	-0.9989	62.4509
OCI-M1	GDSC1	-0.9157	0.0022	-0.9157	61.4432
BALL-1	GDSC1	-0.8953	0.2735	-0.8954	61.1723
VAL	GDSC1	-0.8076	1.4817	-0.8281	59.6295
DoHH2	GDSC1	-0.7855	-0.0266	-0.7855	59.8181
TK [Human B-cell lymphoma]	GDSC1	-0.7725	0.0771	-0.7725	59.6549
VL51	GDSC1	-0.7721	0.1576	-0.7721	59.6488
U266B1	GDSC1	-0.726	0.578	-0.7264	59.0474
ATN-1	GDSC1	-0.6851	0.0474	-0.6851	58.5632
Granta-519	GDSC1	-0.6676	0.2376	-0.6676	58.3432
LP-1	GDSC1	-0.6628	0.1563	-0.6628	58.2838
DB	GDSC1	-0.6491	0.5436	-0.6493	58.1004
KY821	GDSC1	-0.6439	0.2903	-0.6439	58.0466
RPMI-8226	GDSC1	-0.6292	0.1676	-0.6292	57.8642
SU-DHL-1	GDSC1	-0.6194	0.3493	-0.6194	57.7396
DND-41	GDSC1	-0.6122	0.776	-0.6131	57.6209
BC-3	GDSC1	-0.6081	0.3057	-0.6081	57.6002
WIL2 NS	GDSC1	-0.5871	0.6725	-0.5875	57.3229
BL-41	GDSC1	-0.5633	-0.0239	-0.5633	57.0412
PL-21	GDSC1	-0.539	0.4886	-0.539	56.7339
RPMI-6666	GDSC1	-0.5237	1.3487	-0.5321	56.42
Loucy	GDSC1	-0.5011	0.5041	-0.5011	56.2612
BE-13	GDSC1	-0.4996	0.1945	-0.4996	56.2444
PF-382	GDSC1	-0.4587	1.1116	-0.4615	55.6888
MOLT-16	GDSC1	-0.4303	0.1023	-0.4303	55.3784
CCRF-CEM	GDSC1	-0.4268	0.3593	-0.4268	55.3343
ML-2	GDSC1	-0.4244	0.6083	-0.4245	55.3029
RPMI-8866	GDSC1	-0.32	0.8048	-0.3202	53.9961
697	GDSC1	-0.2271	0.9983	-0.2277	52.8342
ARH-77	GDSC1	-0.1998	1.0943	-0.2007	52.4913
CTB-1	GDSC1	-0.1825	0.9308	-0.1827	52.279
DG-75	GDSC1	-0.1786	1.7465	-0.1934	52.1863
Karpas-299	GDSC1	-0.1738	0.8054	-0.1738	52.1713
SUP-B15	GDSC1	-0.1413	1.5056	-0.1473	51.7497
SUP-HD1	GDSC1	-0.1093	2.0039	-0.1358	51.3244
THP-1	GDSC1	-0.0897	0.9953	-0.0899	51.1201
KMOE-2	GDSC1	-0.0781	1.9307	-0.099	50.9519
EJM	GDSC1	-0.0434	0.9523	-0.0435	50.5425
EM-2	GDSC1	-0.031	1.0513	-0.0313	50.3872
HH [Human lymphoma]	GDSC1	-0.0034	2.2913	-0.0476	50.0404
CESS	GDSC1	0.0094	1.1137	0.009	49.8826
HT	GDSC1	0.0429	0.8752	0.0428	49.4641
L-428	GDSC1	0.0563	0.9501	0.0563	49.2963
AMO1	GDSC1	0.1564	1.3931	0.1552	48.048
P12-Ichikawa	GDSC1	0.1822	0.9014	0.1822	47.7226
HEL	GDSC1	0.2007	1.1113	0.2006	47.492
NOMO-1	GDSC1	0.2369	1.4324	0.2358	47.043
ROS-50	GDSC1	0.2508	1.6578	0.2472	46.8773
Raji	GDSC1	0.3005	1.1642	0.3005	46.2437
RPMI-8402	GDSC1	0.3108	1.1961	0.3108	46.115
RC-K8	GDSC1	0.3703	1.6476	0.3681	45.381
LAMA-84	GDSC1	0.3763	1.4506	0.3757	45.2987
KM-H2	GDSC1	0.384	1.2612	0.3839	45.2003
SU-DHL-6	GDSC1	0.4323	1.3928	0.4321	44.5973
Namalwa	GDSC1	0.4666	1.069	0.4666	44.167
P31/FUJ	GDSC1	0.5444	1.2787	0.5444	43.1953
Jiyoye	GDSC1	0.5988	1.9862	0.593	42.5458
KG-1	GDSC1	0.6749	1.8432	0.6729	41.5756
Sc-1	GDSC1	0.6809	2.1607	0.6712	41.5414
IM-9	GDSC1	0.8209	2.6888	0.7814	39.9522
SUP-T1	GDSC1	0.8264	2.1383	0.8205	39.7047
MC116	GDSC1	0.8483	2.2333	0.8398	39.4461
SU-DHL-4	GDSC1	0.8808	1.6824	0.8807	38.9906
HL-60	GDSC1	0.9153	1.9524	0.9139	38.5673
MOLM-13	GDSC1	1.0003	2.3987	0.989	37.5638
A3/Kawakami	GDSC1	1.0154	1.9874	1.0144	37.3136
EHEB	GDSC1	1.0226	2.7508	0.9877	37.4212
ME1	GDSC1	1.0483	2.229	1.0439	36.9229
Daudi	GDSC1	1.1061	2.2781	1.1015	36.2022
L-1236	GDSC1	1.1232	2.7427	1.0941	36.1349
BC-1	GDSC1	1.1995	2.1471	1.1982	35.0148
NB4	GDSC1	1.2095	2.1423	1.2083	34.889
SUP-M2	GDSC1	1.2586	1.9932	1.2584	34.2683
JSC-1	GDSC1	1.2995	2.7677	1.2764	33.8986
GDM-1	GDSC1	1.3318	2.8405	1.3042	33.5231
K-562	GDSC1	1.4291	1.9622	1.4291	32.1359
L-363	GDSC1	1.4487	1.9122	1.4487	31.8917
Karpas-422	GDSC1	1.4636	2.0065	1.4636	31.7053
JURL-MK1	GDSC1	1.6883	3.5011	1.5938	29.4932
WSU-DLCL2	GDSC1	1.7119	2.9341	1.694	28.7139
JVM-2	GDSC1	1.8105	3.5477	1.7171	27.963
Karpas-45	GDSC1	1.8523	3.5562	1.7607	27.4304
CTV-1	GDSC1	2.2889	3.158	2.2786	21.4533
HC-1	GDSC1	2.2953	3.4691	2.253	21.5783
L-540	GDSC1	2.4128	3.6972	2.3401	20.3082
RL	GDSC1	2.9953	3.6571	2.9745	12.6909
JVM-3	GDSC1	3.5578	4.2906	3.4157	6.5098
HDLM-2	GDSC1	3.7581	8.5983	1.4963	19.8379
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⏷ Show the Full List of 149 Cancer Drug Sensitivity Data of This Drug

Cancer Drug Sensitivity Data Curated from 4 Cell Line(s) in Aero Dig Tract Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
KYSE-50	GDSC1	-1.784	-0.2622	-1.7843	71.9558
HCE-4	GDSC1	-1.2673	-0.089	-1.2674	65.8008
TE-12	GDSC1	0.3438	1.7468	0.3396	45.7198
KYSE-220	GDSC1	1.5177	2.3179	1.5169	31.0337
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Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
COLO 684	GDSC1	-1.4053	0.7262	-1.4127	66.804
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Cancer Drug Sensitivity Data Curated from 30 Cell Line(s) in Autonomic Ganglia Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
SJNB-14	GDSC1	-4.4479	-2.0604	-4.4488	93.104
SJNB-17	GDSC1	-2.6322	-1.4147	-2.6322	82.3396
NB69	GDSC1	-2.1155	-1.06	-2.1155	76.3258
SJNB-13	GDSC1	-1.6548	-0.5861	-1.6548	70.6367
KP-N-YS	GDSC1	-1.3318	-0.1048	-1.3318	66.589
NB(TU)1	GDSC1	-1.2984	0.2544	-1.2991	66.0433
SJNB-6	GDSC1	-1.1557	0.1779	-1.156	64.3787
TGW	GDSC1	-0.9607	-0.0912	-0.9607	62.0063
Kelly	GDSC1	-0.9605	0.0084	-0.9605	62.0003
IMR-5	GDSC1	-0.9344	0.0329	-0.9344	61.6753
SK-N-MC-IXC	GDSC1	-0.9047	0.7603	-0.907	61.1652
SK-N-SH	GDSC1	-0.7618	1.0265	-0.7665	59.3634
GI-ME-N	GDSC1	-0.6781	1.3282	-0.6889	58.2476
SJNB-12	GDSC1	-0.4732	1.3923	-0.4819	55.8039
NH-12	GDSC1	-0.4108	0.5721	-0.4108	55.133
SJNB-7	GDSC1	-0.3127	0.6948	-0.3128	53.9074
CHP-126	GDSC1	-0.2959	0.5405	-0.2959	53.6981
MHH-NB-11	GDSC1	-0.0715	1.6312	-0.0795	50.8831
NB1	GDSC1	0.247	1.1936	0.2468	46.9137
CHP-212	GDSC1	0.4304	1.2906	0.4303	44.6207
SK-N-DZ	GDSC1	0.4322	1.1501	0.4322	44.598
SJNB-5	GDSC1	0.5673	1.8768	0.5635	42.9289
SJNB-10	GDSC1	0.8747	2.1566	0.8692	39.0995
SK-N-AS	GDSC1	0.9285	2.5412	0.9064	38.5217
SK-N-BE(2)-M17	GDSC1	1.1799	2.6166	1.1626	35.3573
SK-N-FI	GDSC1	1.341	2.0296	1.3409	33.2382
SiMa	GDSC1	1.4627	3.0286	1.4233	31.9616
LA-N-6	GDSC1	1.712	3.021	1.687	28.7574
GOTO	GDSC1	1.7962	3.8805	1.6264	28.6299
KP-N-YN	GDSC1	2.4068	3.628	2.3469	20.2989
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⏷ Show the Full List of 30 Cancer Drug Sensitivity Data of This Drug

Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Biliary Tract Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
HuCC-T1	GDSC1	-1.5638	-0.7389	-1.5638	69.5406
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Cancer Drug Sensitivity Data Curated from 49 Cell Line(s) in Breast Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
CAL-51	GDSC1	-3.4169	-2.8092	-3.4169	92.3152
MRK-nu-1	GDSC1	-3.2174	-1.9389	-3.2174	88.5334
CAL-85-1	GDSC1	-2.8486	-1.2075	-2.8488	83.7978
DU4475	GDSC1	-2.1537	-1.4077	-2.1537	76.9026
EFM-19	GDSC1	-2.0443	1.4358	-2.1125	70.9294
BT-474	GDSC1	-1.5578	-0.0142	-1.5583	69.208
ZR-75-30	GDSC1	-1.4887	-0.8287	-1.4887	68.608
T-47D	GDSC1	-1.4715	0.5246	-1.4759	67.7395
HCC2157	GDSC1	-1.4323	-0.4204	-1.4323	67.8815
HCC1599	GDSC1	-1.3745	-0.2379	-1.3745	67.1408
Evsa-T	GDSC1	-1.2279	0.2693	-1.2285	65.2078
JIMT-1	GDSC1	-1.0155	0.0892	-1.0155	62.6774
HCC2218	GDSC1	-0.9675	0.845	-0.9715	61.8609
COLO 824	GDSC1	-0.8313	0.8929	-0.8347	60.241
HCC1954	GDSC1	-0.7265	0.3065	-0.7265	59.0755
MDA-MB-157	GDSC1	-0.6376	1.5334	-0.6555	57.6785
AU565	GDSC1	-0.5172	0.424	-0.5173	56.4639
HCC1500	GDSC1	-0.486	2.3585	-0.5645	55.5352
CAL-148	GDSC1	-0.4789	0.8429	-0.4796	55.9696
HDQ-P1	GDSC1	-0.4195	1.2387	-0.4238	55.1891
MCF-7	GDSC1	-0.4004	0.572	-0.4005	55.0039
MFM-223	GDSC1	-0.3851	0.1593	-0.3851	54.8137
HCC1569	GDSC1	-0.3784	1.523	-0.3893	54.635
OCUB-M	GDSC1	-0.3728	1.3647	-0.379	54.5986
HCC38	GDSC1	-0.1781	0.8418	-0.1782	52.2257
MDA-MB-468	GDSC1	-0.0345	0.7278	-0.0345	50.4313
HCC1806	GDSC1	0.0237	0.7901	0.0237	49.7039
MDA-MB-330	GDSC1	0.2937	1.2867	0.2934	46.3302
HCC1187	GDSC1	0.3055	1.6185	0.3031	46.1908
MDA-MB-361	GDSC1	0.3254	1.2388	0.3253	45.9329
BT-549	GDSC1	0.3613	1.1872	0.3613	45.4839
EFM-192A	GDSC1	0.4053	3.9599	0.0879	45.7283
MDA-MB-415	GDSC1	0.4219	1.0792	0.4219	44.7258
HCC1937	GDSC1	0.4259	1.9982	0.4163	44.7185
CAMA-1	GDSC1	0.4264	4.9497	-0.1952	46.0119
MDA-MB-231	GDSC1	0.4644	1.5332	0.4637	44.1991
HCC70	GDSC1	0.6758	1.6094	0.6755	41.5545
CAL-120	GDSC1	0.7881	1.6578	0.7879	40.1497
MDA-MB-453	GDSC1	0.819	2.7151	0.7768	39.9888
Hs 578T	GDSC1	0.8405	3.8292	0.597	40.6059
HCC1419	GDSC1	0.8864	1.7847	0.886	38.9226
MDA-MB-436	GDSC1	0.8995	2.0616	0.8965	38.7743
MDA-MB-175-VII	GDSC1	0.9993	3.7181	0.7976	38.5509
BT-20	GDSC1	1.09	1.8529	1.0898	36.376
UACC-812	GDSC1	2.1314	3.6987	2.0345	23.9821
HCC1395	GDSC1	2.2592	3.7202	2.1686	22.3449
BT-483	GDSC1	2.5451	4.0688	2.3929	19.1888
HCC1428	GDSC1	2.6131	3.2667	2.6076	17.3709
UACC-893	GDSC1	4.9778	9.365	2.0823	11.6532
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⏷ Show the Full List of 49 Cancer Drug Sensitivity Data of This Drug

Cancer Drug Sensitivity Data Curated from 54 Cell Line(s) in Central Nervous System Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
KS-1 [Human Krukenberg tumour]	GDSC1	-4.2983	-0.5217	-4.3256	87.0625
Daoy	GDSC1	-2.7225	-2.1102	-2.7225	83.9965
8-MG-BA	GDSC1	-2.5782	-1.1931	-2.5782	81.4422
Onda 10	GDSC1	-1.9929	-0.8338	-1.9929	74.7661
YKG-1	GDSC1	-1.9452	-0.7769	-1.9453	74.1776
H4	GDSC1	-1.6805	-0.2037	-1.6808	70.746
ONS-76	GDSC1	-1.5614	-0.1246	-1.5617	69.3251
AM-38	GDSC1	-1.5433	-0.6798	-1.5433	69.2822
M059J	GDSC1	-1.54	-0.1097	-1.5403	69.0682
DBTRG-05MG	GDSC1	-1.2167	0.1829	-1.2171	65.1111
LNZTA3WT4	GDSC1	-0.9938	0.0428	-0.9938	62.4125
D-423MG	GDSC1	-0.7669	0.3536	-0.767	59.5756
Hs 683	GDSC1	-0.763	0.1321	-0.763	59.5355
SW1088	GDSC1	-0.7228	6.5726	-2.0295	54.8537
GI-1	GDSC1	-0.6959	0.6638	-0.6965	58.6653
SF295	GDSC1	-0.6313	2.1469	-0.6945	57.227
MOG-G-CCM	GDSC1	-0.5956	0.8577	-0.5969	57.4048
LN-229	GDSC1	-0.4941	0.7228	-0.4945	56.1666
SF126	GDSC1	-0.4387	-0.001	-0.4387	55.4843
D-542MG	GDSC1	-0.4224	1.2793	-0.4275	55.2166
A-172	GDSC1	-0.4062	0.3173	-0.4062	55.0773
U-118MG	GDSC1	-0.3736	1.6269	-0.3884	54.5532
MOG-G-UVW	GDSC1	-0.3331	1.3565	-0.3386	54.1171
CAS-1	GDSC1	-0.3197	1.9609	-0.3516	53.8279
Onda 11	GDSC1	-0.232	1.0595	-0.2329	52.8939
D-566MG	GDSC1	-0.1968	0.7211	-0.1968	52.4592
SF539	GDSC1	-0.119	0.6395	-0.119	51.4877
KALS-1	GDSC1	-0.0946	1.4053	-0.0979	51.1752
SNB-75	GDSC1	-0.0129	2.6182	-0.094	50.1501
SW1783	GDSC1	0.0307	1.3168	0.0294	49.6169
D283 Med	GDSC1	0.0432	1.0327	0.0431	49.4601
NMC-G1	GDSC1	0.2069	1.2317	0.2066	47.4147
U-251MG	GDSC1	0.2096	1.0711	0.2095	47.3807
SK-MG-1	GDSC1	0.2565	1.4443	0.2555	46.7975
D-392MG	GDSC1	0.2828	3.0383	0.1596	46.7473
T98G	GDSC1	0.2856	1.8702	0.2772	46.459
U-87MG ATCC	GDSC1	0.3174	1.0376	0.3174	46.0328
GB-1	GDSC1	0.331	1.8565	0.324	45.8889
42-MG-BA	GDSC1	0.5542	2.0368	0.546	43.1139
KNS-81-FD	GDSC1	0.5656	2.3784	0.5403	43.0488
YH-13	GDSC1	0.6697	3.879	0.3979	42.6752
D-247MG	GDSC1	0.8279	2.5536	0.8007	39.8018
D-336MG	GDSC1	0.8437	3.0692	0.7576	39.8978
GaMG	GDSC1	0.8954	1.7501	0.8951	38.8094
LN-18	GDSC1	0.9841	1.9191	0.9834	37.7028
D-263MG	GDSC1	1.0845	2.2779	1.0795	36.4745
Becker	GDSC1	1.2329	2.0338	1.2325	34.5909
DK-MG	GDSC1	1.3009	3.5587	1.1621	34.5614
LN-405	GDSC1	1.3206	2.0415	1.3204	33.4939
KNS-42	GDSC1	1.3859	2.8968	1.3559	32.8621
SF268	GDSC1	1.978	4.501	1.6387	27.4735
D-502MG	GDSC1	2.2217	3.3604	2.1892	22.4348
KINGS-1	GDSC1	2.3877	7.0046	1.0077	28.9425
PFSK-1	GDSC1	3.1077	5.575	2.3849	16.3612
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⏷ Show the Full List of 54 Cancer Drug Sensitivity Data of This Drug

Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Digestive System Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
ETK-1	GDSC1	0.5378	2.9467	0.4484	43.631
TGBC1TKB	GDSC1	0.677	1.6521	0.6765	41.5405
TGBC24TKB	GDSC1	2.5801	3.929	2.4692	18.4729
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Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Endometrium Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
MFE-319	GDSC1	-1.8052	-0.7958	-1.8052	72.5174
AN3-CA	GDSC1	-1.7897	-0.7881	-1.7897	72.3262
MFE-296	GDSC1	-0.6764	0.3338	-0.6764	58.4506
RL95-2	GDSC1	-0.3849	1.134	-0.3873	54.7797
KLE	GDSC1	-0.2018	1.0447	-0.2025	52.5182
MFE-280	GDSC1	1.4064	3.2727	1.3298	32.8911
ESS-1	GDSC1	1.4799	1.9672	1.4799	31.5011
EN	GDSC1	4.16	9.6583	1.303	19.5203
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⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug

Cancer Drug Sensitivity Data Curated from 25 Cell Line(s) in Kidney Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
LB1047-RCC	GDSC1	-1.6261	1.0151	-1.6482	68.5124
ACHN	GDSC1	-1.5612	-0.4557	-1.5612	69.4655
OS-RC-2	GDSC1	-1.3461	-0.0226	-1.3463	66.7364
786-O	GDSC1	-1.2866	-0.0595	-1.2867	66.0291
VMRC-RCZ	GDSC1	-0.9085	-0.2396	-0.9085	61.3559
VMRC-RCW	GDSC1	-0.8621	-0.0972	-0.8621	60.7761
KMRC-1	GDSC1	-0.8329	0.7306	-0.8345	60.3184
UO-31	GDSC1	-0.7282	0.2147	-0.7282	59.1002
Caki-1	GDSC1	-0.6736	1.3681	-0.6857	58.1767
769-P	GDSC1	-0.6122	0.1816	-0.6122	57.6526
RXF 393L	GDSC1	-0.3935	1.8318	-0.4196	54.7285
HA7-RCC	GDSC1	-0.1987	1.0516	-0.1994	52.4789
BB65-RCC	GDSC1	-0.0966	1.8378	-0.1132	51.1816
TK-10	GDSC1	0.1683	1.6232	0.1642	47.9068
SW13	GDSC1	0.264	1.3757	0.2634	46.7027
BFTC-909	GDSC1	0.4387	1.0991	0.4387	44.5166
LB2241-RCC	GDSC1	0.464	2.0346	0.4539	44.2465
CAL-54	GDSC1	0.578	2.6738	0.5267	43.0021
SW156	GDSC1	1.0771	3.3068	0.9692	37.1439
RCC10RGB	GDSC1	1.2961	2.4704	1.2894	33.8402
A-498	GDSC1	1.7284	12.8905	-2.456	41.9745
A-704	GDSC1	1.8395	2.6856	1.8366	27.0245
SN12C	GDSC1	2.0726	3.3753	2.0284	24.3736
KMRC-20	GDSC1	2.3252	2.9885	2.3228	20.9499
LB996-RCC	GDSC1	2.4915	3.5559	2.4502	19.1198
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⏷ Show the Full List of 25 Cancer Drug Sensitivity Data of This Drug

Cancer Drug Sensitivity Data Curated from 37 Cell Line(s) in Large Intestine Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
SW620	GDSC1	-2.8202	-1.3474	-2.8202	83.9227
HCT 15	GDSC1	-1.7353	0.8222	-1.7521	69.8531
RKO	GDSC1	-1.5949	-1.045	-1.5949	69.9366
NCI-H747	GDSC1	-1.1368	0.1693	-1.137	64.1514
HCT 116	GDSC1	-1.026	-0.2082	-1.026	62.8236
COLO205	GDSC1	-1.0205	0.3217	-1.0209	62.7008
LS123	GDSC1	-1.0029	0.2392	-1.003	62.5017
C2BBe1	GDSC1	-0.9918	0.6782	-0.994	62.2313
COLO 320HSR	GDSC1	-0.811	0.7934	-0.813	60.0348
SW626	GDSC1	-0.6968	0.7187	-0.6976	58.6673
HT-29	GDSC1	-0.6557	0.9377	-0.658	58.121
KM12	GDSC1	-0.4635	1.2092	-0.4679	55.7304
SW1417	GDSC1	-0.1136	1.504	-0.1191	51.4077
MDST8	GDSC1	0.0387	0.8465	0.0387	49.5158
SW48	GDSC1	0.1064	0.9737	0.1064	48.6698
LS411N	GDSC1	0.1993	2.9933	0.0773	47.7153
GP5d	GDSC1	0.2359	1.9831	0.222	47.0907
CaR-1	GDSC1	0.3532	1.3911	0.3528	45.5868
LoVo	GDSC1	0.4332	1.5504	0.4323	44.5901
LS180	GDSC1	0.5518	2.2116	0.5362	43.178
SNU-C1	GDSC1	0.7487	2.0127	0.7447	40.6648
RCM-1 [Human ESC]	GDSC1	0.7548	1.4722	0.7548	40.5652
HT-55	GDSC1	0.8007	1.7021	0.8004	39.9934
LS513	GDSC1	0.8353	1.9132	0.8337	39.5683
COLO 678	GDSC1	0.8388	1.8714	0.8376	39.5224
LS1034	GDSC1	1.096	1.9556	1.0955	36.3028
SW1463	GDSC1	1.3195	2.1082	1.3191	33.5093
SW948	GDSC1	1.609	6.4281	0.4812	35.7861
HT115	GDSC1	1.8282	2.8194	1.8209	27.1933
SW837	GDSC1	2.0417	2.9736	2.0334	24.531
T84	GDSC1	2.2714	3.3114	2.2474	21.7594
CCK-81	GDSC1	2.2907	4.2872	2.049	22.9659
HCC2998	GDSC1	2.6127	3.72	2.5523	17.7299
CL-11	GDSC1	2.6422	3.767	2.5747	17.4077
SNU-C2B	GDSC1	2.7767	4.0847	2.6409	16.1885
CW-2	GDSC1	3.9202	5.0461	3.4091	4.9576
NCI-H716	GDSC1	6.244	8.4929	3.2349	1.3536
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⏷ Show the Full List of 37 Cancer Drug Sensitivity Data of This Drug

Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Leukemia Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
MO-T	GDSC1	0.5275	1.3323	0.5275	43.4062
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Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Liver Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
SNU-398	GDSC1	-2.6156	0.0359	-2.6256	78.5979
HLE	GDSC1	-2.4944	-1.6834	-2.4944	81.103
JHH-7	GDSC1	-1.9933	-1.091	-1.9933	74.8771
Hep 3B2.1-7	GDSC1	-1.6186	-0.8109	-1.6186	70.2259
SNU-423	GDSC1	-1.4456	-0.1976	-1.4457	67.9922
JHH-4	GDSC1	-1.0091	-0.2022	-1.0091	62.6129
SK-HEP-1	GDSC1	-0.826	1.4162	-0.8438	59.8805
Hep-G2/C3A	GDSC1	-0.8152	0.2169	-0.8153	60.1838
JHH-2	GDSC1	-0.465	0.1819	-0.465	55.8128
SNU-449	GDSC1	-0.3698	1.758	-0.3908	54.4724
SNU-387	GDSC1	0.1586	3.2538	-0.0146	48.2372
Huh-7	GDSC1	0.3209	1.0831	0.3209	45.9888
JHH-6	GDSC1	0.5264	0.8341	0.5264	43.4202
JHH-1	GDSC1	0.9158	1.6889	0.9157	38.5531
HuH-1	GDSC1	2.7509	3.4144	2.7414	15.6734
SNU-475	GDSC1	3.1726	4.323	2.992	11.5686
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⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug

Cancer Drug Sensitivity Data Curated from 168 Cell Line(s) in Lung Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
NCI-H2009	GDSC1	-3.3934	-2.4765	-3.3934	91.3221
NCI-H1963	GDSC1	-2.8989	-1.557	-2.899	85.072
A-427	GDSC1	-2.8568	-1.729	-2.8568	85.0528
NCI-H2342	GDSC1	-2.6624	-0.913	-2.6627	81.5813
NCI-H1770	GDSC1	-2.3048	-1.4009	-2.3048	78.7274
IST-SL2	GDSC1	-2.2993	-1.2858	-2.2993	78.599
LB647-SCLC	GDSC1	-2.0608	-0.7004	-2.0609	75.4299
NCI-H1975	GDSC1	-1.9204	-0.5063	-1.9205	73.6942
NCI-H2085	GDSC1	-1.7486	-0.1749	-1.7491	71.4823
COR-L105	GDSC1	-1.7155	0.6066	-1.7249	70.0629
NCI-H1568	GDSC1	-1.6728	-0.5734	-1.6728	70.8509
SW1573	GDSC1	-1.627	0.4083	-1.6312	69.503
NCI-H64	GDSC1	-1.5232	-1.136	-1.5232	69.0399
NCI-H1563	GDSC1	-1.278	-0.0314	-1.2781	65.9171
NCI-H2087	GDSC1	-1.1543	0.2945	-1.1548	64.3223
DMS 273	GDSC1	-1.0661	0.1175	-1.0662	63.2978
NCI-H3122	GDSC1	-1.0655	-0.0282	-1.0655	63.3074
NCI-H810	GDSC1	-0.9661	1.2935	-0.9824	61.5233
NCI-H522	GDSC1	-0.9518	1.2815	-0.9673	61.3767
NCI-H727	GDSC1	-0.9232	1.0467	-0.9306	61.23
HCC44	GDSC1	-0.905	0.3404	-0.9052	61.2833
NCI-H1436	GDSC1	-0.8914	0.0517	-0.8914	61.1382
NCI-H358	GDSC1	-0.828	0.2119	-0.828	60.3428
NCI-H226	GDSC1	-0.8169	0.1798	-0.8169	60.2061
SBC-5	GDSC1	-0.7937	-0.2183	-0.7937	59.9215
NCI-H2405	GDSC1	-0.7861	0.1276	-0.7862	59.8246
SW1271	GDSC1	-0.7847	0.6546	-0.7855	59.7535
LCLC-97TM1	GDSC1	-0.7691	0.2617	-0.7691	59.6075
NCI-H2030	GDSC1	-0.7259	0.3549	-0.7259	59.066
LCLC-103H	GDSC1	-0.6924	2.5704	-0.8133	57.5257
SK-LU-1	GDSC1	-0.6801	1.1761	-0.6867	58.337
NCI-H2171	GDSC1	-0.6454	1.1096	-0.6502	57.9486
NCI-H2869	GDSC1	-0.6424	1.3692	-0.6538	57.8125
Lu-165	GDSC1	-0.6393	0.5467	-0.6395	57.9795
NCI-H292	GDSC1	-0.6365	0.4094	-0.6365	57.9512
COR-L23	GDSC1	-0.586	0.3468	-0.586	57.3231
Lu-134-A	GDSC1	-0.5796	0.8203	-0.5806	57.2142
NCI-H596	GDSC1	-0.576	0.2165	-0.576	57.1995
NCI-H211	GDSC1	-0.5605	0.5589	-0.5606	56.9993
SHP-77	GDSC1	-0.5158	0.1709	-0.5158	56.448
ABC-1	GDSC1	-0.4349	0.846	-0.4355	55.4241
NCI-H1836	GDSC1	-0.3943	0.8762	-0.3949	54.9182
ChaGo-K-1	GDSC1	-0.38	1.0175	-0.3813	54.7309
HCC33	GDSC1	-0.3765	1.353	-0.3825	54.6459
NCI-H650	GDSC1	-0.343	1.0413	-0.3443	54.272
Lu-135	GDSC1	-0.2676	1.2924	-0.2711	53.3211
NCI-H2196	GDSC1	-0.2511	0.8559	-0.2513	53.1364
NCI-H290	GDSC1	-0.2387	0.7073	-0.2387	52.983
NCI-H1694	GDSC1	-0.2147	0.9682	-0.2151	52.6807
BEN	GDSC1	-0.1735	3.5493	-0.44	51.7947
NCI-H2110	GDSC1	-0.1709	1.2873	-0.1734	52.126
NCI-H1355	GDSC1	-0.1462	0.9774	-0.1465	51.8265
NCI-H847	GDSC1	-0.0869	2.6904	-0.1829	50.9987
NCI-H1944	GDSC1	-0.0756	0.9344	-0.0757	50.9445
NCI-H2228	GDSC1	-0.0749	1.4808	-0.0794	50.9298
NCI-H345	GDSC1	-0.0277	2.0567	-0.0545	50.336
NCI-H196	GDSC1	0.0744	1.0416	0.0742	49.0708
EBC-1	GDSC1	0.0784	1.3351	0.0772	49.0215
NCI-H2347	GDSC1	0.0907	1.7696	0.0816	48.878
HOP-62	GDSC1	0.0924	1.1474	0.0921	48.8456
SBC-3	GDSC1	0.1018	1.1188	0.1016	48.7284
NCI-H1299	GDSC1	0.1238	1.2396	0.1233	48.4532
NCI-H520	GDSC1	0.136	1.119	0.1359	48.3
PC-14	GDSC1	0.1777	1.2957	0.1772	47.78
NCI-H2135	GDSC1	0.2016	1.5209	0.1994	47.4869
NCI-H748	GDSC1	0.3218	3.5087	0.1086	46.4604
Calu-3	GDSC1	0.3573	1.3135	0.3571	45.5352
PaCa-3	GDSC1	0.3664	1.2954	0.3663	45.4207
HOP-92	GDSC1	0.3918	1.7585	0.388	45.1198
NCI-H1650	GDSC1	0.3956	1.2617	0.3955	45.0553
NCI-H2803	GDSC1	0.4116	1.9413	0.4036	44.8901
LC-2/ad	GDSC1	0.4148	2.1999	0.3954	44.8926
NCI-H2591	GDSC1	0.4566	1.2419	0.4565	44.2931
A-549	GDSC1	0.4569	1.8527	0.4521	44.3113
NCI-H647	GDSC1	0.4644	2.1241	0.4505	44.2563
SK-MES-1	GDSC1	0.4829	2.9436	0.39	44.3029
RERF-LC-KJ	GDSC1	0.4909	2.8195	0.4163	44.1478
LC-1/sq	GDSC1	0.5289	3.8602	0.2491	44.2854
NCI-H2369	GDSC1	0.5381	1.1172	0.5381	43.2734
NCI-H1437	GDSC1	0.5701	2.229	0.5542	42.951
NCI-H460	GDSC1	0.6342	1.6766	0.6334	42.0768
NCI-H1092	GDSC1	0.6926	2.317	0.6759	41.4312
Lu-99A	GDSC1	0.6959	2.5169	0.6657	41.4563
NCI-H1869	GDSC1	0.6993	1.6895	0.6987	41.2619
NCI-H2081	GDSC1	0.7115	2.0533	0.706	41.1373
NCI-H2722	GDSC1	0.7212	1.4465	0.7212	40.9846
HCC15	GDSC1	0.7235	2.0372	0.7185	40.9847
NCI-H2141	GDSC1	0.7501	1.8997	0.7481	40.6355
NCI-H841	GDSC1	0.7629	1.5937	0.7628	40.4644
DMS 53	GDSC1	0.7712	2.3765	0.7538	40.4562
Ms-1	GDSC1	0.7727	2.2164	0.7631	40.3954
NCI-H3255	GDSC1	0.808	2.4724	0.786	40.0219
CAL-12T	GDSC1	0.8159	2.3723	0.8002	39.8902
NCI-H1781	GDSC1	0.8223	1.6724	0.8221	39.7222
HARA [Human squamous cell lung carcinoma]	GDSC1	0.8384	2.6007	0.8078	39.6889
NCI-H2170	GDSC1	0.9027	1.6716	0.9026	38.7172
LXF 289	GDSC1	0.961	3.9371	0.7004	39.2654
NCI-H2373	GDSC1	1.0363	1.9089	1.0358	37.0494
NCI-H1703	GDSC1	1.1351	2.5758	1.1187	35.9106
IA-LM	GDSC1	1.175	2.262	1.1718	35.3323
NCI-H1993	GDSC1	1.1812	2.2761	1.1777	35.2565
RERF-LC-MS	GDSC1	1.1921	2.9178	1.1493	35.3564
NCI-H1666	GDSC1	1.2683	3.7621	1.0802	35.2343
NCI-H526	GDSC1	1.2826	2.8138	1.255	34.1372
EPLC-272H	GDSC1	1.3121	2.2021	1.311	33.6058
NCI-H2804	GDSC1	1.3168	2.7001	1.2993	33.648
NCI-H187	GDSC1	1.3226	2.7301	1.3033	33.5873
NCI-H1435	GDSC1	1.3248	2.2459	1.3234	33.4483
COR-L95	GDSC1	1.343	2.565	1.3337	33.2704
NCI-H1734	GDSC1	1.4265	2.3729	1.4243	32.1825
Calu-6	GDSC1	1.4315	2.2718	1.4306	32.1116
COLO 668	GDSC1	1.4419	2.3741	1.4398	31.9896
NCI-H2818	GDSC1	1.5863	4.5947	1.1824	32.5939
Lu-139	GDSC1	1.6078	2.7822	1.5958	29.9779
NCI-H1623	GDSC1	1.7069	2.8177	1.6961	28.7315
NCI-H838	GDSC1	1.7888	4.3697	1.4766	29.6147
EKVX	GDSC1	1.8003	5.6177	1.0235	32.1322
NCI-H1915	GDSC1	1.844	3.1535	1.8129	27.1464
NCI-H661	GDSC1	1.8458	2.7897	1.8402	26.9624
NCI-H2444	GDSC1	1.8522	3.0623	1.8303	26.9858
NCI-H209	GDSC1	1.8901	3.4279	1.8246	26.7903
NCI-H1581	GDSC1	1.9089	2.7062	1.9066	26.1527
NCI-H2227	GDSC1	1.9782	4.5272	1.63	27.5283
NCI-H2595	GDSC1	2.0733	3.4836	2.0124	24.4727
LOU-NH91	GDSC1	2.1378	3.2047	2.1173	23.4072
NCI-H1048	GDSC1	2.1671	3.3173	2.1365	23.1053
UMC-11	GDSC1	2.1812	4.0907	1.9896	23.9892
Lu-65	GDSC1	2.2158	3.722	2.1211	22.9141
NCI-H322M	GDSC1	2.2614	3.4229	2.2234	21.9745
NCI-H1876	GDSC1	2.3321	3.0593	2.3278	20.8758
NCI-H441	GDSC1	2.3457	3.2843	2.3283	20.7891
COR-L88	GDSC1	2.4143	3.0839	2.4109	19.8427
NCI-H1688	GDSC1	2.426	3.5545	2.3802	19.9674
NCI-H69	GDSC1	2.4469	5.2836	1.8397	23.542
NCI-H2122	GDSC1	2.4665	3.3172	2.4521	19.2596
HCC78	GDSC1	2.5459	4.069	2.3938	19.1783
HCC827	GDSC1	2.6069	3.2066	2.6036	17.4339
RERF-LC-Sq1	GDSC1	2.6233	5.5436	1.9103	22.1422
NCI-H1648	GDSC1	2.7132	4.4937	2.4355	17.9663
LK-2	GDSC1	2.7159	5.4441	2.0491	20.7024
NCI-H2461	GDSC1	2.827	4.0881	2.6948	15.5361
NCI-H1651	GDSC1	2.8344	4.405	2.5982	16.1672
NCI-H1693	GDSC1	2.8756	4.0254	2.7659	14.7765
NCI-H2795	GDSC1	2.9306	8.3276	0.8911	26.9125
NCI-H1755	GDSC1	3.0476	6.5616	1.8591	20.4406
NCI-H446	GDSC1	3.2353	5.9998	2.3084	16.3453
CPC-N	GDSC1	3.3494	5.06	2.8633	11.637
NCI-H2023	GDSC1	3.4278	5.6096	2.6798	12.6807
NCI-H510A	GDSC1	3.5085	4.8094	3.1373	8.8217
NCI-H1155	GDSC1	3.5483	4.1044	3.475	6.1378
NCI-H1793	GDSC1	3.5758	4.108	3.5036	5.7873
NCI-H1304	GDSC1	3.595	4.6581	3.2932	7.2377
NCI-H2029	GDSC1	3.6456	4.8381	3.2585	7.2721
NCI-H1792	GDSC1	3.7281	5.1402	3.19	7.4465
NCI-H513	GDSC1	3.8169	4.8504	3.414	5.33
SBC-1	GDSC1	3.8969	6.7616	2.5324	11.9154
NCI-H2731	GDSC1	4.0736	7.463	2.3295	12.8082
NCI-H1838	GDSC1	4.296	6.2546	3.1089	6.0254
NCI-H82	GDSC1	4.3486	6.0174	3.2651	4.649
NCI-H1573	GDSC1	4.3494	6.4947	3.0305	6.4678
DMS 114	GDSC1	4.4746	8.1802	2.291	11.7162
NCI-H23	GDSC1	4.5176	7.0893	2.8626	7.2506
NCI-H2291	GDSC1	4.9886	7.5851	2.9492	5.309
DMS 79	GDSC1	5.1341	8.1983	2.7541	6.3727
IST-SL1	GDSC1	5.1524	11.2955	1.2624	16.4597
NCI-H720	GDSC1	5.5183	6.6969	3.6126	0.3842
NCI-H524	GDSC1	5.5596	7.3745	3.3672	1.455
NCI-H2172	GDSC1	5.5791	11.3445	1.546	13.4872
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⏷ Show the Full List of 168 Cancer Drug Sensitivity Data of This Drug

Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Lymphoma Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
CBTCi002-A	GDSC1	0.4354	1.9331	0.4282	44.5898
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Cancer Drug Sensitivity Data Curated from 23 Cell Line(s) in Oesophagus Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
KYSE-270	GDSC1	-1.849	-0.4187	-1.8492	72.8204
KYSE-450	GDSC1	-1.6759	0.3995	-1.6806	70.0107
TE-9	GDSC1	-1.4302	-0.4558	-1.4302	67.8602
KYSE-510	GDSC1	-1.3935	-0.9448	-1.3935	67.4191
TE-15	GDSC1	-1.188	0.4945	-1.1898	64.621
KYSE-140	GDSC1	-1.1185	0.0344	-1.1186	63.9552
KYSE-520	GDSC1	-0.9311	0.5459	-0.932	61.5572
COLO 680N	GDSC1	-0.8576	0.3073	-0.8577	60.7028
T.T	GDSC1	-0.7192	0.2383	-0.7192	58.9873
KYSE-410	GDSC1	-0.6712	0.7362	-0.6721	58.3511
TE-8	GDSC1	-0.399	0.5357	-0.399	54.9868
KYSE-180	GDSC1	-0.137	0.6195	-0.1371	51.713
TE-10	GDSC1	0.011	2.3173	-0.0349	49.8685
KYSE-150	GDSC1	0.2572	1.5462	0.2552	46.792
TE-5	GDSC1	0.3832	1.4208	0.3828	45.2119
TE-11	GDSC1	0.5589	1.6522	0.558	43.0188
OE21	GDSC1	0.5747	1.6311	0.5739	42.8208
KYSE-70	GDSC1	0.6026	1.3145	0.6026	42.4672
OE19	GDSC1	0.7051	1.3644	0.7051	41.1868
OE33	GDSC1	0.9392	1.8031	0.9389	38.262
TE-6	GDSC1	1.5741	3.0089	1.543	30.5185
TE-1	GDSC1	2.4031	3.5642	2.354	20.2749
EC-GI-10	GDSC1	4.9623	8.2208	2.6278	7.7497
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⏷ Show the Full List of 23 Cancer Drug Sensitivity Data of This Drug

Cancer Drug Sensitivity Data Curated from 25 Cell Line(s) in Ovary Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
IGROV-1	GDSC1	-3.1961	-1.2537	-3.1966	86.2146
TOV-112D	GDSC1	-2.5151	-1.8481	-2.5151	81.4108
TOV-21G	GDSC1	-2.0256	0.1876	-2.0307	73.6926
EFO-27	GDSC1	-1.6232	-0.504	-1.6232	70.23
OVCAR-3	GDSC1	-1.1567	0.6402	-1.1597	64.166
OC 314	GDSC1	-0.8995	0.1993	-0.8996	61.2318
OVCAR-8	GDSC1	-0.8436	0.4938	-0.844	60.5053
FU-OV-1	GDSC1	-0.4478	0.552	-0.4478	55.5954
OAW42	GDSC1	-0.2153	1.1911	-0.2171	52.6805
RMG-I	GDSC1	-0.1686	1.5565	-0.1763	52.0818
Caov-3	GDSC1	-0.1241	0.618	-0.1241	51.5507
OVCAR-5	GDSC1	0.0376	0.986	0.0375	49.5297
OVCAR-4	GDSC1	0.1317	1.5976	0.1276	48.3625
OVTOKO	GDSC1	0.2721	2.6941	0.1996	46.7762
OV-90	GDSC1	0.317	1.8886	0.3087	46.068
OAW28	GDSC1	0.5545	1.4139	0.5544	43.0689
OVISE	GDSC1	0.5779	1.1766	0.5779	42.7759
OVKATE	GDSC1	0.6351	1.2096	0.6351	42.0608
TYK-nu	GDSC1	0.7019	2.1902	0.6915	41.2834
ES-2	GDSC1	0.8118	1.4927	0.8118	39.8524
Caov-4	GDSC1	0.8487	2.2521	0.8396	39.4441
SK-OV-3	GDSC1	0.8537	3.3615	0.7172	40.0059
A2780	GDSC1	1.1374	3.3654	1.0235	36.4349
EFO-21	GDSC1	1.2476	2.1666	1.2464	34.4122
Kuramochi	GDSC1	1.4143	3.2693	1.3389	32.7859
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⏷ Show the Full List of 25 Cancer Drug Sensitivity Data of This Drug

Cancer Drug Sensitivity Data Curated from 30 Cell Line(s) in Pancreas Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
MZ-PC-1	GDSC1	-3.1948	-1.8076	-3.1948	87.9907
MIA PaCa-2	GDSC1	-1.7688	-0.0877	-1.7697	71.6113
Panc 03.27	GDSC1	-1.7547	-0.6653	-1.7547	71.8673
BxPC-3	GDSC1	-1.7209	0.4571	-1.727	70.3649
KP-4	GDSC1	-1.5615	-0.945	-1.5615	69.5182
Panc 10.05	GDSC1	-1.1429	-0.2645	-1.1429	64.2826
HuP-T4	GDSC1	-0.9899	0.7813	-0.9932	62.1565
Panc 02.03	GDSC1	-0.5697	-0.0279	-0.5697	57.1211
SW1990	GDSC1	-0.2997	1.3419	-0.3044	53.7103
CFPAC-1	GDSC1	-0.2741	0.6879	-0.2741	53.4253
PL4	GDSC1	-0.2319	1.3276	-0.2355	52.8774
Capan-1	GDSC1	-0.067	0.9961	-0.0672	50.8373
HPAC	GDSC1	0.036	0.9978	0.0359	49.5495
SU.86.86	GDSC1	0.1124	1.004	0.1123	48.5954
PaTu 8988t	GDSC1	0.2214	0.9284	0.2214	47.2325
KP-1N	GDSC1	0.2392	1.7301	0.234	47.0262
HPAF-II	GDSC1	0.3971	1.0468	0.3971	45.036
AsPC-1	GDSC1	0.4057	1.407	0.4054	44.93
SUIT-2	GDSC1	0.4982	0.9879	0.4982	43.7731
HuP-T3	GDSC1	0.5724	1.1573	0.5724	42.8455
Capan-2	GDSC1	0.5827	1.3662	0.5827	42.7163
KP-2	GDSC1	0.5925	1.0315	0.5925	42.5931
Panc 04.03	GDSC1	0.9646	1.9271	0.9638	37.9475
KP-3	GDSC1	1.2028	2.5983	1.1875	35.0591
Hs 766T	GDSC1	1.2095	2.4313	1.2022	34.9263
PaTu 8902	GDSC1	1.5356	1.9322	1.5356	30.8054
YAPC	GDSC1	1.5503	1.9522	1.5503	30.6218
Panc 08.13	GDSC1	1.6866	2.453	1.6857	28.9229
PSN1	GDSC1	4.0292	5.2512	3.3985	4.6389
DAN-G	GDSC1	6.1307	11.0635	2.0466	8.8767
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⏷ Show the Full List of 30 Cancer Drug Sensitivity Data of This Drug

Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Pleura Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
NCI-H2052	GDSC1	-1.0365	0.0419	-1.0366	62.9423
MPP 89	GDSC1	0.1099	2.2713	0.0728	48.6732
NCI-H28	GDSC1	0.3564	1.3621	0.3561	45.5466
IST-Mes1	GDSC1	0.8877	1.6551	0.8876	38.9039
NCI-H2452	GDSC1	3.5438	9.475	0.8736	24.3575
MSTO-211H	GDSC1	5.5485	7.8671	3.1535	2.7344
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⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug

Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Prostate Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
DU145	GDSC1	-2.1244	-1.1729	-2.1244	76.4847
VCaP	GDSC1	-0.5535	1.7466	-0.5802	56.6088
PC-3	GDSC1	0.0399	1.1132	0.0396	49.501
22Rv1	GDSC1	1.5397	3.5873	1.4154	31.5264
LNCaP clone FGC	GDSC1	4.2362	6.5741	2.9041	7.8187
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Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
A-253	GDSC1	-6.9437	-4.4792	-6.9438	99.0197
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Cancer Drug Sensitivity Data Curated from 56 Cell Line(s) in Skin Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
A101D	GDSC1	-4.1942	-2.8997	-4.1942	96.0097
MZ-MEL-7	GDSC1	-3.1075	-1.9339	-3.1075	87.6935
A-431	GDSC1	-2.7834	-1.8904	-2.7834	84.5445
RPMI-7951	GDSC1	-2.5937	-1.5203	-2.5937	82.0878
CHL-1	GDSC1	-2.402	-1.2757	-2.402	79.7475
Mel Ho	GDSC1	-2.3639	-1.6308	-2.3639	79.5182
COLO 679	GDSC1	-2.3546	0.7545	-2.386	74.8187
Hs 940.T	GDSC1	-2.314	-0.5027	-2.3148	77.6767
IGR-1	GDSC1	-2.1544	-1.3087	-2.1544	76.8904
HMV-II	GDSC1	-2.054	0.3629	-2.0629	73.5663
A-375	GDSC1	-1.628	-0.5854	-1.628	70.3106
IGR-37	GDSC1	-1.5787	-0.9567	-1.5787	69.7325
Hs 938.T	GDSC1	-1.465	-0.3175	-1.465	68.2621
Mel JuSo	GDSC1	-1.4412	-0.9412	-1.4412	68.0151
451Lu	GDSC1	-1.328	-0.2381	-1.328	66.5717
MZ-MEL-2	GDSC1	-1.2609	0.3796	-1.2622	65.5345
G-361	GDSC1	-1.0794	0.385	-1.0801	63.3934
G-mel	GDSC1	-1.0537	-0.1514	-1.0537	63.1676
SH-4	GDSC1	-0.9693	0.449	-0.9698	62.046
COLO 829	GDSC1	-0.9451	2.7973	-1.1223	59.6739
SK-MEL-30	GDSC1	-0.8795	0.1423	-0.8795	60.9865
HT-144	GDSC1	-0.8413	1.1384	-0.8497	60.2357
MeWo	GDSC1	-0.8159	2.3398	-0.913	58.9595
WM793	GDSC1	-0.6966	0.8207	-0.6981	58.6453
LOX-IMVI	GDSC1	-0.5334	0.7367	-0.5339	56.6525
WM35	GDSC1	-0.4029	0.9489	-0.4038	55.0195
M14	GDSC1	-0.3249	0.5472	-0.3249	54.0603
MMAc-SF	GDSC1	-0.312	0.3029	-0.312	53.8997
A2058	GDSC1	-0.0351	0.8727	-0.0352	50.4388
WM278	GDSC1	-0.0271	1.3033	-0.0287	50.3381
WM1552C	GDSC1	0.0309	1.1863	0.0303	49.6146
GAK	GDSC1	0.1568	2.1863	0.1284	48.0914
CP66-MEL	GDSC1	0.2457	2.4973	0.1944	47.0515
A-388	GDSC1	0.2662	1.8545	0.258	46.699
SK-MEL-24	GDSC1	0.3258	2.0944	0.3092	45.9848
UACC-62	GDSC1	0.4072	1.4481	0.4067	44.9125
RVH-421	GDSC1	0.4459	1.6507	0.4442	44.4347
CP50-MEL-B	GDSC1	0.7031	1.3634	0.7031	41.2115
SK-MEL-3	GDSC1	1.1426	2.4436	1.1332	35.7753
LB373-MEL-D	GDSC1	1.2148	2.1984	1.213	34.8263
IPC-298	GDSC1	1.2564	3.7531	1.0694	35.3733
SK-MEL-2	GDSC1	1.2951	1.9104	1.2951	33.811
WT2-iPS	GDSC1	1.4053	1.9995	1.4053	32.4338
UACC-257	GDSC1	1.4427	1.8771	1.4427	31.966
LB2518-MEL	GDSC1	1.5161	3.5807	1.3911	31.8228
DJM-1	GDSC1	2.063	3.2613	2.0325	24.4056
SK-MEL-1	GDSC1	2.1596	2.9006	2.1567	23.0233
IST-MEL1	GDSC1	2.2895	3.4433	2.2506	21.6288
COLO 783	GDSC1	3.1423	5.1431	2.6174	14.4641
SK-MEL-5	GDSC1	3.2897	8.8767	0.9471	25.0214
WM115	GDSC1	3.2999	8.9236	0.9329	25.0549
VMRC-MELG	GDSC1	3.3004	4.2533	3.155	9.7295
SK-MEL-28	GDSC1	3.3134	3.7638	3.2995	8.671
COLO 792	GDSC1	3.5312	4.4556	3.3189	7.3524
COLO 800	GDSC1	5.0998	9.5486	2.0803	11.31
EquiPSC Line K2	GDSC1	1.0485	2.7922	1.0109	37.1145
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⏷ Show the Full List of 56 Cancer Drug Sensitivity Data of This Drug

Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Small Intestine Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
HuTu 80	GDSC1	-1.1159	-0.3063	-1.1159	63.9463
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Cancer Drug Sensitivity Data Curated from 22 Cell Line(s) in Soft Tissue Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
SK-UT-1	GDSC1	-3.8232	-2.9524	-3.8232	95.3391
SW982	GDSC1	-3.6964	-1.4317	-3.6975	89.0401
SK-LMS-1	GDSC1	-2.8777	-2.1639	-2.8777	85.8444
A-204	GDSC1	-2.6856	-0.5996	-2.6873	80.928
Hs 633.T	GDSC1	-2.597	-2.0324	-2.597	82.4494
G-401	GDSC1	-2.0315	0.8533	-2.0578	72.2513
HT-1080	GDSC1	-1.8513	-0.1906	-1.852	72.6108
RD	GDSC1	-1.6439	-0.6245	-1.6439	70.5132
Rh30	GDSC1	-1.4328	0.2242	-1.4339	67.6085
SW872	GDSC1	-1.3967	-0.1518	-1.3968	67.3885
TE 441.T	GDSC1	-1.3271	2.1138	-1.4281	63.9662
EW-8	GDSC1	-1.3069	-0.3584	-1.3069	66.326
VA-ES-BJ	GDSC1	-1.2738	-0.1283	-1.2738	65.8876
MES-SA	GDSC1	-0.9706	0.9472	-0.9765	61.8351
G-402	GDSC1	-0.8487	1.2015	-0.859	60.2821
Rh41	GDSC1	-0.4873	0.0951	-0.4873	56.0907
KYM-1	GDSC1	-0.2374	0.9719	-0.2379	52.9636
MFH-ino	GDSC1	-0.2186	1.627	-0.2296	52.6852
GCT	GDSC1	-0.0693	1.3741	-0.072	50.8627
SW684	GDSC1	0.1834	0.9267	0.1834	47.7073
STS-0421	GDSC1	0.5764	1.6812	0.5753	42.8008
RKN	GDSC1	1.1521	2.1742	1.15	35.6118
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⏷ Show the Full List of 22 Cancer Drug Sensitivity Data of This Drug

Cancer Drug Sensitivity Data Curated from 27 Cell Line(s) in Stomach Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
GCIY	GDSC1	-2.7372	-1.5474	-2.7372	83.5882
HGC-27	GDSC1	-2.042	-0.9515	-2.042	75.4058
AGS	GDSC1	-1.4373	-0.8496	-1.4373	67.9657
MKN1	GDSC1	-1.0584	-0.1339	-1.0584	63.2247
MKN28	GDSC1	-0.8762	0.2013	-0.8763	60.9428
MKN45	GDSC1	-0.6555	2.4607	-0.7582	57.2449
RF-48	GDSC1	-0.6384	0.3556	-0.6385	57.9772
Fu97	GDSC1	-0.5286	0.342	-0.5286	56.6067
NUGC-3	GDSC1	-0.3291	1.1483	-0.3313	54.0918
IM95	GDSC1	-0.2131	0.7141	-0.2132	52.6636
ECC10	GDSC1	0.2422	1.9154	0.2313	47.0049
23132/87	GDSC1	0.3639	1.1132	0.3638	45.452
TMK-1	GDSC1	0.5118	2.1797	0.4967	43.6725
SNU-1	GDSC1	0.8131	1.6598	0.8129	39.8369
ECC12	GDSC1	0.9541	2.5847	0.93	38.2143
MKN7	GDSC1	1.0362	2.5781	1.0159	37.1686
NUGC-4	GDSC1	1.0775	2.4404	1.0664	36.5987
NCI-N87	GDSC1	1.0921	4.2489	0.7553	38.0655
TGBC11TKB	GDSC1	1.2651	3.3788	1.1591	34.8171
SNU-5	GDSC1	1.2988	1.9041	1.2988	33.7652
Hs 746.T	GDSC1	2.0862	2.923	2.0812	23.9538
OCUM-1	GDSC1	2.5575	3.3695	2.5428	18.1239
RERF-GC-1B	GDSC1	3.4974	5.6384	2.7317	11.9791
SCH	GDSC1	3.8003	4.8965	3.3761	5.6951
HSC-39	GDSC1	5.9562	7.3294	3.5533	0.3342
SNU-16	GDSC1	6.2314	7.3775	3.6348	0.0898
SNG-M	GDSC1	-1.3572	0.0869	-1.3576	66.8215
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⏷ Show the Full List of 27 Cancer Drug Sensitivity Data of This Drug

Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Thyroid Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
IHH-4	GDSC1	-3.2327	-2.5285	-3.2327	90.0588
ML-1 [Human leukemia]	GDSC1	-2.1196	-0.1322	-2.1217	75.1754
TT2609-C02	GDSC1	-1.7166	-0.718	-1.7166	71.4205
KMH-2	GDSC1	-1.2975	0.4656	-1.2997	65.8924
8305C	GDSC1	-1.1896	0.0728	-1.1897	64.8172
HTC-C3	GDSC1	-0.817	0.355	-0.8172	60.1966
B-CPAP	GDSC1	-0.5545	-0.0254	-0.5545	56.9316
K5	GDSC1	-0.4607	0.6189	-0.4608	55.7547
CAL-62	GDSC1	-0.4103	0.8733	-0.411	55.1174
CGTH-W-1	GDSC1	-0.3185	0.8865	-0.3189	53.9752
ASH-3	GDSC1	-0.1711	0.6754	-0.1711	52.1386
BHT-101	GDSC1	0.5374	1.1562	0.5374	43.2821
TT	GDSC1	1.0584	2.3964	1.0488	36.8283
8505C	GDSC1	1.4463	3.3347	1.3624	32.4392
FTC-133	GDSC1	1.5208	2.6545	1.5124	31.0424
WRO	GDSC1	1.5795	3.3518	1.503	30.7357
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⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug

Cancer Drug Sensitivity Data Curated from 41 Cell Line(s) in Upper Aerodigestive Tract Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
BB30-HNC	GDSC1	-2.5741	-1.0426	-2.5742	81.1177
SCC-9	GDSC1	-2.2854	-0.9542	-2.2854	78.1334
OSC-20	GDSC1	-2.1875	-1.2393	-2.1875	77.2629
HSC-2	GDSC1	-2.0436	-0.5854	-2.0438	75.1222
JHU-029	GDSC1	-2.0148	-0.6958	-2.0149	74.9158
BICR 31	GDSC1	-1.8636	-0.2606	-1.8641	72.8229
PCI-04B	GDSC1	-1.7375	-0.5581	-1.7375	71.6201
SCC-25	GDSC1	-1.5671	-0.2625	-1.5673	69.4677
HSC-3	GDSC1	-1.5487	-0.8944	-1.5487	69.3583
OSC-19	GDSC1	-1.4829	-0.9046	-1.4829	68.5359
BHY	GDSC1	-1.4487	0.1319	-1.4494	67.8577
KON	GDSC1	-1.3246	0.0385	-1.3249	66.4562
Ca9-22	GDSC1	-1.2706	-0.4706	-1.2706	65.8797
JHU-011	GDSC1	-1.258	0.0974	-1.2583	65.6367
HO-1-N-1	GDSC1	-1.134	0.7505	-1.1383	63.8295
PCI-06A	GDSC1	-0.8338	0.1253	-0.8338	60.4188
KOSC-2	GDSC1	-0.5011	1.8959	-0.5358	55.9418
SCC-4	GDSC1	-0.4259	0.4064	-0.4259	55.3238
SCC-15	GDSC1	-0.2348	0.6392	-0.2348	52.9347
BICR 78	GDSC1	-0.151	1.1858	-0.1524	51.8826
SAS	GDSC1	-0.1181	0.7559	-0.1181	51.4761
PCI-15A	GDSC1	-0.074	1.6416	-0.0824	50.9142
NCI-H3118	GDSC1	0.0971	1.4272	0.0952	48.7894
FaDu	GDSC1	0.2785	0.8221	0.2785	46.5187
HSC-4	GDSC1	0.3753	0.8751	0.3753	45.3084
HO-1-u-1	GDSC1	0.4252	1.3242	0.4251	44.6854
PE/CA-PJ15	GDSC1	0.4687	1.076	0.4687	44.1415
CAL-33	GDSC1	0.4787	1.1556	0.4787	44.0167
Detroit 562	GDSC1	1.1099	2.0762	1.1086	36.1342
JHU-022	GDSC1	1.2174	2.3403	1.213	34.8094
DOK	GDSC1	1.2248	3.83	1.016	35.8729
BICR 22	GDSC1	1.3388	2.3023	1.3368	33.2773
PCI-30	GDSC1	1.9273	3.2399	1.8912	26.1379
SKN-3	GDSC1	1.948	3.1686	1.921	25.8204
BICR 10	GDSC1	2.0588	3.1763	2.037	24.4027
CAL-27	GDSC1	2.3464	2.8831	2.3459	20.6733
PCI-38	GDSC1	2.4328	3.0859	2.4298	19.6091
UPCI-SCC-090	GDSC1	2.488	3.4641	2.4594	19.082
LB771-HNC	GDSC1	2.5912	9.2125	0.1433	31.928
SAT [Human HNSCC]	GDSC1	3.5983	5.1754	3.0513	9.0757
BB49-HNC	GDSC1	3.9397	18.6872	-3.3939	36.1089
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⏷ Show the Full List of 41 Cancer Drug Sensitivity Data of This Drug

Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Urinary Tract Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
SW1710	GDSC1	-4.2145	-2.6491	-4.2145	95.0671
J82	GDSC1	-2.6022	-0.6251	-2.6034	80.3767
639V	GDSC1	-2.0204	-1.2378	-2.0204	75.2374
RT-112	GDSC1	-1.5497	-0.6882	-1.5497	69.3613
HT-1197	GDSC1	-1.5161	0.7025	-1.5246	67.9698
BFTC-905	GDSC1	-1.4804	-0.5933	-1.4804	68.4949
647V	GDSC1	-1.4089	-0.6136	-1.4089	67.6083
SW780	GDSC1	-0.7101	0.5061	-0.7103	58.8591
TCCSUP	GDSC1	-0.5684	1.0564	-0.5715	57.036
UM-UC-3	GDSC1	0.0068	2.4118	-0.0487	49.919
HT-1376	GDSC1	0.0766	1.8606	0.0637	49.0568
CAL-29	GDSC1	1.1442	2.1327	1.1427	35.7067
T24	GDSC1	1.2662	3.5642	1.1233	35.0114
RT-4	GDSC1	1.726	3.4862	1.6373	28.9869
KU-19-19	GDSC1	1.8446	3.5038	1.7622	27.4675
5637	GDSC1	3.4988	4.9277	3.0727	9.3569
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⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug

Cancer Drug Sensitivity Data Curated from 29 Cell Line(s) in Urogenital System Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
NT2-D1	GDSC1	-2.6477	-0.9075	-2.648	81.4484
DoTc2 4510	GDSC1	-1.9359	-0.1562	-1.9369	73.4429
PA-1	GDSC1	-1.7161	-0.2694	-1.7163	71.1999
ME-180	GDSC1	-1.408	-0.5159	-1.408	67.5919
NCC-IT	GDSC1	-0.9034	0.0789	-0.9035	61.2876
Ca Ski	GDSC1	-0.829	0.5645	-0.8296	60.3132
SW756	GDSC1	-0.6162	-0.0012	-0.6162	57.702
SKN	GDSC1	-0.5947	0.4881	-0.5948	57.4285
SiSo	GDSC1	-0.5852	0.3941	-0.5853	57.3131
SW962	GDSC1	-0.5259	1.5095	-0.5398	56.3922
SW954	GDSC1	-0.4303	0.6902	-0.4305	55.3745
C-33 A	GDSC1	-0.277	1.8281	-0.2988	53.3563
NEC8	GDSC1	-0.2509	1.2469	-0.2536	53.1184
HT-3	GDSC1	-0.1015	1.2264	-0.1029	51.2653
HeLa	GDSC1	0.1608	0.7538	0.1608	47.9903
BPH-1	GDSC1	0.1695	1.5782	0.1663	47.8896
MS751	GDSC1	0.2111	1.3623	0.2103	47.3641
HEC-1	GDSC1	0.2266	2.1681	0.2022	47.2287
KGN	GDSC1	0.2824	1.4037	0.2817	46.4733
LB831-BLC	GDSC1	0.3727	1.4861	0.3719	45.345
C-4-I	GDSC1	0.4018	1.148	0.4018	44.9771
CAL-39	GDSC1	0.5349	1.5294	0.5344	43.3167
JEG-3	GDSC1	0.5509	1.1202	0.5509	43.1142
OMC-1 [Human cervical carcinoma]	GDSC1	0.8559	1.9589	0.854	39.3125
JAR	GDSC1	1.7189	2.9855	1.6973	28.65
SKG-IIIa	GDSC1	2.129	4.6447	1.7518	25.8704
OVMIU	GDSC1	2.3619	3.6263	2.2986	20.8826
SiHa	GDSC1	2.3833	3.0923	2.379	20.236
DSH1	GDSC1	2.8681	5.6901	2.093	19.6374
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⏷ Show the Full List of 29 Cancer Drug Sensitivity Data of This Drug

References

1	Structure of Mpro from COVID-19 virus and discovery of its inhibitors. Nature. 2020 Apr 9.
2	Shikonin suppresses small cell lung cancer growth via inducing ATF3-mediated ferroptosis to promote ROS accumulation. Chem Biol Interact. 2023 Sep 1;382:110588. doi: 10.1016/j.cbi.2023.110588. Epub 2023 Jun 1.
3	Functional and mechanistic investigation of Shikonin in scarring. Chem Biol Interact. 2015 Feb 25;228:18-27. doi: 10.1016/j.cbi.2014.12.037. Epub 2015 Jan 12.
4	Shikonin suppresses proliferation and induces cell cycle arrest through the inhibition of hypoxia-inducible factor-1 signaling. Chem Biol Interact. 2017 Aug 25;274:58-67. doi: 10.1016/j.cbi.2017.06.029. Epub 2017 Jul 3.