Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM0YOXQ)

Drug Name
SB-431542 Drug Info
Synonyms
301836-41-9; SB-431542; SB 431542; 4-(4-(benzo[d][1,3]dioxol-5-yl)-5-(pyridin-2-yl)-1H-imidazol-2-yl)benzamide; SB431542; UNII-E1557V1V0N; CHEMBL440084; E1557V1V0N; 4-[4-(1,3-BENZODIOXOL-5-YL)-5-(2-PYRIDINYL)-1H-IMIDAZOL-2-YL]BENZAMIDE; 4-(4-(1,3-Benzodioxole-5-yl)-5-(2-pyridyl)-1H-imidazole-2-yl)benzamide; SB 431542 hydrate; C22H16N4O3; 4-[4-(3,4-Methylenedioxyphenyl)-5-(2-pyridyl)-1H-imidazol-2-yl]benzamide; 4-(4-Benzo[1,3]dioxol-5-yl-5-pyridin-2-yl-1H-imidazol-2-yl)-benzamide
Cross-matching ID
PubChem CID
4521392
ChEBI ID
CHEMBL440084
CAS Number
CAS 301836-41-9
TTD Drug ID
D0C7WP

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Ribosome 2.13 0.00e+0 113/158 (71.52%) RPS5;MRPS2;RPL26;...
Pentose phosphate pathway 2.03 0.00e+0 25/30 (83.33%) GPI;PFKP;RPIA;...
DNA replication 1.91 1.76e-2 34/36 (94.44%) MCM2;MCM3;RFC5;...
Starch and sucrose metabolism 1.83 2.20e-2 25/36 (69.44%) GPI;GYG1;GYS1;...
Taurine and hypotaurine metabolism -1.65 4.30e-2 8/11 (72.73%) GAD1;CSAD;BAAT;...
Malaria -1.66 4.30e-2 44/50 (88%) CCL2;CD81;VCAM1;...
Osteoclast differentiation -1.67 4.10e-2 117/127 (92.13%) GRB2;IKBKB;FOS;...
Steroid biosynthesis -1.67 4.08e-2 19/20 (95%) TM7SF2;FDFT1;CYP27B1;...
Melanoma -1.69 3.56e-2 68/72 (94.44%) FGF2;EGF;FGF20;...
B cell receptor signaling pathway -1.69 3.80e-2 71/81 (87.65%) CD81;INPPL1;GRB2;...
Basal cell carcinoma -1.73 3.11e-2 41/63 (65.08%) BMP2;GADD45G;TCF7L1;...
Breast cancer -1.74 3.27e-2 119/147 (80.95%) FGF2;EGF;GRB2;...
Vibrio cholerae infection -1.74 3.45e-2 44/50 (88%) ATP6V0D1;ATP6V0C;ATP6V1A;...
Retinol metabolism -1.75 3.35e-2 41/68 (60.29%) CYP26A1;CYP3A5;HSD17B6;...
Protein digestion and absorption -1.76 3.58e-2 78/103 (75.73%) ATP1B3;COL4A2;PRSS1;...
Epithelial cell signaling in Helicobacter pylori infect... -1.76 3.73e-2 62/70 (88.57%) ATP6V0D1;ATP6V0C;ATP6V1A;...
Focal adhesion -1.77 3.77e-2 180/201 (89.55%) PAK6;PPP1R12A;COL4A2;...
Human papillomavirus infection -1.79 3.51e-2 284/331 (85.8%) FZD7;EP300;FZD2;...
Collecting duct acid secretion -1.80 4.10e-2 22/27 (81.48%) ATP6V0D1;ATP6V0C;ATP6V1A;...
Signaling pathways regulating pluripotency of stem cell... -1.80 4.70e-2 110/143 (76.92%) PIK3CD;PIK3R2;FZD3;...
Bladder cancer -1.91 1.96e-2 40/41 (97.56%) E2F3;CDKN2A;EGFR;...
TGF-beta signaling pathway -1.93 1.86e-2 81/94 (86.17%) BMPR2;SMAD4;HAMP;...
Prostate cancer -1.97 1.12e-2 93/97 (95.88%) EGF;CREBBP;GRB2;...
ECM-receptor interaction -2.01 0.00e+0 80/88 (90.91%) SDC4;LAMB3;LAMA3;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 12.5uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
1HAEo- CVCL_0128 Homo sapiens 10uM 24H
NL20 CVCL_0461 Homo sapiens 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Normal (Fibroblast)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HFL1 CVCL_4295 Homo sapiens 10uM 24H
IMR-90 CVCL_0347 Homo sapiens 10uM 24H
WI-38 CVCL_0579 Homo sapiens 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 1.11uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 0.37uM - 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 1.11uM - 10uM 6H, 24H