General Information of Drug (ID: DM10UHA)

Drug Name
BVB-808 Drug Info
Synonyms JAK2 tyrosine kinase inhibitors (cancer), Novartis; NVP-BSK-805
Cross-matching ID
PubChem CID
90480481
CAS Number
CAS 1414587-22-6
TTD Drug ID
D0N8CN

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name NES FDR q-val Tag % Leading Edge Genes
Steroid biosynthesis 2.54 0.00e+0 19/20 (95%) MSMO1;SQLE;DHCR24;...
Terpenoid backbone biosynthesis 2.43 0.00e+0 18/22 (81.82%) HMGCS1;IDI1;FDPS;...
Biosynthesis of unsaturated fatty acids 2.21 0.00e+0 21/27 (77.78%) SCD;FADS2;FADS1;...
PPAR signaling pathway 2.13 0.00e+0 66/74 (89.19%) HMGCS1;SCD;FADS2;...
Fatty acid degradation 1.89 7.41e-3 40/43 (93.02%) ACAT2;ACSL1;ALDH3A2;...
Butanoate metabolism 1.85 1.15e-2 23/28 (82.14%) HMGCS1;ACAT2;ALDH5A1;...
Lysosome 1.85 1.06e-2 115/128 (89.84%) TPP1;CTSK;NEU1;...
Fatty acid elongation 1.83 1.06e-2 19/27 (70.37%) ELOVL4;ELOVL5;TECR;...
Synthesis and degradation of ketone bodies 1.83 1.00e-2 9/10 (90%) HMGCS1;ACAT2
Pantothenate and CoA biosynthesis 1.81 1.06e-2 14/21 (66.67%) PANK3;ALDH3A2;DPYS;...
Synaptic vesicle cycle 1.80 1.01e-2 63/78 (80.77%) SLC1A1;ATP6V1G1;ATP6V1A;...
Oxidative phosphorylation 1.67 3.93e-2 93/133 (69.92%) ATP6V1G1;NDUFB1;NDUFA7;...
Valine, leucine and isoleucine degradation 1.66 3.91e-2 42/48 (87.5%) HMGCS1;ACAT2;ALDH3A2;...
Peroxisome 1.63 4.95e-2 72/82 (87.8%) IDH1;PHYH;ACSL1;...
Fatty acid biosynthesis 1.63 4.69e-2 16/18 (88.89%) FASN;ACSL1;ACSL3;...
Type I diabetes mellitus -1.66 4.83e-2 38/43 (88.37%) HLA-C;IL1B;LTA;...
Human T-cell leukemia virus 1 infection -1.67 4.92e-2 197/219 (89.95%) CDK2;SRF;SLC2A1;...
Amoebiasis -1.69 4.01e-2 99/102 (97.06%) COL4A1;PRKCA;LAMC3;...
Viral carcinogenesis -1.70 3.94e-2 149/203 (73.4%) SYK;ATF4;HRAS;...
Inflammatory bowel disease -1.70 4.24e-2 58/65 (89.23%) HLA-DRB1;IL18;IL12RB2;...
Homologous recombination -1.70 4.60e-2 35/41 (85.37%) RAD52;RPA2;NBN;...
Ribosome biogenesis in eukaryotes -1.77 2.72e-2 52/108 (48.15%) NXF1;IMP4;RIOK2;...
Pertussis -1.78 3.10e-2 64/76 (84.21%) IL1B;NLRP3;IL10;...
Cellular senescence -1.85 1.67e-2 139/156 (89.1%) HIPK2;KIR2DL4;PPP3CC;...
Morphine addiction -1.86 1.34e-2 80/91 (87.91%) GNG7;PDE3A;GABRA3;...
Dilated cardiomyopathy -1.88 8.36e-3 86/96 (89.58%) MYH6;ITGAV;ITGA9;...
Mismatch repair -1.92 0.00e+0 22/23 (95.65%) POLD2;RPA1;RFC4;...
Cell cycle -2.09 0.00e+0 110/124 (88.71%) MDM2;SMC1A;HDAC2;...
DNA replication -2.60 0.00e+0 34/36 (94.44%) POLD2;RPA1;RNASEH1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 1.11uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 1.11uM - 10uM 24H