Details of the Drug

General Information of Drug (ID: DM10UHA)

Drug Name
BVB-808
Synonyms JAK2 tyrosine kinase inhibitors (cancer), Novartis; NVP-BSK-805
Indication
Disease Entry ICD 11 Status REF
Solid tumour/cancer 2A00-2F9Z Investigative [1]
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 1 Molecular Weight (mw) 533.6
Logarithm of the Partition Coefficient (xlogp) 4.1
Rotatable Bond Count (rotbonds) 6
Hydrogen Bond Donor Count (hbonddonor) 2
Hydrogen Bond Acceptor Count (hbondacc) 9
Chemical Identifiers
Formula
C29H33F2N7O
IUPAC Name
7-[3,5-difluoro-4-(morpholin-4-ylmethyl)phenyl]-N-[4-[(3R,5S)-3,5-dimethylpiperazin-1-yl]phenyl]pyrrolo[2,3-d]pyrimidin-2-amine
Canonical SMILES
C[C@@H]1CN(C[C@@H](N1)C)C2=CC=C(C=C2)NC3=NC=C4C=CN(C4=N3)C5=CC(=C(C(=C5)F)CN6CCOCC6)F
InChI
InChI=1S/C29H33F2N7O/c1-19-16-37(17-20(2)33-19)23-5-3-22(4-6-23)34-29-32-15-21-7-8-38(28(21)35-29)24-13-26(30)25(27(31)14-24)18-36-9-11-39-12-10-36/h3-8,13-15,19-20,33H,9-12,16-18H2,1-2H3,(H,32,34,35)/t19-,20+
InChIKey
VIIPVCPPCBLRRL-BGYRXZFFSA-N
Cross-matching ID
PubChem CID
90480481
CAS Number
1414587-22-6
TTD ID
D0N8CN

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Janus kinase 2 (JAK-2) TTRMX3V JAK2_HUMAN Inhibitor [1]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 145 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JK1 CTRP2 -0.273 3.4798 -0.3555 42.2956
MEC1 CTRP2 2.7826 4.451 2.7621 21.7993
JM1 CTRP2 2.869 5.2184 2.7646 21.511
EoL-1 CTRP2 -1.8569 -0.8267 -1.8569 52.6399
SET-2 CTRP2 -1.7831 0.3562 -1.7838 52.1463
MV4-11 CTRP2 -1.3353 3.105 -1.4375 49.2043
M-07e CTRP2 -0.8127 3.2345 -0.8997 45.8303
F-36P CTRP2 -0.6206 3.1431 -0.6892 44.5469
MOLM-13 CTRP2 -0.5431 2.664 -0.5748 43.9626
MOLM-16 CTRP2 -0.0799 4.2891 -0.2548 41.2455
Ku812 CTRP2 -0.0362 4.4022 -0.2261 40.9963
SEM CTRP2 0.5357 2.9719 0.5204 36.7492
OCI-AML-5 CTRP2 0.5624 3.2255 0.5364 36.6057
Mono-Mac-1 CTRP2 0.612 7.3996 -0.3027 38.5563
JURL-MK1 CTRP2 0.9226 3.2688 0.9051 34.18
AML-193 CTRP2 1.1493 4.2918 1.0589 32.9095
Pfeiffer CTRP2 1.237 3.4006 1.2222 32.0771
MOLM-6 CTRP2 1.2558 3.5903 1.2326 31.9793
HEL CTRP2 1.2682 3.3004 1.2577 31.8549
NCO2 CTRP2 1.2901 2.6402 1.2896 31.6754
OCI-M1 CTRP2 1.5024 2.4084 1.5024 30.2592
Kasumi-1 CTRP2 1.6335 3.6417 1.6189 29.4348
TF-1 CTRP2 1.6499 3.352 1.6446 29.2944
LAMA-84 CTRP2 1.7104 3.2996 1.7068 28.8854
DND-41 CTRP2 1.7514 3.8388 1.7309 28.6689
NU-DUL-1 CTRP2 1.8153 3.6601 1.8045 28.2108
JVM-3 CTRP2 1.8272 4.5443 1.7481 28.3621
HDLM-2 CTRP2 1.8418 4.963 1.7015 28.4724
697 CTRP2 1.8441 2.9954 1.8438 27.9841
Ri-1 CTRP2 1.8518 6.3098 1.3937 29.4784
Peer CTRP2 1.8928 3.4573 1.8887 27.6723
Hs 611.T CTRP2 1.9027 4.1042 1.8711 27.6986
SU-DHL-6 CTRP2 1.9688 5.5272 1.7264 27.977
MOLT-13 CTRP2 1.9958 3.8196 1.9832 27.0143
BV-173 CTRP2 2.0128 4.4425 1.9566 27.0484
KYO-1 CTRP2 2.088 2.9852 2.088 26.358
L-428 CTRP2 2.1094 5.1884 1.9498 26.759
EM-2 CTRP2 2.1262 3.8788 2.1145 26.1427
CML-T1 CTRP2 2.1463 3.4614 2.1445 25.9757
MOTN-1 CTRP2 2.213 4.0741 2.1948 25.5862
MOLT-16 CTRP2 2.2266 3.6363 2.2233 25.4455
KE-37 CTRP2 2.2353 3.1046 2.2353 25.3768
DB CTRP2 2.2421 3.3107 2.2417 25.3325
OCI-AML-3 CTRP2 2.2476 3.2434 2.2474 25.2956
PF-382 CTRP2 2.2506 3.6319 2.2476 25.2849
NALM-6 CTRP2 2.2526 4.8797 2.1563 25.5879
SUP-T1 CTRP2 2.3169 3.8655 2.3098 24.8567
Ki-JK CTRP2 2.3364 3.7103 2.3331 24.7143
RS4;11 CTRP2 2.3408 4.9507 2.2401 25.0161
MHH-CALL-4 CTRP2 2.3436 5.1609 2.208 25.1178
P31/FUJ CTRP2 2.3438 4.3895 2.3095 24.769
SUP-HD1 CTRP2 2.3506 4.6328 2.2929 24.8035
KMS-11 CTRP2 2.3589 4.6727 2.2972 24.7617
Daudi CTRP2 2.368 3.1164 2.368 24.4927
A4/Fukuda CTRP2 2.373 3.0413 2.373 24.4593
KMS-20 CTRP2 2.3942 3.3317 2.394 24.3187
HH [Human lymphoma] CTRP2 2.4037 4.9901 2.3015 24.602
NU-DHL-1 CTRP2 2.4095 3.3313 2.4094 24.2167
Karpas-422 CTRP2 2.4259 3.1158 2.4259 24.107
TALL-1 [Human adult T-ALL] CTRP2 2.4279 4.6321 2.3748 24.273
Kasumi-2 CTRP2 2.4394 3.5983 2.4383 24.0208
Karpas-299 CTRP2 2.4625 3.0774 2.4625 23.863
U266B1 CTRP2 2.4633 3.395 2.4631 23.8582
HEL 92.1.7 CTRP2 2.4768 3.6184 2.4757 23.7715
KMS-12-BM CTRP2 2.4818 3.8084 2.4785 23.7457
RPMI-8402 CTRP2 2.4866 3.7415 2.4843 23.7103
SU-DHL-1 CTRP2 2.5056 2.8959 2.5056 23.5762
SUP-B15 CTRP2 2.532 4.3047 2.5115 23.4691
MOLP-8 CTRP2 2.5396 3.2963 2.5396 23.3494
HuT 78 CTRP2 2.5396 10.904 0.3095 30.6453
OCI-AML-2 CTRP2 2.5479 3.7839 2.5457 23.3015
KMS-26 CTRP2 2.5701 4.5403 2.5336 23.2689
KO52 CTRP2 2.5787 3.3262 2.5787 23.0888
CMK CTRP2 2.5875 3.9915 2.5818 23.0496
Mino CTRP2 2.6152 4.3299 2.5961 22.9097
KMS-21-BM CTRP2 2.6222 5.0356 2.5289 23.1164
Jurkat CTRP2 2.6262 4.6313 2.5841 22.9142
SR CTRP2 2.6565 3.5574 2.6563 22.5715
KCL-22 CTRP2 2.6584 6.507 2.2132 24.1199
SU-DHL-10 CTRP2 2.6616 3.1484 2.6616 22.5368
MOLT-3 CTRP2 2.6842 3.1663 2.6842 22.3859
KE-97 CTRP2 2.6897 4.506 2.6616 22.4437
GA-10 CTRP2 2.6923 3.3157 2.6923 22.3324
K-562 CTRP2 2.6929 3.7573 2.6919 22.3314
JJN-3 CTRP2 2.7091 4.6779 2.6668 22.3625
MM1.S CTRP2 2.7205 3.6286 2.7203 22.1448
P12-Ichikawa CTRP2 2.732 4.0847 2.7263 22.0868
JeKo-1 CTRP2 2.7493 4.3634 2.7329 22.0072
EHEB CTRP2 2.7617 5.8519 2.5126 22.7341
Granta-519 CTRP2 2.7714 4.8936 2.7083 22.0187
SU-DHL-8 CTRP2 2.7933 4.1894 2.7857 21.6846
KHM-1B CTRP2 2.798 4.4462 2.7785 21.6933
SU-DHL-4 CTRP2 2.8087 5.2749 2.6896 21.9639
SUP-M2 CTRP2 2.8376 3.6509 2.8375 21.3644
U-937 CTRP2 2.8434 3.8765 2.8424 21.3288
CA46 CTRP2 2.8435 4.4311 2.8265 21.3815
OPM-2 CTRP2 2.8524 3.9104 2.8511 21.2697
OCI-Ly19 CTRP2 2.8569 4.7615 2.8141 21.3798
SUP-T11 CTRP2 2.8883 4.7299 2.8504 21.1541
DEL CTRP2 2.9079 3.4972 2.9079 20.8957
KM-H2 CTRP2 2.9156 5.7682 2.7012 21.5872
L-540 CTRP2 2.9184 4.3341 2.9084 20.8594
SKM-1 CTRP2 2.9196 3.9177 2.9187 20.8208
KMS-34 CTRP2 2.9323 4.8106 2.8885 20.881
RL CTRP2 2.9397 4.3548 2.9294 20.7181
PL21 CTRP2 2.955 4.5775 2.9328 20.6563
WSU-DLCL2 CTRP2 2.9778 3.7739 2.9776 20.4307
Reh CTRP2 2.9836 4.0644 2.9816 20.398
SIG-M5 CTRP2 3.0249 4.5206 3.0089 20.17
A3/Kawakami CTRP2 3.0472 4.3241 3.0405 19.99
L-363 CTRP2 3.0699 4.5256 3.0552 19.8655
RCH-ACV CTRP2 3.0775 4.9521 3.0264 19.9385
NCI-H929 CTRP2 3.0902 4.438 3.0803 19.7144
NOMO-1 CTRP2 3.126 4.2677 3.1223 19.4552
MC116 CTRP2 3.134 4.1527 3.1322 19.3956
ME1 CTRP2 3.1598 5.4253 3.0412 19.624
HT CTRP2 3.2196 4.0249 3.2193 18.8202
RPMI-8226 CTRP2 3.2358 5.2004 3.1617 18.9631
MHH-CALL-3 CTRP2 3.2732 8.4711 2.1322 22.6279
GDM-1 CTRP2 3.3172 5.5798 3.1809 18.6382
NB4 CTRP2 3.3174 3.9004 3.3174 18.1677
LP-1 CTRP2 3.3535 5.0214 3.3109 18.0708
AMO1 CTRP2 3.3721 5.4949 3.2576 18.1956
KMS-27 CTRP2 3.3842 4.1388 3.3839 17.7238
THP-1 CTRP2 3.4451 5.0516 3.4044 17.4543
Raji CTRP2 3.5151 4.7905 3.5004 16.8999
SK-MM-2 CTRP2 3.5693 5.4303 3.4827 16.7852
MJ CTRP2 3.6326 7.9261 2.7362 19.3727
HPB-ALL CTRP2 3.6611 5.236 3.6113 16.0468
RPMI-6666 CTRP2 3.7015 5.2715 3.6496 15.7849
HD-MY-Z CTRP2 3.7347 5.1848 3.696 15.5182
Ci-1 CTRP2 3.7543 5.267 3.7066 15.4187
MOLP-2 CTRP2 3.8096 5.5218 3.7258 15.1751
EJM CTRP2 3.8996 5.7512 3.7768 14.7128
OCI-Ly10 CTRP2 3.9006 6.3801 3.6053 15.33
HL-60 CTRP2 4.1252 5.312 4.0952 12.8872
Namalwa CTRP2 4.2676 5.5128 4.2203 11.998
BL-70 CTRP2 4.3164 5.4712 4.2785 11.6407
OCI-Ly3 CTRP2 4.4145 6.3343 4.1787 11.6969
KMS-18 CTRP2 4.4186 5.6843 4.3539 11.0528
L-1236 CTRP2 4.5742 8.4842 3.4551 14.0931
P3HR-1 CTRP2 4.8767 8.9067 3.5528 12.9618
Karpas-620 CTRP2 5.4442 6.3624 5.2816 4.5923
REC-1 CTRP2 6.264 7.7926 5.3459 2.5387
Mono-Mac-6 CTRP2 6.7039 26.7722 -3.7752 29.9563
⏷ Show the Full List of 145 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 24 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE15 CTRP2 3.2029 7.3011 2.5281 21.3624
TE8 CTRP2 3.4777 5.4559 3.3792 17.4368
TE-5 CTRP2 2.7512 4.1253 2.7448 21.9609
TE-11 CTRP2 3.0553 5.0894 2.9847 20.1537
KYSE-140 CTRP2 3.3774 6.1405 3.1071 18.7161
TE-14 CTRP2 3.5492 5.6166 3.425 17.0507
KYSE-70 CTRP2 3.593 5.3472 3.5221 16.5729
TE-10 CTRP2 3.6013 5.1859 3.5541 16.4359
KYSE-410 CTRP2 3.6352 6.2503 3.3562 17.0337
KYSE-30 CTRP2 3.6759 5.1822 3.6339 15.9215
TE-6 CTRP2 3.7158 5.2352 3.6697 15.6698
TE-4 CTRP2 3.8438 5.4804 3.7699 14.9129
KYSE-180 CTRP2 3.8603 5.3218 3.8122 14.714
COLO 680N CTRP2 3.9999 6.653 3.6216 14.9788
TE-9 CTRP2 4.2517 5.382 4.2211 12.0464
TE-1 CTRP2 4.3458 5.8565 4.2384 11.6879
OE21 CTRP2 4.3809 5.7406 4.3019 11.354
OE33 CTRP2 4.5111 5.7838 4.4344 10.479
KYSE-150 CTRP2 4.5298 5.2098 4.5252 10.1059
KYSE-520 CTRP2 4.651 6.1962 4.4797 9.8881
OE19 CTRP2 4.9303 5.7226 4.8989 7.5292
EC-GI-10 CTRP2 5.2746 6.0893 5.1916 5.4203
KYSE-510 CTRP2 6.0262 11.5846 3.2591 11.6979
KYSE-450 CTRP2 9.2887 21.9723 0.5955 15.7545
⏷ Show the Full List of 24 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 37 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
N2a-PK1 CTRP2 4.6483 5.4906 4.6287 9.3673
HuP-T4 CTRP2 2.502 5.1857 2.3745 24.0351
Hs 766T CTRP2 2.7098 4.3442 2.6931 22.2716
PaTu 8988s CTRP2 2.7709 4.7747 2.7218 21.9743
MIA PaCa-2 CTRP2 2.8257 3.8517 2.8247 21.4469
Panc 10.05 CTRP2 2.9865 4.5816 2.9653 20.443
Panc 05.04 CTRP2 3.1368 5.2425 3.0487 19.6712
KP-3 CTRP2 3.2318 5.0973 3.1721 18.9403
BxPC-3 CTRP2 3.2904 5.6704 3.1321 18.8942
SNU-213 CTRP2 3.3353 4.4422 3.3307 18.0638
Panc 08.13 CTRP2 3.387 4.5819 3.3789 17.7311
QGP-1 CTRP2 3.6115 6.0467 3.3886 16.988
PK-59 CTRP2 3.6569 5.3076 3.5968 16.1102
CFPAC-1 CTRP2 3.7273 5.0837 3.699 15.5323
SW1990 CTRP2 3.7782 6.1687 3.5361 15.9489
SU.86.86 CTRP2 3.8503 4.8287 3.8439 14.6389
HPAF-II CTRP2 3.9609 6.2051 3.7248 14.7122
TCC-Pan2 CTRP2 3.9768 5.7867 3.8528 14.2034
PaTu 8902 CTRP2 4.1473 5.0044 4.1414 12.6584
HPAC CTRP2 4.1901 5.1395 4.1785 12.3925
KP-2 CTRP2 4.3006 6.3965 4.0348 12.5642
HuP-T3 CTRP2 4.3238 6.2357 4.1111 12.2145
SUIT-2 CTRP2 4.3642 5.4555 4.3316 11.304
L3.3 CTRP2 4.3671 4.9627 4.366 11.178
Capan-2 CTRP2 4.3852 5.9104 4.2685 11.4588
Panc 03.27 CTRP2 4.4101 5.4752 4.3779 10.9971
Capan-1 CTRP2 4.4132 5.889 4.3041 11.2456
YAPC CTRP2 4.4243 5.1193 4.4206 10.8055
KP-4 CTRP2 4.5383 5.6663 4.4863 10.2114
PaTu 8988t CTRP2 4.6491 5.055 4.6489 9.2961
SNU-410 CTRP2 4.806 6.5788 4.5169 9.2994
PSN1 CTRP2 4.8265 6.4606 4.5822 8.994
AsPC-1 CTRP2 4.8375 7.0763 4.3511 9.852
Panc 02.03 CTRP2 4.906 5.6868 4.8783 7.6783
DAN-G CTRP2 4.9508 25.2529 -4.4857 34.0891
PK-45H CTRP2 4.9808 5.9293 4.913 7.3204
Panc 04.03 CTRP2 5.3075 7.6887 4.5492 7.8684
⏷ Show the Full List of 37 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 51 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SH4 CTRP2 2.3118 3.8451 2.3052 24.8891
Hs 934.T CTRP2 0.6476 3.9443 0.5676 36.2077
Hs 940.T CTRP2 1.8782 3.7391 1.8659 27.7972
COLO 792 CTRP2 2.417 3.2517 2.4169 24.1666
UACC-257 CTRP2 2.4314 2.9439 2.4314 24.0704
Mel Ho CTRP2 2.4925 3.7014 2.4908 23.669
Hs 852.T CTRP2 2.5328 4.2239 2.5169 23.4479
SK-MEL-24 CTRP2 2.5446 3.0419 2.5446 23.3164
G-361 CTRP2 2.5506 3.521 2.5503 23.2772
A101D CTRP2 2.5954 3.0061 2.5954 22.9779
Hs 688(A).T CTRP2 2.6164 3.1284 2.6164 22.8379
IGR-1 CTRP2 2.6727 3.1868 2.6727 22.4627
Hs 294T CTRP2 2.8383 3.5162 2.8383 21.3596
IGR-37 CTRP2 2.8468 3.4301 2.8468 21.303
RPMI-7951 CTRP2 3.0012 4.1964 2.9971 20.288
HT-144 CTRP2 3.0447 4.451 3.033 20.0237
WM983B CTRP2 3.1113 5.6559 2.9405 20.1304
K029AX CTRP2 3.1668 4.7012 3.1445 19.2456
Malme-3M CTRP2 3.2468 6.3832 2.8924 19.8898
Hs 936.T CTRP2 3.2803 4.0981 3.2799 18.4162
COLO 800 CTRP2 3.3669 5.2143 3.3 18.065
IGR-39 CTRP2 3.4234 5.1164 3.3737 17.6296
IPC-298 CTRP2 3.4801 5.0347 3.4433 17.2078
MeWo CTRP2 3.5039 5.2681 3.4388 17.1464
A2058 CTRP2 3.5071 4.7622 3.4938 16.9483
Mel JuSo CTRP2 3.513 5.095 3.4714 17.0051
Hs 895.T CTRP2 3.5953 5.1766 3.549 16.473
MDA-MB-435S CTRP2 3.6086 5.296 3.5468 16.4376
SK-MEL-1 CTRP2 3.6298 4.6306 3.6252 16.1018
A-375 CTRP2 3.7795 4.7252 3.7751 15.1038
LOX-IMVI CTRP2 3.7798 5.1798 3.7443 15.2068
SK-MEL-30 CTRP2 3.8541 4.3599 3.8541 14.5919
Hs 944.T CTRP2 3.9012 5.705 3.7886 14.666
WM88 CTRP2 4.111 5.5067 4.0532 13.0775
WM1799 CTRP2 4.2097 5.6375 4.1367 12.4732
COLO 741 CTRP2 4.277 5.8738 4.1593 12.1827
SK-MEL-3 CTRP2 4.3079 5.5766 4.2535 11.7541
WM793 CTRP2 4.3111 5.7871 4.2163 11.8743
WM115 CTRP2 4.3657 4.9362 4.3649 11.1864
SK-MEL-31 CTRP2 4.451 5.1495 4.4468 10.6294
Hs 839.T CTRP2 4.4985 8.9096 3.1826 15.3718
COLO 829 CTRP2 4.5561 7.1254 4.036 11.8386
SK-MEL-5 CTRP2 4.5638 5.035 4.5634 9.8651
UACC-62 CTRP2 4.6225 5.0715 4.6221 9.4742
WM266-4 CTRP2 4.6305 5.0112 4.6304 9.4196
SK-MEL-28 CTRP2 4.6435 5.0133 4.6434 9.3332
WT2-iPS CTRP2 5.0499 6.0903 4.9462 6.9897
SK-MEL-2 CTRP2 5.17 5.856 5.1341 5.9483
CJM [Human melanoma] CTRP2 5.2562 5.9201 5.2147 5.3941
HMCB CTRP2 5.2953 5.8673 5.2676 5.0852
RVH-421 CTRP2 9.0668 24.5937 -0.8478 20.0997
⏷ Show the Full List of 51 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 14 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SK-N-FI CTRP2 2.1579 3.0648 2.1579 25.8925
SK-N-DZ CTRP2 2.3224 3.0835 2.3224 24.7964
SK-N-SH CTRP2 2.4185 3.2072 2.4185 24.1562
Kelly CTRP2 2.443 3.801 2.4394 24.0052
NH-6 CTRP2 2.5749 3.1582 2.5749 23.114
IMR-32 CTRP2 2.6238 3.0375 2.6238 22.7888
SK-N-BE(2) CTRP2 2.7593 4.8753 2.6977 22.0944
MHH-NB-11 CTRP2 2.8012 4.1412 2.7953 21.6262
SK-N-AS CTRP2 2.8799 4.231 2.8728 21.106
CHP-126 CTRP2 3.1217 4.2541 3.1182 19.4831
KP-N-SI9s CTRP2 3.1443 4.9357 3.099 19.4738
CHP-212 CTRP2 3.2793 4.8583 3.2493 18.5224
NB1 CTRP2 4.3689 5.5874 4.3173 11.3382
KP-N-YN CTRP2 5.598 6.631 5.3286 3.9981
⏷ Show the Full List of 14 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 7 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-1079 CTRP2 1.6393 3.4548 1.6313 29.3742
HuH-28 CTRP2 2.8367 4.0608 2.8332 21.3818
SNU-478 CTRP2 3.5039 5.0103 3.4709 17.0364
HuCC-T1 CTRP2 3.5437 4.3643 3.5428 16.663
SNU-308 CTRP2 4.3625 5.3137 4.3451 11.2635
SNU-869 CTRP2 4.4598 5.979 4.3325 11.0003
SNU-1196 CTRP2 4.4893 5.238 4.4823 10.3836
⏷ Show the Full List of 7 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 15 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Hs 888.T CTRP2 2.3172 3.2826 2.317 24.832
A-673 CTRP2 2.4878 3.0176 2.4878 23.6946
Hs 822.T CTRP2 2.5789 3.2117 2.5789 23.0879
SK-N-MC CTRP2 2.5895 2.9064 2.5895 23.0171
SK-ES-1 CTRP2 2.7367 4.0032 2.733 22.0487
U2OS CTRP2 2.9374 4.7076 2.904 20.8116
MHH-ES-1 CTRP2 3.1208 4.7759 3.0904 19.5797
SW1353 CTRP2 3.3998 4.0205 3.3997 17.6189
SaOS-2 CTRP2 3.4145 5.3988 3.3213 17.839
G-292 clone A141B1 CTRP2 3.5655 5.1181 3.5243 16.654
CAL-78 CTRP2 3.7443 5.5853 3.643 15.6711
MG-63 CTRP2 4.0142 5.316 3.9769 13.6515
TC71 CTRP2 4.0597 9.3877 2.5261 19.0505
SJSA-1 CTRP2 4.2662 5.544 4.2139 12.0247
HOS CTRP2 5.2892 7.249 4.7368 7.1517
⏷ Show the Full List of 15 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 71 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Hs 578Bst CTRP2 2.1935 8.7177 0.8984 29.9798
DU4475 CTRP2 2.737 3.3431 2.737 22.0344
AU565 CTRP2 2.78 4.7523 2.7339 21.9034
Hs 578T CTRP2 2.7834 3.755 2.7829 21.7268
HCC1395 CTRP2 2.9957 4.6632 2.9689 20.4009
CAL-51 CTRP2 2.9961 4.3858 2.986 20.342
HCC1143 CTRP2 3.0478 5.9201 2.8073 20.8008
SK-BR-3 CTRP2 3.0961 4.6513 3.0745 19.7144
CAMA-1 CTRP2 3.1717 6.5016 2.7735 20.5481
HCC2218 CTRP2 3.2685 4.5681 3.2578 18.5293
CAL-148 CTRP2 3.3354 4.6918 3.3203 18.0984
MDA-MB-468 CTRP2 3.4123 4.93 3.3824 17.6361
HCC1954 CTRP2 3.4206 5.3059 3.3435 17.7427
HMC-1-8 CTRP2 3.5019 4.2498 3.5015 16.9398
CAL-85-1 CTRP2 3.5872 5.5173 3.4861 16.7164
MDA-MB-415 CTRP2 3.6389 5.2829 3.5811 16.2219
MDA-MB-453 CTRP2 3.6636 4.9137 3.6465 15.9184
BT-474 CTRP2 3.8065 4.5027 3.806 14.911
MDA-MB-231 CTRP2 3.8356 5.6386 3.7314 15.0734
HCC1500 CTRP2 3.8914 5.7083 3.7772 14.737
MCF-7 CTRP2 3.9602 5.7025 3.8533 14.2534
T-47D CTRP2 3.9745 5.8156 3.8435 14.2434
KPL-1 CTRP2 4.1104 5.1903 4.0916 12.9478
EFM-192A CTRP2 4.1282 6.3108 3.8748 13.6637
HCC1806 CTRP2 4.1896 5.571 4.127 12.5706
HCC1428 CTRP2 4.3932 16.4562 -0.5944 28.1884
ZR-75-1 CTRP2 4.3988 5.4826 4.3649 11.0778
CAL-120 CTRP2 4.4157 5.3785 4.3949 10.9206
BT-549 CTRP2 4.4931 5.6917 4.433 10.5406
HCC38 CTRP2 4.5152 5.8763 4.4183 10.523
HCC1937 CTRP2 4.5351 5.9306 4.4269 10.4307
JIMT-1 CTRP2 4.5537 5.1449 4.5516 9.9383
MDA-MB-361 CTRP2 4.5783 31.8262 -8.0878 38.3932
HCC202 CTRP2 5.041 6.0262 4.9543 6.9876
HCC1419 CTRP2 5.1217 6.2387 4.9784 6.6582
ZR-75-30 CTRP2 5.2475 31.7237 -7.4652 36.8238
MDA-MB-157 CTRP2 5.2893 6.3133 5.1339 5.5912
BT-20 CTRP2 5.4818 6.081 5.4201 3.9651
BT 231 CTRP2 2.4268 3.5618 2.4259 24.1038
BT 228 CTRP2 2.4347 2.939 2.4347 24.0485
BT 239 CTRP2 2.4499 2.9828 2.4499 23.9471
BT 416 CTRP2 2.4705 2.9559 2.4705 23.8097
BT 428 CTRP2 2.5239 3.1145 2.5239 23.4538
BT147 CTRP2 2.5248 3.0638 2.5248 23.448
BT 131 CTRP2 2.5291 3.0156 2.5291 23.4191
BT 271 CTRP2 2.5381 3.027 2.5381 23.3595
BT 232 CTRP2 2.5737 2.99 2.5737 23.122
BT 286 CTRP2 2.5771 3.0483 2.5771 23.0994
BT 504 CTRP2 2.5789 2.9207 2.5789 23.0875
BT 139 CTRP2 2.6328 3.2489 2.6328 22.7283
BT 172 CTRP2 2.6406 3.0773 2.6406 22.6763
BT 422 CTRP2 2.6786 3.59 2.6783 22.4245
BT 440 CTRP2 2.6799 3.4288 2.6798 22.4151
BT 340 CTRP2 2.6978 3.159 2.6978 22.2957
BT 248 CTRP2 2.7639 3.4123 2.7639 21.8549
BT 112 CTRP2 2.839 4.0854 2.8351 21.3679
BT 330 CTRP2 2.8539 3.5804 2.8539 21.2554
BT 333 CTRP2 2.8623 3.4537 2.8623 21.1995
BT 444 CTRP2 2.9289 3.7406 2.9287 20.7567
BT 216 CTRP2 2.9854 3.9202 2.9847 20.3819
BT 359 CTRP2 3.0416 4.2321 3.0374 20.0192
BT 245 CTRP2 3.0703 4.0451 3.0692 19.8174
BT 482 CTRP2 3.0969 4.0231 3.0961 19.6393
BT 159 CTRP2 3.3419 3.8834 3.3419 18.0047
BT 498 CTRP2 4.0935 5.2931 4.0636 13.0981
BT 328 CTRP2 4.2203 5.5762 4.1592 12.3608
BT164 CTRP2 4.5348 4.9896 4.5345 10.0582
BT 145 CTRP2 4.6844 5.2263 4.6824 9.0671
BT 320 CTRP2 4.7432 6.3527 4.5296 9.4321
BT 224 CTRP2 4.8263 5.3637 4.823 8.1261
BT 179 CTRP2 5.3143 5.8529 5.2905 4.9451
⏷ Show the Full List of 71 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Tongue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
YD-38 CTRP2 3.4842 4.5664 3.4787 17.0748
Cancer Drug Sensitivity Data Curated from 44 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KG-1-C CTRP2 1.1662 4.2961 1.0763 32.7957
SF539 CTRP2 2.4355 3.4102 2.4353 24.0437
D283 Med CTRP2 2.4757 3.1759 2.4757 23.775
Hs 683 CTRP2 2.5415 2.9764 2.5415 23.3369
42-MG-BA CTRP2 2.7233 21.5897 -4.6441 38.7238
CAS-1 CTRP2 2.8092 3.3843 2.8092 21.5533
LN-229 CTRP2 3.1438 4.2493 3.1407 19.3344
GOS-3 CTRP2 3.2267 4.979 3.1814 18.9252
M059K CTRP2 3.2485 4.5964 3.2358 18.669
SF268 CTRP2 3.2855 4.7356 3.2656 18.4471
LN-18 CTRP2 3.2899 3.8748 3.2899 18.3507
KNS-60 CTRP2 3.291 4.3233 3.2883 18.3526
A-172 CTRP2 3.3017 5.1948 3.233 18.5056
SW1088 CTRP2 3.3489 4.7471 3.3307 18.0189
SNU-1105 CTRP2 3.4066 4.6359 3.3967 17.6065
SNU-466 CTRP2 3.4857 4.0043 3.4857 17.0461
GB-1 CTRP2 3.4997 5.1666 3.4485 17.1265
SNU-201 CTRP2 3.6698 4.8859 3.6549 15.8697
KNS-81 CTRP2 3.6866 4.3512 3.6864 15.7086
SNB-75 CTRP2 3.695 5.8121 3.5399 16.1894
U-251MG CTRP2 3.8771 4.9014 3.8683 14.4683
U-118MG CTRP2 3.8818 5.786 3.7495 14.8652
NMC-G1 CTRP2 3.9332 5.4075 3.8779 14.2531
SF126 CTRP2 3.9615 5.4867 3.8957 14.1009
SNU-626 CTRP2 4.2189 5.4349 4.1795 12.2954
SNU-489 CTRP2 4.237 5.1693 4.2252 12.0809
ONS-76 CTRP2 4.2524 5.5028 4.2056 12.0976
GaMG CTRP2 4.297 5.5982 4.2381 11.8427
DK-MG CTRP2 4.329 5.4949 4.2887 11.5647
Daoy CTRP2 4.332 5.5509 4.2836 11.573
YKG-1 CTRP2 4.3452 5.4155 4.3164 11.4176
GMS-10 CTRP2 4.3794 4.9838 4.3781 11.0965
KALS-1 CTRP2 4.3933 6.2263 4.1898 11.7188
DBTRG-05MG CTRP2 4.3941 5.7368 4.3171 11.259
YH-13 CTRP2 4.4227 5.5221 4.3851 10.9316
U-87MG ATCC CTRP2 4.5223 5.0832 4.521 10.1447
TM-31 CTRP2 4.575 6.2921 4.3669 10.5286
KNS-42 CTRP2 4.5955 5.7798 4.5268 9.8891
SF295 CTRP2 4.8205 5.4633 4.8117 8.1836
CCF-STTG1 CTRP2 5.0312 5.9037 4.9737 6.9486
T98G CTRP2 5.038 6.3958 4.8334 7.4424
SW1783 CTRP2 5.1233 8.2918 4.084 10.2085
Becker CTRP2 5.2867 8.4664 4.1557 9.5329
8-MG-BA CTRP2 5.3612 9.4708 3.7331 11.1138
⏷ Show the Full List of 44 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 22 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JHUEM-2 CTRP2 2.2607 3.448 2.2597 25.2107
JHUEM-7 CTRP2 2.7191 4.3793 2.7008 22.2149
RL95-2 CTRP2 2.8661 4.138 2.8614 21.1899
HEC-1-A CTRP2 3.0466 4.3869 3.0377 20.0013
HEC-1-B CTRP2 3.1044 5.0004 3.0491 19.7739
MFE-296 CTRP2 3.3986 5.0793 3.3519 17.7847
JHUEM-3 CTRP2 3.6132 6.0804 3.3812 17.0094
HEC-151 CTRP2 3.7206 5.3273 3.662 15.6807
HEC-251 CTRP2 3.8113 5.1963 3.7758 14.9973
AN3-CA CTRP2 3.9163 5.9188 3.755 14.7386
HEC-59 CTRP2 3.9766 5.402 3.9251 13.9508
HEC-6 CTRP2 4.2613 5.4424 4.2236 12.007
JHUEM-1 CTRP2 4.2826 5.445 4.246 11.8616
EFE-184 CTRP2 4.3374 5.6347 4.2752 11.5851
ESS-1 CTRP2 4.3782 5.424 4.3503 11.1946
HEC-108 CTRP2 4.4344 4.9003 4.4342 10.7269
EN CTRP2 4.4959 5.6383 4.4456 10.4879
HEC-50B CTRP2 4.5368 6.431 4.2793 10.9654
KLE CTRP2 4.5486 5.8948 4.4503 10.3057
HEC-265 CTRP2 4.9025 5.9658 4.8188 7.8985
MFE-319 CTRP2 5.5346 6.008 5.4976 3.5247
Ishikawa (Heraklio) 02 ER- CTRP2 4.5484 5.6254 4.5042 10.117
⏷ Show the Full List of 22 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 18 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KMRC-3 CTRP2 1.8371 3.8691 1.8178 28.0941
UO-31 CTRP2 2.247 3.825 2.2397 25.3231
CAL-54 CTRP2 2.394 3.4751 2.3934 24.3216
VMRC-RCW CTRP2 3.3499 5.0715 3.3011 18.1161
KMRC-2 CTRP2 3.3903 4.6444 3.3795 17.7179
KMRC-20 CTRP2 3.4844 4.7286 3.4722 17.0961
RCC10RGB CTRP2 3.5013 4.2551 3.5009 16.9439
VMRC-RCZ CTRP2 3.6097 5.1008 3.5732 16.3433
BFTC-909 CTRP2 3.8427 4.7233 3.8394 14.6788
TUHR10TKB CTRP2 4.0527 5.1948 4.0306 13.3435
769-P CTRP2 4.1704 5.598 4.1015 12.7204
OS-RC-2 CTRP2 4.3288 6.3243 4.0888 12.2814
KMRC-1 CTRP2 4.4207 5.0261 4.4192 10.8225
786-O CTRP2 4.5176 6.1432 4.3502 10.761
SNU-1272 CTRP2 4.7724 5.3445 4.7685 8.487
Caki-2 CTRP2 5.1854 6.9679 4.7579 7.3321
ACHN CTRP2 5.2379 8.2099 4.2332 9.3269
Caki-1 CTRP2 5.3274 8.3662 4.2427 9.0808
⏷ Show the Full List of 18 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 47 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-81 CTRP2 -0.1359 4.7881 -0.4035 41.8046
NCI-H716 CTRP2 2.1002 3.4406 2.0983 26.2831
LoVo CTRP2 2.2624 4.4403 2.2197 25.3399
KM12 CTRP2 2.5509 5.1471 2.434 23.673
HT115 CTRP2 2.5575 3.3179 2.5575 23.23
T84 CTRP2 2.5591 3.6411 2.5583 23.2224
HCT 15 CTRP2 2.6674 4.111 2.6597 22.5236
SW948 CTRP2 2.7591 4.2302 2.7492 21.9201
SW1116 CTRP2 2.7681 3.6955 2.7677 46.8877
CL-11 CTRP2 2.9433 5.2134 2.8454 20.9936
SNU-1033 CTRP2 2.9906 17.3504 -2.3191 35.0488
NCI-H747 CTRP2 3.0028 4.7708 2.9669 20.3847
CCK-81 CTRP2 3.2581 5.0254 3.2093 18.7276
SW48 CTRP2 3.2728 5.563 3.1362 18.9345
C2BBe1 CTRP2 3.2812 5.0183 3.2346 18.5666
LS513 CTRP2 3.2944 4.1421 3.2938 18.3228
CW-2 CTRP2 3.504 5.2317 3.4441 17.1277
SNU-C2A CTRP2 3.5183 6.7769 3.0578 18.4794
NCI-H508 CTRP2 3.6046 4.4354 3.6035 16.2579
OUMS-23 CTRP2 3.6448 4.5114 3.643 15.9922
SNU-407 CTRP2 3.6679 5.4347 3.5883 16.1041
HT-55 CTRP2 3.7117 5.028 3.6878 15.6212
SNU-61 CTRP2 3.7919 6.03 3.5901 15.712
COLO 320 CTRP2 3.7955 6.0683 3.5836 15.7243
SNU-C1 CTRP2 3.9128 6.219 3.6682 15.0632
SNU-C5 CTRP2 3.9392 5.6557 3.8403 14.365
COLO 678 CTRP2 4.1088 5.9544 3.9559 13.4275
LS1034 CTRP2 4.1907 5.6793 4.1081 12.633
SK-CO-1 CTRP2 4.2015 5.5357 4.1457 12.4678
LS180 CTRP2 4.2153 5.685 4.1337 12.4659
RKO CTRP2 4.2528 6.024 4.0947 12.4885
HT-29 CTRP2 4.408 5.1891 4.401 10.9254
COLO201 CTRP2 4.4216 5.2135 4.4137 10.8375
MDST8 CTRP2 4.441 4.9425 4.4406 10.6836
SW1417 CTRP2 4.473 5.9178 4.3623 10.8533
HCT 116 CTRP2 4.5165 5.2229 4.511 10.1976
LS123 CTRP2 4.6139 5.3672 4.6035 9.5653
COLO205 CTRP2 4.625 5.0961 4.6244 9.4581
LS411N CTRP2 4.7171 5.4379 4.7058 8.8807
HCT 8 CTRP2 4.794 6.2493 4.6188 8.9525
SNU-C4 CTRP2 4.796 5.9141 4.7152 8.597
RCM-1 [Human ESC] CTRP2 4.8008 6.2859 4.6144 8.9485
DLD-1 CTRP2 4.876 5.3811 4.8731 7.7937
SW620 CTRP2 4.9431 7.025 4.4828 9.0547
HCC-56 CTRP2 5.0752 5.7666 5.0475 6.551
GP2d CTRP2 5.1504 6.0398 5.07 6.2368
SNU-503 CTRP2 5.2349 7.6691 4.4876 8.2941
⏷ Show the Full List of 47 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 19 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Hep-G2 CTRP2 0.0506 12.8476 -3.0898 44.3046
SNU-182 CTRP2 1.7434 4.1984 1.6968 28.8103
Li-7 CTRP2 2.9437 5.2248 2.8439 20.9975
JHH-4 CTRP2 3.3847 4.7583 3.3672 17.7781
Hep 3B2.1-7 CTRP2 3.4288 5.0638 3.3858 17.5711
SNU-761 CTRP2 3.5676 4.8817 3.5489 16.5634
HuH-1 CTRP2 3.6979 5.2259 3.6519 15.7884
SNU-387 CTRP2 3.8296 6.6347 3.4438 16.137
HLF CTRP2 4.2677 5.2353 4.2523 11.8883
SNU-423 CTRP2 4.3371 5.6448 4.2731 11.5933
JHH-1 CTRP2 4.3669 4.8792 4.3666 11.1768
SNU-398 CTRP2 4.6181 5.7864 4.5499 9.7365
SK-HEP-1 CTRP2 4.6186 5.1518 4.6173 9.5032
JHH-5 CTRP2 4.6758 5.6254 4.6408 9.2365
SNU-449 CTRP2 4.7295 6.723 4.3803 10.0347
PLC/PRF/5 CTRP2 4.8325 5.5498 4.8169 8.1263
JHH-2 CTRP2 5.2887 7.0476 4.828 6.7871
JHH-6 CTRP2 5.2918 5.9086 5.2558 5.1376
SNU-475 CTRP2 5.3589 6.1663 5.2598 4.9193
⏷ Show the Full List of 19 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 134 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HOP-92 CTRP2 -0.215 33.1229 -13.0095 47.9893
NCI-H1435 CTRP2 1.9594 4.7173 1.8661 27.53
NCI-H146 CTRP2 2.3808 3.5065 2.38 24.4098
NCI-H1734 CTRP2 2.3978 3.8237 2.3932 24.3095
NCI-H1341 CTRP2 2.4045 3.1251 2.4045 24.2495
SK-MES-1 CTRP2 2.4412 3.6017 2.4401 24.0086
NCI-H1651 CTRP2 2.4496 10.8519 0.2419 31.094
NCI-H810 CTRP2 2.4895 3.2063 2.4895 23.6834
LCLC-97TM1 CTRP2 2.4945 5.3985 2.3256 24.2289
NCI-H211 CTRP2 2.4961 4.6403 2.4459 23.8085
NCI-H1563 CTRP2 2.5537 4.0545 2.5455 23.283
NCI-H1184 CTRP2 2.5612 3.8434 2.5583 23.2152
NCI-H446 CTRP2 2.621 3.1938 2.621 22.8074
NCI-H1666 CTRP2 2.6242 5.069 2.5258 23.1207
NCI-H1694 CTRP2 2.6328 3.2854 2.6328 22.7285
LXF 289 CTRP2 2.6411 4.0193 2.6356 22.6918
DMS 454 CTRP2 2.6526 4.6825 2.6067 22.7512
NCI-H2085 CTRP2 2.6818 6.7952 2.1453 24.2924
EKVX CTRP2 2.6835 7.7197 1.8136 25.4674
EBC-1 CTRP2 2.6914 3.8141 2.6899 22.3432
DMS 53 CTRP2 2.7088 4.1406 2.701 22.2483
NCI-H520 CTRP2 2.7456 3.7025 2.7452 21.9784
HCC44 CTRP2 2.7904 4.0925 2.7855 21.6949
NCI-H2087 CTRP2 2.8106 6.6054 2.3476 23.1768
NCI-H1703 CTRP2 2.8203 5.225 2.7109 21.8526
EPLC-272H CTRP2 2.8616 5.8715 2.6165 22.0554
SK-LU-1 CTRP2 2.878 4.6122 2.8499 21.1895
NCI-H1573 CTRP2 2.8855 5.731 2.6772 21.7658
DMS 79 CTRP2 2.904 5.897 2.6563 21.7829
DV-90 CTRP2 2.9547 4.8455 2.9085 20.74
NCI-H2291 CTRP2 2.9753 5.0774 2.9009 20.6992
COR-L95 CTRP2 2.9875 4.6331 2.9626 20.4489
NCI-H647 CTRP2 2.9941 5.0521 2.9246 20.557
SW1271 CTRP2 3.0349 4.83 2.9949 20.1846
NCI-H1355 CTRP2 3.0511 5.967 2.7985 20.822
NCI-H1568 CTRP2 3.0566 5.3465 2.9443 20.2893
DMS 114 CTRP2 3.0691 4.164 3.0665 19.8304
CAL-12T CTRP2 3.0772 4.9921 3.0212 19.9573
NCI-H1693 CTRP2 3.0894 4.9022 3.0447 19.8378
NCI-H1755 CTRP2 3.1062 5.4215 2.9839 19.9939
HOP-62 CTRP2 3.1372 5.7935 2.9365 20.0641
Calu-3 CTRP2 3.2306 4.4773 3.2227 18.7724
NCI-H1373 CTRP2 3.2634 5.0811 3.208 18.7149
NCI-H1915 CTRP2 3.3117 5.258 3.2342 18.4695
NCI-H1581 CTRP2 3.3439 4.6354 3.3322 18.0303
HCC1588 CTRP2 3.3447 4.544 3.337 18.0118
Sq-1 CTRP2 3.3772 5.0224 3.3358 17.909
COLO 668 CTRP2 3.4168 5.6304 3.2783 17.9826
Calu-1 CTRP2 3.4609 6.4272 3.1118 18.4486
Calu-6 CTRP2 3.4645 4.8726 3.442 17.2632
NCI-H2228 CTRP2 3.4791 4.9306 3.4525 17.1797
HCC1833 CTRP2 3.4925 7.8343 2.6268 20.174
VMRC-LCD CTRP2 3.496 5.9084 3.2992 17.6625
NCI-H2106 CTRP2 3.4984 4.9203 3.4736 17.0452
NCI-H1792 CTRP2 3.504 5.5619 3.3872 17.3257
DMS 273 CTRP2 3.5143 5.4619 3.4176 17.1866
NCI-H358 CTRP2 3.5668 5.8459 3.392 17.1129
NCI-H661 CTRP2 3.5724 6.0269 3.3514 17.2413
HCC2279 CTRP2 3.5819 5.546 3.4748 16.7729
NCI-H1105 CTRP2 3.6191 5.0768 3.5856 16.2707
NCI-H2405 CTRP2 3.6581 5.3845 3.5861 16.1433
NCI-H522 CTRP2 3.664 5.3429 3.599 16.0795
NCI-H650 CTRP2 3.6943 5.7032 3.5641 16.1057
HCC15 CTRP2 3.7183 5.7583 3.5779 15.9822
NCI-H2009 CTRP2 3.7255 4.8868 3.7125 15.4924
NCI-H1838 CTRP2 3.7314 5.0706 3.7045 15.5001
NCI-H69 CTRP2 3.7359 5.1138 3.7051 15.4834
COLO 699 CTRP2 3.736 5.5551 3.6399 15.7083
NCI-H2286 CTRP2 3.7433 5.6693 3.6247 15.7387
NCI-H292 CTRP2 3.749 5.2881 3.698 15.4655
HCC2108 CTRP2 3.756 5.6504 3.6425 15.6362
NCI-H2023 CTRP2 3.7566 14.1347 -0.036 28.2864
NCI-H441 CTRP2 3.7716 5.9432 3.5909 15.7709
NCI-H1650 CTRP2 3.7932 5.8299 3.6427 15.5192
NCI-H2196 CTRP2 3.8027 5.279 3.7565 15.0913
NCI-H1155 CTRP2 3.8354 4.9337 3.8235 14.7563
HCC1438 CTRP2 3.8623 5.1996 3.8294 14.6486
NCI-H23 CTRP2 3.9871 5.8328 3.8532 14.1696
NCI-H2030 CTRP2 3.9879 6.1503 3.7703 14.4654
NCI-H841 CTRP2 3.9905 5.7592 3.8738 14.0862
RERF-LC-A1 CTRP2 4.0323 5.4054 3.9842 13.5681
NCI-H2081 CTRP2 4.0944 5.5708 4.0243 13.2307
HCC2935 CTRP2 4.0956 5.4398 4.0469 13.1487
HCC95 CTRP2 4.1122 5.5647 4.0446 13.1036
MOR/CPR CTRP2 4.1159 4.864 4.1135 12.8559
SHP-77 CTRP2 4.1927 5.1575 4.18 12.3788
Lu-99 CTRP2 4.2054 5.3946 4.1704 12.3701
NCI-H1793 CTRP2 4.2316 6.9299 3.7694 13.7605
A-549 CTRP2 4.2648 5.5546 4.2107 12.0405
HCC1171 CTRP2 4.2963 6.8745 3.8596 13.2351
HARA [Human squamous cell lung carcinoma] CTRP2 4.3151 5.2571 4.3002 11.5711
NCI-H889 CTRP2 4.3529 5.7815 4.263 11.5786
HCC366 CTRP2 4.355 5.336 4.3352 11.3217
NCI-H727 CTRP2 4.3646 5.4533 4.3322 11.3007
NCI-H526 CTRP2 4.377 5.1378 4.3714 11.1271
NCI-H196 CTRP2 4.4195 6.0305 4.2749 11.3305
NCI-H2172 CTRP2 4.4319 5.686 4.3679 10.9618
PC-14 CTRP2 4.4544 5.8793 4.3514 10.9494
NCI-H838 CTRP2 4.4622 5.9462 4.3435 10.9538
LK2 CTRP2 4.4664 5.0378 4.4652 10.517
HCC78 CTRP2 4.4819 5.3006 4.4708 10.4468
Lu-65 CTRP2 4.4843 6.3906 4.2361 11.2793
NCI-H2444 CTRP2 4.5062 5.2041 4.5012 10.2645
NCI-H2126 CTRP2 4.5149 5.7867 4.4378 10.4552
RERF-LC-Ad1 CTRP2 4.5367 5.2767 4.5292 10.0695
NCI-H2122 CTRP2 4.5493 5.5582 4.5152 10.0764
BEN CTRP2 4.573 4.9542 4.573 9.8026
LOU-NH91 CTRP2 4.573 6.2512 4.3777 10.4948
KNS-62 CTRP2 4.5844 5.3958 4.5705 9.7734
NCI-H2029 CTRP2 4.6036 5.4301 4.5876 9.6525
T3M-10 CTRP2 4.6165 5.3513 4.6073 9.5436
LCLC-103H CTRP2 4.6659 5.2736 4.6622 9.1962
ChaGo-K-1 CTRP2 4.6907 6.0884 4.5548 9.4956
NCI-H1395 CTRP2 4.7112 5.9865 4.6048 9.2527
NCI-H322 CTRP2 4.7157 6.6664 4.3872 10.0469
RERF-LC-Ad2 CTRP2 4.7165 5.3146 4.7124 8.86
NCI-H460 CTRP2 4.7812 6.0236 4.6714 8.799
COR-L105 CTRP2 4.8741 6.9291 4.4509 9.3644
LUDLU-1 CTRP2 4.9578 6.0391 4.86 7.5811
NCI-H1299 CTRP2 4.9751 7.0197 4.5183 8.8306
RERF-LC-MS CTRP2 5.05 7.0531 4.5815 8.3839
LC-1/sq-SF CTRP2 5.0606 5.9413 4.997 6.7745
NCI-H226 CTRP2 5.1528 6.8005 4.7961 7.268
NCI-H2342 CTRP2 5.1619 7.4321 4.5256 8.3202
HCC1195 CTRP2 5.1629 6.4929 4.9312 6.7177
NCI-H2170 CTRP2 5.1857 6.5916 4.9166 6.7107
NCI-H1623 CTRP2 5.246 6.1641 5.1377 5.7031
NCI-H2110 CTRP2 5.2573 7.2069 4.7242 7.2823
SW1573 CTRP2 5.2641 11.4673 2.658 15.6941
NCI-H1339 CTRP2 5.3621 5.9598 5.3211 4.6871
SBC-5 CTRP2 5.4139 5.9849 5.3717 4.3468
NCI-H1944 CTRP2 5.4191 21.3433 -2.1322 29.3788
NCI-H1869 CTRP2 5.5838 11.1329 3.1068 13.2139
Hs 888.Lu CTRP2 3.3619 5.243 3.2903 18.1148
⏷ Show the Full List of 134 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 39 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
2004 CTRP2 1.9899 3.9153 1.9729 27.0688
COV434 CTRP2 1.9786 3.8957 1.9622 27.142
FU-OV-1 CTRP2 2.0881 6.857 1.4804 28.4343
A2780 CTRP2 2.4822 4.5418 2.4411 23.8703
JHOS-2 CTRP2 2.5999 3.3501 2.5999 22.9479
COV644 CTRP2 2.6253 4.7561 2.5698 22.9658
OVCAR-5 CTRP2 2.9154 4.4921 2.8973 20.9066
RMG-I CTRP2 2.9256 4.7305 2.8895 20.8996
OC 314 CTRP2 3.1081 3.8749 3.1079 19.5626
TYK-nu CTRP2 3.1243 4.7176 3.0989 19.5397
IGROV-1 CTRP2 3.22 5.1511 3.152 19.0473
Caov-3 CTRP2 3.314 5.4773 3.1981 18.5876
SNU-119 CTRP2 3.3702 5.3885 3.2753 18.14
OVK18 CTRP2 3.4197 4.7719 3.4026 17.5433
OAW28 CTRP2 3.4271 5.3178 3.3486 17.7042
OV7 CTRP2 3.4319 5.8225 3.2507 18.0337
SNU-8 CTRP2 3.4854 4.0431 3.4854 17.0484
COV362 CTRP2 3.5171 5.7928 3.3507 17.4135
OVSAHO CTRP2 3.5389 4.8353 3.5222 16.7481
OVTOKO CTRP2 3.5406 5.7382 3.389 17.2046
ONCO-DG-1 CTRP2 3.6647 4.9067 3.6482 15.9092
SK-OV-3 CTRP2 3.7424 5.8318 3.5868 15.8755
SNU-840 CTRP2 3.8934 6.9319 3.4064 16.0937
JHOC-5 CTRP2 4.041 5.3666 3.9989 13.4894
MCAS CTRP2 4.1744 5.9791 4.0211 12.9924
OAW42 CTRP2 4.3502 4.9492 4.3491 11.2904
HEY A8 CTRP2 4.3622 5.4899 4.3248 11.3338
OVISE CTRP2 4.3644 4.9884 4.3629 11.1974
OVCAR-4 CTRP2 4.4717 5.6209 4.4224 10.6457
OVCAR-8 CTRP2 4.505 5.6144 4.4592 10.4118
EFO-27 CTRP2 4.5115 6.3583 4.2763 11.0504
ES2 CTRP2 4.5511 5.9019 4.4513 10.2943
Kuramochi CTRP2 4.6038 5.6736 4.5557 9.7615
DOV13 CTRP2 4.6125 5.953 4.5057 9.9107
OV56 CTRP2 4.7677 5.1842 4.7672 8.5072
TOV-112D CTRP2 5.17 10.1237 3.2369 13.5762
OV-90 CTRP2 5.1792 5.8919 5.137 5.9091
JHOM-1 CTRP2 5.1871 6.0794 5.0991 6.0204
EFO-21 CTRP2 5.5795 6.053 5.5346 3.2546
⏷ Show the Full List of 39 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 22 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Yamato-SS CTRP2 1.9995 4.6066 1.9235 27.2038
Aska-SS CTRP2 2.5826 4.0436 2.5754 23.0871
A-204 CTRP2 2.0506 3.9942 2.0315 26.6713
TE 441.T CTRP2 2.3202 3.0194 2.3202 24.8109
TTC-709 CTRP2 2.3426 2.9944 2.3426 24.6618
G-401 CTRP2 2.4153 3.81 2.4111 24.1916
Rh18 CTRP2 2.4381 4.7481 2.3722 24.2485
Hs 729.T CTRP2 2.4558 3.0116 2.4558 23.9079
GCT CTRP2 2.523 3.1399 2.523 23.46
TE 617.T CTRP2 2.539 3.1107 2.539 23.3537
BT-16 CTRP2 2.8284 3.8497 2.8275 21.4286
SW982 CTRP2 2.8408 4.3489 2.828 21.3856
Rh41 CTRP2 2.8564 3.517 2.8564 21.2386
BT-12 CTRP2 3.0537 3.6668 3.0537 19.9243
Tm87-16 CTRP2 3.127 3.928 3.1267 19.4372
G-402 CTRP2 3.31 4.6931 3.2939 18.2709
RD CTRP2 3.3293 5.541 3.202 18.5257
KYM-1 CTRP2 3.3878 4.3985 3.385 17.7081
HT-1080 CTRP2 4.1238 5.279 4.0972 12.8852
RKN CTRP2 4.5726 5.4301 4.5551 9.8642
SK-LMS-1 CTRP2 4.6945 6.6237 4.3805 10.1321
SK-UT-1 CTRP2 4.7847 8.1048 3.8397 12.0232
⏷ Show the Full List of 22 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Thigh Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SYO-1 CTRP2 2.3543 3.1779 2.3542 24.5843
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Clivus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
U-CH1 CTRP2 4.4563 5.7813 4.3753 10.8591
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MSTO-211H CTRP2 2.137 9.5369 0.498 31.3336
IST-Mes1 CTRP2 2.8326 4.4556 2.8137 21.4609
NCI-H2452 CTRP2 3.398 5.5383 3.277 18.0462
NCI-H2052 CTRP2 3.5624 5.685 3.4247 17.0104
NCI-H28 CTRP2 3.9215 5.4134 3.8643 14.3376
MPP 89 CTRP2 4.126 5.734 4.0267 13.1227
ACC-MESO-1 CTRP2 4.9269 8.0043 4.0275 10.9131
JL-1 CTRP2 10.4028 39.4459 -7.1778 29.4105
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
VCaP CTRP2 2.6593 3.3006 2.6593 22.552
22Rv1 CTRP2 3.5838 5.5341 3.4792 16.7516
LNCaP clone FGC CTRP2 4.922 6.2253 4.7657 8.0324
DU145 CTRP2 5.2263 7.5311 4.5438 8.0873
PaCa-3 CTRP2 5.3658 5.8918 5.3393 4.6116
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
YD-15 CTRP2 2.8719 4.6399 2.8413 21.2385
Cancer Drug Sensitivity Data Curated from 33 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-16 CTRP2 1.9878 3.0597 1.9876 27.0263
HGC-27 CTRP2 2.2941 4.0199 2.281 25.0289
Fu97 CTRP2 2.3822 3.1483 2.3822 24.3981
ECC10 CTRP2 2.435 3.9229 2.4285 24.0678
GSS CTRP2 2.5392 3.6999 2.5378 23.3568
SNU-1 CTRP2 2.6671 4.4623 2.6414 22.5863
SNU-216 CTRP2 2.8391 5.8014 2.6096 22.1496
Hs 746.T CTRP2 3.0186 4.4624 3.0056 20.202
KATO III CTRP2 3.0431 4.7639 3.0098 20.1072
NCI-N87 CTRP2 3.0858 4.8122 3.0503 19.8301
IM95 CTRP2 3.2034 5.4981 3.0742 19.3706
NUGC-4 CTRP2 3.2405 5.4784 3.1183 19.0995
SNU-620 CTRP2 3.3023 4.8195 3.2767 18.3542
MKN74 CTRP2 3.5351 5.8469 3.3573 17.3345
KE-39 CTRP2 3.5965 6.2529 3.3132 17.307
SNU-719 CTRP2 3.6469 5.3367 3.5817 16.1942
23132/87 CTRP2 3.6797 4.4169 3.6791 15.7558
SNU-5 CTRP2 3.745 5.4424 3.67 15.5746
NUGC-3 CTRP2 4.0297 5.4789 3.9702 13.6248
HuG1-N CTRP2 4.0421 5.9846 3.8752 13.9216
LMSU CTRP2 4.1594 6.7299 3.7664 13.9768
SNU-668 CTRP2 4.2249 5.4757 4.1802 12.2736
MKN1 CTRP2 4.3196 5.1577 4.3114 11.5183
ECC12 CTRP2 4.4269 5.1384 4.4226 10.7902
SNU-601 CTRP2 4.5603 5.3571 4.5484 9.9272
GSU CTRP2 4.6317 4.8656 4.6317 9.4118
AGS CTRP2 5.1278 6.446 4.9116 6.8912
MKN45 CTRP2 5.1481 5.8418 5.1132 6.0905
MKN7 CTRP2 5.2647 6.4834 5.0433 6.005
SH-10-TC CTRP2 5.3431 18.168 -0.6113 26.1456
SNU-685 CTRP2 3.6511 5.0482 3.6223 16.0413
SNG-M CTRP2 3.7314 5.4404 3.6557 15.6681
SNU-1077 CTRP2 4.3595 5.6345 4.2991 11.4314
⏷ Show the Full List of 33 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 12 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SW579 CTRP2 2.246 3.1756 2.2459 25.3059
8305C CTRP2 2.3802 4.045 2.3683 24.4514
CAL-62 CTRP2 3.0398 4.298 3.0338 20.0368
ML-1 [Human leukemia] CTRP2 3.1451 4.8627 3.1077 19.4418
FTC-238 CTRP2 3.2226 4.3012 3.2195 18.8097
TT CTRP2 3.2255 5.2463 3.1435 19.059
BHT-101 CTRP2 3.2463 4.0442 3.246 18.6425
CGTH-W-1 CTRP2 3.7386 5.3034 3.6848 15.5442
8505C CTRP2 3.8338 5.0517 3.8136 14.7955
B-CPAP CTRP2 4.2463 5.7321 4.1576 12.2843
TT2609-C02 CTRP2 4.6076 6.749 4.2401 10.911
FTC-133 CTRP2 5.4355 5.8974 5.4135 4.132
⏷ Show the Full List of 12 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 29 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SCC-25 CTRP2 2.6315 4.2722 2.6162 22.7886
YD-10B CTRP2 2.8181 4.3381 2.8051 21.5376
PE/CA-PJ34 (clone C12) CTRP2 2.8846 5.0486 2.808 21.3111
BHY CTRP2 2.9145 4.3873 2.9021 20.8933
SNU-1214 CTRP2 3.0381 5.2787 2.9364 20.3758
CAL-33 CTRP2 3.175 4.9069 3.1347 19.2521
Detroit 562 CTRP2 3.238 4.7322 3.2164 18.7693
HSC-3 CTRP2 3.2548 5.236 3.1765 18.8513
BICR 31 CTRP2 3.3978 5.7862 3.2223 18.2398
SNU-1076 CTRP2 3.4447 5.4762 3.3397 17.6791
BICR 18 CTRP2 3.563 5.2558 3.5038 16.7325
SCC-4 CTRP2 3.5891 4.8152 3.5756 16.4028
BICR 16 CTRP2 3.5986 5.4685 3.5075 16.6057
SNU-46 CTRP2 3.6043 5.8411 3.434 16.8473
YD-8 CTRP2 3.6699 5.1357 3.6329 15.9441
SNU-1041 CTRP2 3.8559 5.884 3.6979 15.129
SNU-1066 CTRP2 3.9544 5.6421 3.8594 14.2503
SNU-899 CTRP2 3.9719 5.2817 3.9361 13.9285
SCC-9 CTRP2 4.0508 6.0545 3.8659 13.9286
BICR 22 CTRP2 4.101 5.382 4.0608 13.0832
HSC-4 CTRP2 4.4747 5.8405 4.3824 10.7763
CAL-27 CTRP2 4.5063 5.5985 4.4632 10.3938
PE/CA-PJ49 CTRP2 4.536 5.2768 4.5284 10.0748
FaDu CTRP2 4.7348 6.4058 4.5024 9.5578
PE/CA-PJ15 CTRP2 4.8451 6.908 4.4291 9.528
HSC-2 CTRP2 5.2289 6.1117 5.1351 5.7636
BICR 56 CTRP2 5.4018 11.4398 2.7941 14.8571
PE/CA-PJ41 (clone D2) CTRP2 5.4497 5.9461 5.4193 4.0666
BICR 6 CTRP2 5.9715 21.903 -1.9457 27.9319
⏷ Show the Full List of 29 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 24 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
U-BLC1 CTRP2 2.3186 3.8328 2.3125 24.8421
JMSU-1 CTRP2 2.4988 4.6038 2.4526 23.777
647V CTRP2 2.7336 4.335 2.7183 22.1084
253J CTRP2 2.8079 3.7631 2.8073 21.564
5637 CTRP2 3.0253 5.5636 2.8673 20.658
CAL-29 CTRP2 3.0839 5.0569 3.0198 19.9407
VM-CUB-1 CTRP2 3.4251 4.4873 3.4208 17.4644
RT-112 CTRP2 3.5764 5.5451 3.469 16.8105
253J-BV CTRP2 3.6024 4.5676 3.599 16.2801
RT-4 CTRP2 3.6362 5.1663 3.5937 16.1872
BFTC-905 CTRP2 3.658 4.2623 3.6579 15.8987
HT-1376 CTRP2 3.7932 7.3504 3.139 17.3915
SW1710 CTRP2 3.8441 5.6675 3.7345 15.0357
KMBC-2 CTRP2 3.9888 5.5679 3.9109 13.9613
BC-3C CTRP2 4.1921 5.7512 4.0948 12.6756
TCCSUP CTRP2 4.2527 5.455 4.2128 12.072
KU-19-19 CTRP2 4.3657 5.4474 4.3342 11.2902
639V CTRP2 4.4586 4.9614 4.4582 10.5661
SCaBER CTRP2 4.6577 5.939 4.5585 9.5828
UM-UC-3 CTRP2 4.6999 6.3996 4.4668 9.7918
HT-1197 CTRP2 5.1511 5.9673 5.0894 6.1655
J82 CTRP2 5.277 7.4065 4.6519 7.5249
T24 CTRP2 5.5435 8.6721 4.2929 8.3891
UM-UC-1 CTRP2 5.8022 7.2604 5.2244 3.9445
⏷ Show the Full List of 24 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HeLa CTRP2 4.2802 5.4062 4.2484 11.8608

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2048).