Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM1FW0C)

Drug Name
AZD7762 Drug Info
Synonyms
AZD7762; 860352-01-8; AZD-7762; (S)-5-(3-Fluorophenyl)-N-(piperidin-3-yl)-3-ureidothiophene-2-carboxamide; AZD 7762; UNII-5D822Y3L1H; 3-(Carbamoylamino)-5-(3-Fluorophenyl)-N-[(3s)-Piperidin-3-Yl]thiophene-2-Carboxamide; CHEMBL2041933; 5D822Y3L1H; J-502468; 5-(3-Fluorophenyl)-N-[(3s)-3-Piperidyl]-3-Ureido-Thiophene-2-Carboxamide; IAYGCINLNONXHY-LBPRGKRZSA-N; YDJ; AZD7762 hydrochloride; 5-(3-Fluorophenyl)-3-ureidothiophene-N-[(S)-piperidin-3-yl]-2-carboxamide; SCHEMBL1127614; GTPL7713; AOB1915; QCR-261; CHEBI:131156
Cross-matching ID
PubChem CID
11152667
ChEBI ID
CHEMBL2041933
CAS Number
CAS 860352-01-8
TTD Drug ID
D0PM7Q

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
AGE-RAGE signaling pathway in diabetic complications -1.58 4.91e-2 97/100 (97%) AKT3;IL1A;EDN1;...
Other types of O-glycan biosynthesis -1.60 4.50e-2 29/47 (61.7%) ST6GAL1;POFUT1;EOGT;...
Dilated cardiomyopathy -1.60 4.54e-2 86/96 (89.58%) ITGA10;MYL3;CACNG4;...
Amino sugar and nucleotide sugar metabolism -1.61 4.55e-2 38/48 (79.17%) GNPDA1;UAP1;GPI;...
Central carbon metabolism in cancer -1.62 4.56e-2 67/70 (95.71%) PIK3R1;PFKP;FGFR1;...
Gastric acid secretion -1.64 4.13e-2 63/76 (82.89%) ADCY2;SLC4A2;ATP1A2;...
Human papillomavirus infection -1.64 4.26e-2 284/331 (85.8%) LAMA5;PPP2R1B;ATP6V0A4;...
Phagosome -1.64 4.44e-2 118/152 (77.63%) NCF2;MRC2;ATP6V0A4;...
Hippo signaling pathway -1.71 2.18e-2 120/186 (64.52%) PPP2R1B;TEAD1;FZD2;...
Arrhythmogenic right ventricular cardiomyopathy -1.71 2.23e-2 70/77 (90.91%) CTNNA2;CACNG4;CACNA2D3;...
Proteoglycans in cancer -1.72 1.85e-2 172/205 (83.9%) WNT7A;CASP3;CAMK2B;...
Synaptic vesicle cycle -1.74 1.72e-2 63/78 (80.77%) ATP6V0E1;CLTA;ATP6V0C;...
DNA replication -1.75 1.63e-2 34/36 (94.44%) LIG1;POLD3;MCM7;...
Fc gamma R-mediated phagocytosis -1.75 1.73e-2 79/97 (81.44%) HCK;GSN;ARPC5L;...
Fructose and mannose metabolism -1.77 1.29e-2 30/33 (90.91%) PFKFB3;SORD;AKR1B10;...
Cholesterol metabolism -1.78 1.31e-2 44/50 (88%) APOA4;TSPO;CYP27A1;...
Wnt signaling pathway -1.80 1.32e-2 124/166 (74.7%) APC2;CACYBP;NLK;...
Mucin type O-glycan biosynthesis -1.80 1.25e-2 20/36 (55.56%) ST3GAL1;GALNT6;GALNT11;...
Axon guidance -1.81 1.18e-2 151/182 (82.97%) PLXNA3;PAK4;CAMK2G;...
Rap1 signaling pathway -1.82 9.89e-3 184/210 (87.62%) FGFR4;RAPGEF1;PLCB2;...
Epithelial cell signaling in Helicobacter pylori infect... -1.83 1.09e-2 62/70 (88.57%) ATP6V0A4;ATP6V1G1;TJP1;...
Vibrio cholerae infection -1.84 1.09e-2 44/50 (88%) ATP6V0E1;ATP6V0C;ATP6V0A4;...
Endocytosis -1.89 1.09e-2 198/252 (78.57%) PARD3;ACTR3B;ARPC4;...
Melanogenesis -1.90 9.32e-3 74/101 (73.27%) PLCB2;CAMK2G;GNAI2;...
Neomycin, kanamycin and gentamicin biosynthesis -1.93 7.25e-3 5/5 (100%) HK1;HK2
Adherens junction -1.95 6.53e-3 63/71 (88.73%) NLK;FER;FYN;...
Regulation of actin cytoskeleton -2.02 2.72e-3 185/218 (84.86%) FGF8;SLC9A1;APC2;...
Bacterial invasion of epithelial cells -2.08 3.63e-3 59/77 (76.62%) CTNNA2;RAC1;CDH1;...
Focal adhesion -2.08 5.44e-3 180/201 (89.55%) COL4A1;VEGFD;PPP1CB;...
ECM-receptor interaction -2.28 0.00e+0 80/88 (90.91%) LAMB3;VWF;DSPP;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SK-ES-1 CVCL_0627 Homo sapiens 1.11uM - 3.33uM 24H
Bone marrow
Neuroblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SH-SY5Y CVCL_0019 Homo sapiens 0.04uM - 10uM 24H
Brain
Glioma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
GI-1 CVCL_1230 Homo sapiens 1.11uM - 3.33uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 3H, 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 3H, 6H, 24H
MDA-MB-468 CVCL_0419 Homo sapiens 1.11uM - 10uM 24H
SK-BR-3 CVCL_0033 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
Breast carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BT-20 CVCL_0178 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
Hs 578T CVCL_0332 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
Breast ductal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
T-47D CVCL_0553 Homo sapiens 1.11uM - 10uM 24H
Normal (Epithelial)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HME1 CVCL_2950 Homo sapiens 0.04uM - 10uM 3H, 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 3H, 6H, 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
SNU-407 CVCL_5004 Homo sapiens 1.11uM - 10uM 24H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 1.11uM - 10uM 24H
HEC-1-A CVCL_0293 Homo sapiens 1.11uM - 10uM 24H
HEC-251 CVCL_2928 Homo sapiens 1.11uM - 10uM 24H
HEC-265 CVCL_2929 Homo sapiens 1.11uM - 10uM 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 0.04uM - 10uM 24H
CJM CVCL_U797 Homo sapiens 1.11uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 10uM 6H, 24H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHH-5 CVCL_1320 Homo sapiens 1.11uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H
A549/Asc-1 CVCL_YA87 Homo sapiens 0.04uM - 10uM 24H
NCI-H1573 CVCL_1483 Homo sapiens 1.11uM - 10uM 24H
NCI-H838 CVCL_1594 Homo sapiens 1.11uM - 10uM 24H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BEN CVCL_1081 Homo sapiens 1.11uM - 10uM 24H
HCC95 CVCL_1276 Homo sapiens 1.11uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 0.04uM - 10uM 6H, 24H
NCI-H2110 CVCL_1529 Homo sapiens 1.11uM - 10uM 24H
Muscle
Rhabdomyosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-204 CVCL_0134 Homo sapiens 1.11uM - 3.33uM 24H
Ovary
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OVTOKO CVCL_3114 Homo sapiens 1.11uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.04uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
22Rv1 CVCL_1045 Homo sapiens 1.11uM - 10uM 24H
LNCaP CVCL_0395 Homo sapiens 0.04uM - 10uM 3H, 24H
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H
IGR-37 CVCL_1303 Homo sapiens 1.11uM - 3.33uM 24H
Mel-HO CVCL_1402 Homo sapiens 1.11uM - 10uM 24H
SH-4 CVCL_1692 Homo sapiens 1.11uM - 10uM 24H
SK-L CVCL_1699 Homo sapiens 0.04uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.01uM - 10uM 24H
Urinary bladder
Bladder carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BC-3C CVCL_1079 Homo sapiens 1.11uM - 10uM 24H
Bladder transitional cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CAL-29 CVCL_1109 Homo sapiens 1.11uM - 10uM 24H