Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM1H45U)

• Drug Name: A-366 Drug Info
• Synonyms: A 366; A366
• Cross-matching ID:
  PubChem CID: 76285486
  ChEBI ID: CHEMBL3109630
  TTD Drug ID: D0C5EG

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Phagosome	1.90	3.75e-2	118/152 (77.63%)	THBS2;HLA-DQA1;C1R;...
Primary bile acid biosynthesis	1.86	3.13e-2	15/17 (88.24%)	CYP46A1;CYP39A1;SCP2;...
Bacterial invasion of epithelial cells	-1.81	4.64e-2	59/77 (76.62%)	RHOA;ACTR3;PIK3R2;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	1.11uM - 10uM	24H	Hide ▲

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	1.11uM - 10uM	24H	Hide ▲