Details of the Drug

General Information of Drug (ID: DM1H45U)

Drug Name
A-366
Synonyms A 366; A366
Indication
Disease Entry ICD 11 Status REF
Solid tumour/cancer 2A00-2F9Z Preclinical [1]
Drug Type
Small molecular drug
Structure
3D MOL is unavailable 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 329.4
Logarithm of the Partition Coefficient (xlogp) 2.2
Rotatable Bond Count (rotbonds) 6
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 4
Chemical Identifiers
Formula
C19H27N3O2
IUPAC Name
5'-methoxy-6'-(3-pyrrolidin-1-ylpropoxy)spiro[cyclobutane-1,3'-indole]-2'-amine
Canonical SMILES
COC1=C(C=C2C(=C1)C3(CCC3)C(=N2)N)OCCCN4CCCC4
InChI
InChI=1S/C19H27N3O2/c1-23-16-12-14-15(21-18(20)19(14)6-4-7-19)13-17(16)24-11-5-10-22-8-2-3-9-22/h12-13H,2-11H2,1H3,(H2,20,21)
InChIKey
BKCDJTRMYWSXMC-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
76285486
TTD ID
D0C5EG

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Euchromatic histone-lysine N-methyltransferase 1 (EHMT1) TTOFXD7 EHMT1_HUMAN Inhibitor [2]
Histone-lysine N-methyltransferase EHMT2 (EHMT2) TTS6RZT EHMT2_HUMAN Inhibitor [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 35 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RPMI-3460/CS1 GDSC2 5.6356 8.3192 2.3868 1.717
EW-22 GDSC2 3.4163 6.4265 1.8475 9.0553
ES1 GDSC2 4.1341 6.266 2.4592 3.5027
HOS GDSC2 4.1409 6.0241 2.5771 2.7991
CAL-72 GDSC2 4.221 6.8324 2.2476 4.588
EW-24 GDSC2 4.2428 8.4863 1.4612 9.2898
SJSA-1 GDSC2 4.3172 9.4479 1.0436 11.5633
SaOS-2 GDSC2 4.3261 7.8483 1.8311 6.8711
EW-1 GDSC2 4.4213 8.0496 1.7997 6.8514
NY GDSC2 4.4405 7.9881 1.8424 6.5543
EW-7 GDSC2 4.4864 13.73 -0.9463 20.9282
ES8 GDSC2 4.6097 8.1773 1.8654 6.0655
EW-18 GDSC2 4.6914 7.8016 2.0945 4.5708
EW-13 GDSC2 4.7421 7.3822 2.3176 3.2245
A-673 GDSC2 4.7911 9.9363 1.1446 9.8773
SK-PN-DW GDSC2 4.7992 12.0726 0.1084 15.4021
SK-ES-1 GDSC2 4.8194 6.7187 2.6495 1.4126
NOS-1 [Human HNSCC] GDSC2 4.8846 8.9131 1.6967 6.5004
HuO9 GDSC2 4.9965 11.8316 0.3691 13.6214
ES4 GDSC2 5.0324 7.4181 2.4624 2.0491
ES6 GDSC2 5.11 7.576 2.4354 2.0838
EW-3 GDSC2 5.1325 9.9432 1.3713 7.8705
HuO-3N1 GDSC2 5.1627 11.8727 0.4665 12.7418
G-292 clone A141B1 GDSC2 5.1848 8.3038 2.1588 3.3922
CADO-ES1 GDSC2 5.2516 6.9759 2.7451 0.6462
CAL-78 GDSC2 5.413 9.3466 1.8223 4.8432
EW-11 GDSC2 5.4644 11.8632 0.6779 10.9871
CHSA8926 GDSC2 5.5035 7.4539 2.6694 0.7319
TC-71 GDSC2 5.5962 7.339 2.7499 0.4401
EW-16 GDSC2 5.6127 9.0532 2.0651 3.2663
MHH-ES-1 GDSC2 5.6769 12.9249 0.3129 12.4133
U2OS GDSC2 5.8147 8.5519 2.377 1.5845
ES7 GDSC2 6.0498 8.715 2.4188 1.2208
H-EMC-SS GDSC2 6.2471 9.4072 2.2339 1.7728
MG-63 GDSC2 6.7962 16.9616 -0.865 15.472
⏷ Show the Full List of 35 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 9 Cell Line(s) in Aero Dig Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
OACM5.1 C GDSC2 4.7113 8.1281 1.9546 5.3428
ESO-51 GDSC2 5.1345 7.2715 2.5751 1.4072
KYSE-50 GDSC2 5.5031 7.0889 2.8043 0.3443
SK-GT-4 GDSC2 5.5174 9.9587 1.6057 5.8493
KYAE-1 GDSC2 5.6067 7.4669 2.7071 0.5532
ESO-26 GDSC2 5.854 7.4535 2.8062 0.222
FLO-1 GDSC2 5.8954 15.2609 -0.6627 16.456
KYSE-220 GDSC2 6.1151 9.3566 2.1923 2.0739
OACP4 C GDSC2 6.4642 8.8011 2.5574 0.5421
⏷ Show the Full List of 9 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 GDSC2 4.9843 7.7349 2.2984 2.9522
Cancer Drug Sensitivity Data Curated from 21 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Kelly GDSC2 3.905 6.3448 2.2646 5.1768
GOTO GDSC2 3.9852 6.277 2.354 4.4473
IMR-5 GDSC2 4.5523 6.6439 2.5397 2.3173
SK-N-FI GDSC2 4.6141 6.1708 2.7758 1.0639
CHP-212 GDSC2 4.746 9.0551 1.5377 7.7065
SJNB-14 GDSC2 4.8736 9.0315 1.6336 6.8875
SK-N-AS GDSC2 4.9218 9.343 1.5176 7.4596
SK-N-SH GDSC2 5.0162 7.9228 2.233 3.2523
NB(TU)1 GDSC2 5.1495 11.5293 0.6234 11.9488
CHP-134 GDSC2 5.1548 6.6661 2.8216 0.4645
SK-N-DZ GDSC2 5.168 6.4962 2.8888 0.2797
TGW GDSC2 5.3518 7.0439 2.761 0.5348
SJNB-10 GDSC2 5.4064 7.4477 2.63 0.9399
NB69 GDSC2 5.5377 8.2278 2.377 1.8619
NH-12 GDSC2 5.5675 7.4073 2.7134 0.5562
SJNB-13 GDSC2 5.6201 7.2865 2.7781 0.359
SJNB-12 GDSC2 5.6559 11.7872 0.8406 9.7404
SiMa GDSC2 5.7093 7.7936 2.6269 0.739
SK-N-BE(2)-M17 GDSC2 6.0169 7.8383 2.7314 0.3162
GI-ME-N GDSC2 6.2771 9.1972 2.3307 1.3695
SJNB-7 GDSC2 6.5823 17.1859 -1.1171 16.8922
⏷ Show the Full List of 21 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuCC-T1 GDSC2 4.7662 6.9743 2.5126 2.1496
Cancer Drug Sensitivity Data Curated from 44 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
DU4475 GDSC2 3.8166 7.7619 1.4995 10.1249
HCC1143 GDSC2 3.9475 6.6425 2.1497 5.7869
HCC1500 GDSC2 4.0798 6.475 2.3235 4.4274
JIMT-1 GDSC2 4.2141 6.1793 2.5506 2.8177
MDA-MB-415 GDSC2 4.2681 6.4514 2.4579 3.254
CAMA-1 GDSC2 4.3596 9.9038 0.8507 12.555
COLO 824 GDSC2 4.5231 7.3792 2.1856 4.3578
HCC1806 GDSC2 4.5951 8.195 1.8473 6.2018
BT-474 GDSC2 4.6398 8.3979 1.7804 6.5048
MDA-MB-468 GDSC2 4.6488 8.7342 1.6258 7.3961
EFM-192A GDSC2 4.6569 7.5283 2.1998 4.0303
HCC1954 GDSC2 4.8248 6.6562 2.6782 1.2758
MDA-MB-175-VII GDSC2 4.8873 6.6987 2.6909 1.1546
MDA-MB-231 GDSC2 4.9317 10.6684 0.8883 11.0005
MFM-223 GDSC2 4.9419 6.9362 2.6197 1.413
BT-549 GDSC2 4.9938 10.6233 0.9531 10.5053
MRK-nu-1 GDSC2 5.0328 7.0539 2.6154 1.3355
MDA-MB-157 GDSC2 5.0696 7.5736 2.4153 2.2338
CAL-120 GDSC2 5.0939 6.8 2.7451 0.7573
MDA-MB-361 GDSC2 5.1317 10.4778 1.1167 9.302
HCC1428 GDSC2 5.1452 6.657 2.8211 0.4713
UACC-812 GDSC2 5.1767 7.5773 2.4689 1.8432
Evsa-T GDSC2 5.2137 6.6798 2.8401 0.382
HCC1419 GDSC2 5.2178 7.1197 2.6748 0.9213
CAL-148 GDSC2 5.2428 6.7868 2.8124 0.444
BT-483 GDSC2 5.468 6.8998 2.8582 0.2385
MDA-MB-453 GDSC2 5.5112 7.9319 2.4852 1.4201
MDA-MB-436 GDSC2 5.5847 7.4446 2.7065 0.5671
HCC70 GDSC2 5.5864 7.3714 2.7342 0.4872
HDQ-P1 GDSC2 5.624 7.787 2.5932 0.9098
HCC38 GDSC2 5.6679 7.8218 2.5986 0.8599
MCF-7 GDSC2 5.7126 7.769 2.6375 0.7032
HCC1187 GDSC2 5.8035 7.446 2.7904 0.2666
ZR-75-30 GDSC2 5.8211 7.4554 2.7935 0.2549
CAL-85-1 GDSC2 5.8238 8.7217 2.3124 1.8489
HCC1937 GDSC2 5.8503 8.1164 2.5636 0.8553
HCC1395 GDSC2 5.918 7.9009 2.6713 0.4962
Hs 578T GDSC2 5.9526 15.4914 -0.7344 16.6373
EFM-19 GDSC2 5.9622 8.2029 2.5775 0.7409
AU565 GDSC2 6.0127 8.4938 2.4883 0.9999
BT-20 GDSC2 6.0601 7.7873 2.7651 0.2386
OCUB-M GDSC2 6.0738 8.0651 2.6723 0.4264
T-47D GDSC2 6.1301 8.4104 2.5685 0.6735
CAL-51 GDSC2 6.335 7.9739 2.7984 0.1306
⏷ Show the Full List of 44 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 37 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
LN-18 GDSC2 3.8759 7.9544 1.4496 10.2744
YH-13 GDSC2 4.0944 6.3952 2.3716 4.1065
SW1783 GDSC2 4.185 8.2726 1.5238 9.0525
SF539 GDSC2 4.243 6.8699 2.2444 4.5619
CAS-1 GDSC2 4.3723 6.6193 2.4447 3.1405
Daoy GDSC2 4.4731 7.8818 1.9153 6.0508
GI-1 GDSC2 4.5107 8.442 1.6721 7.4187
A-172 GDSC2 4.7605 10.1374 1.0259 10.618
DK-MG GDSC2 4.8347 6.722 2.6558 1.3667
U-87MG ATCC GDSC2 4.8547 7.6451 2.2647 3.3333
LNZTA3WT4 GDSC2 4.8816 8.5948 1.8443 5.6555
H4 GDSC2 4.908 9.609 1.3817 8.2694
SK-MG-1 GDSC2 4.9179 7.6794 2.2856 3.1209
MOG-G-UVW GDSC2 4.9612 8.1987 2.0764 4.1971
SF268 GDSC2 5.0106 7.2496 2.5228 1.7845
D283 Med GDSC2 5.0899 7.1932 2.5857 1.4069
42-MG-BA GDSC2 5.2485 8.3056 2.1934 3.1172
U-118MG GDSC2 5.2939 8.0251 2.3392 2.3218
AM-38 GDSC2 5.301 7.2418 2.6639 0.8964
U-251MG GDSC2 5.3111 6.7874 2.839 0.3404
LN-405 GDSC2 5.3581 6.7946 2.8544 0.285
ONS-76 GDSC2 5.4322 7.0552 2.789 0.4141
M059J GDSC2 5.458 7.5863 2.5986 1.0163
D-392MG GDSC2 5.5444 7.9495 2.4936 1.355
KALS-1 GDSC2 5.5791 8.3841 2.3325 2.0177
D-263MG GDSC2 5.6342 7.44 2.728 0.4805
GB-1 GDSC2 5.6463 7.4061 2.7451 0.4296
Becker GDSC2 5.8375 7.4842 2.7895 0.2576
8-MG-BA GDSC2 5.8742 7.7589 2.7058 0.4284
LN-229 GDSC2 5.9037 7.2972 2.8769 0.1077
KS-1 [Human Krukenberg tumour] GDSC2 6.0336 8.3255 2.5609 0.7501
KINGS-1 GDSC2 6.2894 8.2935 2.6722 0.3471
SW1088 GDSC2 6.3156 8.0742 2.7577 0.1884
GaMG GDSC2 6.4486 8.1607 2.7748 0.1402
MOG-G-CCM GDSC2 6.5491 8.6718 2.6353 0.3374
DBTRG-05MG GDSC2 7.0973 17.9118 -1.1173 15.9
T98G GDSC2 7.8079 17.2541 -0.3554 11.5476
⏷ Show the Full List of 37 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Digestive System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TGBC1TKB GDSC2 4.8076 7.9581 2.0939 4.3646
TGBC24TKB GDSC2 5.5618 7.5191 2.6691 0.6956
ETK-1 GDSC2 5.8605 8.0636 2.5878 0.7698
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ESS-1 GDSC2 4.2425 7.9894 1.7038 7.8298
EN GDSC2 4.2484 5.8986 2.6992 1.9264
MFE-319 GDSC2 5.0201 13.6977 -0.5278 17.8439
MFE-296 GDSC2 5.4759 7.3295 2.705 0.6344
MFE-280 GDSC2 5.6047 9.0403 2.0663 3.2707
RL95-2 GDSC2 5.6689 6.9304 2.9191 0.0959
AN3-CA GDSC2 5.97 7.7292 2.7524 0.289
KLE GDSC2 6.0808 8.0807 2.6693 0.4306
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 129 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
GDM-1 GDSC2 1.2219 7.7305 -0.808 30.9517
WSU-DLCL2 GDSC2 1.9696 3.0197 1.9163 13.8454
MV4-11 GDSC2 1.9954 3.6539 1.7717 14.5172
EB2 GDSC2 2.1688 3.6811 1.9498 12.7575
SU-DHL-10 GDSC2 3.629 5.1302 2.6591 3.3837
WIL2 NS GDSC2 3.683 7.1363 1.7067 9.2019
A3/Kawakami GDSC2 3.7963 5.0988 2.7909 2.2073
RC-K8 GDSC2 3.853 6.2676 2.2648 5.2973
SCC-3 GDSC2 3.9171 6.0722 2.4057 4.2822
DEL GDSC2 3.9638 7.1658 1.9051 7.2581
SR GDSC2 3.9985 8.1364 1.4526 9.9419
VAL GDSC2 4.0007 6.9041 2.0602 6.214
HH [Human lymphoma] GDSC2 4.0585 7.1568 1.9783 6.5825
NALM-6 GDSC2 4.0655 8.8075 1.1715 11.4499
Karpas-45 GDSC2 4.101 8.7048 1.249 10.9025
IM-9 GDSC2 4.1099 6.5459 2.3099 4.4459
MN-60 GDSC2 4.1551 6.9911 2.1267 5.4581
L-428 GDSC2 4.1772 6.8895 2.1908 5.022
Karpas-1106P GDSC2 4.1783 6.7672 2.2501 4.662
MHH-CALL-2 GDSC2 4.2126 7.1221 2.1031 5.4755
Ramos.2G6.4C10 GDSC2 4.2173 9.818 0.7866 13.2715
697 GDSC2 4.2287 6.3338 2.4879 3.153
K-562 GDSC2 4.2352 7.0268 2.1642 5.059
JVM-3 GDSC2 4.2465 6.2348 2.545 2.7916
Jurkat GDSC2 4.2694 6.0829 2.6283 2.2825
OCI-AML-3 GDSC2 4.3214 8.3787 1.5704 8.4508
P30/OHK GDSC2 4.3396 6.5872 2.4394 3.2294
BE-13 GDSC2 4.3396 8.6635 1.4444 9.1609
Hs 445 GDSC2 4.3583 8.631 1.4737 8.9429
CESS GDSC2 4.3742 6.5165 2.4931 2.8621
ST486 GDSC2 4.3744 6.1279 2.6686 1.8982
Raji GDSC2 4.4449 9.043 1.3347 9.5637
BC-1 GDSC2 4.5088 7.1257 2.2946 3.7542
Karpas-620 GDSC2 4.5295 9.4607 1.1915 10.2024
ATN-1 GDSC2 4.5602 9.9658 0.9669 11.4148
NOMO-1 GDSC2 4.5652 6.8195 2.4684 2.6827
Mono-Mac-6 GDSC2 4.5786 12.4961 -0.2646 17.735
NKM-1 GDSC2 4.6003 8.3166 1.7928 6.5129
ALL-PO GDSC2 4.6038 9.9582 1.0019 11.1143
P12-Ichikawa GDSC2 4.6357 6.5912 2.6088 1.8379
RPMI-8866 GDSC2 4.6381 8.3053 1.8233 6.2556
MOLT-16 GDSC2 4.6476 7.4642 2.2237 3.9111
TUR GDSC2 4.6549 6.322 2.7332 1.2124
NCI-H929 GDSC2 4.672 14.4721 -1.1718 21.3528
ML-2 GDSC2 4.6816 7.2612 2.3369 3.2173
SUP-T1 GDSC2 4.6828 10.8831 0.6068 13.1085
Daudi GDSC2 4.7077 7.0067 2.466 2.476
KOPN-8 GDSC2 4.7111 7.3097 2.3323 3.1941
WSU-NHL GDSC2 4.7208 19.721 -3.7429 28.9511
EoL-1 GDSC2 4.7785 7.3637 2.3471 3.0055
SUP-B15 GDSC2 4.7796 7.8615 2.1213 4.2589
KE-37 GDSC2 4.7888 6.0574 2.8994 0.4396
KY821 GDSC2 4.8011 6.3913 2.7749 0.8847
MOLM-13 GDSC2 4.8027 7.2288 2.4209 2.5741
BV-173 GDSC2 4.8075 7.7861 2.1728 3.9201
L-363 GDSC2 4.8152 11.7529 0.2768 14.5182
EJM GDSC2 4.8527 7.3585 2.3914 2.6557
SUP-M2 GDSC2 4.8758 13.9781 -0.7731 19.2446
MLMA GDSC2 4.8821 11.4931 0.4523 13.456
H9 GDSC2 4.8828 8.4531 1.9112 5.2699
OCI-AML-5 GDSC2 4.8915 6.268 2.8626 0.4934
SU-DHL-5 GDSC2 4.8964 5.9788 2.9705 0.1983
KCL-22 GDSC2 4.9069 8.1157 2.0818 4.2594
HDLM-2 GDSC2 4.9361 7.7942 2.2447 3.313
GA-10 GDSC2 4.9875 6.2117 2.9219 0.2744
OCI-M1 GDSC2 4.9976 6.0258 2.9911 0.129
U-698-M GDSC2 5.0188 13.4642 -0.4139 17.3411
BL-41 GDSC2 5.0237 6.3654 2.8801 0.3664
P31/FUJ GDSC2 5.0529 6.3271 2.9055 0.2869
Karpas-231 GDSC2 5.0665 6.427 2.8745 0.3607
MM1.S GDSC2 5.0709 8.215 2.1335 3.7034
HL-60 GDSC2 5.0748 6.1254 2.9844 0.1212
LAMA-84 GDSC2 5.0782 6.9488 2.6794 1.0221
P32/ISH GDSC2 5.0866 6.7128 2.7756 0.6548
DB GDSC2 5.1084 7.9149 2.2879 2.8273
L-1236 GDSC2 5.1234 7.5805 2.4404 2.0428
ALL-SIL GDSC2 5.1361 6.6765 2.8101 0.51
SK-MM-2 GDSC2 5.145 7.3416 2.5514 1.5014
MHH-PREB-1 GDSC2 5.1649 7.6441 2.4347 2.0194
RPMI-8402 GDSC2 5.1758 13.2793 -0.209 16.0363
OPM-2 GDSC2 5.1833 6.8457 2.7659 0.6223
OCI-AML-2 GDSC2 5.1931 6.2719 2.9762 0.1078
LC4-1 GDSC2 5.2092 12.4892 0.2 13.991
Ku812 GDSC2 5.2221 8.2853 2.1877 3.1851
TK [Human B-cell lymphoma] GDSC2 5.2468 6.6445 2.8658 0.3024
EM-2 GDSC2 5.2508 7.2963 2.6198 1.1079
MEG-01 GDSC2 5.2668 8.2768 2.216 2.9748
Namalwa GDSC2 5.2943 7.1415 2.6999 0.7712
SU-DHL-8 GDSC2 5.2991 7.0577 2.734 0.652
ME1 GDSC2 5.3169 6.4961 2.9434 0.1293
Loucy GDSC2 5.327 6.8637 2.8175 0.3883
U266B1 GDSC2 5.3329 7.7315 2.482 1.6114
Reh GDSC2 5.355 6.9594 2.7936 0.4393
MOLT-13 GDSC2 5.365 7.21 2.7038 0.7088
A4/Fukuda GDSC2 5.3714 14.7026 -0.7639 18.0398
ARH-77 GDSC2 5.383 9.9643 1.5209 6.5541
BALL-1 GDSC2 5.3989 7.0511 2.7774 0.4621
CTV-1 GDSC2 5.4104 7.332 2.6765 0.7709
HAL-01 GDSC2 5.4185 7.6929 2.5383 1.2872
Karpas-299 GDSC2 5.4401 7.1322 2.7639 0.4786
JJN-3 GDSC2 5.4474 7.028 2.8048 0.3666
KMS-12-BM GDSC2 5.4542 7.0428 2.8021 0.3704
CCRF-CEM GDSC2 5.4811 6.9427 2.848 0.255
MOLP-8 GDSC2 5.4908 7.1384 2.7817 0.406
DND-41 GDSC2 5.5609 7.728 2.5886 0.9729
JSC-1 GDSC2 5.6177 7.9668 2.5202 1.1851
CA46 GDSC2 5.6224 7.2481 2.7927 0.3243
L-540 GDSC2 5.6269 16.0333 -1.2301 19.3359
KG-1 GDSC2 5.6366 7.3446 2.7636 0.3874
Granta-519 GDSC2 5.6416 7.5697 2.683 0.6049
RPMI-6666 GDSC2 5.6467 7.2617 2.7971 0.3056
RS4;11 GDSC2 5.6531 7.5995 2.6766 0.6177
CML-T1 GDSC2 5.6914 7.6268 2.682 0.5805
VL51 GDSC2 5.693 8.0549 2.5192 1.1272
KMOE-2 GDSC2 5.7298 7.5706 2.7179 0.4618
GR-ST GDSC2 5.7517 15.7741 -1.0137 18.2137
JVM-2 GDSC2 5.7544 7.9644 2.5809 0.861
DG-75 GDSC2 5.76 7.6334 2.7068 0.4768
JURL-MK1 GDSC2 5.7972 7.3667 2.8157 0.2206
YT GDSC2 5.8197 7.6024 2.7411 0.3664
MOLT-4 GDSC2 5.8471 7.1695 2.9002 0.0903
Jiyoye GDSC2 5.849 7.3941 2.8249 0.1915
SU-DHL-6 GDSC2 5.8668 7.2494 2.8803 0.1097
KM-H2 GDSC2 5.8978 7.5898 2.7747 0.2677
RPMI-8226 GDSC2 5.9152 7.7596 2.7212 0.375
HC-1 GDSC2 5.9359 7.7134 2.7454 0.3146
PF-382 GDSC2 6.4134 8.0119 2.8125 0.1034
SUP-HD1 GDSC2 6.5125 8.5413 2.6675 0.288
Karpas-422 GDSC2 7.2054 24.9182 -4.4356 25.5607
⏷ Show the Full List of 129 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 17 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KTCTL-195 GDSC2 3.3764 8.6185 0.7189 15.9665
KMRC-1 GDSC2 4.0147 6.5545 2.2403 5.0763
BFTC-909 GDSC2 4.337 6.8834 2.2994 4.0486
SW13 GDSC2 4.3796 6.527 2.4916 2.8616
KMRC-20 GDSC2 4.7505 7.0943 2.4512 2.491
A-498 GDSC2 4.7883 8.1507 1.9927 4.9774
786-O GDSC2 4.8806 8.9695 1.6675 6.6774
A-704 GDSC2 4.9327 11.8563 0.3113 14.0654
CAL-54 GDSC2 5.1889 8.6489 2.0065 4.2049
OS-RC-2 GDSC2 5.3635 7.2089 2.7036 0.7106
SN12C GDSC2 5.4095 7.1362 2.7501 0.5349
LB996-RCC GDSC2 5.5712 7.9853 2.4916 1.3386
ACHN GDSC2 5.7242 12.9712 0.3226 12.2669
VMRC-RCZ GDSC2 5.7333 7.4651 2.7573 0.3626
RCC10RGB GDSC2 5.7855 7.3533 2.8161 0.2232
TK-10 GDSC2 5.8424 8.8225 2.28 1.9708
769-P GDSC2 6.0342 12.8262 0.5954 10.2774
⏷ Show the Full List of 17 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 43 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
LoVo GDSC2 3.884 8.4943 1.1879 11.8244
HT-29 GDSC2 4.1795 8.1309 1.5893 8.6707
RCM-1 [Human ESC] GDSC2 4.2589 12.9463 -0.7334 20.6374
LS513 GDSC2 4.295 9.169 1.1644 10.9182
HCT 15 GDSC2 4.4261 6.4166 2.5691 2.3542
SK-CO-1 GDSC2 4.4569 9.4392 1.1499 10.6133
SW1463 GDSC2 4.6679 7.3888 2.2706 3.61
HT-55 GDSC2 4.707 6.8958 2.5146 2.2222
LS411N GDSC2 4.7115 7.1398 2.4089 2.7757
HCT 116 GDSC2 4.7654 7.6153 2.2256 3.6962
MDST8 GDSC2 4.786 8.3869 1.8809 5.6268
SNU-175 GDSC2 4.8751 7.4501 2.3634 2.7705
C2BBe1 GDSC2 4.9837 16.7806 -2.0777 23.8006
LS123 GDSC2 5.0994 11.5931 0.5577 12.4072
SW837 GDSC2 5.1131 6.95 2.6948 0.9309
SW48 GDSC2 5.1149 7.4875 2.4755 1.8851
HCC2998 GDSC2 5.1232 7.487 2.4799 1.8545
COLO205 GDSC2 5.1374 6.4097 2.9081 0.2473
CCK-81 GDSC2 5.153 7.7081 2.4013 2.196
COLO 320HSR GDSC2 5.1937 7.1725 2.643 1.0655
LS1034 GDSC2 5.1941 6.7077 2.8221 0.4419
LS180 GDSC2 5.2603 7.083 2.7078 0.768
RKO GDSC2 5.3482 7.2104 2.6965 0.7452
GP5d GDSC2 5.4052 7.1939 2.7267 0.6089
SNU-C5 GDSC2 5.4321 11.9185 0.6297 11.3076
SW1417 GDSC2 5.447 7.4028 2.665 0.7851
CW-2 GDSC2 5.4817 7.8716 2.4958 1.404
SNU-C2B GDSC2 5.5599 9.0769 2.026 3.5384
SW620 GDSC2 5.5735 7.3701 2.7295 0.5066
T84 GDSC2 5.6218 7.8586 2.5645 1.0147
SNU-61 GDSC2 5.6289 7.753 2.6084 0.8533
COLO 678 GDSC2 5.6573 7.568 2.69 0.5756
NCI-H716 GDSC2 5.6849 7.7919 2.6173 0.7857
KM12 GDSC2 5.6975 7.4957 2.7325 0.4388
SNU-C1 GDSC2 5.729 7.6161 2.7009 0.5076
SW948 GDSC2 5.7672 7.2727 2.8374 0.1911
SW1116 GDSC2 5.7992 7.0737 2.9158 0.0807
SNU-407 GDSC2 5.8493 8.7946 2.2947 1.8995
NCI-H747 GDSC2 5.9566 8.1764 2.5851 0.7208
CaR-1 GDSC2 6.0299 8.0403 2.6643 0.4641
CL-11 GDSC2 6.0578 7.6992 2.7946 0.19
SW626 GDSC2 6.241 8.4684 2.5912 0.5558
DiFi GDSC2 6.2997 8.5753 2.5753 0.5702
⏷ Show the Full List of 43 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Leukemia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MO-T GDSC2 4.5607 7.0463 2.3628 3.2754
Cancer Drug Sensitivity Data Curated from 14 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SK-HEP-1 GDSC2 4.5348 6.8643 2.4304 2.9417
JHH-6 GDSC2 4.6936 5.829 2.9459 0.3525
JHH-2 GDSC2 4.7323 8.8584 1.6225 7.2402
JHH-1 GDSC2 4.7688 10.5357 0.8382 11.6463
SNU-398 GDSC2 5.1001 7.6511 2.398 2.2798
Hep-G2/C3A GDSC2 5.1072 6.4999 2.8639 0.3694
SNU-423 GDSC2 5.2433 11.8432 0.5368 12.1979
Huh-7 GDSC2 5.2513 7.0957 2.699 0.806
HLE GDSC2 5.3812 10.7435 1.155 8.5838
JHH-4 GDSC2 5.4846 7.5441 2.6267 0.8925
JHH-7 GDSC2 5.5008 7.3745 2.6984 0.6401
HuH-1 GDSC2 5.5196 7.0857 2.8117 0.3204
SNU-449 GDSC2 5.5854 7.7176 2.6033 0.9021
SNU-387 GDSC2 5.9755 7.6543 2.7806 0.2342
⏷ Show the Full List of 14 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 131 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Ms-1 GDSC2 2.5722 3.755 2.3551 8.7219
Lu-165 GDSC2 3.8791 6.0777 2.3762 4.5488
NCI-H2085 GDSC2 4.0339 8.7184 1.1916 11.4117
NCI-H526 GDSC2 4.1023 9.7382 0.7387 13.8351
NCI-H226 GDSC2 4.1499 11.5955 -0.1467 18.291
LCLC-103H GDSC2 4.155 7.3087 1.9729 6.3944
NCI-H82 GDSC2 4.2062 9.0737 1.1456 11.2467
NCI-H2141 GDSC2 4.2181 6.483 2.4113 3.6208
Lu-139 GDSC2 4.292 6.1974 2.5896 2.4604
NCI-H720 GDSC2 4.32 7.6739 1.9111 6.4022
EPLC-272H GDSC2 4.3209 6.8487 2.3054 4.0446
NCI-H196 GDSC2 4.3405 7.3103 2.0994 5.2279
CPC-N GDSC2 4.401 9.4476 1.1053 11.0044
NCI-H1915 GDSC2 4.4357 7.1009 2.2604 4.0877
COR-L279 GDSC2 4.4449 11.6815 0.0372 16.6309
DMS 114 GDSC2 4.4578 7.7754 1.9559 5.8409
COLO 668 GDSC2 4.4826 6.831 2.4144 3.1193
NCI-H211 GDSC2 4.4838 9.415 1.181 10.3696
NCI-H2122 GDSC2 4.5067 9.7845 1.0169 11.2583
NCI-H520 GDSC2 4.516 6.7863 2.4547 2.8381
NCI-H1299 GDSC2 4.5192 7.1424 2.2934 3.7428
NCI-H847 GDSC2 4.5286 6.4085 2.6304 1.8749
NCI-H1793 GDSC2 4.5363 6.5712 2.5629 2.2177
DMS 53 GDSC2 4.5602 7.4518 2.1751 4.3491
NCI-H69 GDSC2 4.5926 7.1885 2.317 3.4789
SBC-3 GDSC2 4.5986 10.9237 0.5254 13.7462
NCI-H2009 GDSC2 4.6149 10.0016 0.9887 11.1628
NCI-H2023 GDSC2 4.6176 8.0166 1.9467 5.5716
NCI-H23 GDSC2 4.6249 7.6818 2.1086 4.6129
NCI-H727 GDSC2 4.6339 7.8684 2.027 5.07
NCI-H2369 GDSC2 4.6745 7.0732 2.4176 2.7866
NCI-H1568 GDSC2 4.6976 9.8242 1.1337 10.1491
NCI-H1581 GDSC2 4.7008 6.9295 2.4964 2.3263
HCC827 GDSC2 4.7164 7.0381 2.457 2.5108
PC-14 GDSC2 4.7684 7.7138 2.1824 3.9334
NCI-H1563 GDSC2 4.7808 10.0861 1.065 10.3518
SBC-5 GDSC2 4.7895 5.9528 2.9386 0.3223
NCI-H1341 GDSC2 4.7956 6.5927 2.6902 1.2534
Lu-65 GDSC2 4.815 8.9527 1.6325 7.0121
HCC78 GDSC2 4.8155 7.6256 2.2506 3.4743
NCI-H1944 GDSC2 4.8177 7.7592 2.1912 3.7998
NCI-H2228 GDSC2 4.8227 10.1774 1.05 10.3426
EBC-1 GDSC2 4.8252 7.1881 2.4512 2.3829
HOP-62 GDSC2 4.8262 7.7087 2.2192 3.6301
NCI-H1573 GDSC2 4.8483 7.0625 2.5183 2.01
NCI-H1869 GDSC2 4.8596 8.0425 2.0867 4.3136
NCI-H524 GDSC2 4.906 11.374 0.5275 13.0061
NCI-H1092 GDSC2 4.9431 7.0816 2.5594 1.6911
KNS-62 GDSC2 4.9598 7.6015 2.3437 2.7498
NCI-H64 GDSC2 4.9742 6.3551 2.864 0.4394
NCI-H1155 GDSC2 4.9821 6.9455 2.6355 1.2998
NCI-H3122 GDSC2 4.9837 7.1996 2.5302 1.7816
NCI-H2087 GDSC2 5.0164 8.1378 2.1366 3.7734
COR-L23 GDSC2 5.0317 6.8467 2.6988 0.9853
NCI-H835 GDSC2 5.0392 8.0183 2.2034 3.3755
NCI-H596 GDSC2 5.0543 12.6227 0.0243 15.2094
NCI-H358 GDSC2 5.0645 9.6934 1.4451 7.5875
NCI-H1781 GDSC2 5.0704 6.3257 2.9127 0.2627
NCI-H522 GDSC2 5.071 8.1259 2.1735 3.4872
NCI-H1963 GDSC2 5.0849 7.0452 2.6437 1.1622
NCI-H810 GDSC2 5.1021 7.73 2.365 2.4422
NCI-H841 GDSC2 5.1083 8.1715 2.1744 3.425
LCLC-97TM1 GDSC2 5.1265 10.2721 1.2113 8.7838
NCI-H1688 GDSC2 5.1453 7.5945 2.4457 1.9906
HCC15 GDSC2 5.1682 9.4177 1.6409 6.2773
SHP-77 GDSC2 5.2052 13.0418 -0.0719 15.3239
Lu-99A GDSC2 5.2254 8.4431 2.1197 3.5381
COR-L88 GDSC2 5.2462 7.268 2.629 1.0756
UMC-11 GDSC2 5.2888 7.2238 2.6655 0.8997
Lu-135 GDSC2 5.2921 7.3856 2.6031 1.1386
IA-LM GDSC2 5.2993 6.8668 2.8054 0.4345
NCI-H2731 GDSC2 5.3123 9.2287 1.8162 5.0437
NCI-H1435 GDSC2 5.32 7.2586 2.6657 0.8749
NCI-H1755 GDSC2 5.3434 7.4163 2.6142 1.0503
LXF 289 GDSC2 5.3437 9.3551 1.7773 5.2047
SW1271 GDSC2 5.3689 7.5149 2.5867 1.1366
NCI-H2722 GDSC2 5.3829 7.4777 2.6077 1.0426
RERF-LC-KJ GDSC2 5.4034 7.1765 2.7325 0.592
NCI-H1694 GDSC2 5.4219 7.0143 2.7999 0.3905
NCI-H441 GDSC2 5.4266 7.916 2.4515 1.6481
NCI-H1975 GDSC2 5.458 7.2877 2.7133 0.6191
NCI-H1876 GDSC2 5.4595 7.5278 2.6221 0.928
SK-MES-1 GDSC2 5.4661 7.9939 2.4386 1.664
NCI-H2347 GDSC2 5.472 7.4036 2.6753 0.7333
COR-L95 GDSC2 5.4751 7.1163 2.7836 0.4083
NCI-H209 GDSC2 5.4903 7.9792 2.4562 1.5634
SK-LU-1 GDSC2 5.5095 11.694 0.7886 10.3093
LK-2 GDSC2 5.5101 7.1248 2.7941 0.3662
NCI-H2170 GDSC2 5.5216 7.1393 2.7933 0.3633
NCI-H446 GDSC2 5.5409 7.9159 2.5055 1.3097
LOU-NH91 GDSC2 5.5434 7.5238 2.6597 0.7382
DMS 273 GDSC2 5.5641 7.3877 2.7193 0.5409
PaCa-3 GDSC2 5.5917 9.5439 1.837 4.4799
NCI-H1355 GDSC2 5.5943 10.0349 1.6169 5.6575
NCI-H2818 GDSC2 5.6059 7.4952 2.6963 0.5854
Calu-6 GDSC2 5.6062 7.3245 2.7591 0.4118
NCI-H650 GDSC2 5.6338 7.5296 2.6948 0.5745
NCI-H1993 GDSC2 5.6496 7.2493 2.8025 0.2928
NCI-H2595 GDSC2 5.6765 8.1757 2.4639 1.3562
NCI-H2373 GDSC2 5.6858 7.6804 2.6597 0.6502
EMC-BAC-2 GDSC2 5.7177 8.4659 2.3661 1.724
COR-L311 GDSC2 5.7278 7.6966 2.6708 0.5933
NCI-H1703 GDSC2 5.7582 12.7958 0.4292 11.6633
NCI-H1623 GDSC2 5.7628 8.0476 2.5526 0.9529
NCI-H1650 GDSC2 5.7788 8.0422 2.5615 0.9105
NCI-H1048 GDSC2 5.7969 7.4251 2.7953 0.259
NCI-H2795 GDSC2 5.8314 7.9484 2.6191 0.6896
NCI-H1693 GDSC2 5.84 7.7583 2.6927 0.4766
A-549 GDSC2 5.8562 11.7078 1.0058 8.4826
NCI-H2066 GDSC2 5.9003 8.4038 2.4744 1.1316
NCI-H1651 GDSC2 5.9021 9.6313 1.9694 3.3577
NCI-H1838 GDSC2 5.9035 7.7021 2.7372 0.3435
NCI-H1666 GDSC2 5.9088 9.1469 2.1783 2.3549
Calu-3 GDSC2 5.975 7.8586 2.7085 0.381
HCC44 GDSC2 5.9765 7.8287 2.7197 0.3553
VMRC-LCD GDSC2 5.9809 8.1351 2.6103 0.6325
NCI-H322M GDSC2 6.0427 9.5285 2.0856 2.6291
HARA [Human squamous cell lung carcinoma] GDSC2 6.0537 12.0453 0.9721 8.3002
SW1573 GDSC2 6.0928 8.6257 2.4719 1.0009
NCI-H513 GDSC2 6.0956 15.2061 -0.4976 15.3254
NCI-H2591 GDSC2 6.1639 8.5204 2.5413 0.7348
NCI-H2342 GDSC2 6.1754 7.9766 2.7412 0.2494
RERF-LC-Sq1 GDSC2 6.2085 8.4188 2.5965 0.557
NCI-H2405 GDSC2 6.3088 8.3875 2.6463 0.3956
LC-1/sq GDSC2 6.3167 8.8904 2.4655 0.8778
NCI-H661 GDSC2 6.3554 8.0432 2.7821 0.1472
NCI-H1648 GDSC2 6.4933 8.8341 2.5567 0.5312
COR-L105 GDSC2 6.5172 8.5025 2.6826 0.2602
HOP-92 GDSC2 6.5949 9.4027 2.3877 0.9534
NCI-H2461 GDSC2 7.0442 17.2089 -0.8184 14.8134
NCI-H1792 GDSC2 8.9041 20.0745 -0.9861 12.3424
⏷ Show the Full List of 131 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Lymphoma Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CBTCi002-A GDSC2 5.987 8.2096 2.5851 0.7034
Cancer Drug Sensitivity Data Curated from 21 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KYSE-150 GDSC2 4.2337 6.6782 2.3293 4.0753
OE21 GDSC2 4.4803 7.0307 2.321 3.6545
KYSE-70 GDSC2 4.5004 8.979 1.4052 9.0218
TE-9 GDSC2 4.508 7.499 2.1198 4.771
KYSE-450 GDSC2 4.55 7.1277 2.319 3.5418
KYSE-270 GDSC2 4.8039 7.3564 2.3649 2.8702
TE-5 GDSC2 5.0585 10.4029 1.1032 9.5308
T.T GDSC2 5.1594 7.4581 2.5102 1.672
COLO 680N GDSC2 5.1757 6.8729 2.7522 0.6732
OE33 GDSC2 5.2064 9.4221 1.6627 6.0844
TE-4 GDSC2 5.3185 8.2269 2.2655 2.6537
TE-15 GDSC2 5.332 9.0127 1.9258 4.4129
KYSE-180 GDSC2 5.3542 7.2165 2.6968 0.7401
TE-6 GDSC2 5.3936 7.2876 2.6863 0.7487
TE-1 GDSC2 5.4825 7.2743 2.7284 0.5589
KYSE-410 GDSC2 5.5253 8.2073 2.3794 1.8645
TE-8 GDSC2 5.5873 12.4524 0.4788 11.7634
OE19 GDSC2 5.609 6.8845 2.9139 0.1122
EC-GI-10 GDSC2 5.6368 7.2685 2.7909 0.3229
KYSE-140 GDSC2 5.7112 8.1308 2.4975 1.1951
KYSE-520 GDSC2 6.0168 8.1241 2.6287 0.5628
⏷ Show the Full List of 21 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 25 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
DOV13 GDSC2 4.3708 8.8615 1.3701 9.5281
OVISE GDSC2 4.4102 7.7747 1.9242 6.1298
OV56 GDSC2 4.4898 5.8538 2.8461 0.8836
OAW42 GDSC2 4.4998 6.1239 2.7381 1.372
OVCAR-4 GDSC2 4.5886 6.7795 2.4998 2.476
IGROV-1 GDSC2 4.8308 7.4126 2.3551 2.8814
FU-OV-1 GDSC2 4.9023 8.4907 1.9058 5.2643
A2780 GDSC2 4.9209 8.0663 2.1127 4.0629
ES-2 GDSC2 4.9369 7.1281 2.5365 1.8079
OVKATE GDSC2 4.9695 8.5567 1.9169 5.0789
TOV-21G GDSC2 4.9944 7.7152 2.3128 2.8617
OVCAR-3 GDSC2 5.0479 7.858 2.2795 2.9579
SK-OV-3 GDSC2 5.1307 8.7111 1.9439 4.6461
OVTOKO GDSC2 5.141 7.0661 2.6614 1.0387
EFO-21 GDSC2 5.2185 7.1123 2.678 0.9086
RMG-I GDSC2 5.2266 8.2415 2.2095 3.0653
TOV-112D GDSC2 5.4757 8.575 2.1988 2.7799
OVCAR-8 GDSC2 5.4948 14.1482 -0.4046 16.2043
OC 314 GDSC2 5.4967 7.1469 2.7809 0.4054
Caov-4 GDSC2 5.6781 8.6933 2.2527 2.2731
TYK-nu GDSC2 5.6872 7.4767 2.7354 0.4361
OV-90 GDSC2 5.8453 17.0975 -1.5929 20.2041
Kuramochi GDSC2 6.0658 7.8178 2.7565 0.2523
OAW28 GDSC2 6.0693 9.6383 2.0529 2.7501
OVCAR-5 GDSC2 8.0088 26.9424 -4.8468 25.0764
⏷ Show the Full List of 25 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 29 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KP-4 GDSC2 4.5633 6.3863 2.6588 1.6826
Capan-1 GDSC2 4.5828 6.4119 2.6581 1.6605
SU.86.86 GDSC2 4.6576 6.2918 2.7471 1.1463
Panc 08.13 GDSC2 4.6861 6.8671 2.5157 2.2466
PaTu 8988t GDSC2 4.7394 6.6428 2.641 1.5465
CFPAC-1 GDSC2 4.7426 7.0771 2.4544 2.4862
SUIT-2 GDSC2 4.7982 6.4425 2.7529 0.9779
PSN1 GDSC2 4.8153 6.6644 2.6701 1.3227
HPAF-II GDSC2 4.8189 8.389 1.9008 5.4487
DAN-G GDSC2 4.8738 6.1868 2.8859 0.4308
Hs 766T GDSC2 4.9308 6.8205 2.662 1.2362
MIA PaCa-2 GDSC2 5.0183 6.5583 2.8056 0.5989
Panc 10.05 GDSC2 5.0593 10.3587 1.1249 9.4079
KP-1N GDSC2 5.092 7.6306 2.4026 2.2679
BxPC-3 GDSC2 5.1205 7.5921 2.434 2.0775
SW1990 GDSC2 5.2687 7.5198 2.5379 1.4327
HPAC GDSC2 5.3338 8.3477 2.2214 2.8547
KP-2 GDSC2 5.3585 6.8554 2.8328 0.3357
Panc 03.27 GDSC2 5.373 7.0057 2.7837 0.4574
HuP-T3 GDSC2 5.6484 11.3442 1.0443 8.6677
PaTu 8902 GDSC2 5.703 7.0971 2.8747 0.1476
HuP-T4 GDSC2 5.8079 17.3106 -1.7243 20.7505
AsPC-1 GDSC2 5.8363 8.4102 2.4434 1.2995
KP-3 GDSC2 5.8812 7.9455 2.6404 0.5992
Panc 02.03 GDSC2 6.1034 14.4532 -0.1311 13.666
YAPC GDSC2 6.1195 12.8418 0.6426 9.8765
PL4 GDSC2 6.1692 7.9896 2.7344 0.2633
Panc 04.03 GDSC2 6.1809 7.8109 2.7999 0.1562
Capan-2 GDSC2 6.3703 8.3398 2.6858 0.2951
⏷ Show the Full List of 29 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H2052 GDSC2 4.2424 6.181 2.5672 2.6723
MPP 89 GDSC2 4.6947 17.0475 -2.433 25.5872
NCI-H28 GDSC2 4.8058 6.8017 2.6077 1.6256
NCI-H2452 GDSC2 4.9364 8.0136 2.1459 3.853
MSTO-211H GDSC2 5.3491 10.3274 1.3301 7.6776
IST-Mes1 GDSC2 5.5879 7.6076 2.6465 0.7524
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
VCaP GDSC2 4.3916 9.1307 1.2536 10.1647
PC-3 GDSC2 4.7324 6.9764 2.4932 2.2974
DU145 GDSC2 5.3184 7.7276 2.4765 1.651
22Rv1 GDSC2 5.3444 10.2024 1.3857 7.3777
LNCaP clone FGC GDSC2 5.5513 7.7918 2.5594 1.0892
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 GDSC2 5.3675 7.3697 2.6433 0.9207
Cancer Drug Sensitivity Data Curated from 31 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
LOX-IMVI GDSC2 1.827 4.5369 1.2511 18.2128
A2058 GDSC2 3.8883 5.6514 2.5887 3.2307
UACC-62 GDSC2 4.064 7.4547 1.8366 7.439
SK-MEL-2 GDSC2 4.1253 6.0672 2.5471 3.0028
UACC-257 GDSC2 4.5563 9.5169 1.1831 10.1888
COLO 679 GDSC2 4.6112 7.27 2.2908 3.5943
GAK GDSC2 4.6594 6.7529 2.5511 2.1002
A101D GDSC2 4.68 6.2579 2.7719 1.0129
M14 GDSC2 4.7241 7.144 2.4142 2.7276
CHL-1 GDSC2 4.7573 10.2717 0.9584 11.0043
SH-4 GDSC2 4.9039 7.3582 2.4198 2.4346
WT2-iPS GDSC2 4.9395 6.3557 2.8495 0.5055
IGR-1 GDSC2 5.0146 6.7983 2.7103 0.9543
A-375 GDSC2 5.0149 7.0837 2.5944 1.4479
WM115 GDSC2 5.0191 6.5422 2.8121 0.5766
RPMI-7951 GDSC2 5.15 7.7003 2.4031 2.1912
G-361 GDSC2 5.2227 6.6562 2.8522 0.3461
WM1552C GDSC2 5.2259 13.4301 -0.2467 16.0953
WM35 GDSC2 5.2334 7.86 2.3783 2.2075
SK-MEL-1 GDSC2 5.3856 6.5402 2.9526 0.1028
SK-MEL-24 GDSC2 5.4168 6.9587 2.818 0.3471
IST-MEL1 GDSC2 5.4472 9.4843 1.78 5.0168
HT-144 GDSC2 5.459 7.8885 2.4782 1.4998
Mel JuSo GDSC2 5.5521 6.9165 2.883 0.1694
COLO 792 GDSC2 5.6253 7.5736 2.6749 0.6389
WM793 GDSC2 5.66 7.0756 2.8669 0.1693
MeWo GDSC2 5.7383 7.4702 2.7574 0.3604
COLO 829 GDSC2 5.7421 7.7164 2.6692 0.5901
HMV-II GDSC2 6.0948 8.3068 2.5926 0.6233
IGR-37 GDSC2 6.1405 15.0562 -0.3949 14.7822
WM278 GDSC2 6.1999 14.6636 -0.167 13.6364
⏷ Show the Full List of 31 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 20 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SW684 GDSC2 3.7295 5.8406 2.384 4.8535
KYM-1 GDSC2 4.1932 7.1799 2.062 5.7671
MES-SA GDSC2 4.3773 6.4385 2.5306 2.6466
HT-1080 GDSC2 4.4275 6.6822 2.4493 3.0175
EW-8 GDSC2 4.5472 6.627 2.5443 2.3006
MFH-ino GDSC2 4.7025 7.0667 2.4364 2.6416
SW982 GDSC2 4.747 6.2451 2.8084 0.7978
Rh41 GDSC2 4.8903 11.69 0.3621 13.9045
Hs 633.T GDSC2 4.9673 7.1023 2.5629 1.6461
SK-UT-1 GDSC2 5.0114 9.6443 1.4336 7.76
SK-LMS-1 GDSC2 5.4642 7.511 2.6306 0.8935
RKN GDSC2 5.5177 7.8129 2.5359 1.2084
RD GDSC2 5.5534 8.7692 2.1562 2.8892
G-401 GDSC2 5.632 17.8538 -2.1202 22.4669
Rh30 GDSC2 5.6936 7.4159 2.7598 0.3727
SW872 GDSC2 5.7169 7.5487 2.7208 0.4602
VA-ES-BJ GDSC2 5.7655 7.5189 2.7503 0.3662
GCT GDSC2 5.7709 7.3552 2.8102 0.2383
A-204 GDSC2 6.082 10.8903 1.5152 5.4122
G-402 GDSC2 6.5304 16.5277 -0.8363 15.8741
⏷ Show the Full List of 20 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 25 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MKN45 GDSC2 3.9107 6.2885 2.2961 4.9695
SNU-5 GDSC2 4.2867 7.099 2.1643 4.9509
KATO III GDSC2 4.3866 6.4473 2.5321 2.6226
MKN1 GDSC2 4.4516 7.1911 2.2283 4.2447
SNU-1 GDSC2 4.539 7.6605 2.0637 5.0393
TGBC11TKB GDSC2 4.5983 6.6924 2.544 2.2257
RF-48 GDSC2 4.6263 8.678 1.6375 7.3746
Fu97 GDSC2 4.6544 9.6981 1.1645 10.0707
Hs 746.T GDSC2 4.6925 6.5187 2.6695 1.4666
ECC10 GDSC2 4.7623 7.9674 2.0617 4.6293
NCI-N87 GDSC2 5.2034 8.1849 2.2216 3.0356
MKN28 GDSC2 5.3078 7.4421 2.5877 1.1868
SNU-16 GDSC2 5.3595 6.9754 2.7895 0.4483
NUGC-4 GDSC2 5.3772 7.6415 2.5398 1.3195
GCIY GDSC2 5.3772 11.1329 0.9679 9.6155
IM95 GDSC2 5.4242 7.5305 2.6054 1.0176
23132/87 GDSC2 5.622 13.703 -0.0993 14.5257
AGS GDSC2 5.6912 7.3135 2.7954 0.2934
HSC-39 GDSC2 5.6943 7.3027 2.8003 0.282
NUGC-3 GDSC2 5.7644 7.6661 2.6966 0.5019
OCUM-1 GDSC2 5.8048 7.5494 2.7544 0.3419
HGC-27 GDSC2 5.9004 8.1939 2.5552 0.8503
RERF-GC-1B GDSC2 6.0395 8.2622 2.5869 0.669
SK-GT-2 GDSC2 6.2318 8.3328 2.6366 0.4469
SNG-M GDSC2 4.8331 6.8987 2.5805 1.7231
⏷ Show the Full List of 25 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 14 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TT GDSC2 4.5421 6.3658 2.6563 1.7238
8505C GDSC2 4.6138 8.1507 1.8807 5.9669
CAL-62 GDSC2 4.6198 9.9445 1.02 10.9744
K5 GDSC2 4.665 10.1268 0.9634 11.1888
ASH-3 GDSC2 4.7604 7.0337 2.4834 2.3084
IHH-4 GDSC2 4.9346 6.9023 2.6301 1.3739
8305C GDSC2 4.9721 8.967 1.7275 6.154
B-CPAP GDSC2 5.0203 7.213 2.5431 1.6773
FTC-133 GDSC2 5.0657 6.4154 2.8784 0.3504
HTC-C3 GDSC2 5.0734 7.4585 2.4664 1.9785
TT2609-C02 GDSC2 5.1618 6.964 2.711 0.8301
WRO GDSC2 5.2058 6.7677 2.8045 0.4869
BHT-101 GDSC2 5.2323 6.7772 2.8117 0.4515
CGTH-W-1 GDSC2 5.7507 7.2132 2.852 0.1716
⏷ Show the Full List of 14 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 26 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
BICR 22 GDSC2 4.0785 10.6225 0.2814 16.3552
HSC-4 GDSC2 4.1083 6.8614 2.157 5.3765
FaDu GDSC2 4.2261 6.0434 2.6205 2.399
HO-1-u-1 GDSC2 4.442 12.3752 -0.3085 18.2849
SCC-9 GDSC2 4.4901 6.8827 2.3952 3.2144
HSC-2 GDSC2 4.5044 6.6238 2.5212 2.4913
SAS GDSC2 4.5508 9.6042 1.1367 10.4686
Ca9-22 GDSC2 4.5599 9.2745 1.3036 9.4813
HO-1-N-1 GDSC2 4.681 11.1339 0.4826 13.7738
BICR 10 GDSC2 4.6861 7.3123 2.3164 3.3235
HSC-3 GDSC2 4.7539 6.3887 2.7538 1.0172
Detroit 562 GDSC2 4.7782 7.1618 2.4368 2.5261
JHU-022 GDSC2 5.0721 8.6894 1.9185 4.888
BICR 78 GDSC2 5.1864 8.9368 1.8742 4.9379
NCI-H3118 GDSC2 5.2336 8.2302 2.2183 3.01
CAL-27 GDSC2 5.3478 7.2624 2.6764 0.8158
PCI-30 GDSC2 5.4067 12.9824 0.0995 14.045
SKN-3 GDSC2 5.4549 8.0953 2.3912 1.8875
CAL-33 GDSC2 5.4881 7.3179 2.7143 0.5982
LB771-HNC GDSC2 5.5738 8.1689 2.4187 1.6413
SCC-15 GDSC2 5.6286 7.8559 2.5685 0.9949
SCC-4 GDSC2 5.7463 8.5402 2.3495 1.7668
OSC-20 GDSC2 5.9117 7.6415 2.7617 0.2891
UPCI-SCC-090 GDSC2 5.9199 8.0247 2.6266 0.618
SAT [Human HNSCC] GDSC2 5.9889 9.1794 2.2041 2.1521
DOK GDSC2 6.3948 10.5766 1.8222 3.4457
⏷ Show the Full List of 26 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 14 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RT-4 GDSC2 3.9584 7.1256 1.9209 7.1737
BFTC-905 GDSC2 4.4935 8.3342 1.7122 7.2175
RT-112 GDSC2 4.6209 9.9127 1.0364 10.8789
639V GDSC2 4.976 5.9276 3.017 0.0943
KU-19-19 GDSC2 5.0022 6.451 2.8396 0.4983
SW1710 GDSC2 5.0419 9.2721 1.629 6.5838
HT-1376 GDSC2 5.1372 8.3171 2.1258 3.6406
5637 GDSC2 5.2923 8.8418 1.9797 4.1849
SW780 GDSC2 5.4448 7.542 2.61 0.9838
647V GDSC2 5.6537 7.0947 2.858 0.1854
CAL-29 GDSC2 5.692 7.1942 2.8374 0.2109
TCCSUP GDSC2 5.9579 7.4473 2.8452 0.1379
J82 GDSC2 6.1116 10.9367 1.5113 5.3867
UM-UC-3 GDSC2 7.5176 16.1575 -0.0278 10.6052
⏷ Show the Full List of 14 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 29 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NEC8 GDSC2 3.8848 7.0783 1.8897 7.5469
SiHa GDSC2 4.1323 7.0036 2.1049 5.641
DSH1 GDSC2 4.136 6.4101 2.3922 3.8977
PA-1 GDSC2 4.2606 6.7691 2.3038 4.1724
C-33 A GDSC2 4.3249 6.4597 2.4892 2.9705
SiSo GDSC2 4.4205 7.7642 1.9362 6.0363
PEO1 GDSC2 4.4618 7.7117 1.9888 5.6368
ME-180 GDSC2 4.5215 8.7077 1.5514 8.1108
HeLa GDSC2 4.6399 6.854 2.4957 2.4197
NT2-D1 GDSC2 4.8356 6.7714 2.6356 1.459
SW756 GDSC2 4.9288 8.3806 1.9733 4.8325
LB831-BLC GDSC2 4.9311 8.6547 1.8476 5.5439
TC-YIK GDSC2 5.0472 7.0913 2.607 1.3575
SKG-IIIa GDSC2 5.0566 8.7003 1.9041 4.9962
HEC-1 GDSC2 5.3236 6.9732 2.7759 0.5065
HT-3 GDSC2 5.3414 8.0219 2.365 2.1393
MS751 GDSC2 5.3534 7.0074 2.7752 0.492
OVCA420 GDSC2 5.3616 7.542 2.5725 1.1996
SKN GDSC2 5.4343 8.1997 2.3372 2.1608
NCC-IT GDSC2 5.4734 7.4628 2.6532 0.8071
C-4-I GDSC2 5.5103 7.182 2.7734 0.4185
OVMIU GDSC2 5.5322 8.0966 2.4282 1.6418
KGN GDSC2 5.533 10.2098 1.4998 6.4016
DoTc2 4510 GDSC2 5.5973 7.4169 2.7218 0.5161
CAL-39 GDSC2 5.7219 8.0383 2.5384 1.0337
PWR-1E GDSC2 5.7773 7.5681 2.7372 0.3926
HEY GDSC2 5.7899 8.0056 2.5803 0.8396
Ca Ski GDSC2 6.1005 8.5049 2.521 0.8343
BPH-1 GDSC2 6.3561 9.4526 2.2655 1.5525
⏷ Show the Full List of 29 Cancer Drug Sensitivity Data of This Drug

References

1 Epigenetics and beyond: targeting writers of protein lysine methylation to treat disease. Nat Rev Drug Discov. 2021 Apr;20(4):265-286.
2 Discovery and development of potent and selective inhibitors of histone methyltransferase g9a. ACS Med Chem Lett. 2014 Jan 2;5(2):205-9.