Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM1KS78)

Drug Name
Talazoparib Drug Info
Synonyms Talazoparib (BMN 673); UNII-9QHX048FRV; 9QHX048FRV; Talazoparib [USAN:INN]; Talzenna; 4pjt; 2YQ
Cross-matching ID
PubChem CID
135565082
ChEBI ID
CHEMBL3137320
CAS Number
CAS 1207456-01-6
TTD Drug ID
D0GV8J
ACDINA Drug ID
D01457

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Glutathione metabolism 2.06 1.41e-2 43/57 (75.44%) GSTM3;GPX2;GSTP1;...
p53 signaling pathway 2.05 7.07e-3 63/73 (86.3%) CDKN1A;SESN1;DDB2;...
Metabolism of xenobiotics by cytochrome P450 2.03 1.41e-2 49/77 (63.64%) GSTM3;GSTP1;AKR1C1;...
Butanoate metabolism 1.96 1.77e-2 23/28 (82.14%) HMGCS2;ABAT;BDH2;...
Fructose and mannose metabolism 1.96 1.41e-2 30/33 (90.91%) AKR1B10;ALDOB;GMDS;...
Pentose and glucuronate interconversions 1.89 1.65e-2 17/34 (50%) AKR1B10;CRYL1;UGT2B15;...
Influenza A 1.87 1.41e-2 156/172 (90.7%) FAS;TNFRSF10B;OAS1;...
Drug metabolism 1.85 1.24e-2 78/151 (51.66%) GSTM3;GSTP1;RRM2;...
Glioma 1.83 1.57e-2 67/75 (89.33%) CDKN1A;DDB2;CALML3;...
Asthma 1.76 4.38e-2 25/31 (80.65%) CD40;HLA-DOB;FCER1A;...
Tryptophan metabolism 1.76 4.11e-2 35/42 (83.33%) KYNU;DLD;CYP1B1;...
Oxidative phosphorylation 1.76 3.77e-2 93/133 (69.92%) COX15;ATP6V0D1;ATP6V1E1;...
Valine, leucine and isoleucine degradation 1.74 4.78e-2 42/48 (87.5%) DLD;PCCB;HMGCS2;...
Retinol metabolism 1.73 4.54e-2 41/68 (60.29%) ALDH1A3;CYP3A5;ALDH1A1;...
Synthesis and degradation of ketone bodies 1.72 4.81e-2 9/10 (90%) HMGCS2;BDH2;ACAT1;...
Steroid hormone biosynthesis 1.71 4.77e-2 43/61 (70.49%) AKR1C3;HSD17B2;AKR1C1;...
Hepatitis B 1.70 4.91e-2 151/162 (93.21%) CDKN1A;DDB2;SRC;...
Allograft rejection 1.69 4.84e-2 32/38 (84.21%) FAS;CD40;HLA-DOB;...
Small cell lung cancer 1.69 4.59e-2 90/92 (97.83%) CDKN1A;DDB2;COL4A5;...
Amoebiasis 1.68 4.91e-2 99/102 (97.06%) COL4A5;SERPINB3;CXCL2;...
Rheumatoid arthritis 1.66 4.95e-2 78/93 (83.87%) CXCL2;CXCL1;CXCL8;...
RNA transport -1.67 4.53e-2 128/186 (68.82%) RAE1;EIF2B5;NUP205;...
Selenocompound metabolism -1.70 3.57e-2 11/17 (64.71%) CTH;TXNRD1;SEPHS1;...
Mineral absorption -1.77 2.13e-2 48/60 (80%) CLCN2;SLC31A1;MT1X;...
Ribosome biogenesis in eukaryotes -1.93 2.71e-3 52/108 (48.15%) RPP40;IMP3;RIOK2;...
mRNA surveillance pathway -2.01 2.03e-3 71/98 (72.45%) GSPT2;PPP1CB;PCF11;...
Spliceosome -2.42 0.00e+0 101/150 (67.33%) SF3A1;RBMXL2;PPIH;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 0.05uM - 4uM 6H, 24H, 48H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H, 48H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Fibrocystic breast disease
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A (Parent) CVCL_0598 Homo sapiens 1.11uM - 10uM 3H, 6H, 12H, 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H, 48H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.04uM - 10uM 24H