Details of the Drug

General Information of Drug (ID: DM1KS78)

Drug Name
Talazoparib
Synonyms Talazoparib (BMN 673); UNII-9QHX048FRV; 9QHX048FRV; Talazoparib [USAN:INN]; Talzenna; 4pjt; 2YQ
Indication
Disease Entry ICD 11 Status REF
Breast cancer 2C60-2C65 Approved [1]
Psoriatic arthritis FA21 Phase 3 [2]
ATC Code
L01XK04: Talazoparib
L01XK: Poly (ADP-ribose) polymerase (PARP) inhibitors
L01X: OTHER ANTINEOPLASTIC AGENTS
L01: ANTINEOPLASTIC AGENTS
L: ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 380.4
Logarithm of the Partition Coefficient (xlogp) 2.3
Rotatable Bond Count (rotbonds) 2
Hydrogen Bond Donor Count (hbonddonor) 2
Hydrogen Bond Acceptor Count (hbondacc) 7
Chemical Identifiers
Formula
C19H14F2N6O
IUPAC Name
(11S,12R)-7-fluoro-11-(4-fluorophenyl)-12-(2-methyl-1,2,4-triazol-3-yl)-2,3,10-triazatricyclo[7.3.1.05,13]trideca-1,5(13),6,8-tetraen-4-one
Canonical SMILES
CN1C(=NC=N1)[C@@H]2[C@H](NC3=CC(=CC4=C3C2=NNC4=O)F)C5=CC=C(C=C5)F
InChI
InChI=1S/C19H14F2N6O/c1-27-18(22-8-23-27)15-16(9-2-4-10(20)5-3-9)24-13-7-11(21)6-12-14(13)17(15)25-26-19(12)28/h2-8,15-16,24H,1H3,(H,26,28)/t15-,16-/m1/s1
InChIKey
HWGQMRYQVZSGDQ-HZPDHXFCSA-N
Cross-matching ID
PubChem CID
135565082
CAS Number
1207456-01-6
UNII
9QHX048FRV
DrugBank ID
DB11760
TTD ID
D0GV8J
ACDINA ID
D01457
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug
Repurposed Drugs (RPD) Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Poly [ADP-ribose] polymerase (PARP) TTEBCY8 NOUNIPROTAC Inhibitor [1]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Breast cancer resistance protein (ABCG2) DTI7UX6 ABCG2_HUMAN Substrate [3]
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [3]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Gene/Protein Processing [4]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Gene/Protein Processing [4]
Breast cancer type 1 susceptibility protein (BRCA1) OT5BN6VH BRCA1_HUMAN Drug Response [4]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Gene/Protein Processing [4]
Fumarate hydratase, mitochondrial (FH) OTEQWU6Q FUMH_HUMAN Drug Response [5]
G1/S-specific cyclin-D1 (CCND1) OT8HPTKJ CCND1_HUMAN Gene/Protein Processing [4]
Poly polymerase 2 (PARP2) OTYL81ZI PARP2_HUMAN Gene/Protein Processing [6]
Retinoblastoma-associated protein (RB1) OTQJUJMZ RB_HUMAN Gene/Protein Processing [4]
Succinate dehydrogenase iron-sulfur subunit, mitochondrial (SDHB) OTRE1M1T SDHB_HUMAN Drug Response [5]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 40 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RPMI-3460/CS1 GDSC1; GDSC2 3.2087 12.2852 -1.2544 25.6539
SK-ES-1 GDSC1; GDSC2 -7.4055 4.4088 -8.6991 73.1696
ES8 GDSC1; GDSC2 -5.7574 -0.1729 -5.8963 78.1983
EW-3 GDSC1; GDSC2 -5.7344 3.2906 -6.553 70.9298
EW-22 GDSC1; GDSC2 -5.2866 1.4998 -5.6454 72.821
EW-12 GDSC2 -4.8897 -0.93 -4.9271 76.7952
ES7 GDSC1; GDSC2 -3.722 -0.039 -3.7714 68.2226
ES1 GDSC1; GDSC2 -3.7136 1.7929 -3.9993 65.2723
EW-1 GDSC1; GDSC2 -2.9601 2.5707 -3.3443 59.782
A-673 GDSC1; GDSC2 -2.3015 5.8938 -3.6689 53.7476
TC-71 GDSC1; GDSC2 -2.1994 1.8378 -2.373 54.7257
MHH-ES-1 GDSC1; GDSC2 -2.0304 6.0932 -3.4554 52.1788
CADO-ES1 GDSC1; GDSC2 -1.6406 4.7415 -2.5386 49.8606
EW-11 GDSC1; GDSC2 -1.2901 4.8226 -2.1884 47.3473
ES4 GDSC1; GDSC2 -1.1295 4.4498 -1.8849 45.9901
EW-7 GDSC1; GDSC2 -1.1087 5.9534 -2.4203 46.4058
ES5 GDSC1; GDSC2 -0.4052 20.7283 -8.6538 46.8122
SK-PN-DW GDSC1; GDSC2 -0.3063 4.9888 -1.1914 39.572
EW-13 GDSC1; GDSC2 -0.0075 9.5505 -2.8685 41.4932
EW-16 GDSC1; GDSC2 0.1453 5.7427 -1.0115 36.615
HuO9 GDSC1; GDSC2 0.7369 5.1592 -0.1499 30.3672
HOS GDSC1; GDSC2 3.3069 4.7514 2.5946 4.6486
CAL-72 GDSC1; GDSC2 3.5633 9.2797 0.5417 16.4022
H-EMC-SS GDSC1; GDSC2 3.6429 8.4491 1.0207 13.4656
SJSA-1 GDSC1; GDSC2 3.7111 8.9726 0.814 14.4669
EW-24 GDSC1; GDSC2 3.781 17.5665 -3.4216 30.4351
NY GDSC1; GDSC2 3.9095 8.7593 1.0761 12.4155
CAL-78 GDSC1; GDSC2 3.9481 8.213 1.3766 10.5292
MG-63 GDSC2 4.0742 14.816 -1.8109 25.1827
ES6 GDSC1; GDSC2 4.381 13.6775 -1.0019 21.4222
SaOS-2 GDSC1; GDSC2 4.4024 9.5227 1.0695 11.2072
U-CH2 GDSC2 4.4435 10.522 0.6085 13.6814
CHSA0108 GDSC1; GDSC2 4.5519 11.8856 0.0169 16.46
HuO-3N1 GDSC1; GDSC2 4.7365 9.6345 1.2526 9.3801
EW-18 GDSC1; GDSC2 4.8548 13.3014 -0.455 17.9189
CHSA0011 GDSC1; GDSC2 4.9569 13.7123 -0.5816 18.2303
CHSA8926 GDSC1; GDSC2 4.9717 10.1553 1.1631 9.3794
NOS-1 [Human HNSCC] GDSC1; GDSC2 5.1108 10.6346 1.0276 9.8409
G-292 clone A141B1 GDSC1; GDSC2 5.2766 13.2729 -0.1336 15.4525
U2OS GDSC1; GDSC2 6.2775 16.489 -0.9909 17.0092
⏷ Show the Full List of 40 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 168 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JM1 GDSC1; GDSC2 -0.9358 1.892 -1.0267 43.0387
DoHH2 GDSC2 -6.9764 -2.3254 -7.0088 87.0461
MY-M12 GDSC2 -6.6104 -3.9388 -6.6111 91.3809
SU-DHL-1 GDSC2 -6.0143 3.5861 -6.9403 71.2314
697 GDSC1; GDSC2 -5.7147 -3.0919 -5.7159 86.1609
SUP-B15 GDSC2 -5.3022 -2.1773 -5.3088 81.8822
MC116 GDSC1; GDSC2 -4.8832 6.5321 -6.6764 64.058
SU-DHL-5 GDSC1; GDSC2 -4.3224 1.3189 -4.5714 69.2306
SUP-M2 GDSC1; GDSC2 -4.3059 0.4615 -4.4312 70.8024
Farage GDSC1; GDSC2 -4.1795 1.3972 -4.4308 68.3881
RL GDSC1; GDSC2 -3.6029 11.7351 -7.476 56.6372
NB4 GDSC1; GDSC2 -3.097 2.8973 -3.572 60.3025
CML-T1 GDSC1; GDSC2 -3.0898 0.4514 -3.149 62.9503
BV-173 GDSC1; GDSC2 -2.9387 -0.9938 -2.9402 62.6992
KOPN-8 GDSC1; GDSC2 -2.7227 5.5224 -3.9839 56.1649
TALL-1 [Human adult T-ALL] GDSC2 -2.7133 10.7153 -6.1161 54.0741
RCH-ACV GDSC1; GDSC2 -2.665 0.6106 -2.7178 59.3433
MHH-CALL-4 GDSC2 -2.4541 2.3587 -2.7472 56.454
SCC-3 GDSC2 -2.2381 4.6296 -3.1474 53.8326
DEL GDSC1; GDSC2 -2.1804 2.1341 -2.4053 54.4451
CTB-1 GDSC1; GDSC2 -2.0703 36.2883 -17.8457 50.5828
SU-DHL-8 GDSC1; GDSC2 -2.0333 0.2304 -2.0447 53.6805
MOLT-16 GDSC1; GDSC2 -1.7569 0.7625 -1.7839 50.9414
CESS GDSC1; GDSC2 -1.7387 5.9415 -3.0858 50.4801
NALM-6 GDSC1; GDSC2 -1.5334 0.6289 -1.5475 48.7397
NU-DUL-1 GDSC1; GDSC2 -1.4487 1.1782 -1.4921 47.9386
Namalwa GDSC1; GDSC2 -1.3878 4.7761 -2.2774 48.0558
HAL-01 GDSC1; GDSC2 -1.2321 1.5618 -1.301 45.8709
BONNA-12 GDSC2 -1.209 7.1779 -3.0274 47.4031
CRO-AP2 GDSC1; GDSC2 -1.1567 8.3408 -3.4749 47.3729
OCI-AML-2 GDSC1; GDSC2 -0.8742 1.8831 -0.9598 42.4187
MOLT-4 GDSC1; GDSC2 -0.8358 2.6681 -1.0552 42.448
ML-2 GDSC1; GDSC2 -0.7887 3.4177 -1.1907 42.4912
JVM-2 GDSC1; GDSC2 -0.6356 7.2206 -2.4504 43.8319
MV4-11 GDSC1; GDSC2 -0.6253 5.5732 -1.757 42.6857
SUP-B8 GDSC1; GDSC2 -0.571 8.6502 -3.0168 44.2013
RPMI-8402 GDSC1; GDSC2 -0.53 3.7515 -1.0065 40.3601
P32/ISH GDSC1; GDSC2 -0.5104 1.7291 -0.5568 38.6685
MOLM-13 GDSC1; GDSC2 -0.4577 6.7742 -2.0745 42.3338
JSC-1 GDSC1; GDSC2 -0.4477 3.2055 -0.7608 39.0763
ARH-77 GDSC1; GDSC2 -0.4264 4.6022 -1.1781 40.2245
P30/OHK GDSC1; GDSC2 -0.423 1.5363 -0.4493 37.7054
OCI-Ly19 GDSC1; GDSC2 -0.362 8.113 -2.5633 42.6335
GR-ST GDSC1; GDSC2 -0.282 9.5316 -3.131 43.0363
RS4;11 GDSC1; GDSC2 -0.2636 3.6954 -0.6991 37.7813
Raji GDSC1; GDSC2 -0.2466 4.0664 -0.7985 38.0307
JVM-3 GDSC1; GDSC2 -0.2218 4.4019 -0.8862 38.1816
BALL-1 GDSC1; GDSC2 -0.2074 3.3448 -0.536 36.8491
OCI-M1 GDSC1; GDSC2 -0.138 2.2735 -0.2281 35.1529
LC4-1 GDSC1; GDSC2 -0.1149 3.0834 -0.3665 35.6421
HEL GDSC1; GDSC2 -0.0765 2.0739 -0.1354 34.3917
HT GDSC1; GDSC2 -0.0493 167.7904 -81.7383 49.4729
Jurkat GDSC1; GDSC2 -0.0016 6.9375 -1.6741 39.1913
OCI-Ly7 GDSC2 0.0531 2.942 -0.1493 33.7766
BL-41 GDSC1; GDSC2 0.122 3.9132 -0.348 34.2901
SUP-HD1 GDSC1; GDSC2 0.2439 6.1235 -1.0686 36.3003
A3/Kawakami GDSC1; GDSC2 0.2649 4.0082 -0.2241 33.0131
Karpas-231 GDSC1; GDSC2 0.296 3.0581 0.0877 31.4036
WIL2 NS GDSC1; GDSC2 0.3731 3.1468 0.1498 30.7128
NKM-1 GDSC1; GDSC2 0.3837 6.7988 -1.2185 36.0861
L-540 GDSC1; GDSC2 0.4025 3.8139 -0.0109 31.3429
QIMR-WIL GDSC1; GDSC2 0.4897 4.3419 -0.0972 31.3133
HC-1 GDSC1; GDSC2 0.5868 4.5287 -0.0617 30.6761
Karpas-1106P GDSC1; GDSC2 0.6386 6.8349 -0.9753 34.1057
CMK GDSC1 0.6469 2.2037 0.6151 33.6337
Reh GDSC1; GDSC2 0.7964 2.3815 0.7542 25.5584
ALL-SIL GDSC1; GDSC2 0.8107 3.2736 0.5944 26.3236
Hs 445 GDSC1; GDSC2 0.8383 5.0293 0.0098 29.153
CCRF-CEM GDSC1; GDSC2 0.8694 3.0626 0.7115 25.4297
DND-41 GDSC1; GDSC2 0.8845 2.8961 0.7649 25.0767
JURL-MK1 GDSC1 0.8893 3.5392 0.6047 32.143
IM-9 GDSC1; GDSC2 0.9193 5.501 -0.1019 29.3061
RPMI-6666 GDSC1; GDSC2 0.9312 6.783 -0.6564 31.6155
Mono-Mac-6 GDSC1; GDSC2 1.0694 3.1377 0.9115 23.4273
Granta-519 GDSC1; GDSC2 1.1282 7.4077 -0.7484 31.1179
ATN-1 GDSC1; GDSC2 1.3634 3.0226 1.2582 20.1999
JeKo-1 GDSC1; GDSC2 1.4512 5.2059 0.5757 23.5728
EB2 GDSC1; GDSC2 1.532 4.3341 1.0222 20.7526
P12-Ichikawa GDSC1; GDSC2 1.5337 2.9793 1.4521 18.3667
NOMO-1 GDSC1; GDSC2 1.5562 3.3066 1.3991 18.5464
CTV-1 GDSC1; GDSC2 1.5944 4.0355 1.203 19.4653
H9 GDSC1; GDSC2 1.6203 5.5555 0.5943 22.774
MM1.S GDSC2 1.6251 4.2411 1.1576 19.5908
THP-1 GDSC1; GDSC2 1.6493 4.6963 0.9987 20.3936
KE-37 GDSC1; GDSC2 1.6539 3.9405 1.3018 18.6505
EoL-1 GDSC1; GDSC2 1.6957 4.5037 1.1272 19.4673
NK-92MI GDSC2 1.9151 4.0169 1.5534 16.1021
SUP-T1 GDSC1; GDSC2 2.0473 8.5326 -0.4093 26.0918
Ku812 GDSC1; GDSC2 2.0682 7.0196 0.3468 22.3603
MOLP-8 GDSC1; GDSC2 2.2458 7.2027 0.4251 21.294
NCI-H929 GDSC1; GDSC2 2.3799 5.5008 1.374 15.3515
SR GDSC1; GDSC2 2.486 3.6061 2.3189 9.2957
Karpas-299 GDSC1; GDSC2 2.6114 7.405 0.6617 18.7166
VAL GDSC1; GDSC2 2.7555 9.1872 -0.0951 22.1789
MOLT-13 GDSC1; GDSC2 2.8241 7.2339 0.937 16.4333
OCI-AML-3 GDSC1; GDSC2 2.8536 8.3088 0.4282 19.1928
A4/Fukuda GDSC1; GDSC2 2.8686 6.9765 1.1043 15.3012
EM-2 GDSC1; GDSC2 2.9057 5.7947 1.7236 11.3893
Daudi GDSC1; GDSC2 2.9256 10.5967 -0.6508 24.1389
OCI-AML-5 GDSC1 3.0064 8.1879 0.6212 21.3583
MOLM-16 GDSC1; GDSC2 3.0471 14.9694 -2.7324 30.6994
VL51 GDSC1; GDSC2 3.1109 7.6754 0.9669 15.3463
SKM-1 GDSC1; GDSC2 3.1667 8.527 0.589 17.3251
DB GDSC1; GDSC2 3.1962 8.0201 0.8673 15.6631
TK [Human B-cell lymphoma] GDSC1; GDSC2 3.2097 7.0361 1.3705 12.6245
HL-60 GDSC1; GDSC2 3.2741 5.0068 2.4393 5.7289
WSU-NHL GDSC1; GDSC2 3.304 8.9759 0.48 17.5021
KG-1 GDSC1; GDSC2 3.3277 6.7637 1.6059 10.8217
KY821 GDSC1; GDSC2 3.3676 4.9722 2.5346 4.8538
TUR GDSC1; GDSC2 3.5088 5.7569 2.2565 6.221
SU-DHL-16 GDSC1; GDSC2 3.517 14.5199 -2.1153 27.6553
L-428 GDSC1; GDSC2 3.5275 6.2763 2.0124 7.7087
MHH-CALL-2 GDSC1; GDSC2 3.5993 7.0898 1.6639 9.6935
BC-3 GDSC2 3.6505 6.9082 1.7947 8.7413
Jiyoye GDSC1; GDSC2 3.6631 9.2662 0.6291 15.6375
WSU-DLCL2 GDSC1; GDSC2 3.7495 12.067 -0.6996 21.8814
MN-60 GDSC1; GDSC2 3.8239 8.2377 1.2688 11.5017
ALL-PO GDSC1; GDSC2 3.8649 7.187 1.8211 8.0214
GA-10 GDSC1; GDSC2 3.8985 10.8795 0.0123 18.2032
AMO1 GDSC1; GDSC2 3.9243 5.7779 2.5525 3.3737
EHEB GDSC1 3.9382 11.8447 -0.4374 23.5644
RPMI-8866 GDSC1 4.0391 6.8588 2.1097 7.2365
HDLM-2 GDSC1; GDSC2 4.0396 7.7906 1.6538 8.6166
MHH-PREB-1 GDSC1; GDSC2 4.0669 9.2664 0.9454 12.7593
MLMA GDSC1; GDSC2 4.0983 8.724 1.2375 10.9769
OPM-2 GDSC1; GDSC2 4.1869 6.4216 2.4201 3.6303
GDM-1 GDSC1; GDSC2 4.2232 7.7679 1.7979 7.3036
KCL-22 GDSC1; GDSC2 4.2722 9.026 1.2179 10.6613
KMS-12-BM GDSC2 4.2741 6.0628 2.6402 2.209
YT GDSC1; GDSC2 4.3594 7.0044 2.2569 4.2548
PL-21 GDSC1; GDSC2 4.3672 7.692 1.9347 6.1583
Karpas-422 GDSC1; GDSC2 4.3809 6.8563 2.34 3.7273
ME1 GDSC1; GDSC2 4.3882 8.3346 1.639 7.8871
RC-K8 GDSC1; GDSC2 4.4205 9.2797 1.2015 10.4001
SU-DHL-6 GDSC1; GDSC2 4.4257 6.8719 2.3608 3.5251
Sc-1 GDSC1 4.4618 6.6286 2.4942 3.3725
L-363 GDSC1; GDSC2 4.4774 8.7933 1.4791 8.6375
KM-H2 GDSC1; GDSC2 4.4988 11.0267 0.401 14.6483
LAMA-84 GDSC1; GDSC2 4.499 11.4955 0.1699 15.8338
SIG-M5 GDSC2 4.5285 12.0895 -0.1014 17.0919
JJN-3 GDSC1; GDSC2 4.5612 6.2355 2.7223 1.3728
MEG-01 GDSC1; GDSC2 4.6158 11.8564 0.0791 15.9951
SU-DHL-4 GDSC1; GDSC2 4.627 6.5528 2.6207 1.7891
BC-1 GDSC1; GDSC2 4.691 14.7431 -1.2917 21.7635
DG-75 GDSC1; GDSC2 4.6991 9.7538 1.1688 9.9449
P31/FUJ GDSC1; GDSC2 4.807 6.1161 2.8848 0.4751
BE-13 GDSC1; GDSC2 4.8122 10.2313 1.0166 10.5536
PF-382 GDSC1; GDSC2 4.8149 6.9106 2.566 1.8166
Kasumi-1 GDSC1; GDSC2 4.8347 8.6133 1.8057 5.9682
SK-MM-2 GDSC1; GDSC2 4.8668 7.0095 2.5508 1.8257
ROS-50 GDSC1; GDSC2 4.8996 8.2859 1.9991 4.7382
ST486 GDSC1; GDSC2 4.9736 6.9227 2.6407 1.2858
Ramos.2G6.4C10 GDSC1; GDSC2 5.0033 6.6004 2.783 0.6883
SU-DHL-10 GDSC1; GDSC2 5.0076 6.1345 2.9569 0.1888
EJM GDSC1; GDSC2 5.023 6.7313 2.7406 0.8292
CA46 GDSC1; GDSC2 5.0712 10.8314 0.9061 10.5957
Karpas-620 GDSC1; GDSC2 5.1004 6.4317 2.8861 0.3147
L-1236 GDSC1; GDSC2 5.1193 10.1436 1.2676 8.4821
RPMI-8226 GDSC1; GDSC2 5.1275 11.7763 0.4885 12.706
K-562 GDSC1; GDSC2 5.1895 7.2638 2.6044 1.2272
HH [Human lymphoma] GDSC1; GDSC2 5.3009 7.5096 2.5574 1.3183
LP-1 GDSC1; GDSC2 5.533 7.0566 2.8271 0.2811
Loucy GDSC1; GDSC2 5.6226 8.3125 2.3833 1.7452
U266B1 GDSC1; GDSC2 5.7049 7.4139 2.7648 0.3563
U-698-M GDSC1; GDSC2 5.7085 7.7331 2.6493 0.6688
KMOE-2 GDSC1; GDSC2 5.8504 7.5949 2.7553 0.3231
Karpas-45 GDSC1; GDSC2 5.9308 7.5846 2.7886 0.2323
KMS-11 GDSC1; GDSC2 5.9612 15.7821 -0.8692 17.1776
⏷ Show the Full List of 168 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 11 Cell Line(s) in Aero Dig Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KYSE-220 GDSC1; GDSC2 3.3649 9.4712 0.283 18.3652
HCE-4 GDSC1; GDSC2 3.6241 6.4516 2.0012 7.5193
OACP4 C GDSC1; GDSC2 4.4268 11.4665 0.1298 16.2177
FLO-1 GDSC1; GDSC2 4.4403 10.935 0.4025 14.7869
ESO-26 GDSC1; GDSC2 4.5086 9.8531 0.9847 11.4363
KYSE-50 GDSC1; GDSC2 4.6705 8.6525 1.6794 7.0349
OACM5.1 C GDSC1; GDSC2 4.7373 7.8942 2.0801 4.5695
TE-12 GDSC1; GDSC2 5.2286 11.3328 0.7726 10.9815
KYAE-1 GDSC1; GDSC2 5.2812 7.8391 2.4116 1.9904
SK-GT-4 GDSC1; GDSC2 5.8678 14.873 -0.4941 15.7882
ESO-51 GDSC1; GDSC2 6.3811 8.1876 2.7422 0.1974
⏷ Show the Full List of 11 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 GDSC1; GDSC2 5.404 13.9323 -0.3641 16.2259
Cancer Drug Sensitivity Data Curated from 32 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SK-N-MC-IXC GDSC1; GDSC2 -6.1898 -3.3386 -6.1915 88.5103
MHH-NB-11 GDSC2 -3.7475 2.196 -4.1174 64.8598
CHP-126 GDSC1; GDSC2 -3.0645 11.9493 -7.0255 54.9054
SJNB-10 GDSC1; GDSC2 -2.6122 3.8462 -3.3045 56.5569
KP-N-RT-BM-1 GDSC2 -2.0939 7.0497 -3.9023 52.3297
IMR-5 GDSC1; GDSC2 -1.9429 3.1229 -2.3706 52.2467
NB69 GDSC2 -1.4339 3.9854 -2.0635 48.2587
CHP-134 GDSC2 -1.4271 4.4004 -2.1909 48.2787
CHP-212 GDSC1; GDSC2 -1.1913 8.7142 -3.6751 47.6352
SJNB-17 GDSC1; GDSC2 -0.8613 8.7613 -3.3606 45.8815
SK-N-SH GDSC1; GDSC2 -0.6886 12.0297 -4.7015 46.0509
SiMa GDSC1; GDSC2 -0.1761 4.98 -1.0487 38.4352
Kelly GDSC1; GDSC2 0.2217 7.3772 -1.6413 38.0311
SJNB-13 GDSC1; GDSC2 0.8245 5.6055 -0.2449 30.3854
SJNB-5 GDSC1; GDSC2 1.0274 12.1967 -3.1476 37.9683
GOTO GDSC1; GDSC2 1.0975 10.3067 -2.1618 35.6183
NH-12 GDSC2 1.7726 6.6406 0.2437 24.0245
SJNB-14 GDSC1; GDSC2 2.342 10.1898 -0.9593 27.3114
GI-ME-N GDSC1; GDSC2 2.4858 11.1941 -1.331 28.1966
KP-N-YS GDSC2 2.6814 12.0001 -1.5619 28.3572
KP-N-YN GDSC1; GDSC2 2.8635 15.816 -3.3111 32.5953
NB1 GDSC1; GDSC2 3.867 5.991 2.4098 4.3695
LA-N-6 GDSC1; GDSC2 4.215 11.3737 0.0139 17.3411
SK-N-FI GDSC1; GDSC2 4.4925 7.8657 1.9359 5.8878
SK-N-BE(2)-M17 GDSC1; GDSC2 4.5266 8.5529 1.6295 7.6366
NB(TU)1 GDSC1; GDSC2 4.5477 6.9318 2.4073 3.0485
SJNB-12 GDSC1; GDSC2 4.585 8.5728 1.6599 7.3305
SJNB-6 GDSC2 4.8772 6.5088 2.7629 0.8652
SK-N-DZ GDSC1; GDSC2 5.248 21.0137 -3.9745 28.3266
SJNB-7 GDSC1; GDSC2 5.3981 12.3837 0.3828 12.654
TGW GDSC1; GDSC2 5.5299 14.5227 -0.5621 16.8204
SK-N-AS GDSC1; GDSC2 5.6074 13.6833 -0.0999 14.56
⏷ Show the Full List of 32 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuCC-T1 GDSC1; GDSC2 3.2888 9.7009 0.1048 19.5076
Cancer Drug Sensitivity Data Curated from 52 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CAL-148 GDSC2 -0.8703 6.8894 -2.5527 45.1923
CAL-51 GDSC1; GDSC2 -0.6787 4.5325 -1.4257 42.3375
DU4475 GDSC1; GDSC2 1.52 22.7251 -7.9194 42.0068
HCC1806 GDSC1; GDSC2 1.8353 27.833 -10.1935 42.7711
UACC-812 GDSC2 2.379 5.8763 1.1936 16.438
AU565 GDSC1; GDSC2 3.1162 9.9897 -0.1849 21.4519
HCC1599 GDSC2 3.4967 7.9382 1.1578 13.0686
MDA-MB-175-VII GDSC1; GDSC2 3.6463 6.0791 2.2035 6.1917
JIMT-1 GDSC1; GDSC2 3.6495 10.7737 -0.1346 19.6183
MDA-MB-468 GDSC1; GDSC2 3.8509 11.9804 -0.5747 21.0602
MCF-7 GDSC1; GDSC2 3.8908 9.7439 0.5718 15.3194
OCUB-M GDSC1; GDSC2 3.964 8.6108 1.1917 11.5921
MDA-MB-157 GDSC1; GDSC2 3.9973 7.2362 1.8952 7.2385
HCC2218 GDSC1; GDSC2 4.1754 7.2421 2.0195 6.0647
MRK-nu-1 GDSC1; GDSC2 4.2142 7.6965 1.8262 7.1524
HCC1569 GDSC1; GDSC2 4.2314 18.8547 -3.7001 29.9789
CAL-120 GDSC1; GDSC2 4.2823 12.8819 -0.6832 20.3622
BT-20 GDSC1; GDSC2 4.3693 7.1191 2.2092 4.5168
CAL-85-1 GDSC1; GDSC2 4.3955 7.4896 2.0506 5.4057
HCC70 GDSC1; GDSC2 4.4416 8.2092 1.7368 7.1837
BT-474 GDSC1; GDSC2 4.4453 6.4224 2.5776 2.2778
BT-549 GDSC1; GDSC2 4.498 10.2977 0.759 12.7249
MDA-MB-415 GDSC1; GDSC2 4.5155 7.1372 2.2935 3.7486
HCC1395 GDSC1; GDSC2 4.5408 20.0357 -4.0422 30.0179
YMB-1-E GDSC2 4.583 10.5346 0.705 12.816
HDQ-P1 GDSC1; GDSC2 4.6303 8.4717 1.7389 6.7687
MDA-MB-453 GDSC1; GDSC2 4.6782 7.9026 2.0391 4.9152
MDA-MB-231 GDSC1; GDSC2 4.7116 14.361 -1.0865 20.9218
HCC38 GDSC1; GDSC2 4.7221 12.7267 -0.2707 17.4059
HCC202 GDSC1 4.7537 12.8527 -0.3093 20.4173
HCC1419 GDSC1; GDSC2 4.8324 6.6533 2.6831 1.2459
EFM-192A GDSC1; GDSC2 4.8438 9.7982 1.2475 9.1748
Evsa-T GDSC1; GDSC2 4.8686 12.5847 -0.0922 16.2099
ZR-75-30 GDSC1; GDSC2 4.8871 10.0374 1.1621 9.5674
MFM-223 GDSC1; GDSC2 4.9359 9.5542 1.4265 7.9546
UACC-893 GDSC1; GDSC2 4.9877 8.3492 2.0235 4.4466
BT-483 GDSC1; GDSC2 5.0208 10.5173 1.0227 10.0603
HCC1143 GDSC1; GDSC2 5.0459 10.839 0.885 10.7664
CAMA-1 GDSC1; GDSC2 5.0547 7.0999 2.6071 1.3495
Hs 578T GDSC1; GDSC2 5.0836 11.8421 0.4257 13.1307
HCC1954 GDSC1; GDSC2 5.1795 7.8446 2.3567 2.382
T-47D GDSC1; GDSC2 5.2634 7.4321 2.5711 1.2966
HCC2157 GDSC1; GDSC2 5.2777 7.0422 2.7309 0.6763
HCC1428 GDSC1; GDSC2 5.3879 7.7851 2.4865 1.5351
HCC1500 GDSC1; GDSC2 5.5594 7.2332 2.774 0.3949
MDA-MB-436 GDSC1; GDSC2 5.5697 16.691 -1.5944 20.814
COLO 824 GDSC1; GDSC2 5.6292 10.1706 1.5758 5.8213
HCC1187 GDSC1; GDSC2 5.7918 7.6616 2.7091 0.4563
HCC1937 GDSC1; GDSC2 5.8425 13.0885 0.3458 11.9097
MDA-MB-361 GDSC1; GDSC2 6.1918 8.1062 2.702 0.3186
EFM-19 GDSC1; GDSC2 6.4488 14.1695 0.2301 11.2936
MDA-MB-330 GDSC1; GDSC2 7.0366 19.4022 -1.8725 18.767
⏷ Show the Full List of 52 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 55 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
D283 Med GDSC1; GDSC2 -2.4117 11.3902 -6.1137 52.839
H4 GDSC1; GDSC2 -1.4862 6.6751 -3.1094 48.9755
8-MG-BA GDSC1; GDSC2 -0.6534 10.5988 -3.9946 45.4491
Daoy GDSC1; GDSC2 -0.1684 5.0753 -1.0769 38.4775
GB-1 GDSC1; GDSC2 0.058 5.257 -0.9068 36.726
D-566MG GDSC1; GDSC2 0.1706 6.2794 -1.2112 37.1023
SF295 GDSC1; GDSC2 0.4576 5.6545 -0.6478 33.7815
SF539 GDSC1; GDSC2 1.1981 6.29 -0.1639 28.3607
Becker GDSC1; GDSC2 1.6435 7.8499 -0.4576 27.8332
SF126 GDSC1; GDSC2 1.6989 8.591 -0.763 28.8747
Hs 683 GDSC1; GDSC2 2.0947 6.4908 0.6265 20.7508
MOG-G-UVW GDSC1; GDSC2 2.1465 6.6831 0.5836 20.7961
D-245MG GDSC2 2.1874 10.3054 -1.1551 28.5767
GI-1 GDSC1; GDSC2 2.3562 7.9231 0.1742 22.2089
Onda 10 GDSC1; GDSC2 2.4523 8.8735 -0.2082 23.7376
D-502MG GDSC1; GDSC2 2.4966 13.7858 -2.6128 32.0023
LNZTA3WT4 GDSC1 2.7332 10.5472 -0.7923 29.431
A-172 GDSC1; GDSC2 2.8284 15.9134 -3.3896 32.8644
YKG-1 GDSC1; GDSC2 2.9996 11.9834 -1.2803 26.3817
42-MG-BA GDSC1; GDSC2 3.0454 9.5098 -0.0054 20.8081
D-336MG GDSC1; GDSC2 3.3376 11.0191 -0.5136 22.2755
T98G GDSC1; GDSC2 3.4562 6.4268 1.8799 8.7394
SF268 GDSC1; GDSC2 3.4621 8.0236 1.0868 13.5897
NMC-G1 GDSC1; GDSC2 3.6455 13.7667 -1.6334 25.741
M059J GDSC1; GDSC2 3.6811 7.096 1.7252 9.0923
U-251MG GDSC1; GDSC2 3.7137 6.86 1.8678 8.1182
D-392MG GDSC1; GDSC2 3.771 10.7494 -0.0245 18.7394
D-423MG GDSC1; GDSC2 3.7889 11.5579 -0.4137 20.5195
SW1783 GDSC1; GDSC2 3.8232 15.2828 -2.2461 27.2222
SK-MG-1 GDSC1; GDSC2 4.0533 11.9652 -0.4064 19.7564
AM-38 GDSC1; GDSC2 4.1052 7.1027 2.0379 6.1102
GaMG GDSC1; GDSC2 4.1226 8.1054 1.5602 8.9833
CAS-1 GDSC1; GDSC2 4.165 7.7197 1.7799 7.5478
ONS-76 GDSC1; GDSC2 4.2303 9.883 0.7642 13.3631
KS-1 [Human Krukenberg tumour] GDSC1; GDSC2 4.3201 7.7536 1.8727 6.6338
D-263MG GDSC1; GDSC2 4.3993 11.5419 0.0716 16.5776
LN-405 GDSC1; GDSC2 4.4213 8.0246 1.8117 6.7794
MOG-G-CCM GDSC1; GDSC2 4.4544 11.0222 0.37 14.9214
YH-13 GDSC1; GDSC2 4.5489 11.3519 0.278 15.1605
KINGS-1 GDSC1; GDSC2 4.5895 8.4794 1.7078 7.0381
SW1088 GDSC1; GDSC2 4.7169 8.8883 1.598 7.4157
U-87MG ATCC GDSC1; GDSC2 4.7337 12.7318 -0.2645 17.3487
KNS-81-FD GDSC1; GDSC2 4.7551 11.7623 0.2284 14.9079
DBTRG-05MG GDSC1; GDSC2 4.7781 11.3669 0.439 13.7702
LN-229 GDSC1; GDSC2 4.8157 15.689 -1.6651 22.8154
SNB-75 GDSC1; GDSC2 4.8526 12.9575 -0.2873 17.1637
U-118MG GDSC1; GDSC2 4.8745 14.6013 -1.0819 20.5045
LN-18 GDSC1; GDSC2 4.9022 11.1167 0.6501 12.3629
Onda 11 GDSC1; GDSC2 5.2545 12.2176 0.3636 13.0664
KALS-1 GDSC1; GDSC2 5.3787 12.0147 0.5472 11.8512
D-247MG GDSC1; GDSC2 5.7404 25.8032 -5.9723 31.175
PFSK-1 GDSC1; GDSC2 5.9691 22.3466 -4.0844 27.0951
KNS-42 GDSC1; GDSC2 6.3169 14.656 -0.0856 13.0304
DK-MG GDSC1; GDSC2 6.3898 14.3997 0.0836 12.1006
D-542MG GDSC1; GDSC2 6.4769 23.0084 -4.0317 25.9846
⏷ Show the Full List of 55 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Digestive System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ETK-1 GDSC1; GDSC2 1.2991 11.6705 -2.6384 35.9856
TGBC24TKB GDSC1; GDSC2 4.7741 7.5249 2.2719 3.4245
TGBC1TKB GDSC1; GDSC2 5.7585 12.4363 0.6004 10.7906
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ESS-1 GDSC1; GDSC2 0.6204 4.9234 -0.1782 31.0471
MFE-296 GDSC1; GDSC2 3.4894 11.1428 -0.4499 21.5425
KLE GDSC1; GDSC2 4.0736 8.1813 1.4867 9.548
EN GDSC1; GDSC2 4.5492 9.9016 0.9904 11.3078
MFE-280 GDSC1; GDSC2 4.8461 10.2753 1.0189 10.465
MFE-319 GDSC1; GDSC2 5.0548 10.988 0.8193 11.1061
AN3-CA GDSC1; GDSC2 5.3449 10.9949 1.0121 9.4399
RL95-2 GDSC1; GDSC2 6.4344 19.1637 -2.1787 20.9681
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 33 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
LB996-RCC GDSC1; GDSC2 0.8958 6.8983 -0.7445 32.1109
BFTC-909 GDSC1; GDSC2 1.1048 9.567 -1.7976 34.6412
KTCTL-140 GDSC1; GDSC2 1.1832 13.5788 -3.6823 38.3617
LB1047-RCC GDSC1; GDSC2 1.9025 8.3449 -0.4523 26.817
LB2241-RCC GDSC1; GDSC2 2.1353 11.2091 -1.6495 30.4328
KTCTL-1M GDSC1; GDSC2 2.4681 8.8516 -0.1832 23.5662
KTCTL-13 GDSC1; GDSC2 2.6519 6.2814 1.2524 15.131
769-P GDSC1; GDSC2 3.0558 13.2869 -1.884 28.2576
KTCTL-21 GDSC1; GDSC2 3.1049 12.3023 -1.3504 26.3145
CAL-54 GDSC1; GDSC2 3.1592 8.2526 0.7197 16.6188
HA7-RCC GDSC1; GDSC2 3.2836 11.8951 -0.9967 24.4482
KTCTL-195 GDSC1; GDSC2 3.3086 5.3125 2.3155 6.4111
Caki-1 GDSC1; GDSC2 3.3408 12.0395 -1.0211 24.3739
RXF 393L GDSC1; GDSC2 3.4485 14.3212 -2.0725 27.7148
UO-31 GDSC1; GDSC2 3.5262 12.2681 -0.9821 23.6785
NCC010 GDSC1; GDSC2 3.5662 10.9995 -0.3153 20.7074
A-498 GDSC1; GDSC2 3.6688 7.7626 1.3837 11.2263
SN12C GDSC1; GDSC2 3.7116 9.5756 0.5136 16.1326
ACHN GDSC1; GDSC2 4.0233 5.901 2.5596 3.1277
BB65-RCC GDSC1; GDSC2 4.0817 11.8459 -0.3246 19.3067
OS-RC-2 GDSC1; GDSC2 4.1817 8.9194 1.2034 10.9691
SW13 GDSC1; GDSC2 4.2395 7.9289 1.7311 7.6713
KMRC-1 GDSC2 4.4196 8.0758 1.7859 6.9374
TK-10 GDSC1; GDSC2 4.5678 8.8998 1.4906 8.3673
SW156 GDSC1; GDSC2 4.7516 9.8715 1.1485 9.9432
A-704 GDSC1; GDSC2 4.7994 16.6781 -2.1684 24.5265
VMRC-RCW GDSC2 5.0253 6.7742 2.7247 0.8885
RCC10RGB GDSC1; GDSC2 5.1271 9.7305 1.4682 7.3325
KMRC-20 GDSC1; GDSC2 5.1972 9.5816 1.5827 6.5515
786-O GDSC1; GDSC2 5.2031 11.5293 0.6605 11.635
NCC021 GDSC1; GDSC2 5.4027 16.4475 -1.5978 21.2018
KTCTL-26A GDSC1; GDSC2 6.1076 15.0563 -0.4173 14.949
VMRC-RCZ GDSC1; GDSC2 6.6156 13.3906 0.6958 8.7225
⏷ Show the Full List of 33 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 48 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SK-CO-1 GDSC1; GDSC2 -3.9614 2.2418 -4.3598 65.8944
SW48 GDSC1; GDSC2 1.2586 7.2577 -0.5498 29.7793
HCC2998 GDSC1; GDSC2 1.3148 14.1578 -3.8479 38.2058
MDST8 GDSC1; GDSC2 2.7486 8.9586 0.0127 21.6768
SW620 GDSC1; GDSC2 2.8533 10.585 -0.7071 24.6061
CaR-1 GDSC1; GDSC2 2.9904 6.2034 1.5963 11.9093
KM12 GDSC1; GDSC2 3.2998 9.4671 0.2309 18.8317
SNU-C5 GDSC1; GDSC2 3.5144 10.1658 0.0591 19.0638
DiFi GDSC1; GDSC2 3.6643 6.7445 1.8869 8.1287
HCT 116 GDSC1; GDSC2 3.7914 15.5641 -2.4124 27.7957
RKO GDSC1; GDSC2 3.9261 8.0302 1.4504 10.1397
SW948 GDSC1; GDSC2 3.9269 8.4199 1.2579 11.2957
SNU-175 GDSC2 3.9279 7.6827 1.6237 9.0787
CCK-81 GDSC1; GDSC2 4.1171 8.2407 1.4897 9.4232
NCI-H508 GDSC1; GDSC2 4.1682 10.6814 0.3214 15.9097
C2BBe1 GDSC1; GDSC2 4.1746 7.0974 2.0889 5.6447
LS180 GDSC1; GDSC2 4.1927 11.7563 -0.1934 18.3983
LoVo GDSC1; GDSC2 4.2346 7.523 1.9248 6.5077
T84 GDSC1; GDSC2 4.2437 9.3435 1.0405 11.7631
SW1417 GDSC1; GDSC2 4.4223 6.6766 2.4487 3.0296
CL-11 GDSC1; GDSC2 4.4273 12.9188 -0.5893 19.5804
GP5d GDSC1; GDSC2 4.4432 13.4103 -0.8209 20.5246
NCI-H716 GDSC1; GDSC2 4.5173 6.8696 2.4175 3.0425
SW1463 GDSC1; GDSC2 4.521 8.8091 1.502 8.4045
SW1116 GDSC1; GDSC2 4.5455 7.0169 2.3671 3.2773
SNU-283 GDSC2 4.5574 9.2088 1.3337 9.3114
LS123 GDSC1; GDSC2 4.592 10.1022 0.9232 11.5855
SNU-407 GDSC1; GDSC2 4.6517 18.1206 -3.0005 27.2819
LS513 GDSC1 4.6657 6.4985 2.6644 1.8982
COLO205 GDSC1; GDSC2 4.7505 11.9995 0.1085 15.5194
SW837 GDSC1; GDSC2 4.8053 8.0169 2.0653 4.5308
HT-55 GDSC2 4.9495 9.5552 1.4351 7.8775
LS1034 GDSC1; GDSC2 5.0551 9.369 1.592 6.7694
SNU-1040 GDSC1 5.0786 6.7222 2.7685 0.8531
HT115 GDSC1; GDSC2 5.1108 12.9811 -0.1101 15.7228
RCM-1 [Human ESC] GDSC1; GDSC2 5.1294 7.5676 2.4489 1.9944
SNU-C1 GDSC1; GDSC2 5.1489 7.2484 2.5915 1.3214
COLO 320HSR GDSC1; GDSC2 5.1553 14.8469 -0.9931 19.4809
LS411N GDSC1; GDSC2 5.1772 12.7982 0.0269 14.9136
COLO 678 GDSC1; GDSC2 5.3143 9.6447 1.6264 6.0918
CW-2 GDSC1; GDSC2 5.3321 13.5342 -0.2213 15.7362
SW626 GDSC1; GDSC2 5.3766 11.1624 0.9535 9.6949
SNU-81 GDSC1; GDSC2 5.4111 7.0452 2.7843 0.4367
NCI-H747 GDSC1; GDSC2 5.532 13.3767 -0.004 14.2696
HT-29 GDSC1; GDSC2 5.7274 11.6859 0.9344 9.1036
SNU-61 GDSC1; GDSC2 5.8858 8.1526 2.5647 0.8284
HCT 15 GDSC1; GDSC2 6.169 16.1946 -0.9238 16.9636
SNU-C2B GDSC1; GDSC2 6.8632 15.9441 -0.3382 13.1241
⏷ Show the Full List of 48 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Leukemia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MO-T GDSC1; GDSC2 3.5552 9.2696 0.5401 16.4343
Cancer Drug Sensitivity Data Curated from 15 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SK-HEP-1 GDSC1; GDSC2 1.5258 10.3458 -1.7799 32.9861
JHH-6 GDSC1; GDSC2 3.4451 13.3263 -1.578 26.1162
HuH-1 GDSC1; GDSC2 3.6438 11.3187 -0.4115 20.9217
JHH-2 GDSC1; GDSC2 3.9207 7.7337 1.593 9.2846
Hep-G2/C3A GDSC1; GDSC2 4.0348 7.2445 1.9184 7.0064
SNU-449 GDSC1; GDSC2 4.3283 7.1153 2.1841 4.7474
SNU-423 GDSC1; GDSC2 4.3849 10.4934 0.5789 13.9879
SNU-398 GDSC1; GDSC2 4.4157 10.154 0.7691 12.8712
HLE GDSC1; GDSC2 4.4493 7.1948 2.225 4.2681
JHH-7 GDSC1; GDSC2 4.5862 7.3773 2.226 4.0075
Huh-7 GDSC1; GDSC2 5.1348 17.4354 -2.2868 24.111
SNU-387 GDSC1; GDSC2 5.1777 13.6091 -0.369 16.7657
JHH-4 GDSC1; GDSC2 5.4423 13.576 -0.1635 15.2204
Hep 3B2.1-7 GDSC1; GDSC2 5.6778 15.8497 -1.1036 18.7321
JHH-1 GDSC1; GDSC2 5.9122 12.778 0.5391 10.799
⏷ Show the Full List of 15 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 186 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H209 GDSC1; GDSC2 -5.3498 3.058 -6.071 70.1373
NCI-H1876 GDSC1; GDSC2 -4.7139 5.1215 -5.9978 65.0514
NCI-H460 GDSC1; GDSC2 -3.708 3.2684 -4.3355 63.2026
NCI-H1781 GDSC1; GDSC2 -2.7664 6.179 -4.2744 56.0273
NCI-H292 GDSC1; GDSC2 -2.5366 2.5104 -2.8698 56.9569
COR-L279 GDSC1; GDSC2 -2.5365 3.2032 -3.0395 56.4899
IST-SL2 GDSC1; GDSC2 -1.4589 5.629 -2.6671 48.6881
NCI-H1734 GDSC2 -1.3883 2.817 -1.6899 47.6453
NCI-H1623 GDSC1; GDSC2 -0.5206 8.2082 -2.767 43.669
NCI-H1694 GDSC1; GDSC2 -0.5166 7.672 -2.5248 43.3306
NCI-H2023 GDSC1; GDSC2 -0.0352 8.8222 -2.5577 41.1172
NCI-H1048 GDSC1; GDSC2 0.0486 7.0019 -1.6508 38.8882
NCI-H211 GDSC1; GDSC2 0.084 48.3297 -21.9342 48.0232
NCI-H748 GDSC2 0.1213 4.79 -0.6586 35.523
DMS 79 GDSC1; GDSC2 0.1671 21.3384 -8.4339 45.3738
HCC78 GDSC1; GDSC2 0.2343 5.2193 -0.705 35.1088
COR-L311 GDSC2 0.6239 9.4623 -2.2096 37.6083
NCI-H1155 GDSC1; GDSC2 0.7428 5.0474 -0.0982 30.1034
NCI-H1105 GDSC1; GDSC2 0.8598 4.3371 0.3026 27.6101
Lu-134-A GDSC1; GDSC2 0.8987 37.8716 -16.0116 46.2323
NCI-H1651 GDSC1; GDSC2 0.9354 9.2349 -1.8004 35.3263
SK-LU-1 GDSC1; GDSC2 1.0386 8.2705 -1.2418 33.2438
NCI-H2170 GDSC1; GDSC2 1.1825 6.8355 -0.429 29.5965
LC-2/ad GDSC1; GDSC2 1.1966 6.0135 -0.0409 27.7946
EMC-BAC-2 GDSC1; GDSC2 1.2251 9.9235 -1.8558 34.3329
NCI-H2810 GDSC1; GDSC2 1.2737 10.1415 -1.9158 34.3109
NCI-H2227 GDSC1; GDSC2 1.3601 16.877 -5.1527 39.8656
COLO 668 GDSC1; GDSC2 1.3906 7.4851 -0.5276 29.1417
NCI-H2795 GDSC1; GDSC2 1.4795 8.1514 -0.7592 29.7162
NCI-H2110 GDSC1; GDSC2 1.6394 10.2491 -1.6274 32.1133
NCI-H1341 GDSC1; GDSC2 1.8271 6.0694 0.5655 22.1079
SBC-5 GDSC1; GDSC2 1.8614 6.1206 0.5753 21.9202
DMS 273 GDSC1; GDSC2 1.957 6.7927 0.3497 22.7633
HOP-62 GDSC1; GDSC2 2.281 10.2669 -1.0521 27.8734
NCI-H290 GDSC1; GDSC2 2.2832 10.9383 -1.3832 29.0534
NCI-H2804 GDSC1; GDSC2 2.4436 15.6842 -3.6056 34.3908
Lu-99A GDSC1; GDSC2 2.4591 14.1674 -2.8356 32.6643
NCI-H1792 GDSC1; GDSC2 2.7302 9.9905 -0.5174 24.1967
DMS 53 GDSC1; GDSC2 2.7853 12.2359 -1.5898 28.1245
HARA [Human squamous cell lung carcinoma] GDSC1; GDSC2 2.8277 13.2888 -2.0792 29.5354
NCI-H526 GDSC1; GDSC2 2.9431 7.0066 1.1551 14.7582
NCI-H2461 GDSC1; GDSC2 2.9528 9.2491 0.0454 20.8511
A-549 GDSC1; GDSC2 3.062 9.8929 -0.1826 21.6105
NCI-H2171 GDSC2 3.0768 13.9398 -2.1926 29.133
NCI-H82 GDSC1; GDSC2 3.146 9.0862 0.2919 18.9859
NCI-H2373 GDSC1; GDSC2 3.2902 9.3371 0.2878 18.5652
COR-L303 GDSC2 3.3587 9.9222 0.0523 19.5591
NCI-H2009 GDSC1; GDSC2 3.3641 11.2083 -0.5861 22.5129
LXF 289 GDSC1; GDSC2 3.4378 9.562 0.2979 18.0705
SW1573 GDSC1; GDSC2 3.4747 13.9013 -1.841 26.9111
HCC44 GDSC1; GDSC2 3.4891 10.8515 -0.3045 20.883
ABC-1 GDSC1; GDSC2 3.5254 6.7147 1.792 9.0982
RERF-LC-MS GDSC1; GDSC2 3.5587 9.306 0.5249 16.507
NCI-H2228 GDSC2 3.5777 12.0761 -0.8439 22.9726
Calu-3 GDSC1; GDSC2 3.6093 11.305 -0.4327 21.1167
NCI-H2196 GDSC2 3.6662 7.5904 1.4674 10.7228
SBC-3 GDSC1; GDSC2 3.6861 15.0261 -2.2295 27.5391
NCI-H2405 GDSC1; GDSC2 3.7358 8.8493 0.8951 13.9348
NCI-H3122 GDSC1; GDSC2 3.7483 9.5827 0.5394 15.8896
COR-L32 GDSC1; GDSC2 3.7568 14.6472 -1.9825 26.5866
SW1271 GDSC1; GDSC2 3.7644 9.0116 0.8369 14.1889
NCI-H2087 GDSC1; GDSC2 3.7912 12.2057 -0.7352 21.915
NCI-H650 GDSC1; GDSC2 3.8325 11.2132 -0.2067 19.4418
NCI-H2803 GDSC1; GDSC2 3.9501 10.5623 0.211 17.0637
NCI-H1963 GDSC2 3.9997 7.7213 1.6584 8.6866
NCI-H1581 GDSC1; GDSC2 4.0133 7.5959 1.7302 8.2139
PC-14 GDSC1; GDSC2 4.0222 12.2552 -0.5753 20.5914
NCI-H1573 GDSC1; GDSC2 4.0223 5.7278 2.6405 2.6523
LCLC-97TM1 GDSC1; GDSC2 4.0398 9.8512 0.6346 14.5753
SK-MES-1 GDSC1; GDSC2 4.0795 12.4121 -0.6083 20.5796
NCI-H838 GDSC1; GDSC2 4.0881 9.7188 0.7374 13.8799
COR-L321 GDSC1; GDSC2 4.0905 6.872 2.1394 5.5232
NCI-H226 GDSC1; GDSC2 4.0994 10.7776 0.2205 16.6121
NCI-H1299 GDSC1; GDSC2 4.1231 8.6143 1.3102 10.4838
NCI-H146 GDSC1; GDSC2 4.1246 14.2676 -1.4972 23.9667
EPLC-272H GDSC1; GDSC2 4.1261 11.5595 -0.1473 18.3573
COR-L95 GDSC1 4.1602 9.3969 0.9516 15.1476
NCI-H1648 GDSC1; GDSC2 4.1864 8.7851 1.2731 10.5465
NCI-H2731 GDSC1; GDSC2 4.1891 11.3351 0.0131 17.4136
Lu-165 GDSC1; GDSC2 4.2096 7.1899 2.0684 5.6925
NCI-H1793 GDSC1; GDSC2 4.2472 7.9888 1.7075 7.7966
LCLC-103H GDSC1; GDSC2 4.2611 8.5479 1.4443 9.3468
NCI-H1437 GDSC1; GDSC2 4.2727 8.9321 1.2643 10.387
COR-L88 GDSC1; GDSC2 4.2737 8.1012 1.6715 7.9524
IA-LM GDSC1; GDSC2 4.3109 6.6898 2.3736 3.6639
NCI-H441 GDSC1; GDSC2 4.3288 8.3926 1.5688 8.4432
NCI-H2172 GDSC1; GDSC2 4.3409 9.7948 0.8904 12.3777
NCI-H2066 GDSC1; GDSC2 4.4068 6.3574 2.5846 2.3004
NCI-H1838 GDSC1; GDSC2 4.4092 6.9863 2.2972 3.9236
NCI-H23 GDSC1; GDSC2 4.4185 14.7669 -1.5143 23.2668
NCI-H1770 GDSC1; GDSC2 4.4472 6.3471 2.6123 2.0886
PaCa-3 GDSC1; GDSC2 4.4524 9.5552 1.0899 10.97
BEN GDSC1; GDSC2 4.4558 11.2661 0.2507 15.5332
NCI-H2444 GDSC1; GDSC2 4.4572 6.3852 2.601 2.1338
VMRC-LCD GDSC1; GDSC2 4.4699 8.5348 1.5991 7.942
NCI-H69 GDSC1; GDSC2 4.4755 12.9552 -0.5703 19.3739
A-427 GDSC1; GDSC2 4.5084 9.1007 1.3516 9.3181
EBC-1 GDSC1; GDSC2 4.5154 14.4328 -1.2729 22.1321
NCI-H2081 GDSC1; GDSC2 4.5432 16.1698 -2.1147 24.9781
NCI-H520 GDSC1; GDSC2 4.55 8.4177 1.7106 7.105
NCI-H446 GDSC1; GDSC2 4.5572 8.7465 1.5574 7.9968
Lu-135 GDSC1; GDSC2 4.5574 12.9785 -0.5194 18.9419
NCI-H2141 GDSC1; GDSC2 4.5676 6.795 2.4808 2.6111
NCI-H187 GDSC1 4.5725 6.772 2.494 3.1529
NCI-H2369 GDSC1; GDSC2 4.5755 11.5526 0.1988 15.497
NCI-H1703 GDSC1; GDSC2 4.5805 8.6313 1.6288 7.524
RERF-LC-KJ GDSC1; GDSC2 4.5857 7.748 2.0526 5.0135
KNS-62 GDSC1; GDSC2 4.5879 6.2425 2.7329 1.2902
NCI-H522 GDSC1; GDSC2 4.6034 7.6774 2.097 4.7207
NCI-H835 GDSC1; GDSC2 4.6119 7.7062 2.089 4.7514
NCI-H1915 GDSC1; GDSC2 4.6264 17.358 -2.6408 26.355
NCI-H2085 GDSC1; GDSC2 4.6295 7.5738 2.1617 4.2979
NCI-H1650 GDSC2 4.6426 7.9233 2.0067 5.1714
NCI-H810 GDSC1; GDSC2 4.6632 13.0477 -0.4734 18.4723
NCI-H720 GDSC1; GDSC2 4.685 6.1995 2.798 0.8968
NCI-H345 GDSC1; GDSC2 4.7191 5.9903 2.8956 0.4971
NCI-H2122 GDSC1; GDSC2 4.7468 15.3384 -1.5441 22.5544
NCI-H1836 GDSC1; GDSC2 4.7495 6.7424 2.6038 1.7142
NCI-H596 GDSC1; GDSC2 4.7669 8.6794 1.7305 6.5384
NCI-H2818 GDSC1; GDSC2 4.7772 7.6352 2.2235 3.688
EMC-BAC-1 GDSC1; GDSC2 4.7905 14.4838 -1.0873 20.7307
NCI-H196 GDSC1; GDSC2 4.8033 8.0026 2.0707 4.5041
NCI-H1975 GDSC1; GDSC2 4.8146 12.18 0.067 15.5691
NCI-H1944 GDSC1; GDSC2 4.8429 19.8736 -3.723 28.6326
LC-1/sq GDSC1; GDSC2 4.8571 9.9463 1.1854 9.5
LK-2 GDSC1; GDSC2 4.8703 17.3072 -2.4259 25.1497
NCI-H524 GDSC1; GDSC2 4.8805 12.3515 0.031 15.5871
SBC-1 GDSC1; GDSC2 4.8907 11.6359 0.3887 13.7661
NCI-H358 GDSC1; GDSC2 4.9019 9.1209 1.6098 6.9684
IST-SL1 GDSC1; GDSC2 4.9091 10.745 0.8355 11.3418
Calu-6 GDSC1; GDSC2 4.9625 12.6089 -0.0354 15.7138
NCI-H250 GDSC2 4.9787 16.0852 -1.737 22.6747
NCI-H322M GDSC1; GDSC2 4.9831 9.6998 1.3885 8.0748
NCI-H1436 GDSC1; GDSC2 4.9941 6.521 2.8096 0.6019
HCC827 GDSC1; GDSC2 4.9964 10.9339 0.805 11.3131
NCI-H513 GDSC1; GDSC2 5.0016 10.6511 0.9451 10.5325
NCI-H2135 GDSC1; GDSC2 5.0192 6.8788 2.6802 1.0725
NCI-H2595 GDSC1; GDSC2 5.0335 10.238 1.1653 9.2355
NCI-H661 GDSC1; GDSC2 5.0586 10.7863 0.9192 10.5513
NCI-H740 GDSC2 5.0962 22.4334 -4.7984 30.3559
NCI-H1693 GDSC1; GDSC2 5.1163 13.2272 -0.2266 16.2561
NCI-H3255 GDSC1; GDSC2 5.1577 14.7256 -0.9317 19.2268
NCI-H1355 GDSC1; GDSC2 5.1644 10.4305 1.161 8.9873
NCI-H2869 GDSC1; GDSC2 5.1724 14.6857 -0.9012 19.0684
COR-L23 GDSC1; GDSC2 5.1788 13.1056 -0.122 15.6219
NCI-H1755 GDSC1; GDSC2 5.2047 16.5296 -1.786 22.3143
EKVX GDSC1; GDSC2 5.2128 10.5606 1.1312 9.0534
NCI-H647 GDSC1; GDSC2 5.2244 17.4875 -2.2446 23.7743
NCI-H1304 GDSC1 5.2283 6.876 2.7732 0.71
NCI-H1435 GDSC1; GDSC2 5.2316 6.9537 2.7451 0.6594
NCI-H1688 GDSC1; GDSC2 5.2586 7.5983 2.5008 1.6064
NCI-H1666 GDSC1; GDSC2 5.2739 14.3029 -0.6389 17.7326
SHP-77 GDSC1; GDSC2 5.2759 13.2332 -0.1147 15.3653
NCI-H2342 GDSC1; GDSC2 5.2891 14.8874 -0.9145 18.8513
NCI-H1563 GDSC1; GDSC2 5.295 10.6944 1.1219 8.9382
DMS 114 GDSC1; GDSC2 5.3153 14.1096 -0.5143 17.0962
NCI-H2347 GDSC1; GDSC2 5.3322 13.439 -0.1748 15.5197
Lu-139 GDSC1 5.3499 7.5288 2.5724 1.5077
RERF-LC-Sq1 GDSC1; GDSC2 5.3719 14.5063 -0.6674 17.6302
NCI-H64 GDSC2 5.3789 14.4203 -0.6204 17.4124
CPC-N GDSC1; GDSC2 5.4125 14.9366 -0.8487 18.2988
CAL-12T GDSC1; GDSC2 5.4126 14.2811 -0.5281 16.9354
NCI-H2291 GDSC1; GDSC2 5.422 16.1874 -1.4555 20.6423
HCC33 GDSC2 5.4348 6.9814 2.8167 0.3427
NCI-H1092 GDSC1; GDSC2 5.4383 13.8171 -0.2836 15.7833
NCI-H1993 GDSC1; GDSC2 5.4728 9.5675 1.7574 5.0974
NCI-H2029 GDSC1; GDSC2 5.4774 7.9422 2.4651 1.5378
NCI-H1568 GDSC1; GDSC2 5.5367 12.4761 0.4332 12.1016
NCI-H841 GDSC1; GDSC2 5.6776 14.6757 -0.5317 16.3623
COR-L105 GDSC1; GDSC2 5.6909 12.2519 0.6433 10.7043
HOP-92 GDSC1; GDSC2 5.7132 14.7366 -0.5362 16.3045
NCI-H2591 GDSC1; GDSC2 5.7491 13.2095 0.2254 12.6959
NCI-H510A GDSC2 5.834 20.477 -3.2627 25.3656
LB647-SCLC GDSC1; GDSC2 5.8881 18.8822 -2.4369 22.9118
NCI-H727 GDSC1; GDSC2 5.9018 7.907 2.6627 0.5266
HCC366 GDSC1; GDSC2 5.9288 17.6425 -1.7991 20.7503
HCC15 GDSC1; GDSC2 6.0077 13.2014 0.4011 11.3047
NCI-H2722 GDSC1; GDSC2 6.0245 14.6518 -0.2797 14.506
NCI-H2030 GDSC1; GDSC2 6.0537 22.8106 -4.25 27.2992
UMC-11 GDSC1; GDSC2 6.0649 16.6702 -1.2274 18.3784
Ms-1 GDSC1; GDSC2 6.1841 15.2649 -0.4655 15.0036
Lu-65 GDSC1; GDSC2 6.5847 16.7708 -0.916 16.0905
NCI-H847 GDSC1; GDSC2 6.8398 21.963 -3.2543 23.3445
NCI-H1869 GDSC1; GDSC2 7.0874 14.9651 0.2588 10.0207
LOU-NH91 GDSC1; GDSC2 7.4827 20.7042 -2.1938 19.0042
ChaGo-K-1 GDSC1; GDSC2 7.8861 19.6917 -1.4435 15.7033
⏷ Show the Full List of 186 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Lymphoma Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CBTCi002-A GDSC1; GDSC2 5.1421 7.2243 2.598 1.3002
Cancer Drug Sensitivity Data Curated from 24 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
EC-GI-10 GDSC1; GDSC2 1.8115 7.6913 -0.2211 26.1313
KYSE-270 GDSC1; GDSC2 2.5692 6.1047 1.2624 15.3546
KYSE-510 GDSC1; GDSC2 3.2746 4.4621 2.712 4.0017
TE-5 GDSC1; GDSC2 3.4045 6.4988 1.8018 9.376
TE-11 GDSC1; GDSC2 3.652 9.835 0.3362 17.2473
OE19 GDSC1; GDSC2 3.6896 11.447 -0.4384 20.9117
OE33 GDSC1; GDSC2 3.8166 9.5787 0.5956 15.393
TE-4 GDSC1; GDSC2 3.874 8.9746 0.9415 13.2917
TE-8 GDSC1; GDSC2 4.0615 12.4288 -0.6308 20.7256
KYSE-150 GDSC1; GDSC2 4.4025 7.8241 1.8953 6.3195
TE-10 GDSC1; GDSC2 4.4383 12.8781 -0.5607 19.4271
KYSE-450 GDSC1; GDSC2 4.5627 7.9208 1.9561 5.6255
KYSE-140 GDSC2 4.848 10.4758 0.9232 10.9949
OE21 GDSC1; GDSC2 4.9324 10.0873 1.169 9.4301
KYSE-70 GDSC1; GDSC2 4.9949 9.5998 1.4438 7.735
T.T GDSC1; GDSC2 5.0373 10.5089 1.038 9.9402
KYSE-520 GDSC1; GDSC2 5.1498 8.7991 1.9152 4.7728
TE-9 GDSC1; GDSC2 5.2333 12.1571 0.378 13.0396
TE-6 GDSC1; GDSC2 5.2425 7.1221 2.6848 0.8642
COLO 680N GDSC1; GDSC2 5.3633 11.4774 0.7944 10.5797
KYSE-410 GDSC1; GDSC2 5.8808 16.5123 -1.2815 18.9772
TE-15 GDSC1 6.0354 8.0997 2.6449 0.6362
TE-1 GDSC1; GDSC2 6.1145 13.4212 0.3669 11.2657
KYSE-180 GDSC1; GDSC2 7.3532 16.4769 -0.2764 11.9758
⏷ Show the Full List of 24 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 30 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
OC 314 GDSC1; GDSC2 -0.8137 4.0492 -1.4091 43.1491
A2780 GDSC1; GDSC2 -0.1639 9.1597 -2.8416 42.1313
TOV-112D GDSC1; GDSC2 0.3327 3.1293 0.1103 31.1088
TYK-nu GDSC1; GDSC2 0.797 9.0597 -1.8507 36.0267
JHOS-2 GDSC1; GDSC2 1.4217 10.1692 -1.7906 33.4041
DOV13 GDSC1; GDSC2 2.1089 6.2939 0.7344 20.0955
OVCAR-8 GDSC1; GDSC2 2.525 10.5405 -0.9713 26.74
Caov-3 GDSC2 2.5608 8.4361 0.1058 21.8443
IGROV-1 GDSC1; GDSC2 2.5801 14.744 -3.0185 32.7372
ES-2 GDSC1; GDSC2 2.5999 6.9352 0.8832 17.4948
Caov-4 GDSC1; GDSC2 2.8496 11.9869 -1.4102 27.3097
OAW28 GDSC1; GDSC2 2.8657 10.8779 -0.8426 25.1223
JHOS-4 GDSC1; GDSC2 2.9743 14.6646 -2.6417 30.671
OAW42 GDSC1; GDSC2 3.3358 11.605 -0.808 23.5338
OVK18 GDSC1; GDSC2 3.4514 15.4849 -2.652 29.3716
SK-OV-3 GDSC1; GDSC2 3.689 9.5855 0.4906 16.3206
TOV-21G GDSC1; GDSC2 3.7589 9.831 0.424 16.481
OV56 GDSC1; GDSC2 3.8944 6.1919 2.3315 4.7889
FU-OV-1 GDSC1; GDSC2 4.6236 10.304 0.8473 11.9348
OVCAR-5 GDSC1; GDSC2 4.6484 8.8576 1.5663 7.7465
OVKATE GDSC1; GDSC2 4.7061 8.5932 1.7314 6.6567
OVTOKO GDSC1; GDSC2 4.962 10.5247 0.9788 10.4328
Kuramochi GDSC1; GDSC2 5.1041 10.7799 0.9533 10.2653
OVISE GDSC1; GDSC2 5.1488 10.0624 1.3255 8.0961
RMG-I GDSC1; GDSC2 5.222 7.8513 2.376 2.2326
EFO-21 GDSC1; GDSC2 5.7282 11.2821 1.1238 8.0901
OVCAR-3 GDSC1; GDSC2 6.0391 16.1719 -1.0036 17.556
OV-90 GDSC1; GDSC2 6.1716 14.0967 0.0842 12.5218
OVCAR-4 GDSC1; GDSC2 6.494 17.1642 -1.1672 17.263
EFO-27 GDSC1; GDSC2 8.3791 19.4731 -1.0291 13.3286
⏷ Show the Full List of 30 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 31 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Capan-1 GDSC1; GDSC2 2.5487 9.2108 -0.2893 23.7829
CFPAC-1 GDSC1; GDSC2 2.5846 7.3634 0.658 18.8286
PSN1 GDSC1; GDSC2 2.7866 9.1822 -0.0654 21.9331
SUIT-2 GDSC1; GDSC2 3.0515 9.1791 0.1651 19.9357
HuP-T4 GDSC1; GDSC2 3.1732 9.1198 0.2981 18.8691
PL4 GDSC1; GDSC2 3.4004 8.5206 0.7877 15.5065
MIA PaCa-2 GDSC1; GDSC2 3.5549 5.332 2.5038 4.5408
MZ-PC-1 GDSC1; GDSC2 3.6336 6.3299 2.0692 7.0679
Panc 03.27 GDSC1; GDSC2 3.8852 8.5505 1.1609 11.9805
KP-4 GDSC1; GDSC2 3.9015 7.1224 1.8804 7.5633
Panc 10.05 GDSC1; GDSC2 3.9037 6.1785 2.3446 4.687
KP-1N GDSC1; GDSC2 4.0158 8.8556 1.1099 11.9387
SW1990 GDSC1; GDSC2 4.1385 7.8495 1.6974 8.1125
PaTu 8988t GDSC1; GDSC2 4.1542 9.1316 1.0782 11.7698
KP-2 GDSC1; GDSC2 4.2467 6.5282 2.4084 3.5827
YAPC GDSC1; GDSC2 4.3291 7.8932 1.8115 6.9826
HPAF-II GDSC1; GDSC2 4.4537 10.5666 0.5941 13.7342
SU.86.86 GDSC1; GDSC2 4.5577 13.2813 -0.6691 19.5926
Panc 08.13 GDSC1; GDSC2 4.6349 7.6089 2.1488 4.3624
QGP-1 GDSC1; GDSC2 4.6743 9.2599 1.3905 8.719
HPAC GDSC2 4.8103 14.1258 -0.8953 19.9108
AsPC-1 GDSC1; GDSC2 4.9059 10.9093 0.7535 11.7962
BxPC-3 GDSC1; GDSC2 4.922 8.8925 1.7305 6.2332
DAN-G GDSC2 4.9446 11.9846 0.2572 14.3123
KP-3 GDSC1; GDSC2 5.1957 7.7625 2.4003 2.1477
Panc 02.03 GDSC1; GDSC2 5.552 13.3833 0.0067 14.1752
HuP-T3 GDSC1; GDSC2 5.7242 13.1246 0.2492 12.6307
Panc 04.03 GDSC2 5.9761 12.2697 0.8192 9.2382
PaTu 8902 GDSC1; GDSC2 6.2076 17.7533 -1.6532 19.6516
Hs 766T GDSC1; GDSC2 6.5889 14.1537 0.3263 10.5743
Capan-2 GDSC1; GDSC2 6.6255 15.8534 -0.4507 14.064
⏷ Show the Full List of 31 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H2452 GDSC1; GDSC2 2.8793 18.9587 -4.8683 35.4775
MSTO-211H GDSC1; GDSC2 2.8903 4.9953 2.1031 9.0705
NCI-H28 GDSC1; GDSC2 3.9025 8.2178 1.3394 10.8713
MPP 89 GDSC1; GDSC2 4.1792 7.315 1.9869 6.2545
NCI-H2052 GDSC2 5.5351 13.872 -0.2418 15.3774
IST-Mes1 GDSC1; GDSC2 6.0652 16.7641 -1.2729 18.5514
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
LNCaP clone FGC GDSC1; GDSC2 1.5181 8.9965 -1.1301 30.9389
22Rv1 GDSC1; GDSC2 3.3836 11.9271 -0.9294 23.8844
DU145 GDSC1; GDSC2 4.0076 11.7967 -0.3584 19.6626
VCaP GDSC1; GDSC2 4.1297 8.5227 1.3602 10.1694
PC-3 GDSC1; GDSC2 4.8708 11.8734 0.2583 14.4804
NCI-H660 GDSC2 5.2432 6.7893 2.8116 0.4459
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 GDSC1; GDSC2 4.313 7.1963 2.1355 5.069
Cancer Drug Sensitivity Data Curated from 57 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A2058 GDSC1; GDSC2 -1.9637 17.3296 -8.4596 50.8405
COLO 800 GDSC1; GDSC2 0.8635 9.7509 -2.1164 36.4208
LOX-IMVI GDSC1; GDSC2 0.9511 10.3327 -2.313 36.5399
A-375 GDSC1; GDSC2 1.3975 8.3796 -0.9472 30.756
WM793 GDSC1; GDSC2 1.4544 8.9908 -1.1875 31.3856
IST-MEL1 GDSC1; GDSC2 1.6582 7.3239 -0.1916 26.5929
G-mel GDSC1; GDSC2 1.8501 9.3867 -1.0101 29.2517
RPMI-7951 GDSC1; GDSC2 2.6446 8.9622 -0.0808 22.4791
WM278 GDSC1; GDSC2 2.6807 13.788 -2.4546 31.0352
M14 GDSC1; GDSC2 2.7076 9.9205 -0.5023 24.2053
A-431 GDSC1; GDSC2 3.0899 9.1295 0.2227 19.5198
DJM-1 GDSC1; GDSC2 3.1654 9.6651 0.019 20.3134
WT2-iPS GDSC1; GDSC2 3.4691 7.5011 1.3537 11.9657
IGR-37 GDSC1; GDSC2 3.5846 10.5595 -0.0803 19.5439
IPC-298 GDSC1; GDSC2 3.6402 6.1153 2.1808 6.3496
SK-MEL-2 GDSC1; GDSC2 3.6684 7.1399 1.6934 9.3235
SK-MEL-28 GDSC1; GDSC2 3.7392 10.6797 -0.0152 18.7839
A-388 GDSC1; GDSC2 3.752 12.9583 -1.1427 23.6635
COLO 679 GDSC1; GDSC2 3.9095 6.7752 2.0571 6.4493
Hs 940.T GDSC1; GDSC2 3.9669 12.8498 -0.9158 22.1748
451Lu GDSC1; GDSC2 3.9919 7.0427 1.986 6.6916
MZ-MEL-2 GDSC1; GDSC2 4.0302 15.6623 -2.2684 26.7474
COLO 783 GDSC1; GDSC2 4.0668 8.1733 1.4855 9.572
SH-4 GDSC1; GDSC2 4.1132 13.4223 -1.0849 22.4538
SK-MEL-30 GDSC1; GDSC2 4.2346 12.0443 -0.304 18.8034
IGR-1 GDSC1; GDSC2 4.563 13.1554 -0.6027 19.2927
CP66-MEL GDSC1; GDSC2 4.5637 7.8175 2.0057 5.3319
WM35 GDSC1; GDSC2 4.5878 12.5021 -0.2606 17.6931
MZ-MEL-7 GDSC1; GDSC2 4.6044 12.3119 -0.1541 17.1518
MeWo GDSC1; GDSC2 4.628 8.1684 1.8816 5.9331
UACC-257 GDSC1; GDSC2 4.6342 7.6257 2.1406 4.4109
Mel Ho GDSC1; GDSC2 4.6437 9.9854 1.0171 10.9353
WM1552C GDSC1; GDSC2 4.6687 8.8249 1.5958 7.5303
CHL-1 GDSC1; GDSC2 4.6735 11.7064 0.1958 15.2708
A101D GDSC1; GDSC2 4.7004 16.1631 -1.9892 24.1902
UACC-62 GDSC1; GDSC2 4.7095 11.6821 0.2343 14.9884
CP50-MEL-B GDSC1; GDSC2 4.7226 19.5661 -3.6644 28.7657
HMV-II GDSC1; GDSC2 4.7309 10.5259 0.816 11.8566
COLO 829 GDSC1; GDSC2 4.7761 13.1904 -0.4591 18.1292
SK-MEL-24 GDSC1; GDSC2 4.9216 11.7543 0.3531 13.877
Mel JuSo GDSC1; GDSC2 5.0201 9.1112 1.6905 6.2742
VMRC-MELG GDSC1; GDSC2 5.031 12.9552 -0.1553 16.1227
GAK GDSC1; GDSC2 5.0536 6.5062 2.84 0.4665
RVH-421 GDSC1; GDSC2 5.0903 10.7539 0.9564 10.2778
SK-MEL-1 GDSC1; GDSC2 5.0903 6.4501 2.8754 0.3468
G-361 GDSC1; GDSC2 5.1096 13.4294 -0.3305 16.7496
MMAc-SF GDSC1; GDSC2 5.2604 12.1885 0.3817 12.9607
SK-MEL-31 GDSC1; GDSC2 5.4451 11.6561 0.7638 10.5728
HT-144 GDSC1; GDSC2 5.4638 12.3459 0.4461 12.1905
LB2518-MEL GDSC1; GDSC2 5.5108 17.1046 -1.8412 21.8078
WM115 GDSC1; GDSC2 5.5163 18.3139 -2.4331 23.703
SK-MEL-3 GDSC1; GDSC2 5.8542 26.808 -6.3833 31.6185
SK-MEL-5 GDSC1; GDSC2 5.9477 13.8727 0.0418 13.1734
COLO 792 GDSC1; GDSC2 6.1639 14.5333 -0.1288 13.5332
Hs 938.T GDSC1; GDSC2 6.2852 20.8595 -3.1165 24.0546
LB373-MEL-D GDSC1; GDSC2 7.5104 16.0865 0.0004 10.4913
EquiPSC Line K2 GDSC1; GDSC2 4.9052 12.7142 -0.1289 16.2967
⏷ Show the Full List of 57 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Small Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuTu 80 GDSC1; GDSC2 -4.097 2.5653 -4.5812 66.0535
Cancer Drug Sensitivity Data Curated from 23 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
EW-8 GDSC1; GDSC2 -0.4156 2.4467 -0.5557 38.1193
KYM-1 GDSC1; GDSC2 -0.2163 4.5024 -0.9158 38.2464
G-401 GDSC1; GDSC2 0.936 10.739 -2.5238 37.0662
VA-ES-BJ GDSC1; GDSC2 1.0941 4.5819 0.4595 25.7357
STS-0421 GDSC1; GDSC2 1.5323 8.3855 -0.8213 29.7482
G-402 GDSC1; GDSC2 2.2076 10.4733 -1.2202 28.741
MFH-ino GDSC1; GDSC2 2.2446 9.3857 -0.6487 26.4067
SW982 GDSC1; GDSC2 2.3417 13.7082 -2.7091 32.7145
TE 441.T GDSC2 2.4082 10.3077 -0.9589 27.0843
SW872 GDSC1; GDSC2 2.4551 5.7617 1.3213 15.3992
Hs 633.T GDSC1; GDSC2 3.0649 10.0403 -0.2538 21.9352
SK-UT-1 GDSC1; GDSC2 3.4502 7.0945 1.5414 10.8679
HT-1080 GDSC1; GDSC2 3.467 7.9091 1.1481 13.2114
RKN GDSC1; GDSC2 3.5712 6.4839 1.9435 8.0232
SK-LMS-1 GDSC1; GDSC2 3.6075 5.6812 2.371 5.24
GCT GDSC1; GDSC2 3.8669 15.5577 -2.3479 27.4092
MES-SA GDSC1; GDSC2 4.1375 11.0497 0.1149 17.0449
A-204 GDSC1; GDSC2 4.6472 14.6761 -1.292 21.8735
SW684 GDSC1; GDSC2 4.7109 10.1923 0.9642 11.0781
Rh30 GDSC1; GDSC2 4.7435 18.497 -3.1159 27.3704
Rh41 GDSC1; GDSC2 4.9902 11.5193 0.5166 12.8697
RD GDSC1; GDSC2 5.875 13.3156 0.2592 12.2716
Rh18 GDSC1 6.1961 15.5756 -0.6066 17.9689
⏷ Show the Full List of 23 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 29 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HGC-27 GDSC1; GDSC2 -8.4407 21.1239 -16.6043 62.2066
NUGC-3 GDSC1; GDSC2 -0.1075 6.5554 -1.6177 39.5898
SNU-5 GDSC1; GDSC2 1.9711 4.8793 1.2527 17.6239
TMK-1 GDSC1; GDSC2 3.0898 11.4433 -0.9338 24.7867
23132/87 GDSC1; GDSC2 3.2633 12.0106 -1.0713 24.7994
HSC-39 GDSC1; GDSC2 3.4055 6.3268 1.8885 8.8283
SK-GT-2 GDSC1; GDSC2 3.6073 10.7898 -0.1769 19.9413
OCUM-1 GDSC1; GDSC2 3.6671 13.4874 -1.4761 25.1324
NCI-N87 GDSC1; GDSC2 3.6849 10.3175 0.1218 18.2568
SNU-1 GDSC1; GDSC2 3.9932 7.4784 1.7731 7.9993
GCIY GDSC2 4.2131 6.429 2.4335 3.5004
SNU-16 GDSC1; GDSC2 4.2894 8.2052 1.6321 8.1544
MKN45 GDSC1; GDSC2 4.5052 10.9339 0.4514 14.3675
Fu97 GDSC1; GDSC2 4.5969 13.0572 -0.5283 18.8815
ECC10 GDSC1; GDSC2 4.6952 9.9413 1.0751 10.4879
RERF-GC-1B GDSC1; GDSC2 4.7149 12.3681 -0.0992 16.6172
RF-48 GDSC1; GDSC2 4.893 10.7066 0.8428 11.3377
MKN1 GDSC1; GDSC2 4.9839 6.4437 2.8347 0.5252
NUGC-4 GDSC1; GDSC2 5.0693 15.0408 -1.1526 20.3145
IM95 GDSC2 5.1828 7.2972 2.5877 1.3043
MKN28 GDSC2 5.4574 8.1431 2.3726 1.9698
KATO III GDSC1; GDSC2 5.4783 9.2307 1.9122 4.2552
TGBC11TKB GDSC1; GDSC2 5.5208 7.6479 2.6022 0.9538
MKN7 GDSC1; GDSC2 5.7794 13.5519 0.0817 13.3308
SCH GDSC1; GDSC2 5.8091 16.8523 -1.4991 19.9431
Hs 746.T GDSC1; GDSC2 5.9193 17.301 -1.639 20.2093
ECC12 GDSC2 6.2464 23.825 -4.6061 27.6937
AGS GDSC2 6.7399 20.337 -2.5328 21.4723
SNG-M GDSC1; GDSC2 2.9726 4.8927 2.2293 8.005
⏷ Show the Full List of 29 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CAL-62 GDSC1; GDSC2 -0.38 6.5122 -1.8825 41.5741
IHH-4 GDSC1; GDSC2 1.5124 5.2079 0.6379 22.9791
K5 GDSC1; GDSC2 1.6023 12.9337 -2.9828 35.6889
FTC-133 GDSC1; GDSC2 2.6571 7.5596 0.6264 18.7595
BHT-101 GDSC1; GDSC2 3.2521 10.196 -0.1734 20.9788
CGTH-W-1 GDSC1; GDSC2 3.3078 8.5212 0.7105 16.2183
ML-1 [Human leukemia] GDSC1; GDSC2 3.3643 10.0009 0.0177 19.7137
B-CPAP GDSC1; GDSC2 3.6014 9.2398 0.5926 16.0143
ASH-3 GDSC1; GDSC2 3.8551 8.3795 1.2226 11.6942
TT2609-C02 GDSC1; GDSC2 3.8982 10.5024 0.1999 17.2628
HTC-C3 GDSC1; GDSC2 4.2031 6.6557 2.3198 4.193
WRO GDSC1; GDSC2 4.6299 10.4822 0.7647 12.3766
KMH-2 GDSC1; GDSC2 4.7478 15.2766 -1.5127 22.4393
TT GDSC1; GDSC2 4.9711 10.8155 0.8446 11.1526
8305C GDSC1; GDSC2 6.5771 15.4766 -0.3037 13.5123
8505C GDSC1; GDSC2 6.6806 19.5611 -2.1974 20.537
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 41 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
PCI-04B GDSC1; GDSC2 -0.6372 5.1981 -1.6247 42.5013
HSC-4 GDSC1; GDSC2 0.5588 4.7397 -0.1719 31.3157
BB30-HNC GDSC1; GDSC2 0.6719 6.1727 -0.6476 32.759
PCI-15A GDSC1; GDSC2 1.2033 6.7128 -0.3516 29.1757
SAS GDSC1; GDSC2 1.263 5.7947 0.1241 26.7119
CAL-33 GDSC1; GDSC2 1.4105 6.791 -0.1822 27.5503
BB49-HNC GDSC1; GDSC2 1.4139 9.7491 -1.5934 32.8525
BICR 22 GDSC1; GDSC2 1.5185 7.494 -0.4077 28.1141
HO-1-N-1 GDSC1; GDSC2 1.5584 6.1969 0.2399 24.8982
KON GDSC1; GDSC2 1.7711 16.9222 -4.8102 38.285
FaDu GDSC1; GDSC2 1.8614 7.2601 0.034 24.7307
JHU-011 GDSC2 1.994 9.1013 -0.7374 27.6686
CAL-27 GDSC1; GDSC2 2.0396 8.5539 -0.4269 26.197
HSC-2 GDSC1; GDSC2 2.1972 4.4338 1.6797 14.2081
DOK GDSC1; GDSC2 2.2623 8.2917 -0.0932 23.8619
HSC-3 GDSC1; GDSC2 2.2759 5.8819 1.0919 17.4148
PCI-38 GDSC1 2.3127 8.7654 -0.2807 29.0438
NCI-H3118 GDSC1; GDSC2 3.1343 8.4638 0.5931 17.4026
KOSC-2 GDSC1; GDSC2 3.2406 9.1014 0.3642 18.3142
JHU-029 GDSC1; GDSC2 3.3723 14.9991 -2.4748 29.1031
SCC-15 GDSC1; GDSC2 3.4946 7.16 1.5448 10.7214
JHU-022 GDSC1; GDSC2 3.618 7.9625 1.2435 12.2135
PCI-30 GDSC1; GDSC2 3.6903 11.1442 -0.2866 20.2175
PE/CA-PJ15 GDSC1; GDSC2 3.8002 9.028 0.857 13.9757
HO-1-u-1 GDSC1; GDSC2 3.8594 6.4967 2.1571 5.9497
OSC-20 GDSC1; GDSC2 3.9845 6.6057 2.1941 5.4277
PCI-06A GDSC1; GDSC2 4.1081 10.6486 0.2914 16.2246
OSC-19 GDSC1; GDSC2 4.172 7.7703 1.7602 7.6511
Ca9-22 GDSC1; GDSC2 4.1759 9.415 0.9545 12.4275
Detroit 562 GDSC1; GDSC2 4.2718 11.026 0.23 16.1097
SCC-9 GDSC1; GDSC2 4.3181 9.8678 0.8376 12.7316
BICR 78 GDSC1; GDSC2 4.326 8.4851 1.5218 8.731
BICR 10 GDSC1; GDSC2 4.3701 15.799 -2.0661 25.254
SCC-4 GDSC1; GDSC2 4.9516 11.5786 0.4603 13.2529
SKN-3 GDSC1; GDSC2 4.9861 12.7485 -0.0867 15.9036
SAT [Human HNSCC] GDSC1; GDSC2 5.1442 12.3044 0.2439 13.919
SCC-25 GDSC1; GDSC2 5.1865 9.6133 1.5612 6.6929
BICR 31 GDSC2 5.3078 12.9096 0.0653 14.4312
LB771-HNC GDSC1; GDSC2 5.3217 8.5606 2.1216 3.3853
UPCI-SCC-090 GDSC1; GDSC2 5.4514 15.3704 -1.0329 18.9578
BHY GDSC1; GDSC2 8.5508 20.0519 -1.1909 13.6635
⏷ Show the Full List of 41 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
647V GDSC1; GDSC2 -1.2272 5.2989 -2.2945 47.0233
639V GDSC1; GDSC2 0.7361 6.2077 -0.597 32.2642
CAL-29 GDSC1; GDSC2 2.2971 6.7185 0.7089 19.5503
KU-19-19 GDSC1; GDSC2 2.7623 9.9761 -0.4823 23.9383
UM-UC-3 GDSC1; GDSC2 3.0845 9.5906 -0.0125 20.7201
BFTC-905 GDSC1; GDSC2 3.4754 7.6453 1.2868 12.3542
T24 GDSC1; GDSC2 3.5273 7.7225 1.2904 12.1853
5637 GDSC1; GDSC2 3.7974 11.9482 -0.6017 21.3273
SW1710 GDSC1; GDSC2 3.8334 7.3269 1.7281 8.6764
J82 GDSC1; GDSC2 4.4708 7.2785 2.1995 4.3762
RT-112 GDSC1; GDSC2 4.8495 8.6494 1.7982 5.9824
SW780 GDSC1; GDSC2 4.9004 11.4626 0.4803 13.2667
HT-1376 GDSC1; GDSC2 5.0495 7.6424 2.3748 2.4634
HT-1197 GDSC1; GDSC2 6.121 14.719 -0.2465 14.1579
TCCSUP GDSC1; GDSC2 6.4637 14.7961 -0.0557 12.6079
RT-4 GDSC1; GDSC2 6.7067 16.8112 -0.8531 15.5966
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 39 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NT2-D1 GDSC1; GDSC2 -2.8595 9.927 -5.9178 54.8429
JEG-3 GDSC1; GDSC2 -2.1934 12.0822 -6.2106 51.9544
TC-YIK GDSC1; GDSC2 -0.717 4.4558 -1.4404 42.6053
SW954 GDSC1; GDSC2 0.4402 7.1889 -1.3354 36.17
HT-3 GDSC1; GDSC2 0.7504 4.9458 -0.0493 29.8406
C-33 A GDSC1; GDSC2 1.435 9.8407 -1.6181 32.847
ACC-OV7 GDSC1; GDSC2 1.554 8.8742 -1.0369 30.468
BPH-1 GDSC1; GDSC2 1.6766 7.2968 -0.161 26.3787
PA-1 GDSC2 2.2952 8.8423 -0.3345 24.8663
OVCA433 GDSC1; GDSC2 2.4289 17.1698 -4.3596 35.8075
SW756 GDSC1; GDSC2 2.7119 7.6618 0.6247 18.5852
SiSo GDSC1; GDSC2 2.8903 8.1803 0.5243 18.553
CAL-39 GDSC1; GDSC2 2.9132 8.1696 0.5495 18.341
KGN GDSC1; GDSC2 2.9648 12.4716 -1.5538 27.4507
MS751 GDSC1; GDSC2 3.0322 9.5379 -0.0307 20.9735
PWR-1E GDSC1; GDSC2 3.2993 10.9311 -0.5015 22.3375
OVMIU GDSC1; GDSC2 3.456 8.2784 0.9545 14.3839
SKN GDSC1; GDSC2 3.5582 8.1672 1.0933 13.2763
ME-180 GDSC1; GDSC2 3.5767 6.8392 1.7709 9.089
JAR GDSC1; GDSC2 3.682 6.7027 1.9215 7.8661
HEC-1 GDSC1; GDSC2 3.6939 11.0721 -0.2477 20.0259
Ca Ski GDSC1; GDSC2 3.7678 9.1911 0.7502 14.6698
C-4-I GDSC2 3.8685 6.1662 2.3256 4.8851
SiHa GDSC1; GDSC2 3.9922 8.8115 1.1137 11.9777
LB831-BLC GDSC1; GDSC2 4.0367 10.8425 0.1395 17.1917
HEY GDSC1; GDSC2 4.1053 10.0556 0.5836 14.6813
DoTc2 4510 GDSC1; GDSC2 4.2014 10.3693 0.5017 14.8715
OMC-1 [Human cervical carcinoma] GDSC1; GDSC2 4.2421 9.2505 1.0852 11.5085
NCC-IT GDSC2 4.3011 6.3807 2.5111 2.8879
SKG-IIIa GDSC1; GDSC2 4.4333 6.9223 2.3421 3.6189
SW962 GDSC1; GDSC2 4.5727 12.3848 -0.2141 17.5141
UWB1.289 GDSC1; GDSC2 4.7071 21.5001 -4.6401 30.8685
HeLa GDSC1; GDSC2 4.7249 14.3181 -1.0552 20.7654
NEC8 GDSC2 4.7301 7.9053 2.0705 4.6378
OVCA420 GDSC1; GDSC2 4.8902 8.9456 1.6851 6.5569
JHOS-3 GDSC1; GDSC2 4.9573 13.0773 -0.2691 16.8278
PEO1 GDSC1; GDSC2 5.0001 12.6078 -0.0075 15.4908
OV17R GDSC1; GDSC2 5.9925 19.6014 -2.7136 23.5185
DSH1 GDSC1; GDSC2 6.1881 7.8041 2.8047 0.1483
⏷ Show the Full List of 39 Cancer Drug Sensitivity Data of This Drug

Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Same Disease as Talazoparib
DDI Drug Name DDI Drug ID Severity Mechanism Disease REF
HKI-272 DM6QOVN Moderate Decreased clearance of Talazoparib due to the transporter inhibition by HKI-272. Breast cancer [2C60-2C6Y] [7]
Alpelisib DMEXMYK Moderate Decreased clearance of Talazoparib due to the transporter inhibition by Alpelisib. Breast cancer [2C60-2C6Y] [7]
Coadministration of a Drug Treating the Disease Different from Talazoparib (Comorbidity)
DDI Drug Name DDI Drug ID Severity Mechanism Comorbidity REF
Gilteritinib DMTI0ZO Moderate Decreased clearance of Talazoparib due to the transporter inhibition by Gilteritinib. Acute myeloid leukaemia [2A60] [7]
Ag-221 DMS0ZBI Moderate Decreased clearance of Talazoparib due to the transporter inhibition by Ag-221. BCR-ABL1-negative chronic myeloid leukaemia [2A41] [8]
PF-04449913 DMSB068 Moderate Decreased clearance of Talazoparib due to the transporter inhibition by PF-04449913. Chronic myelomonocytic leukaemia [2A40] [7]
Ingrezza DMVPLNC Moderate Decreased clearance of Talazoparib due to the transporter inhibition by Ingrezza. Dystonic disorder [8A02] [7]
Berotralstat DMWA2DZ Moderate Decreased clearance of Talazoparib due to the transporter inhibition by Berotralstat. Innate/adaptive immunodeficiency [4A00] [7]
Capmatinib DMYCXKL Moderate Decreased clearance of Talazoparib due to the transporter inhibition by Capmatinib. Lung cancer [2C25] [7]
Siponimod DM2R86O Major Additive immunosuppressive effects by the combination of Talazoparib and Siponimod. Multiple sclerosis [8A40] [8]
Ocrelizumab DMEZ2KH Moderate Additive immunosuppressive effects by the combination of Talazoparib and Ocrelizumab. Multiple sclerosis [8A40] [9]
Ozanimod DMT6AM2 Major Additive immunosuppressive effects by the combination of Talazoparib and Ozanimod. Multiple sclerosis [8A40] [10]
Rucaparib DM9PVX8 Moderate Decreased clearance of Talazoparib due to the transporter inhibition by Rucaparib. Ovarian cancer [2C73] [7]
Darolutamide DMV7YFT Moderate Decreased clearance of Talazoparib due to the transporter inhibition by Darolutamide. Prostate cancer [2C82] [7]
Tedizolid DMG2SKR Moderate Decreased clearance of Talazoparib due to the transporter inhibition by Tedizolid. Skin and skin-structure infection [1F28-1G0Z] [7]
Elagolix DMB2C0E Moderate Decreased clearance of Talazoparib due to the transporter inhibition by Elagolix. Uterine fibroid [2E86] [7]
⏷ Show the Full List of 13 DDI Information of This Drug

Drug Inactive Ingredient(s) (DIG) and Formulation(s) of This Drug

DIG
DIG Name DIG ID PubChem CID Functional Classification
Ferric oxide black E00522 16211978 Colorant
Hypromellose E00634 Not Available Coating agent
Potassium hydroxide E00233 14797 Alkalizing agent
Propylene glycol E00040 1030 Antimicrobial preservative; Humectant; Plasticizing agent; Solvent
Titanium dioxide E00322 26042 Coating agent; Colorant; Opacifying agent
Colcothar yellow E00436 518696 Colorant
Haematite red E00236 14833 Colorant
Ammonium hydroxide E00687 Not Available Alkalizing agent
Shellac E00695 Not Available Coating agent; Film/membrane-forming agent; Microencapsulating agent; Modified-release agent
⏷ Show the Full List of 9 Pharmaceutical Excipients of This Drug
Pharmaceutical Formulation
Formulation Name Drug Dosage Dosage Form Route
Talazoparib 0.25 mg capsule 0.25 mg Capsule Oral
Talazoparib 1 mg capsule 1 mg Capsule Oral
Jump to Detail Pharmaceutical Formulation Page of This Drug

References

1 2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89.
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8313).
3 DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. (ID: DB11760)
4 BMN 673 (talazoparib): A potent PARP inhibitor for triple negative breast cancer with different genetic profile. J Biochem Mol Toxicol. 2019 May;33(5):e22286. doi: 10.1002/jbt.22286. Epub 2019 Jan 23.
5 Krebs-cycle-deficient hereditary cancer syndromes are defined by defects in homologous-recombination DNA repair. Nat Genet. 2018 Aug;50(8):1086-1092. doi: 10.1038/s41588-018-0170-4. Epub 2018 Jul 16.
6 Structural Basis for Potency and Promiscuity in Poly(ADP-ribose) Polymerase (PARP) and Tankyrase Inhibitors. J Med Chem. 2017 Feb 23;60(4):1262-1271. doi: 10.1021/acs.jmedchem.6b00990. Epub 2016 Dec 21.
7 Product Information. Talzenna (talazoparib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
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9 Product Information. Ocrevus (ocrelizumab). Genentech, South San Francisco, CA.
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