Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM1S5UO)

• Drug Name: GSK4112 Drug Info
• Synonyms: SR6452; GSK-4112
• Cross-matching ID:
  PubChem CID: 50905018
  ChEBI ID: CHEMBL1961795
  TTD Drug ID: D07IZG

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Proteasome	2.11	0.00e+0	44/46 (95.65%)	PSMB3;PSMD14;PSMA5;...
Ribosome	2.03	3.57e-3	113/158 (71.52%)	MRPL13;RPS5;MRPL35;...
Oxidative phosphorylation	1.84	1.90e-2	93/133 (69.92%)	COX7B;COX7A2L;COX7A2;...
Folate biosynthesis	1.79	2.68e-2	23/26 (88.46%)	AKR1C3;AKR1B10;GGH;...
Huntington disease	1.77	3.00e-2	233/306 (76.14%)	COX7B;COX7A2L;GPX2;...
Ubiquinone and other terpenoid-quinone biosynthesis	1.76	2.50e-2	9/11 (81.82%)	NQO1;COQ2;VKORC1;...
Parkinson disease	1.72	3.67e-2	176/249 (70.68%)	COX7B;COX7A2L;PSMB3;...
DNA replication	1.70	3.92e-2	34/36 (94.44%)	POLE2;DNA2;RPA3;...
Aminoacyl-tRNA biosynthesis	1.68	4.44e-2	15/66 (22.73%)	NARS2;GATC;GATB;...
PPAR signaling pathway	-1.89	3.65e-2	66/74 (89.19%)	EHHADH;GK;ACSL6;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	1.11uM - 10uM	24H	Hide ▲

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	1.11uM - 10uM	24H	Hide ▲