Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM1WEHC)

Drug Name
Buparlisib Drug Info
Synonyms BKM120
Cross-matching ID
PubChem CID
16654980
ChEBI ID
CHEMBL2017974
CAS Number
CAS 944396-07-0
TTD Drug ID
D01QSO

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
ECM-receptor interaction 1.93 8.08e-3 80/88 (90.91%) ITGB5;ITGB4;VWF;...
Basal cell carcinoma 1.88 1.62e-2 41/63 (65.08%) FZD2;PTCH1;FZD6;...
Wnt signaling pathway 1.83 1.35e-2 124/166 (74.7%) MYC;SFRP1;SMAD3;...
Proteoglycans in cancer 1.79 2.02e-2 172/205 (83.9%) MYC;ITGB5;IGF1R;...
Fc epsilon RI signaling pathway -1.64 4.48e-2 57/68 (83.82%) NRAS;MAP2K1;FCER1A;...
Protein export -1.66 3.75e-2 17/23 (73.91%) SEC63;SRP9;SEC61B;...
Prion disease -1.67 3.83e-2 209/273 (76.56%) NDUFS1;ATP5MC1;SDHD;...
Antigen processing and presentation -1.68 3.37e-2 60/78 (76.92%) HLA-DRA;KLRC3;TAP1;...
Citrate cycle (TCA cycle) -1.74 1.63e-2 30/30 (100%) SUCLA2;PCK2;DLST;...
Glutathione metabolism -1.74 1.76e-2 43/57 (75.44%) GGT1;CHAC1;GSTA1;...
Collecting duct acid secretion -1.76 1.70e-2 22/27 (81.48%) SLC12A7;TCIRG1;ATP6V1G1;...
Type I diabetes mellitus -1.77 1.20e-2 38/43 (88.37%) IL2;HLA-DPA1;HLA-DRA;...
Glycolysis / Gluconeogenesis -1.84 6.01e-3 56/67 (83.58%) LDHA;ALDH3A1;PCK2;...
Arginine and proline metabolism -1.87 5.34e-3 39/50 (78%) CKB;PYCR1;ALDH3A2;...
Glycine, serine and threonine metabolism -1.89 6.01e-3 31/40 (77.5%) SHMT1;GCAT;SHMT2;...
Proteasome -1.90 5.15e-3 44/46 (95.65%) PSMD1;PSMA1;ADRM1;...
Terpenoid backbone biosynthesis -1.93 4.01e-3 18/22 (81.82%) MVK;FDPS;DHDDS;...
Folate biosynthesis -2.03 0.00e+0 23/26 (88.46%) MOCOS;PAH;GPHN;...
Protein processing in endoplasmic reticulum -2.03 0.00e+0 127/171 (74.27%) PDIA3;RBX1;SEC61G;...
Pentose phosphate pathway -2.03 0.00e+0 25/30 (83.33%) PRPS1;PFKL;RPIA;...
Fructose and mannose metabolism -2.16 0.00e+0 30/33 (90.91%) PFKL;PMM2;SORD;...
Steroid biosynthesis -2.27 0.00e+0 19/20 (95%) HSD17B7;NSDHL;FDFT1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 3H, 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
SK-BR-3 CVCL_0033 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
Breast carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BT-20 CVCL_0178 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
Hs 578T CVCL_0332 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.04uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 0.04uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H