Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM20VSK)

Drug Name
Istradefylline Drug Info
Synonyms
KW 6002; Istradefylline [USAN:INN]; Istradefylline (JAN/USAN/INN); (E)-8-(3,4-Dimethoxystyryl)-1,3-diethyl-7-methyl-3,7-dihydro-1H-purine-2,6-dione; (E)-8-(3,4-Dimethoxystyryl)-1,3-diethyl-7-methylxanthine; 8-((1E)-2-(3,4-Dimethoxyphenyl)ethenyl)-1,3-diethyl-7-methyl-3,7-dihydro-1H-purine-2,6-dione; 8-(2-(3,4-dimethoxyphenyl)ethenyl)-1,3-diethyl-3,7-dihydro-7-methyl-1H-purine-2,6-dione; 8-[(E)-2-(3,4-dimethoxyphenyl)ethenyl]-1,3-diethyl-7-methylpurine-2,6-dione
Cross-matching ID
PubChem CID
5311037
ChEBI ID
CHEMBL431770
CAS Number
CAS 155270-99-8
TTD Drug ID
D0F4ZY
VARIDT Drug ID
DR00611
INTEDE Drug ID
DR0892
ACDINA Drug ID
D01185

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Nitrogen metabolism 1.87 3.98e-2 16/17 (94.12%) GLUL;CA12;CA8;...
Cell adhesion molecules -1.66 4.99e-2 118/148 (79.73%) HLA-DRA;SDC3;MPZ;...
Pancreatic secretion -1.68 4.29e-2 87/102 (85.29%) PNLIPRP1;ATP1A2;PRSS1;...
Viral myocarditis -1.69 4.34e-2 53/60 (88.33%) HLA-DRA;CASP8;CD86;...
Biosynthesis of unsaturated fatty acids -1.71 3.21e-2 21/27 (77.78%) ACAA1;ACOT7;ELOVL6;...
Cholesterol metabolism -1.72 3.28e-2 44/50 (88%) ANGPTL4;APOA2;APOC1;...
Steroid biosynthesis -1.74 2.71e-2 19/20 (95%) FDFT1;CYP51A1;SC5D;...
Graft-versus-host disease -1.78 1.91e-2 32/42 (76.19%) KLRD1;KIR3DL1;PRF1;...
Type I diabetes mellitus -1.79 1.59e-2 38/43 (88.37%) IL12B;INS;IFNG;...
PPAR signaling pathway -1.82 1.34e-2 66/74 (89.19%) PDPK1;PLIN1;PPARD;...
Fat digestion and absorption -1.87 8.52e-3 35/43 (81.4%) PNLIPRP1;LIPF;PNLIP;...
Epstein-Barr virus infection -1.87 9.94e-3 189/202 (93.56%) E2F1;IRF3;NFKB1;...
Allograft rejection -1.88 7.16e-3 32/38 (84.21%) IL12B;IFNG;HLA-DRA;...
Alcoholism -1.90 8.94e-3 86/186 (46.24%) GNG12;GNG11;CREB1;...
Proteasome -1.91 7.95e-3 44/46 (95.65%) PSMC6;PSMC2;PSMB3;...
alpha-Linolenic acid metabolism -1.93 1.19e-2 17/25 (68%) PLA2G1B;ACAA1;PLA2G12A;...
Autoimmune thyroid disease -2.26 0.00e+0 46/53 (86.79%) TSHB;CGA;HLA-DRA;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SK-ES-1 CVCL_0627 Homo sapiens 1.11uM - 10uM 24H
Brain
Glioma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
GI-1 CVCL_1230 Homo sapiens 1.11uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MDA-MB-468 CVCL_0419 Homo sapiens 1.11uM - 10uM 24H
Breast ductal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
T-47D CVCL_0553 Homo sapiens 1.11uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SNU-407 CVCL_5004 Homo sapiens 1.11uM - 10uM 24H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 1.11uM - 10uM 24H
HEC-1-A CVCL_0293 Homo sapiens 1.11uM - 10uM 24H
HEC-251 CVCL_2928 Homo sapiens 1.11uM - 10uM 24H
HEC-265 CVCL_2929 Homo sapiens 1.11uM - 10uM 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CJM CVCL_U797 Homo sapiens 1.11uM - 10uM 24H
Liver
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHH-5 CVCL_1320 Homo sapiens 1.11uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1573 CVCL_1483 Homo sapiens 1.11uM - 10uM 24H
NCI-H838 CVCL_1594 Homo sapiens 1.11uM - 10uM 24H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BEN CVCL_1081 Homo sapiens 1.11uM - 10uM 24H
HCC95 CVCL_1276 Homo sapiens 1.11uM - 10uM 24H
Muscle
Rhabdomyosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-204 CVCL_0134 Homo sapiens 1.11uM - 10uM 24H
Ovary
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OVTOKO CVCL_3114 Homo sapiens 1.11uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
22Rv1 CVCL_1045 Homo sapiens 1.11uM - 10uM 24H
PC-3 CVCL_0035 Homo sapiens 1.11uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 1.11uM - 10uM 24H
IGR-37 CVCL_1303 Homo sapiens 1.11uM - 10uM 24H
Mel-HO CVCL_1402 Homo sapiens 1.11uM - 10uM 24H
SH-4 CVCL_1692 Homo sapiens 1.11uM - 10uM 24H
Urinary bladder
Bladder carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BC-3C CVCL_1079 Homo sapiens 1.11uM - 10uM 24H
Bladder transitional cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CAL-29 CVCL_1109 Homo sapiens 1.11uM - 10uM 24H