Details of the Drug

General Information of Drug (ID: DM20VSK)

Drug Name
Istradefylline
Synonyms
KW 6002; Istradefylline [USAN:INN]; Istradefylline (JAN/USAN/INN); (E)-8-(3,4-Dimethoxystyryl)-1,3-diethyl-7-methyl-3,7-dihydro-1H-purine-2,6-dione; (E)-8-(3,4-Dimethoxystyryl)-1,3-diethyl-7-methylxanthine; 8-((1E)-2-(3,4-Dimethoxyphenyl)ethenyl)-1,3-diethyl-7-methyl-3,7-dihydro-1H-purine-2,6-dione; 8-(2-(3,4-dimethoxyphenyl)ethenyl)-1,3-diethyl-3,7-dihydro-7-methyl-1H-purine-2,6-dione; 8-[(E)-2-(3,4-dimethoxyphenyl)ethenyl]-1,3-diethyl-7-methylpurine-2,6-dione
Indication
Disease Entry ICD 11 Status REF
Parkinson disease 8A00.0 Approved [1]
Substance use disorder 6C4Z Phase 1 [2]
ATC Code
N04CX01: Istradefylline
N04CX: Other antiparkinson drugs
N04C: OTHER ANTIPARKINSON DRUGS
N04: ANTI-PARKINSON DRUGS
N: NERVOUS SYSTEM
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 384.4
Logarithm of the Partition Coefficient (xlogp) 2.5
Rotatable Bond Count (rotbonds) 6
Hydrogen Bond Donor Count (hbonddonor) 0
Hydrogen Bond Acceptor Count (hbondacc) 5
ADMET Property
Absorption AUC
The area under the plot of plasma concentration (AUC) of drug is 11,100 mcgh/L [3]
Absorption Cmax
The maximum plasma concentration (Cmax) of drug is 181.1 mcg/L [3]
Absorption Tmax
The time to maximum plasma concentration (Tmax) is 2 h [3]
Clearance
The clearance of drug is 4.1-6.0 L/h [3]
Elimination
A 3mg/kg oral dose given to male rats was 17.6% elminated in the urine and 68.3% eliminated in the feces [4]
Half-life
The concentration or amount of drug in body reduced by one-half in 64 - 69 hours [3]
Metabolism
The drug is metabolized via the CYP1A1, CYP3A4, and CYP3A5 [3]
Vd
The volume of distribution (Vd) of drug is 448-557 L [3]
Chemical Identifiers
Formula
C20H24N4O4
IUPAC Name
8-[(E)-2-(3,4-dimethoxyphenyl)ethenyl]-1,3-diethyl-7-methylpurine-2,6-dione
Canonical SMILES
CCN1C2=C(C(=O)N(C1=O)CC)N(C(=N2)/C=C/C3=CC(=C(C=C3)OC)OC)C
InChI
InChI=1S/C20H24N4O4/c1-6-23-18-17(19(25)24(7-2)20(23)26)22(3)16(21-18)11-9-13-8-10-14(27-4)15(12-13)28-5/h8-12H,6-7H2,1-5H3/b11-9+
InChIKey
IQVRBWUUXZMOPW-PKNBQFBNSA-N
Cross-matching ID
PubChem CID
5311037
ChEBI ID
CHEBI:134726
CAS Number
155270-99-8
UNII
2GZ0LIK7T4
DrugBank ID
DB11757
TTD ID
D0F4ZY
VARIDT ID
DR00611
INTEDE ID
DR0892
ACDINA ID
D01185
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug
Repurposed Drugs (RPD) Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Adenosine A2a receptor (ADORA2A) TTM2AOE AA2AR_HUMAN Modulator [1]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4)
Main DME 		DE4LYSA CP3A4_HUMAN Substrate [5]
Cytochrome P450 2D6 (CYP2D6) DECB0K3 CP2D6_HUMAN Substrate [5]
Cytochrome P450 2C9 (CYP2C9) DE5IED8 CP2C9_HUMAN Substrate [5]
Cytochrome P450 1A2 (CYP1A2) DEJGDUW CP1A2_HUMAN Substrate [5]
Cytochrome P450 3A5 (CYP3A5)
Main DME 		DEIBDNY CP3A5_HUMAN Substrate [5]
Cytochrome P450 2B6 (CYP2B6) DEPKLMQ CP2B6_HUMAN Substrate [5]
Cytochrome P450 2C8 (CYP2C8) DES5XRU CP2C8_HUMAN Substrate [5]
Cytochrome P450 2C18 (CYP2C18) DEZMWRE CP2CI_HUMAN Substrate [5]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 60 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MEC1 CTRP2 6.4229 7.9379 4.5213 0.5835
JM1 CTRP2 5.3579 7.2139 4.2085 2.9528
EoL-1 CTRP2 4.5604 5.7208 4.25 4.4081
MOLT-3 CTRP2 4.565 6.99 3.648 6.8656
GA-10 CTRP2 4.7258 9.289 2.651 10.6808
KMS-20 CTRP2 4.8405 6.0579 4.3591 3.3
697 CTRP2 4.8785 6.5121 4.1681 4.0168
HH [Human lymphoma] CTRP2 4.948 7.0443 3.963 4.7349
OPM-2 CTRP2 4.9706 6.4681 4.2701 3.3998
Daudi CTRP2 5.0015 5.9485 4.5561 2.1368
ST486 CTRP2 5.3394 6.7988 4.3992 2.1929
Mino CTRP2 5.4006 7.2358 4.2295 2.7961
Pfeiffer CTRP2 5.45 8.3117 3.7352 4.768
JJN-3 CTRP2 5.5037 7.1898 4.3262 2.2393
CA46 CTRP2 5.5875 7.6431 4.1651 2.7699
EB1 CTRP2 5.6233 7.2937 4.3579 1.9409
HD-MY-Z CTRP2 5.6312 7.3757 4.3241 2.0648
SUP-M2 CTRP2 5.6386 7.6009 4.221 2.4682
TF-1 CTRP2 5.6507 7.5424 4.2574 2.3046
HL-60 CTRP2 5.669 7.3604 4.3564 1.885
A3/Kawakami CTRP2 5.7422 6.9768 4.5791 0.9498
A4/Fukuda CTRP2 5.8291 11.3723 2.5083 9.2063
Namalwa CTRP2 5.8466 8.0993 4.1226 2.5724
SET-2 CTRP2 5.864 7.2094 4.5446 0.9499
F-36P CTRP2 5.8819 8.2066 4.095 2.6343
HEL 92.1.7 CTRP2 5.906 8.6057 3.9205 3.2971
KO52 CTRP2 5.9075 9.5114 3.4829 5.0725
JeKo-1 CTRP2 5.9314 8.2233 4.1194 2.4724
DB CTRP2 6.0077 7.8047 4.3604 1.4626
Ci-1 CTRP2 6.0099 6.8427 4.7671 0.1903
L-428 CTRP2 6.0296 9.3707 3.6371 4.2625
LP-1 CTRP2 6.0358 8.9205 3.8573 3.3694
OCI-AML-5 CTRP2 6.0653 8.496 4.0771 2.4659
U266B1 CTRP2 6.0747 8.0478 4.2897 1.6493
SUP-B15 CTRP2 6.1228 8.0095 4.3349 1.4336
Toledo CTRP2 6.1889 19.2723 -1.1397 21.3196
OCI-M1 CTRP2 6.2461 7.7748 4.5029 0.7583
CMK CTRP2 6.3244 9.4238 3.8074 3.1859
HuT 78 CTRP2 6.3538 8.5829 4.2105 1.6424
AML-193 CTRP2 6.3612 7.6995 4.5881 0.442
SIG-M5 CTRP2 6.4755 7.3597 4.7598 0.0754
OCI-Ly3 CTRP2 6.484 9.5247 3.86 2.7897
M-07e CTRP2 6.5286 8.6385 4.2816 1.2361
RPMI-6666 CTRP2 6.5642 8.9069 4.1843 1.5302
OCI-Ly10 CTRP2 6.6074 12.0923 2.7227 7.1014
NU-DHL-1 CTRP2 6.6624 8.3811 4.4543 0.6202
BL-70 CTRP2 6.6631 7.6848 4.715 0.0939
OCI-AML-3 CTRP2 6.6798 7.882 4.6516 0.179
K-562 CTRP2 6.7154 8.2171 4.5417 0.3787
SEM CTRP2 6.8202 8.1168 4.621 0.1893
DND-41 CTRP2 6.8295 11.9858 2.925 5.9829
Karpas-422 CTRP2 6.8776 8.5316 4.4904 0.421
MOTN-1 CTRP2 6.9457 8.3217 4.5955 0.1957
RL CTRP2 6.9483 8.4908 4.5348 0.3007
Kasumi-2 CTRP2 7.0797 16.6071 0.859 13.4709
OCI-Ly19 CTRP2 7.1295 9.1623 4.3558 0.6155
EJM CTRP2 7.2749 13.2816 2.6034 6.6362
Kasumi-1 CTRP2 7.4923 8.9388 4.5801 0.1052
SUP-HD1 CTRP2 7.8034 9.8984 4.3575 0.3423
Granta-519 CTRP2 7.8339 18.7644 0.3472 14.0534
⏷ Show the Full List of 60 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 13 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE15 CTRP2 7.1759 9.1861 4.3668 0.566
OE21 CTRP2 5.9491 9.3995 3.567 4.6658
TE-5 CTRP2 6.084 10.901 2.9308 7.058
EC-GI-10 CTRP2 6.182 12.7198 2.1086 10.2241
KYSE-520 CTRP2 6.6767 9.3224 4.0638 1.8398
TE-11 CTRP2 6.7316 11.289 3.1915 5.0661
OE19 CTRP2 6.7851 8.3488 4.5209 0.3939
KYSE-450 CTRP2 6.7861 8.4425 4.4854 0.4752
TE-14 CTRP2 7.2243 8.9484 4.4765 0.3152
KYSE-510 CTRP2 7.2253 8.9046 4.4929 0.2853
OE33 CTRP2 7.2721 9.2407 4.3869 0.4771
KYSE-150 CTRP2 7.314 8.7381 4.5855 0.1282
KYSE-30 CTRP2 7.5115 8.7218 4.6595 0.0414
⏷ Show the Full List of 13 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 18 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
N2a-PK1 CTRP2 6.5093 10.9889 3.1865 5.3892
MIA PaCa-2 CTRP2 5.4675 6.8437 4.4683 1.7164
Capan-1 CTRP2 5.9213 7.8795 4.2739 1.8857
PaTu 8988s CTRP2 5.9786 9.2993 3.6362 4.3403
Panc 10.05 CTRP2 6.1143 7.8366 4.4069 1.1876
Capan-2 CTRP2 6.1557 8.9592 3.9175 2.9721
DAN-G CTRP2 6.7659 8.588 4.4191 0.653
PaTu 8988t CTRP2 6.8231 8.2885 4.5594 0.2983
SW1990 CTRP2 6.9935 8.9222 4.3896 0.6027
KP-2 CTRP2 7.0247 8.2937 4.6348 0.1228
Panc 04.03 CTRP2 7.1833 9.0371 4.4268 0.4287
Panc 02.03 CTRP2 7.2968 9.058 4.465 0.3122
Panc 08.13 CTRP2 7.3296 9.0778 4.4707 0.2917
PSN1 CTRP2 7.3799 8.9869 4.5226 0.1959
HuP-T3 CTRP2 7.396 9.31 4.4118 0.3776
Hs 766T CTRP2 7.4145 9.2988 4.4233 0.3494
PK-45H CTRP2 7.4632 19.5817 -0.3202 16.7617
AsPC-1 CTRP2 7.7149 9.7342 4.3826 0.3261
⏷ Show the Full List of 18 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 32 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SH4 CTRP2 7.1333 23.105 -2.3096 22.7056
Hs 940.T CTRP2 6.1469 8.5909 4.0841 2.339
LOX-IMVI CTRP2 6.3785 7.9585 4.4918 0.6961
Hs 839.T CTRP2 6.4216 7.6216 4.6443 0.2812
IGR-1 CTRP2 6.4841 9.3424 3.9436 2.4759
Hs 934.T CTRP2 6.5071 7.9539 4.5532 0.4517
SK-MEL-3 CTRP2 6.5088 8.0664 4.5095 0.5635
SK-MEL-2 CTRP2 6.5306 8.0087 4.5422 0.4668
HMCB CTRP2 6.5815 7.7285 4.669 0.1784
WM115 CTRP2 6.6545 7.8901 4.6388 0.208
WM266-4 CTRP2 6.6675 7.8559 4.6562 0.1749
Hs 688(A).T CTRP2 6.7101 7.6341 4.7489 0.0529
CJM [Human melanoma] CTRP2 6.7681 7.8409 4.6988 0.0939
WT2-iPS CTRP2 6.7963 7.9913 4.6566 0.1418
Hs 895.T CTRP2 6.8095 8.1279 4.6128 0.2056
UACC-62 CTRP2 6.8311 8.0118 4.6624 0.1265
COLO 792 CTRP2 6.8496 8.7342 4.3991 0.6572
Hs 294T CTRP2 6.8734 8.023 4.6739 0.1041
A2058 CTRP2 6.9282 7.8834 4.7402 0.0378
RVH-421 CTRP2 6.9471 8.2476 4.6224 0.1553
IGR-39 CTRP2 6.9561 8.2777 4.6151 0.1636
A101D CTRP2 6.9805 8.233 4.6398 0.1251
IGR-37 CTRP2 7.0375 8.2768 4.6453 0.1081
HT-144 CTRP2 7.0442 8.3717 4.6147 0.1444
UACC-257 CTRP2 7.0821 8.6945 4.5132 0.2952
K029AX CTRP2 7.1561 8.6488 4.5585 0.1978
MeWo CTRP2 7.3615 8.7859 4.586 0.1194
WM88 CTRP2 7.4556 8.941 4.5663 0.1255
SK-MEL-24 CTRP2 7.5337 9.1399 4.5256 0.1591
COLO 829 CTRP2 7.6131 9.5551 4.4079 0.3134
COLO 800 CTRP2 7.9674 9.5507 4.5387 0.0824
WM983B CTRP2 8.4339 15.7093 2.2022 6.6863
⏷ Show the Full List of 32 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 CTRP2 5.7221 8.6554 3.7678 4.1909
Cancer Drug Sensitivity Data Curated from 7 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KP-N-YN CTRP2 5.414 8.7779 3.476 5.9122
NH-6 CTRP2 6.0014 8.2491 4.152 2.2561
SK-N-AS CTRP2 6.0174 7.8971 4.3242 1.5853
CHP-212 CTRP2 6.2328 9.2011 3.8533 3.1237
SK-N-DZ CTRP2 6.691 7.9936 4.6153 0.2384
SK-N-SH CTRP2 7.2964 9.0588 4.4646 0.3131
SK-N-BE(2) CTRP2 7.5297 18.0048 0.5005 14.0045
⏷ Show the Full List of 7 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-869 CTRP2 6.5021 8.5567 4.3027 1.1895
Cancer Drug Sensitivity Data Curated from 9 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TC71 CTRP2 5.4001 6.9532 4.3678 2.2267
A-673 CTRP2 5.6567 7.0684 4.4858 1.3957
Hs 822.T CTRP2 5.8389 6.9247 4.6547 0.6012
SK-ES-1 CTRP2 5.9538 7.6336 4.4062 1.3535
SK-N-MC CTRP2 6.0848 7.113 4.6953 0.3205
Hs 888.T CTRP2 6.5779 9.1458 4.0867 1.8563
MG-63 CTRP2 6.6108 8.8282 4.2433 1.2916
SaOS-2 CTRP2 7.032 9.1336 4.3233 0.7516
G-292 clone A141B1 CTRP2 7.4847 9.2662 4.4626 0.26
⏷ Show the Full List of 9 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 56 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MDA-MB-157 CTRP2 4.2015 7.8061 2.9107 10.7381
DU4475 CTRP2 5.2096 7.0743 4.1637 3.3951
BT-20 CTRP2 6.0812 7.8908 4.3642 1.3716
AU565 CTRP2 6.3595 10.3531 3.3899 4.7866
HCC1428 CTRP2 6.454 8.6002 4.2583 1.3798
ZR-75-30 CTRP2 6.4563 9.269 3.9606 2.4441
T-47D CTRP2 6.5139 10.2237 3.5531 3.934
SK-BR-3 CTRP2 6.5311 9.3469 3.9695 2.3279
MDA-MB-468 CTRP2 6.6359 9.4747 3.9729 2.2036
MDA-MB-415 CTRP2 6.6381 10.5401 3.4841 4.0438
Hs 578T CTRP2 6.6822 9.3677 4.0468 1.8938
MDA-MB-361 CTRP2 6.7108 9.0223 4.2125 1.3079
BT-474 CTRP2 6.7111 8.2024 4.5454 0.3722
HCC1419 CTRP2 6.8744 8.5544 4.4803 0.4451
HCC202 CTRP2 6.8747 16.4318 0.7947 14.0287
UACC-812 CTRP2 6.9311 8.3837 4.5674 0.2467
Hs 578Bst CTRP2 6.9946 15.8842 1.1514 12.5577
EFM-192A CTRP2 7.0453 8.773 4.4691 0.3959
HCC2218 CTRP2 7.1991 9.0506 4.4283 0.4192
HCC38 CTRP2 7.5471 9.1635 4.5223 0.1606
BT-549 CTRP2 7.5609 9.422 4.4358 0.2821
CAL-85-1 CTRP2 7.7511 10.6845 4.0339 1.1002
HCC1500 CTRP2 9.8899 26.0929 -1.7665 17.299
MDA-MB-453 CTRP2 10.0245 24.6071 -0.9626 14.977
BT 416 CTRP2 6.0589 8.0566 4.2763 1.7165
BT 340 CTRP2 6.1946 7.5434 4.5735 0.5842
BT 232 CTRP2 6.3135 7.7626 4.5408 0.5986
BT 444 CTRP2 6.329 7.5481 4.633 0.3482
BT 333 CTRP2 6.3731 7.6661 4.6065 0.39
BT 504 CTRP2 6.4207 9.8108 3.6873 3.5305
BT 112 CTRP2 6.4557 10.8126 3.2348 5.2717
BT 422 CTRP2 6.5137 7.5494 4.7073 0.1361
BT 239 CTRP2 6.5332 8.0717 4.5185 0.5256
BT 498 CTRP2 6.5434 7.8809 4.5971 0.3317
BT 228 CTRP2 6.553 8.3041 4.4341 0.7449
BT164 CTRP2 6.5786 7.8278 4.6315 0.2467
BT 320 CTRP2 6.6378 7.8736 4.6382 0.2142
BT 231 CTRP2 6.6549 10.7023 3.4186 4.2773
BT 248 CTRP2 6.8187 8.7475 4.3796 0.7276
BT 286 CTRP2 6.8924 8.0469 4.6724 0.1024
BT 131 CTRP2 6.9426 8.0156 4.7009 0.066
BT 172 CTRP2 6.9466 8.2109 4.6351 0.1381
BT 330 CTRP2 6.9476 8.1975 4.6402 0.1313
BT 328 CTRP2 6.966 8.0153 4.7091 0.0564
BT147 CTRP2 6.9952 8.3686 4.5975 0.1798
BT 359 CTRP2 7.0151 8.4575 4.5732 0.2121
BT 139 CTRP2 7.1023 8.3127 4.656 0.0865
BT 159 CTRP2 7.1444 8.6415 4.5567 0.2036
BT 245 CTRP2 7.1445 8.76 4.5139 0.2737
BT 482 CTRP2 7.1579 8.8623 4.4817 0.3282
BT 145 CTRP2 7.2 8.8939 4.4869 0.3043
BT 271 CTRP2 7.2671 8.6897 4.5853 0.1371
BT 224 CTRP2 7.3257 14.9968 1.8172 9.579
BT 440 CTRP2 7.3831 8.848 4.5724 0.1311
BT 179 CTRP2 7.6396 13.7004 2.6407 6.0245
BT 216 CTRP2 10.1944 28.8157 -2.871 19.5446
⏷ Show the Full List of 56 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 23 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SW1783 CTRP2 5.8616 9.7212 3.3471 5.702
CCF-STTG1 CTRP2 6.0618 7.9287 4.336 1.4935
TM-31 CTRP2 6.4448 7.9727 4.5175 0.5803
SF268 CTRP2 6.4799 8.6931 4.2318 1.4462
SF539 CTRP2 6.5761 9.8479 3.7674 3.0319
42-MG-BA CTRP2 6.6056 9.1958 4.0801 1.8524
GMS-10 CTRP2 6.6595 8.6726 4.3339 0.9664
DK-MG CTRP2 6.7026 7.97 4.6285 0.2109
Hs 683 CTRP2 6.7693 7.9628 4.6567 0.148
M059K CTRP2 6.7755 8.4093 4.4936 0.4608
KG-1-C CTRP2 6.8559 7.8862 4.7145 0.0649
YH-13 CTRP2 7.0173 9.5451 4.1478 1.2684
8-MG-BA CTRP2 7.0216 8.9191 4.4031 0.5552
A-172 CTRP2 7.034 8.9338 4.4028 0.5499
D283 Med CTRP2 7.0653 8.6214 4.5333 0.2645
KNS-42 CTRP2 7.1228 8.4765 4.6069 0.1383
U-118MG CTRP2 7.1428 8.7243 4.5262 0.253
T98G CTRP2 7.1918 11.2238 3.5078 3.3028
Becker CTRP2 7.3795 9.2311 4.4343 0.3409
YKG-1 CTRP2 7.3877 8.5254 4.6827 0.0372
U-251MG CTRP2 7.4493 8.9752 4.5523 0.1427
GOS-3 CTRP2 7.5419 9.3063 4.4701 0.2334
SNB-75 CTRP2 8.6391 10.3702 4.4942 0.0545
⏷ Show the Full List of 23 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 9 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ESS-1 CTRP2 5.6747 7.6087 4.2419 2.3333
JHUEM-1 CTRP2 6.2677 7.4913 4.6283 0.391
HEC-1-A CTRP2 6.4161 9.4181 3.8676 2.8414
MFE-296 CTRP2 6.7694 8.6689 4.3883 0.7341
JHUEM-7 CTRP2 6.834 8.3367 4.5458 0.3212
EN CTRP2 6.8894 9.1828 4.2354 1.0962
JHUEM-3 CTRP2 6.9838 9.5712 4.1199 1.3821
AN3-CA CTRP2 7.0134 9.3362 4.2326 1.0165
MFE-319 CTRP2 7.3879 8.7916 4.5935 0.1073
⏷ Show the Full List of 9 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 13 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KMRC-2 CTRP2 6.1339 8.0356 4.3295 1.4415
TUHR14TKB CTRP2 6.2003 10.7592 3.0836 6.2549
Caki-2 CTRP2 6.3031 8.5531 4.1948 1.7506
RCC10RGB CTRP2 6.4224 10.3829 3.4178 4.5889
KMRC-1 CTRP2 6.6188 8.2726 4.4776 0.5838
KMRC-3 CTRP2 6.77 9.7214 3.9392 2.1864
786-O CTRP2 6.7716 9.1213 4.2018 1.2921
VMRC-RCZ CTRP2 6.8076 8.8889 4.3169 0.9118
A-498 CTRP2 6.9274 15.9799 1.0555 13.0128
UO-31 CTRP2 7.4183 12.5992 3.0144 4.8825
ACHN CTRP2 7.7282 9.4942 4.4732 0.1866
CAL-54 CTRP2 7.7905 9.6261 4.4499 0.2041
Caki-1 CTRP2 7.9302 9.7252 4.4663 0.1568
⏷ Show the Full List of 13 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 18 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-1033 CTRP2 5.984 9.1467 3.7136 4.019
T84 CTRP2 6.059 8.4924 4.0748 2.4828
SW948 CTRP2 6.0617 10.2224 3.2465 5.8026
SNU-C1 CTRP2 6.5317 8.6177 4.2921 1.1991
HCT 8 CTRP2 6.5813 7.906 4.6034 0.3022
HCC-56 CTRP2 6.6913 7.7051 4.7181 0.0854
SNU-C4 CTRP2 6.8036 7.7813 4.7317 0.0564
LS1034 CTRP2 6.8222 8.2233 4.5831 0.2537
HCT 15 CTRP2 7.0625 8.5269 4.5665 0.21
SNU-503 CTRP2 7.2185 9.2707 4.3525 0.579
COLO 678 CTRP2 7.2905 9.2883 4.3765 0.4916
GP2d CTRP2 7.2989 10.1733 4.0258 1.4312
RCM-1 [Human ESC] CTRP2 7.3059 8.5881 4.6339 0.0798
SW1417 CTRP2 7.3563 9.2156 4.4307 0.3555
C2BBe1 CTRP2 7.5246 9.182 4.5076 0.1842
COLO 320 CTRP2 7.7039 10.2379 4.1889 0.7299
NCI-H716 CTRP2 7.7627 16.5168 1.385 10.5506
NCI-H747 CTRP2 9.7037 25.9735 -1.8376 17.7286
⏷ Show the Full List of 18 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 13 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JHH-6 CTRP2 5.4679 7.6405 4.0801 3.3054
JHH-5 CTRP2 6.3947 8.8986 4.0924 2.0253
SNU-387 CTRP2 6.4367 10.2342 3.4979 4.2521
SNU-475 CTRP2 6.6033 8.9987 4.1655 1.5585
HLF CTRP2 6.6901 8.535 4.4053 0.7371
PLC/PRF/5 CTRP2 6.7735 8.9471 4.2761 1.058
JHH-1 CTRP2 6.9051 8.1223 4.6509 0.1261
JHH-4 CTRP2 6.952 9.111 4.2952 0.8778
HuH-1 CTRP2 6.9655 8.2215 4.6383 0.13
SK-HEP-1 CTRP2 7.0948 8.4931 4.5907 0.1658
SNU-449 CTRP2 7.7283 9.638 4.4224 0.2582
SNU-423 CTRP2 7.9294 9.6954 4.4763 0.1459
JHH-2 CTRP2 8.0181 9.5803 4.5462 0.0717
⏷ Show the Full List of 13 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 61 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H1568 CTRP2 4.6962 8.2566 3.1397 8.7034
DMS 53 CTRP2 5.4543 8.4494 3.6703 5.0315
NCI-H2081 CTRP2 5.4777 9.3582 3.2371 6.7987
COLO 668 CTRP2 5.515 7.5243 4.1714 2.8548
NCI-H810 CTRP2 5.5275 7.1456 4.364 2.0511
COR-L51 CTRP2 5.5444 7.633 4.1394 2.9405
NCI-H1703 CTRP2 5.576 7.4367 4.257 2.4134
NCI-H1694 CTRP2 5.6546 7.2633 4.3929 1.7603
NCI-H1105 CTRP2 5.8455 7.6678 4.325 1.782
DMS 454 CTRP2 5.8747 9.0919 3.6639 4.3823
LK2 CTRP2 5.8864 7.588 4.387 1.4989
NCI-H1092 CTRP2 5.9165 7.609 4.3954 1.4339
NCI-H838 CTRP2 5.9989 7.8752 4.3232 1.6095
NCI-H1341 CTRP2 6.0419 10.3684 3.161 6.1826
DV-90 CTRP2 6.0633 8.2927 4.1704 2.11
NCI-H1693 CTRP2 6.1713 8.8706 3.9691 2.7515
NCI-H2110 CTRP2 6.1748 9.7412 3.5582 4.3721
COR-L88 CTRP2 6.21 9.5765 3.6607 3.9133
ChaGo-K-1 CTRP2 6.2259 8.6439 4.108 2.1554
HCC4006 CTRP2 6.2556 8.5138 4.1849 1.8369
HCC1438 CTRP2 6.2921 7.9488 4.4529 0.8786
COR-L105 CTRP2 6.3176 9.4607 3.7857 3.2787
NCI-H1915 CTRP2 6.3771 7.7267 4.5846 0.4425
NCI-H647 CTRP2 6.4723 9.5712 3.8314 2.912
NCI-H146 CTRP2 6.4752 8.4701 4.3257 1.1371
NCI-H1793 CTRP2 6.488 10.0171 3.6335 3.654
T3M-10 CTRP2 6.4922 10.6841 3.3207 4.8787
SK-MES-1 CTRP2 6.5084 8.5932 4.2904 1.2246
NCI-H1395 CTRP2 6.5339 10.7383 3.3226 4.8147
NCI-H522 CTRP2 6.5527 8.2427 4.4589 0.6747
DMS 114 CTRP2 6.5905 8.5616 4.3459 0.9813
IA-LM CTRP2 6.5985 7.9408 4.5974 0.3078
NCI-H322 CTRP2 6.6311 8.4663 4.4052 0.7759
NCI-H1651 CTRP2 6.6784 9.5512 3.9631 2.1949
NCI-H841 CTRP2 6.6972 8.3021 4.501 0.4817
NCI-H1944 CTRP2 6.762 9.5722 4.001 1.9764
RERF-LC-Ad2 CTRP2 6.8013 11.1922 3.2823 4.6197
RERF-LC-MS CTRP2 6.8082 8.7523 4.3728 0.7528
NCI-H1339 CTRP2 6.8269 8.4806 4.4883 0.4488
NCI-H520 CTRP2 6.9662 8.7091 4.4602 0.4489
NCI-H2342 CTRP2 6.986 15.6639 1.253 12.2
LC-1/sq-SF CTRP2 7.0417 8.0682 4.7173 0.043
HOP-62 CTRP2 7.0788 8.9293 4.4238 0.48
DMS 273 CTRP2 7.1117 16.0487 1.1555 12.3583
NCI-H1869 CTRP2 7.1344 10.3818 3.8504 2.1429
HCC2935 CTRP2 7.1647 8.8936 4.4728 0.3428
Calu-1 CTRP2 7.1657 8.8617 4.4851 0.3192
LUDLU-1 CTRP2 7.1666 8.7609 4.5222 0.2527
KNS-62 CTRP2 7.1827 8.5736 4.5949 0.1415
NCI-H2029 CTRP2 7.2884 8.6168 4.618 0.0972
NCI-H1623 CTRP2 7.2884 13.7574 2.3862 7.4562
COR-L95 CTRP2 7.3268 8.6022 4.6364 0.0751
NCI-H2196 CTRP2 7.3915 8.9036 4.5561 0.1489
HOP-92 CTRP2 7.489 10.2214 4.0983 1.0858
NCI-H2170 CTRP2 7.4966 8.8845 4.6001 0.0858
VMRC-LCD CTRP2 7.802 9.2571 4.5802 0.0681
EKVX CTRP2 8.7287 10.6916 4.418 0.0955
NCI-H2141 CTRP2 9.6122 25.3837 -1.6161 17.2833
Lu-65 CTRP2 10.8155 24.7787 -0.5278 12.7654
NCI-H1563 CTRP2 11.8325 28.7336 -1.7337 14.8165
Hs 888.Lu CTRP2 7.6133 9.625 4.3825 0.358
⏷ Show the Full List of 61 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Thigh Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
H-STS CTRP2 2.0625 12.9348 -1.5963 31.4779
P-STS CTRP2 6.6858 8.294 4.4992 0.4921
SYO-1 CTRP2 7.0828 8.4905 4.5872 0.1736
Cancer Drug Sensitivity Data Curated from 20 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Yamato-SS CTRP2 6.6116 7.7869 4.6595 0.1854
Aska-SS CTRP2 6.8634 8.3685 4.5459 0.3099
TE 441.T CTRP2 5.4802 7.031 4.3867 2.0283
TE 617.T CTRP2 5.9961 7.6887 4.4059 1.3096
G-401 CTRP2 6.0113 10.3404 3.1526 6.2647
BT-16 CTRP2 6.0273 7.3243 4.5819 0.6812
A-204 CTRP2 6.062 10.4902 3.1159 6.3357
BT-12 CTRP2 6.112 6.8457 4.8062 0.0891
Hs 729.T CTRP2 6.3433 8.5605 4.2145 1.6388
G-402 CTRP2 6.4043 9.4598 3.8408 2.9577
SW982 CTRP2 6.4486 7.6731 4.6361 0.2874
GCT CTRP2 6.4749 8.321 4.3887 0.937
HT-1080 CTRP2 6.5817 7.8989 4.6062 0.2961
MES-SA CTRP2 6.5896 7.7515 4.6638 0.1847
KYM-1 CTRP2 6.9167 8.5737 4.4908 0.403
SK-UT-1 CTRP2 6.9602 15.3195 1.4028 11.6874
Tm87-16 CTRP2 7.2103 8.6975 4.5616 0.1802
SK-LMS-1 CTRP2 7.3368 9.2496 4.4103 0.4024
TTC-709 CTRP2 7.6661 9.1416 4.5722 0.0893
RD CTRP2 9.1898 17.1661 1.9906 6.5765
⏷ Show the Full List of 20 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Clivus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
U-CH1 CTRP2 6.7168 8.4262 4.4611 0.5713
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
2004 CTRP2 7.7456 9.8211 4.363 0.3506
COV434 CTRP2 6.2315 8.7314 4.0712 2.2876
TOV-112D CTRP2 6.36 8.5933 4.2094 1.6401
OAW42 CTRP2 6.5552 7.6013 4.7045 0.1301
OV56 CTRP2 6.6092 7.8164 4.6479 0.2062
COV644 CTRP2 6.6303 12.2191 2.6773 7.2487
TOV-21G CTRP2 6.8867 8.2215 4.6089 0.1905
JHOS-2 CTRP2 6.9396 8.5238 4.519 0.3349
JHOM-1 CTRP2 7.1015 8.4256 4.6168 0.1301
OC 314 CTRP2 7.2612 8.6445 4.5988 0.1222
EFO-27 CTRP2 7.3181 8.8964 4.5315 0.1978
OVCAR-5 CTRP2 7.3182 9.0777 4.4663 0.3031
EFO-21 CTRP2 7.3455 8.865 4.5528 0.1624
COV362 CTRP2 7.352 10.2863 4.0051 1.4547
OV-90 CTRP2 7.365 9.2057 4.4379 0.3391
OAW28 CTRP2 7.8669 10.6174 4.1127 0.8319
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MPP 89 CTRP2 7.0533 8.413 4.6035 0.1574
IST-Mes1 CTRP2 7.1561 14.2103 2.0796 8.8247
JL-1 CTRP2 7.5457 8.6026 4.7097 0.0176
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H660 CTRP2 5.8692 12.962 1.7502 12.1755
LNCaP clone FGC CTRP2 6.0942 8.5077 4.0898 2.381
DU145 CTRP2 6.2242 9.1921 3.852 3.1399
PaCa-3 CTRP2 6.9419 7.8388 4.7595 0.0259
VCaP CTRP2 7.2543 8.7702 4.5523 0.183
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 CTRP2 6.876 8.9807 4.3121 0.8795
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-16 CTRP2 4.8106 6.1393 4.2917 3.646
NCC-StC-K140 CTRP2 5.0527 6.8543 4.1463 8.0723
HuG1-N CTRP2 6.0417 7.7456 4.4065 1.2606
MKN7 CTRP2 6.0727 10.5652 3.0869 6.4376
KATO III CTRP2 6.1289 8.0964 4.2994 1.5553
HGC-27 CTRP2 6.4219 8.3753 4.3385 1.1404
KE-39 CTRP2 6.5613 9.9113 3.7289 3.1957
SNU-216 CTRP2 6.663 8.5317 4.3937 0.7876
SH-10-TC CTRP2 6.7303 8.0841 4.5977 0.2578
SNU-1 CTRP2 6.7716 8.9955 4.255 1.1245
IM95 CTRP2 7.0214 9.1055 4.3297 0.7408
SNU-601 CTRP2 7.1342 10.1771 3.9393 1.843
Hs 746.T CTRP2 7.1625 8.9645 4.4455 0.398
LMSU CTRP2 7.2178 8.8226 4.5197 0.2421
MKN74 CTRP2 9.0344 18.6575 1.2063 9.4829
SNU-685 CTRP2 7.2936 8.7767 4.5646 0.1578
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 4 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
FTC-238 CTRP2 5.9322 9.2847 3.6108 4.5123
SW579 CTRP2 6.2014 7.5632 4.5686 0.5936
FTC-133 CTRP2 6.7007 8.1577 4.558 0.3493
TT2609-C02 CTRP2 6.8543 8.7414 4.3984 0.6565
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
PE/CA-PJ15 CTRP2 6.0434 8.8329 3.904 3.1733
PE/CA-PJ34 (clone C12) CTRP2 6.1234 8.755 3.9928 2.72
SCC-9 CTRP2 6.2945 8.2289 4.3337 1.2697
BICR 22 CTRP2 6.4985 7.9659 4.5447 0.4777
BICR 6 CTRP2 6.5356 7.6764 4.67 0.1903
PE/CA-PJ49 CTRP2 6.592 8.3212 4.4456 0.6869
BICR 18 CTRP2 6.7178 8.4468 4.4534 0.5906
HSC-2 CTRP2 6.7556 8.2433 4.5486 0.3466
FaDu CTRP2 6.8498 8.6349 4.4384 0.5569
BICR 16 CTRP2 6.8586 9.6381 4.0251 1.8015
CAL-27 CTRP2 6.9241 8.4754 4.5308 0.3173
PE/CA-PJ41 (clone D2) CTRP2 7.0937 11.4492 3.346 4.0159
SCC-4 CTRP2 7.3029 9.2806 4.3846 0.4689
BICR 56 CTRP2 7.5844 14.7063 2.1309 8.0281
CAL-33 CTRP2 7.8355 9.5576 4.4901 0.1462
BICR 31 CTRP2 7.9273 13.7005 2.8176 5.0229
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 9 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
U-BLC1 CTRP2 5.8967 10.7973 2.8436 7.718
647V CTRP2 6.3387 8.1747 4.3808 1.0725
UM-UC-1 CTRP2 6.4101 9.6565 3.7529 3.2891
KMBC-2 CTRP2 6.4181 8.4123 4.3205 1.203
HT-1197 CTRP2 6.5853 8.7036 4.2833 1.1829
BC-3C CTRP2 6.953 8.7507 4.4385 0.5048
SCaBER CTRP2 7.1338 8.2896 4.6748 0.0654
T24 CTRP2 7.1535 9.0548 4.4076 0.483
J82 CTRP2 7.5251 11.4235 3.6079 2.6091
⏷ Show the Full List of 9 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HeLa CTRP2 6.5569 7.6458 4.6893 0.1525

Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Disease Different from Istradefylline (Comorbidity)
DDI Drug Name DDI Drug ID Severity Mechanism Comorbidity REF
Arn-509 DMT81LZ Major Increased metabolism of Istradefylline caused by Arn-509 mediated induction of CYP450 enzyme. Acute myeloid leukaemia [2A60] [6]
Gilteritinib DMTI0ZO Moderate Decreased metabolism of Istradefylline caused by Gilteritinib mediated inhibition of CYP450 enzyme. Acute myeloid leukaemia [2A60] [7]
Troleandomycin DMUZNIG Major Decreased metabolism of Istradefylline caused by Troleandomycin mediated inhibition of CYP450 enzyme. Bacterial infection [1A00-1C4Z] [6]
MK-8228 DMOB58Q Moderate Decreased metabolism of Istradefylline caused by MK-8228 mediated inhibition of CYP450 enzyme. Cytomegaloviral disease [1D82] [6]
Eslicarbazepine DMZREFQ Moderate Increased metabolism of Istradefylline caused by Eslicarbazepine mediated induction of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [6]
Berotralstat DMWA2DZ Moderate Decreased metabolism of Istradefylline caused by Berotralstat mediated inhibition of CYP450 enzyme. Innate/adaptive immunodeficiency [4A00] [8]
PF-06463922 DMKM7EW Moderate Increased metabolism of Istradefylline caused by PF-06463922 mediated induction of CYP450 enzyme. Lung cancer [2C25] [6]
Selpercatinib DMZR15V Moderate Decreased metabolism of Istradefylline caused by Selpercatinib mediated inhibition of CYP450 enzyme. Lung cancer [2C25] [7]
IPI-145 DMWA24P Moderate Decreased metabolism of Istradefylline caused by IPI-145 mediated inhibition of CYP450 enzyme. Mature B-cell leukaemia [2A82] [6]
Rimegepant DMHOAUG Moderate Decreased clearance of Istradefylline due to the transporter inhibition by Rimegepant. Migraine [8A80] [9]
Fedratinib DM4ZBK6 Moderate Decreased metabolism of Istradefylline caused by Fedratinib mediated inhibition of CYP450 enzyme. Myeloproliferative neoplasm [2A20] [6]
Abametapir DM2RX0I Moderate Decreased metabolism of Istradefylline caused by Abametapir mediated inhibition of CYP450 enzyme. Pediculosis [1G00] [10]
Lefamulin DME6G97 Moderate Decreased clearance of Istradefylline due to the transporter inhibition by Lefamulin. Pneumonia [CA40] [11]
Voxelotor DMCS6M5 Moderate Decreased metabolism of Istradefylline caused by Voxelotor mediated inhibition of CYP450 enzyme. Sickle-cell disorder [3A51] [6]
Telotristat ethyl DMDIYFZ Moderate Increased metabolism of Istradefylline caused by Telotristat ethyl mediated induction of CYP450 enzyme. Small intestine developmental anomaly [DA90] [7]
Betrixaban DM2C4RF Moderate Decreased clearance of Istradefylline due to the transporter inhibition by Betrixaban. Venous thromboembolism [BD72] [12]
⏷ Show the Full List of 16 DDI Information of This Drug

Drug Inactive Ingredient(s) (DIG) and Formulation(s) of This Drug

DIG
DIG Name DIG ID PubChem CID Functional Classification
Crospovidone E00626 Not Available Disintegrant
Ferric hydroxide oxide yellow E00539 23320441 Colorant
Hypromellose E00634 Not Available Coating agent
Lactose monohydrate E00393 104938 Binding agent; Diluent; Dry powder inhaler carrier; Lyophilization aid
Magnesium stearate E00208 11177 lubricant
Polyethylene glycol 3350 E00652 Not Available Coating agent; Diluent; Ointment base; Plasticizing agent; Solvent; Suppository base; lubricant
Polyvinyl alcohol E00666 Not Available Coating agent; Emulsion stabilizing agent; Film/Membrane-forming agent
Titanium dioxide E00322 26042 Coating agent; Colorant; Opacifying agent
Triacetin E00080 5541 Humectant; Plasticizing agent; Solvent
Haematite red E00236 14833 Colorant
Cellulose microcrystalline E00698 Not Available Adsorbent; Suspending agent; Diluent
⏷ Show the Full List of 11 Pharmaceutical Excipients of This Drug
Pharmaceutical Formulation
Formulation Name Drug Dosage Dosage Form Route
Istradefylline 20 mg tablet 20 mg Tablet Oral
Jump to Detail Pharmaceutical Formulation Page of This Drug

References

1 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2019
2 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3 Effects of Rifampin on the Pharmacokinetics of a Single Dose of Istradefylline in Healthy Subjects. J Clin Pharmacol. 2018 Feb;58(2):193-201. doi: 10.1002/jcph.1003. Epub 2017 Sep 7.
4 Pharmaceuticals and Medical Devices Agency Japan: Report on Istradefylline
5 Effects of rifampin on the pharmacokinetics of a single dose of istradefylline in healthy subjects. J Clin Pharmacol. 2018 Feb;58(2):193-201.
6 Product Information. Nourianz (istradefylline). Kyowa Kirin, Inc, Bedminster, NJ.
7 Cerner Multum, Inc. "UK Summary of Product Characteristics.".
8 Product Information. Orladeyo (berotralstat). BioCryst Pharmaceuticals Inc, Durham, NC.
9 Product Information. Nurtec ODT (rimegepant). Biohaven Pharmaceuticals, New Haven, CT.
10 Product Information. Xeglyze (abametapir topical). Dr. Reddy's Laboratories Inc, Upper Saddle River, NJ.
11 Product Information. Xenleta (lefamulin). Nabriva Therapeutics US, Inc., King of Prussia, PA.
12 Product Information. Bevyxxa (betrixaban). Portola Pharmaceuticals, South San Francisco, CA.