Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM26AMU)

Drug Name
AGK2 Drug Info
Synonyms AGK-2; AGK 2
Cross-matching ID
PubChem CID
2130404
ChEBI ID
CHEMBL94578
CAS Number
CAS 304896-28-4
TTD Drug ID
D0E3NT

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 2.28 0.00e+0 34/36 (94.44%) MCM5;MCM4;MCM3;...
Base excision repair 2.06 0.00e+0 29/33 (87.88%) POLE2;FEN1;LIG1;...
Cell cycle 2.03 0.00e+0 110/124 (88.71%) CCNE2;CCND1;MCM5;...
Viral protein interaction with cytokine and cytokine re... 1.99 0.00e+0 84/100 (84%) CXCL9;TNFSF10;CXCL13;...
Spliceosome 1.93 2.15e-3 101/150 (67.33%) HSPA6;HSPA1A;HSPA8;...
Protein processing in endoplasmic reticulum 1.92 1.79e-3 127/171 (74.27%) DNAJB1;HSPA6;HSPA1A;...
TNF signaling pathway 1.92 3.07e-3 103/112 (91.96%) PTGS2;VCAM1;FOS;...
Acute myeloid leukemia 1.91 6.71e-3 66/67 (98.51%) CCND1;CCNA2;CD14;...
Fanconi anemia pathway 1.80 1.67e-2 36/54 (66.67%) FANCI;FANCG;RAD51;...
Legionellosis 1.80 1.72e-2 51/57 (89.47%) HSPA6;HSPA1A;HSPA8;...
Systemic lupus erythematosus 1.79 1.66e-2 45/135 (33.33%) C1QA;C3;C1QB;...
Progesterone-mediated oocyte maturation 1.74 2.95e-2 75/100 (75%) HSP90AA1;CCNA2;CDC25A;...
Pyrimidine metabolism 1.72 4.05e-2 40/56 (71.43%) PNP;RRM2;TK1;...
Amoebiasis 1.70 4.37e-2 99/102 (97.06%) GNA11;CXCL2;CD14;...
mRNA surveillance pathway 1.69 4.08e-2 71/98 (72.45%) FUS;EIF4A3;NXF1;...
Taurine and hypotaurine metabolism -1.61 4.72e-2 8/11 (72.73%) CDO1;GGT1;GAD2;...
Pathways of neurodegeneration -1.64 3.83e-2 354/475 (74.53%) BRAF;RELA;KLC2;...
Parkinson disease -1.65 3.62e-2 176/249 (70.68%) SEM1;CASP9;ITPR3;...
Steroid hormone biosynthesis -1.66 3.62e-2 43/61 (70.49%) STS;HSD17B7;HSD17B12;...
Tyrosine metabolism -1.66 3.81e-2 30/36 (83.33%) TH;TYRP1;HGD;...
Huntington disease -1.66 4.10e-2 233/306 (76.14%) CREB5;KLC2;PSMA2;...
Cardiac muscle contraction -1.67 4.22e-2 64/87 (73.56%) CACNG1;TPM2;HRC;...
Pentose phosphate pathway -1.71 3.20e-2 25/30 (83.33%) PFKL;TALDO1;PGD;...
Glycerolipid metabolism -1.73 2.62e-2 44/61 (72.13%) DGKA;AGPAT3;DGKQ;...
Diabetic cardiomyopathy -1.74 2.91e-2 162/203 (79.8%) NDUFA8;NCF4;ATP2A1;...
Lysosome -1.77 2.71e-2 115/128 (89.84%) IDUA;MANBA;TCIRG1;...
Mitophagy -1.77 3.10e-2 56/68 (82.35%) ULK1;RELA;RRAS;...
Histidine metabolism -1.83 1.36e-2 16/22 (72.73%) ALDH9A1;ALDH2;ASPA;...
Tryptophan metabolism -1.95 3.62e-3 35/42 (83.33%) MAOA;KYAT3;AOC1;...
Steroid biosynthesis -1.96 2.26e-3 19/20 (95%) LIPA;SC5D;HSD17B7;...
Other glycan degradation -2.01 3.01e-3 13/18 (72.22%) MAN2B1;HEXB;NEU1;...
Oxidative phosphorylation -2.12 0.00e+0 93/133 (69.92%) NDUFB3;ATP6V0B;ATP6V1H;...
Metabolism of xenobiotics by cytochrome P450 -2.26 0.00e+0 49/77 (63.64%) GSTM5;CYP2F1;ADH7;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-673 CVCL_0080 Homo sapiens 10uM 6H
Bone marrow
Neuroblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SH-SY5Y CVCL_0019 Homo sapiens 0.04uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.04uM - 10uM 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.04uM - 10uM 24H
Normal (Epithelial)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HME1 CVCL_2950 Homo sapiens 0.04uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.04uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.04uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CL-34 CVCL_1123 Homo sapiens 10uM 6H
HT-29 CVCL_0320 Homo sapiens 0.04uM - 10uM 6H, 24H
LoVo CVCL_0399 Homo sapiens 10uM 6H
MDST8 CVCL_1400 Homo sapiens 10uM 6H
NCI-H508 CVCL_1561 Homo sapiens 10uM 6H
SNU-1040 CVCL_5001 Homo sapiens 10uM 6H
SNU-C4 CVCL_5008 Homo sapiens 10uM 6H
SNU-C5 CVCL_5009 Homo sapiens 10uM 6H
SW480 CVCL_0546 Homo sapiens 10uM 6H
SW620 CVCL_0547 Homo sapiens 10uM 6H
SW948 CVCL_0550 Homo sapiens 10uM 6H
Colorectal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCT 116 CVCL_0291 Homo sapiens 10uM 6H
HT115 CVCL_1294 Homo sapiens 10uM 6H
RKO CVCL_0504 Homo sapiens 10uM 6H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 10uM 6H
SNG-M CVCL_1707 Homo sapiens 10uM 6H
Endometrial carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHUEM-2 CVCL_1327 Homo sapiens 10uM 6H
Fibroblast
Nasopharyngeal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
FIBRNPC CVCL_UK07 Homo sapiens 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 0.04uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.04uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.04uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 10uM 6H, 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.04uM - 10uM 6H, 24H
A549/Asc-1 CVCL_YA87 Homo sapiens 0.04uM - 10uM 24H
DV-90 CVCL_1184 Homo sapiens 10uM 6H
SK-LU-1 CVCL_0624 Homo sapiens 10uM 6H
Lung adenosquamous carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H596 CVCL_1571 Homo sapiens 10uM 6H
Lung large cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COR-L23 CVCL_1133 Homo sapiens 10uM 6H
T3M-10 CVCL_1729 Homo sapiens 10uM 6H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC15 CVCL_1253 Homo sapiens 10uM 6H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1299 CVCL_0060 Homo sapiens 10uM 6H
HCC515 CVCL_5134 Homo sapiens 0.04uM - 10uM 6H, 24H
NCI-H2073 CVCL_1523 Homo sapiens 10uM 6H
Small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1694 CVCL_1495 Homo sapiens 10uM 6H
NCI-H1836 CVCL_1502 Homo sapiens 10uM 6H
Lymph node
Diffuse large B-cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
WSU-DLCL2 CVCL_1787 Homo sapiens 10uM 6H
Ovary
Ovarian carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
EFO-27 CVCL_1194 Homo sapiens 10uM 6H
OV7 CVCL_1623 Homo sapiens 10uM 6H
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
RMG-I CVCL_1663 Homo sapiens 10uM 6H
Ovarian mucinous cystadenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COV644 CVCL_2011 Homo sapiens 10uM 6H
RMUG-S CVCL_1666 Homo sapiens 10uM 6H
Ovarian undifferentiated carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
TYK-nu CVCL_1774 Homo sapiens 10uM 6H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.04uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.04uM - 10uM 6H, 24H
Acute myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NOMO-1 CVCL_1609 Homo sapiens 10uM 6H
PL-21 CVCL_2161 Homo sapiens 10uM 6H
SKM-1 CVCL_0010 Homo sapiens 10uM 6H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Pleural effusion
Histiocytic lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-937 CVCL_0007 Homo sapiens 10uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.04uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.04uM - 10uM 6H, 24H
SK-L CVCL_1699 Homo sapiens 0.04uM - 10uM 24H
SK-MEL-1 CVCL_0523 Homo sapiens 10uM 6H
SK-MEL-28 CVCL_0526 Homo sapiens 10uM 6H
Stomach
Gastric adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
AGS CVCL_0139 Homo sapiens 10uM 6H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.04uM - 10uM 24H