Details of the Drug Pharmacogenomic Perturbation Atlas

AT13387 Drug Info

Therapeutic Class

Anticancer Agents

Cross-matching ID

PubChem CID

11955716

ChEBI ID

CHEMBL1214827

CAS Number

CAS 912999-49-6

TTD Drug ID

D06YSP

General Information of Drug (ID: DM2B9E0)

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Spliceosome	1.91	1.33e-2	101/150 (67.33%)	HSPA1A;HSPA8;PRPF8;...
Protein processing in endoplasmic reticulum	1.90	9.95e-3	127/171 (74.27%)	HSPA1A;HSPA8;HSPH1;...
Longevity regulating pathway	1.85	1.33e-2	90/151 (59.6%)	HSPA1A;HSPA8;CRYAB;...
Human cytomegalovirus infection	-1.63	4.57e-2	201/225 (89.33%)	GNAS;ADCY2;GNG11;...
Epstein-Barr virus infection	-1.64	4.14e-2	189/202 (93.56%)	CDKN1A;SAP30;BLNK;...
Malaria	-1.64	4.08e-2	44/50 (88%)	TLR2;HGF;IL18;...
Viral protein interaction with cytokine and cytokine re...	-1.65	3.95e-2	84/100 (84%)	CCL7;IL37;CCL19;...
Influenza A	-1.65	4.18e-2	156/172 (90.7%)	CHUK;MYD88;TLR7;...
Leishmaniasis	-1.68	3.53e-2	67/77 (87.01%)	MYD88;ITGA4;FCGR2C;...
Tuberculosis	-1.69	3.77e-2	159/180 (88.33%)	RAB7A;FCGR2C;HLA-DQB1;...
Base excision repair	-1.69	3.76e-2	29/33 (87.88%)	POLD3;MPG;PCNA;...
TNF signaling pathway	-1.73	2.73e-2	103/112 (91.96%)	BIRC3;BAG4;BCL3;...
Kaposi sarcoma-associated herpesvirus infection	-1.73	2.52e-2	172/193 (89.12%)	HLA-C;FGF2;PPP3CC;...
TGF-beta signaling pathway	-1.74	2.39e-2	81/94 (86.17%)	RBL1;ACVR1;SMAD3;...
Pyrimidine metabolism	-1.76	1.84e-2	40/56 (71.43%)	DCTD;NT5C;RRM2;...
NF-kappa B signaling pathway	-1.82	1.32e-2	90/104 (86.54%)	TNFAIP3;CCL21;BLNK;...
Pertussis	-1.83	1.48e-2	64/76 (84.21%)	IRF1;TICAM1;GNAI3;...
Graft-versus-host disease	-1.88	9.39e-3	32/42 (76.19%)	GZMB;HLA-DQB1;HLA-C;...
Rheumatoid arthritis	-1.88	1.10e-2	78/93 (83.87%)	VEGFA;ATP6V0A2;HLA-DQA1;...
IL-17 signaling pathway	-1.91	1.05e-2	84/94 (89.36%)	CXCL5;TRAF4;FADD;...
Homologous recombination	-1.93	9.86e-3	35/41 (85.37%)	PALB2;POLD3;RPA2;...
Mismatch repair	-2.13	0.00e+0	22/23 (95.65%)	POLD3;RPA2;MLH1;...
Fanconi anemia pathway	-2.21	0.00e+0	36/54 (66.67%)	REV1;PALB2;RPA2;...
DNA replication	-2.47	0.00e+0	34/36 (94.44%)	DNA2;POLA1;POLD3;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point
MCF7	CVCL_0031	Homo sapiens	0.01uM - 10uM	24H

MDA-MB-231	CVCL_0062	Homo sapiens	0.01uM - 10uM	24H

Breast epithelium

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF-10A	CVCL_0598	Homo sapiens	0.01uM - 10uM	24H

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	24H

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	24H

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	24H

Normal (Transformed)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HEK293	CVCL_0045	Homo sapiens	0.01uM - 10uM	24H

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.01uM - 10uM	24H

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H

Peripheral blood

Acute monocytic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
THP-1	CVCL_0006	Homo sapiens	0.04uM - 10uM	24H

T-cell acute lymphoblastic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Jurkat	CVCL_0367	Homo sapiens	0.04uM - 10uM	24H

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	24H

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	24H

Umbilical vein

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HUVEC-C	CVCL_2959	Homo sapiens	0.04uM - 10uM	24H