Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM2HGNU)

Drug Name
DL-TBOA Drug Info
Synonyms dl-threo-beta-benzyloxyaspartate
Cross-matching ID
PubChem CID
5311218
ChEBI ID
CHEMBL79140
CAS Number
CAS 208706-75-6
TTD Drug ID
D07GUB
VARIDT Drug ID
DR01066

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 2.79 0.00e+0 34/36 (94.44%) MCM4;MCM3;MCM2;...
Cell cycle 2.56 0.00e+0 110/124 (88.71%) CCNA2;CDC20;CCNB1;...
Spliceosome 2.46 0.00e+0 101/150 (67.33%) SRSF1;HNRNPM;FUS;...
Progesterone-mediated oocyte maturation 2.21 0.00e+0 75/100 (75%) CCNA2;CCNB1;PLK1;...
Oocyte meiosis 2.20 0.00e+0 90/129 (69.77%) CDC20;CCNB1;PLK1;...
Pyrimidine metabolism 2.19 0.00e+0 40/56 (71.43%) RRM2;TYMS;DUT;...
Mismatch repair 2.09 0.00e+0 22/23 (95.65%) RFC3;RFC5;MSH2;...
Base excision repair 2.09 0.00e+0 29/33 (87.88%) POLE2;NEIL3;HMGB1;...
RNA transport 2.07 0.00e+0 128/186 (68.82%) PNN;FUS;TACC3;...
Fanconi anemia pathway 2.03 0.00e+0 36/54 (66.67%) FANCI;RAD51;FANCG;...
Homologous recombination 2.01 0.00e+0 35/41 (85.37%) RAD54B;RAD51;POLD1;...
Ribosome biogenesis in eukaryotes 1.94 6.51e-4 52/108 (48.15%) GAR1;TCOF1;RAN;...
Nucleotide excision repair 1.79 6.61e-3 40/47 (85.11%) POLE2;RFC3;RFC5;...
Aminoacyl-tRNA biosynthesis 1.77 7.25e-3 15/66 (22.73%) FARSA;DARS2;GATC;...
Non-homologous end-joining 1.76 8.33e-3 11/13 (84.62%) PRKDC;FEN1;XRCC5;...
One carbon pool by folate 1.65 3.86e-2 15/20 (75%) TYMS;DHFR;GART;...
Steroid biosynthesis -1.72 4.72e-2 19/20 (95%) SQLE;LSS;CYP24A1;...
Autophagy -1.78 3.63e-2 113/169 (66.86%) DAPK1;ATG9A;ATG13;...
Phagosome -1.79 3.84e-2 118/152 (77.63%) SCARB1;SEC61B;HLA-A;...
Mineral absorption -1.82 3.63e-2 48/60 (80%) FXYD2;TF;MT1M;...
Other glycan degradation -1.92 6.06e-3 13/18 (72.22%) ENGASE;MAN2B2;MAN2B1;...
Mitophagy -1.93 4.04e-3 56/68 (82.35%) ULK1;PINK1;RHOT1;...
Lysosome -2.06 6.06e-3 115/128 (89.84%) GLA;NAGLU;GUSB;...
Ferroptosis -2.14 0.00e+0 36/41 (87.8%) CP;TP53;NCOA4;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-673 CVCL_0080 Homo sapiens 150uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 150uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CL-34 CVCL_1123 Homo sapiens 150uM 6H
HT-29 CVCL_0320 Homo sapiens 150uM 6H, 24H
LoVo CVCL_0399 Homo sapiens 150uM 6H
MDST8 CVCL_1400 Homo sapiens 150uM 6H
NCI-H508 CVCL_1561 Homo sapiens 150uM 6H
SNU-1040 CVCL_5001 Homo sapiens 150uM 6H
SNU-C4 CVCL_5008 Homo sapiens 150uM 6H
SNU-C5 CVCL_5009 Homo sapiens 150uM 6H
SW480 CVCL_0546 Homo sapiens 150uM 6H
SW620 CVCL_0547 Homo sapiens 150uM 6H
SW948 CVCL_0550 Homo sapiens 150uM 6H
Colorectal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCT 116 CVCL_0291 Homo sapiens 150uM 6H
HT115 CVCL_1294 Homo sapiens 150uM 6H
RKO CVCL_0504 Homo sapiens 150uM 6H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 150uM 6H
SNG-M CVCL_1707 Homo sapiens 150uM 6H
Endometrial carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHUEM-2 CVCL_1327 Homo sapiens 150uM 6H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 150uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 150uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 150uM 6H, 24H
DV-90 CVCL_1184 Homo sapiens 150uM 6H
SK-LU-1 CVCL_0624 Homo sapiens 150uM 6H
Lung adenosquamous carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H596 CVCL_1571 Homo sapiens 150uM 6H
Lung large cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COR-L23 CVCL_1133 Homo sapiens 150uM 6H
T3M-10 CVCL_1729 Homo sapiens 150uM 6H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC15 CVCL_1253 Homo sapiens 150uM 6H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1299 CVCL_0060 Homo sapiens 150uM 6H
HCC515 CVCL_5134 Homo sapiens 150uM 6H, 24H
NCI-H2073 CVCL_1523 Homo sapiens 150uM 6H
Small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1694 CVCL_1495 Homo sapiens 150uM 6H
NCI-H1836 CVCL_1502 Homo sapiens 150uM 6H
Lymph node
Diffuse large B-cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
WSU-DLCL2 CVCL_1787 Homo sapiens 150uM 6H
Ovary
Ovarian carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
EFO-27 CVCL_1194 Homo sapiens 150uM 6H
OV7 CVCL_1623 Homo sapiens 150uM 6H
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
RMG-I CVCL_1663 Homo sapiens 150uM 6H
Ovarian mucinous cystadenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COV644 CVCL_2011 Homo sapiens 150uM 6H
RMUG-S CVCL_1666 Homo sapiens 150uM 6H
Ovarian undifferentiated carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
TYK-nu CVCL_1774 Homo sapiens 150uM 6H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 150uM 6H
Acute myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NOMO-1 CVCL_1609 Homo sapiens 150uM 6H
PL-21 CVCL_2161 Homo sapiens 150uM 6H
SKM-1 CVCL_0010 Homo sapiens 150uM 6H
Pleural effusion
Histiocytic lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-937 CVCL_0007 Homo sapiens 150uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 150uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 150uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 150uM 6H, 24H
SK-MEL-1 CVCL_0523 Homo sapiens 150uM 6H
SK-MEL-28 CVCL_0526 Homo sapiens 150uM 6H
Stomach
Gastric adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
AGS CVCL_0139 Homo sapiens 150uM 6H