Details of the Drug

General Information of Drug (ID: DM2HGNU)

Drug Name
DL-TBOA
Synonyms dl-threo-beta-benzyloxyaspartate
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Drug Type
Small molecular drug
Structure
3D MOL is unavailable 2D MOL
#Ro5 Violations (Lipinski): 1 Molecular Weight (mw) 239.22
Logarithm of the Partition Coefficient (xlogp) -2.4
Rotatable Bond Count (rotbonds) 6
Hydrogen Bond Donor Count (hbonddonor) 3
Hydrogen Bond Acceptor Count (hbondacc) 6
Chemical Identifiers
Formula
C11H13NO5
IUPAC Name
(2S,3S)-2-amino-3-phenylmethoxybutanedioic acid
Canonical SMILES
C1=CC=C(C=C1)CO[C@@H]([C@@H](C(=O)O)N)C(=O)O
InChI
InChI=1S/C11H13NO5/c12-8(10(13)14)9(11(15)16)17-6-7-4-2-1-3-5-7/h1-5,8-9H,6,12H2,(H,13,14)(H,15,16)/t8-,9-/m0/s1
InChIKey
BYOBCYXURWDEDS-IUCAKERBSA-N
Cross-matching ID
PubChem CID
5311218
CAS Number
208706-75-6
TTD ID
D07GUB
VARIDT ID
DR01066

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Excitatory amino acid transporter 1 (SLC1A3) TT8WRDA EAA1_HUMAN Inhibitor [2]
Excitatory amino acid transporter 2 (SLC1A2) TT2F078 EAA2_HUMAN Inhibitor [2]
Excitatory amino acid transporter 3 (SLC1A1) TTG2A6F EAA3_HUMAN Inhibitor [3]
Excitatory amino acid transporter 4 (SLC1A6) TT6KMPN EAA4_HUMAN Inhibitor [4]
Excitatory amino acid transporter 5 (SLC1A7) TTK41DM EAA5_HUMAN Inhibitor [4]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
U2OS CTRP1 10.3535 12.4814 8.2681 3.2244
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MCF-7 CTRP1 10.6271 13.0516 8.1683 3.4026
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SF295 CTRP1 7.1214 8.2248 4.7067 0.1171
GaMG CTRP1 7.5807 8.8881 4.6422 0.1218
LN-229 CTRP1 10.6069 12.5973 8.3525 2.1527
Cancer Drug Sensitivity Data Curated from 10 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HEC-265 CTRP1 5.6477 9.0465 3.532 11.3453
HEC-251 CTRP1 6.3577 9.3273 3.8855 6.2118
HEC-108 CTRP1 6.5314 9.036 4.122 3.9435
HEC-6 CTRP1 7.0425 8.837 4.4576 0.9854
HEC-59 CTRP1 7.2801 8.6272 4.6258 0.2308
MFE-319 CTRP1 7.6773 13.6371 2.706 11.4018
KLE CTRP1 7.7404 9.6608 4.433 0.5675
HEC-151 CTRP1 9.1217 11.1377 8.0714 8.638
JHUEM-2 CTRP1 11.1406 12.74 8.5338 0.5792
Ishikawa (Heraklio) 02 ER- CTRP1 6.5237 7.5421 4.7279 0.2751
⏷ Show the Full List of 10 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 24 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MC116 CTRP1 6.3799 7.3535 4.7407 0.3131
BL-70 CTRP1 6.585 7.4645 4.777 0.125
HT CTRP1 6.6218 12.6315 2.4828 15.8222
KE-97 CTRP1 6.6986 10.1649 3.7085 6.7299
P3HR-1 CTRP1 6.8282 11.2455 3.2865 9.5997
Ku812 CTRP1 7.3936 9.0299 4.5267 0.4528
OCI-AML-3 CTRP1 9.2404 10.8285 8.3205 5.9406
NU-DUL-1 CTRP1 9.4314 15.7559 6.0155 22.8696
SU-DHL-5 CTRP1 9.9041 11.5469 8.4288 2.9883
SKM-1 CTRP1 10.0648 12.6046 8.0379 5.7611
LP-1 CTRP1 10.2385 12.2085 8.3246 3.0428
KMS-11 CTRP1 10.3451 13.867 7.6237 8.3505
WSU-DLCL2 CTRP1 10.3992 11.2958 8.7685 0.2143
RPMI-8226 CTRP1 10.4593 11.8886 8.5713 1.0211
AMO1 CTRP1 10.6318 11.8359 8.6637 0.4316
SU-DHL-4 CTRP1 10.7362 12.0116 8.6406 0.4486
U-937 CTRP1 10.8173 12.1397 8.6257 0.451
EJM CTRP1 10.8346 12.1278 8.6367 0.4017
THP-1 CTRP1 10.8681 12.3375 8.5734 0.6181
MOLM-16 CTRP1 10.9247 12.6207 8.4902 0.9417
OCI-Ly10 CTRP1 10.9896 15.7754 7.141 10.2268
NOMO-1 CTRP1 11.0027 12.4303 8.5924 0.4547
GDM-1 CTRP1 11.098 12.9313 8.4451 0.992
PL21 CTRP1 11.4463 12.7403 8.6456 0.1448
⏷ Show the Full List of 24 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
VMRC-RCW CTRP1 7.3798 9.1317 4.4848 0.6036
RCC10RGB CTRP1 11.0163 12.3782 8.6162 0.3687
Cancer Drug Sensitivity Data Curated from 37 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
DLD-1 CTRP1 5.8905 7.4071 4.484 2.585
LS411N CTRP1 6.2278 8.5129 4.1814 4.1748
SW48 CTRP1 6.4644 9.0773 4.065 4.5292
SK-CO-1 CTRP1 6.5812 8.1701 4.5149 1.1875
SW403 CTRP1 6.9328 11.3464 3.3058 9.1757
LS513 CTRP1 6.9383 8.6259 4.494 0.9106
GP2d CTRP1 7.1011 8.8196 4.4885 0.7918
SNU-C2A CTRP1 7.3144 10.8611 3.7518 5.0204
COLO205 CTRP1 7.3279 8.7918 4.5861 0.3107
C2BBe1 CTRP1 7.6543 9.7267 4.3755 0.833
LS180 CTRP1 8.9867 10.1764 8.4389 5.8943
SNU-81 CTRP1 9.4518 11.6036 8.0973 7.1635
SW620 CTRP1 9.7815 11.3769 8.4324 3.2628
HCT 116 CTRP1 9.785 11.3538 8.4453 3.1486
SNU-C4 CTRP1 9.8475 12.0919 8.1386 5.5354
MDST8 CTRP1 10.1893 11.6822 8.5264 1.6839
SNU-175 CTRP1 10.2391 14.2044 7.3909 10.5189
HCT 8 CTRP1 10.3564 11.3481 8.7335 0.354
HT115 CTRP1 10.522 11.7297 8.659 0.53
SNU-1040 CTRP1 10.6426 11.9772 8.6159 0.6172
CL-34 CTRP1 10.6475 11.938 8.6324 0.5433
HT-29 CTRP1 10.66 11.6457 8.7417 0.1781
COLO 320 CTRP1 10.6711 13.66 7.9225 5.1488
NCI-H508 CTRP1 10.8417 12.2916 8.5797 0.612
SW948 CTRP1 10.8643 11.9911 8.6959 0.2136
RCM-1 [Human ESC] CTRP1 10.88 12.1662 8.6402 0.3646
SW480 CTRP1 10.8865 12.9993 8.3231 1.9121
LS123 CTRP1 10.995 12.705 8.4877 0.8874
HT-55 CTRP1 11.0906 12.2552 8.6858 0.1622
CW-2 CTRP1 11.1544 12.9388 8.4658 0.847
SNU-C5 CTRP1 11.1555 12.9097 8.4771 0.7968
KM12 CTRP1 11.1561 12.9747 8.453 0.9027
RKO CTRP1 11.2652 12.5312 8.6533 0.177
COLO 678 CTRP1 11.3789 13.1205 8.4885 0.5907
SNU-61 CTRP1 11.4695 13.1452 8.5143 0.4523
CL-40 CTRP1 11.5689 13.0023 8.5998 0.1968
LoVo CTRP1 11.7365 13.4307 8.5126 0.3366
⏷ Show the Full List of 37 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 4 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JHH-6 CTRP1 6.6222 7.7934 4.6754 0.395
SNU-449 CTRP1 8.3461 9.7946 4.5997 0.0641
SNU-398 CTRP1 10.5871 15.3497 7.0779 11.8336
Hep-G2 CTRP1 11.0147 12.1959 8.6792 0.1994
Cancer Drug Sensitivity Data Curated from 91 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H2126 CTRP1 6.1421 9.6506 3.591 9.2176
Calu-3 CTRP1 6.2952 8.6213 4.172 4.0894
BEN CTRP1 6.3107 7.1776 4.7773 0.2311
NCI-H82 CTRP1 6.3893 9.29 3.9225 5.8339
NCI-H2009 CTRP1 6.5269 8.8815 4.1879 3.4605
NCI-H1048 CTRP1 6.5548 10.6474 3.3914 9.5712
LCLC-103H CTRP1 6.5858 8.3942 4.4264 1.708
NCI-H2286 CTRP1 6.759 8.2109 4.5761 0.694
NCI-H1975 CTRP1 6.7669 9.5706 4.0172 4.2252
COR-L88 CTRP1 6.768 10.2069 3.7313 6.3831
COR-L279 CTRP1 6.7892 8.2149 4.5869 0.6227
NCI-H810 CTRP1 6.7956 8.9185 4.3123 2.1145
NCI-H1944 CTRP1 6.8226 9.5583 4.0534 3.8466
Lu-99 CTRP1 6.8296 8.599 4.4572 1.2101
HCC78 CTRP1 6.836 9.1297 4.2443 2.4932
NCI-H358 CTRP1 6.8456 9.6621 4.0205 4.039
NCI-H1568 CTRP1 6.9126 10.1805 3.8282 5.3145
NCI-H650 CTRP1 6.9279 8.7896 4.4262 1.2643
SHP-77 CTRP1 6.9377 8.373 4.588 0.5114
NCI-H1435 CTRP1 6.9658 8.7721 4.4496 1.1008
NCI-H2029 CTRP1 6.98 8.6368 4.5073 0.8113
DMS 273 CTRP1 6.9817 9.1804 4.2945 1.9511
NCI-H1930 CTRP1 6.9827 8.469 4.5706 0.5465
ChaGo-K-1 CTRP1 7.02 11.1477 3.4521 7.8679
LCLC-97TM1 CTRP1 7.0224 10.1556 3.901 4.5455
NCI-H2405 CTRP1 7.0232 9.3724 4.2358 2.2538
LC-1/sq-SF CTRP1 7.0536 10.8873 3.5915 6.7532
NCI-H1437 CTRP1 7.0605 9.7034 4.1163 2.97
HCC33 CTRP1 7.0689 8.7195 4.5127 0.7147
Calu-6 CTRP1 7.0766 9.0807 4.378 1.3529
NCI-H1793 CTRP1 7.0795 8.7284 4.5137 0.7023
COLO 668 CTRP1 7.1054 9.223 4.3349 1.5541
DV-90 CTRP1 7.1636 8.6201 4.5857 0.3878
EPLC-272H CTRP1 7.1656 9.364 4.3062 1.6406
VMRC-LCD CTRP1 7.173 9.7267 4.1626 2.4889
KNS-62 CTRP1 7.2129 9.3376 4.3378 1.4132
NCI-H1573 CTRP1 7.2204 9.1969 4.3956 1.1123
NCI-H727 CTRP1 7.2482 9.1517 4.4245 0.9507
RERF-LC-KJ CTRP1 7.254 8.5764 4.6339 0.2212
EBC-1 CTRP1 7.2615 9.126 4.4396 0.8717
NCI-H522 CTRP1 7.2619 9.2806 4.3812 1.1415
HARA [Human squamous cell lung carcinoma] CTRP1 7.2831 9.1797 4.4284 0.9031
NCI-H1355 CTRP1 7.3024 9.7922 4.1978 2.089
NCI-H23 CTRP1 7.3563 9.7771 4.2288 1.8403
NCI-H1666 CTRP1 7.3856 13.405 2.6291 12.6553
Lu-65 CTRP1 7.4117 8.8803 4.5858 0.2784
NCI-H1915 CTRP1 7.4274 9.1624 4.4921 0.5483
NCI-H1373 CTRP1 7.4412 11.2158 3.6659 5.3693
A-549 CTRP1 7.4681 9.6238 4.3376 1.1529
NCI-H1792 CTRP1 7.5066 11.3699 3.6342 5.4591
HCC44 CTRP1 7.5559 9.3781 4.4639 0.5694
NCI-H661 CTRP1 7.6594 9.2192 4.5578 0.2568
LXF 289 CTRP1 7.6973 9.4075 4.5064 0.3687
NCI-H1299 CTRP1 7.8823 9.689 4.4758 0.3729
NCI-H596 CTRP1 9.3615 11.15 8.2536 6.0969
NCI-H2141 CTRP1 10.046 12.055 8.2817 3.818
NCI-H1963 CTRP1 10.0635 11.8819 8.3706 3.074
HCC1359 CTRP1 10.2466 10.9147 8.8451 0.0865
NCI-H1781 CTRP1 10.4901 11.9226 8.5717 0.9832
SCLC-21H CTRP1 10.5013 11.7207 8.6539 0.5685
HCC4006 CTRP1 10.5091 12.3656 8.4005 1.9946
NCI-H841 CTRP1 10.5517 12.2343 8.4754 1.4559
HCC15 CTRP1 10.6759 14.1823 7.6866 6.9576
NCI-H460 CTRP1 10.6934 11.8882 8.6687 0.3754
NCI-H2122 CTRP1 10.6967 12.2515 8.5343 0.9526
T3M-10 CTRP1 10.7229 12.4594 8.4644 1.2973
COR-L51 CTRP1 10.7561 12.3673 8.5152 0.9871
COR-L23 CTRP1 10.7656 11.9654 8.6686 0.3352
NCI-H1694 CTRP1 10.8593 12.589 8.4742 1.0878
Sq-1 CTRP1 10.8858 12.2545 8.6107 0.4617
NCI-H3255 CTRP1 10.9003 12.8067 8.407 1.4014
NCI-H2342 CTRP1 10.9088 12.7738 8.4239 1.2987
SK-LU-1 CTRP1 10.9666 12.6201 8.508 0.8198
NCI-H2073 CTRP1 10.9809 12.4439 8.5791 0.5161
NCI-H1836 CTRP1 10.9895 12.3138 8.629 0.343
NCI-H1105 CTRP1 10.9986 13.269 8.2665 2.0993
NCI-H2110 CTRP1 10.9994 13.0884 8.3401 1.6575
NCI-H2081 CTRP1 11.058 13.0143 8.3958 1.2797
NCI-H2172 CTRP1 11.0866 12.3764 8.6428 0.261
HCC827 CTRP1 11.1946 12.6748 8.578 0.3958
CAL-12T CTRP1 11.2741 12.8545 8.544 0.4617
NCI-H1755 CTRP1 11.2975 12.8142 8.5671 0.3777
COLO 699 CTRP1 11.3195 12.8491 8.563 0.3792
NCI-H2023 CTRP1 11.3336 12.7618 8.5986 0.2764
NCI-H2030 CTRP1 11.3652 12.7933 8.5991 0.2633
HCC1833 CTRP1 11.3714 13.321 8.4117 0.9023
NCI-H1876 CTRP1 11.3744 13.065 8.5068 0.5291
HCC2935 CTRP1 11.4481 12.9419 8.5776 0.2849
HCC1195 CTRP1 11.4586 12.7766 8.6376 0.1555
NCI-H441 CTRP1 11.5422 13.1116 8.5528 0.3106
HCC2108 CTRP1 11.6184 13.0523 8.6001 0.1828
⏷ Show the Full List of 91 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KYSE-450 CTRP1 7.2272 8.596 4.6176 0.2698
KYSE-410 CTRP1 7.5373 9.9819 4.2293 1.6235
KYSE-140 CTRP1 7.5523 10.0738 4.1999 1.7635
Cancer Drug Sensitivity Data Curated from 26 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COV318 CTRP1 6.6526 7.6544 4.736 0.1946
JHOS-4 CTRP1 6.752 9.6617 3.9684 4.62
OVMANA CTRP1 6.9626 8.3944 4.5899 0.4882
HEY A8 CTRP1 7.1613 11.2569 3.4872 7.2661
EFO-21 CTRP1 7.1622 9.5692 4.2221 2.1371
SK-OV-3 CTRP1 7.4658 8.8781 4.6058 0.2145
OVCAR-4 CTRP1 8.9763 10.755 8.141 8.6191
OVK18 CTRP1 9.3642 11.789 7.9392 8.8761
JHOC-5 CTRP1 9.5909 10.6152 8.6667 1.8461
OVKATE CTRP1 10.0563 14.4824 7.1268 13.1572
OVCAR-8 CTRP1 10.1257 12.0766 8.3191 3.3336
JHOM-1 CTRP1 10.2686 11.5582 8.6158 1.0048
COV362 CTRP1 10.3903 12.4698 8.2935 2.9601
OAW42 CTRP1 10.5319 11.5806 8.7173 0.3046
Caov-3 CTRP1 10.5445 12.1658 8.4998 1.321
COV434 CTRP1 10.6142 12.829 8.2579 2.7864
RMG-I CTRP1 10.6214 13.2112 8.095 3.9543
TYK-nu CTRP1 10.9658 12.3959 8.5906 0.4837
SNU-840 CTRP1 11.0025 14.9386 7.5375 7.277
A2780 CTRP1 11.2415 12.9085 8.5119 0.5937
OV7 CTRP1 11.2492 12.7395 8.5754 0.3763
EFO-27 CTRP1 11.2833 12.922 8.5233 0.5264
OV-90 CTRP1 11.3158 12.7496 8.5964 0.2889
COV644 CTRP1 11.3353 12.7743 8.5949 0.2851
IGROV-1 CTRP1 11.5176 13.412 8.4367 0.6913
RMUG-S CTRP1 11.6683 17.9154 6.5705 12.2888
⏷ Show the Full List of 26 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 10 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SUIT-2 CTRP1 6.3626 8.5267 4.2531 3.3173
Panc 03.27 CTRP1 6.4647 9.4494 3.8952 5.8591
PaTu 8902 CTRP1 6.6388 8.3574 4.4665 1.3916
QGP-1 CTRP1 6.8081 8.3225 4.5544 0.7488
Panc 10.05 CTRP1 7.041 9.2837 4.2807 1.9521
HPAC CTRP1 7.0944 8.9963 4.4186 1.1243
CFPAC-1 CTRP1 7.3021 9.0168 4.4962 0.6121
Capan-2 CTRP1 7.4267 9.393 4.4074 0.8758
HuP-T4 CTRP1 7.5568 9.4715 4.4304 0.6886
KP-3 CTRP1 7.6904 10.224 4.2022 1.597
⏷ Show the Full List of 10 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H28 CTRP1 7.048 8.9389 4.4207 1.1615
MSTO-211H CTRP1 7.1476 9.7807 4.1277 2.7519
NCI-H2052 CTRP1 7.5875 10.0919 4.2084 1.6775
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
PaCa-3 CTRP1 6.3404 9.567 3.7624 7.2496
Cancer Drug Sensitivity Data Curated from 9 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Hs 936.T CTRP1 6.6385 9.1653 4.1247 3.6982
Hs 944.T CTRP1 6.9835 9.5009 4.1627 2.7905
Hs 852.T CTRP1 7.011 8.8152 4.4525 1.0406
COLO 741 CTRP1 7.1018 9.5383 4.2057 2.3254
G-361 CTRP1 7.2446 8.7147 4.5825 0.3576
SK-MEL-28 CTRP1 9.8653 10.7577 8.7504 0.7464
SK-MEL-5 CTRP1 10.1864 11.4796 8.6091 1.155
SK-MEL-1 CTRP1 10.3845 11.6546 8.6298 0.7939
A-375 CTRP1 10.8409 12.473 8.511 0.9223
⏷ Show the Full List of 9 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
G-401 CTRP1 7.5569 13.3698 2.7549 11.3889
HT-1080 CTRP1 10.5275 12.1135 8.5129 1.2667
RKN CTRP1 11.271 12.2991 8.7325 0.0589
Cancer Drug Sensitivity Data Curated from 7 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SH-10-TC CTRP1 6.2883 7.5243 4.6382 0.8559
MKN74 CTRP1 7.0292 9.5117 4.1811 2.5948
NUGC-4 CTRP1 7.0518 15.8536 1.2189 21.4209
MKN7 CTRP1 7.2999 8.9469 4.5207 0.5256
Fu97 CTRP1 7.5732 9.5704 4.4007 0.7916
AGS CTRP1 9.9589 11.4052 8.5237 2.1344
SNG-M CTRP1 7.0295 8.6544 4.521 0.7108
⏷ Show the Full List of 7 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HSC-2 CTRP1 6.8089 8.3678 4.5376 0.8256
SCC-9 CTRP1 11.2306 12.4155 8.6803 0.1362
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
UM-UC-3 CTRP1 6.7779 8.5088 4.4696 1.2023
RT-4 CTRP1 7.1847 10.4494 3.8611 4.5055
HT-1376 CTRP1 7.2687 9.3121 4.372 1.1795
KMBC-2 CTRP1 7.4118 12.0352 3.2818 8.1506
5637 CTRP1 7.4914 9.5963 4.3578 1.0389

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4631).
2 DL-threo-beta-benzyloxyaspartate, a potent blocker of excitatory amino acid transporters. Mol Pharmacol. 1998 Feb;53(2):195-201.
3 Syntheses of optically pure beta-hydroxyaspartate derivatives as glutamate transporter blockers. Bioorg Med Chem Lett. 2000 Nov 6;10(21):2407-10.
4 Effects of threo-beta-hydroxyaspartate derivatives on excitatory amino acid transporters (EAAT4 and EAAT5). J Neurochem. 2001 Oct;79(2):297-302.