Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM2L3PE)

Drug Name
Hyperforin Drug Info
Synonyms
hyperforin; 11079-53-1; hyperforine; hiperforina; UNII-RM741E34FP; CHEBI:5834; RM741E34FP; CHEMBL1237210; (1R,5S,6R,7S)-4-hydroxy-6-methyl-1,3,7-tris(3-methylbut-2-en-1-yl)-6-(4-methylpent-3-en-1-yl)-5-(2-methylpropanoyl)bicyclo[3.3.1]non-3-ene-2,9-dione; (1R,5S,6R,7S)-4-hydroxy-5-isobutyryl-6-methyl-1,3,7-tris(3-methylbut-2-en-1-yl)-6-(4-methylpent-3-en-1-yl)bicyclo[3.3.1]non-3-ene-2,9-dione; HSDB 7646; (+)-Hyperforin; Spectrum5_002025; SCHEMBL98723; CHEMBL501711; GTPL2764; SCHEMBL15557965; Hyperforin, &gt
Cross-matching ID
PubChem CID
441298
ChEBI ID
CHEMBL5834
CAS Number
CAS 11079-53-1
TTD Drug ID
D09VTJ
VARIDT Drug ID
DR00582

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Cysteine and methionine metabolism 2.19 0.00e+0 43/50 (86%) CBS;CTH;PHGDH;...
Glycine, serine and threonine metabolism 2.08 0.00e+0 31/40 (77.5%) CBS;SHMT2;CTH;...
Alanine, aspartate and glutamate metabolism 2.07 0.00e+0 27/37 (72.97%) ASNS;ASS1;GFPT1;...
One carbon pool by folate 2.07 0.00e+0 15/20 (75%) MTHFD2;SHMT2;FTCD;...
Protein processing in endoplasmic reticulum 1.97 0.00e+0 127/171 (74.27%) HERPUD1;SEC24D;EIF2AK3;...
Arginine biosynthesis 1.92 1.66e-3 17/22 (77.27%) ASS1;GOT1;ASL;...
Cortisol synthesis and secretion 1.90 1.42e-3 58/65 (89.23%) AGTR1;PRKACB;CREB3L2;...
Protein export 1.87 2.49e-3 17/23 (73.91%) SRPRB;SRP72;SRPRA;...
Complement and coagulation cascades 1.77 2.11e-2 76/85 (89.41%) FGG;F7;SERPINF2;...
Steroid biosynthesis 1.76 2.09e-2 19/20 (95%) HSD17B7;MSMO1;CYP51A1;...
Steroid hormone biosynthesis 1.74 3.08e-2 43/61 (70.49%) UGT2B15;HSD17B7;UGT2B28;...
Primary bile acid biosynthesis 1.71 3.49e-2 15/17 (88.24%) ACOX2;AKR1D1;SLC27A5;...
Pyruvate metabolism 1.70 3.84e-2 41/47 (87.23%) PCK2;ALDH2;ALDH3A2;...
Vasopressin-regulated water reabsorption 1.69 4.06e-2 40/44 (90.91%) PRKACB;CREB3L2;GNAS;...
Arginine and proline metabolism 1.68 4.59e-2 39/50 (78%) PYCR1;GOT1;ALDH2;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
1HAEo- CVCL_0128 Homo sapiens 10uM 24H
NL20 CVCL_0461 Homo sapiens 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
Normal (Fibroblast)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HFL1 CVCL_4295 Homo sapiens 10uM 24H
IMR-90 CVCL_0347 Homo sapiens 10uM 24H
WI-38 CVCL_0579 Homo sapiens 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H