Details of the Drug

General Information of Drug (ID: DM2L3PE)

Drug Name
Hyperforin
Synonyms
hyperforin; 11079-53-1; hyperforine; hiperforina; UNII-RM741E34FP; CHEBI:5834; RM741E34FP; CHEMBL1237210; (1R,5S,6R,7S)-4-hydroxy-6-methyl-1,3,7-tris(3-methylbut-2-en-1-yl)-6-(4-methylpent-3-en-1-yl)-5-(2-methylpropanoyl)bicyclo[3.3.1]non-3-ene-2,9-dione; (1R,5S,6R,7S)-4-hydroxy-5-isobutyryl-6-methyl-1,3,7-tris(3-methylbut-2-en-1-yl)-6-(4-methylpent-3-en-1-yl)bicyclo[3.3.1]non-3-ene-2,9-dione; HSDB 7646; (+)-Hyperforin; Spectrum5_002025; SCHEMBL98723; CHEMBL501711; GTPL2764; SCHEMBL15557965; Hyperforin, &gt
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 3 Molecular Weight (mw) 536.8
Logarithm of the Partition Coefficient (xlogp) 9.6
Rotatable Bond Count (rotbonds) 11
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 4
ADMET Property
Half-life
The concentration or amount of drug in body reduced by one-half in 9 hours [2]
Chemical Identifiers
Formula
C35H52O4
IUPAC Name
(1R,5R,7S,8R)-4-hydroxy-8-methyl-3,5,7-tris(3-methylbut-2-enyl)-8-(4-methylpent-3-enyl)-1-(2-methylpropanoyl)bicyclo[3.3.1]non-3-ene-2,9-dione
Canonical SMILES
CC(C)C(=O)[C@]12C(=O)C(=C([C@](C1=O)(C[C@@H]([C@@]2(C)CCC=C(C)C)CC=C(C)C)CC=C(C)C)O)CC=C(C)C
InChI
InChI=1S/C35H52O4/c1-22(2)13-12-19-33(11)27(16-14-23(3)4)21-34(20-18-25(7)8)30(37)28(17-15-24(5)6)31(38)35(33,32(34)39)29(36)26(9)10/h13-15,18,26-27,37H,12,16-17,19-21H2,1-11H3/t27-,33+,34+,35-/m0/s1
InChIKey
KGSZHKRKHXOAMG-HQKKAZOISA-N
Cross-matching ID
PubChem CID
441298
ChEBI ID
CHEBI:5834
CAS Number
11079-53-1
UNII
RM741E34FP
DrugBank ID
DB01892
TTD ID
D09VTJ
VARIDT ID
DR00582

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Arachidonate 5-lipoxygenase (5-LOX) TT2J34L LOX5_HUMAN Inhibitor [3]
Pregnane X receptor (NR1I2) TT7LCTF NR1I2_HUMAN Binder [4]
Prostaglandin G/H synthase 1 (COX-1) TT8NGED PGH1_HUMAN Inhibitor [3]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial (CYP24A1) OTG2T749 CP24A_HUMAN Gene/Protein Processing [5]
5-aminolevulinate synthase, non-specific, mitochondrial (ALAS1) OTQY6ZSF HEM1_HUMAN Gene/Protein Processing [6]
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Gene/Protein Processing [7]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Gene/Protein Processing [8]
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Gene/Protein Processing [6]
Bcl-2 homologous antagonist/killer (BAK1) OTDP6ILW BAK_HUMAN Gene/Protein Processing [7]
CASP8 and FADD-like apoptosis regulator (CFLAR) OTX14BAS CFLAR_HUMAN Gene/Protein Processing [7]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Protein Interaction/Cellular Processes [7]
Caspase-8 (CASP8) OTA8TVI8 CASP8_HUMAN Protein Interaction/Cellular Processes [7]
Cytochrome c (CYCS) OTBFALJD CYC_HUMAN Gene/Protein Processing [8]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Prostaglandin G/H synthase 1 (COX-1) DTT PTGS1 3.97E-03 0.16 0.43
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 127 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MEC1 CTRP2 4.3759 9.5861 2.7447 17.4092
JK1 CTRP2 8.7484 11.0221 5.2899 0.4878
JM1 CTRP2 4.7395 8.406 3.6553 12.8787
EoL-1 CTRP2 -2.1965 27.9104 -12.337 51.3096
WSU-DLCL2 CTRP2 0.6313 3.0605 0.6149 36.1166
KMS-34 CTRP2 0.6768 1.5272 0.6768 35.7594
Daudi CTRP2 1.6187 4.0649 1.5776 29.6221
EB1 CTRP2 1.9085 3.5927 1.9016 27.5769
KMS-26 CTRP2 2.0863 3.7131 2.0793 26.3927
CML-T1 CTRP2 2.2047 5.0593 2.076 26.0186
NALM-6 CTRP2 2.4225 4.2984 2.3983 24.211
AML-193 CTRP2 2.4296 4.5648 2.3836 24.2371
KM-H2 CTRP2 2.4711 5.8071 2.2069 24.7188
Pfeiffer CTRP2 2.5335 6.4731 2.0877 24.9476
GA-10 CTRP2 2.8181 4.5024 2.7957 21.5693
TF-1 CTRP2 2.879 6.5064 2.4535 22.5885
Ku812 CTRP2 2.9744 4.787 2.9354 20.5844
ST486 CTRP2 3.0241 6.8108 2.5112 21.9459
U-937 CTRP2 3.0563 4.999 2.9981 20.1042
L-428 CTRP2 3.2228 6.1924 2.6572 15.2291
HuT 78 CTRP2 3.2693 6.4701 2.8897 19.8323
DEL CTRP2 3.2699 4.7245 3.2502 18.5504
KMS-11 CTRP2 3.2831 5.3368 3.1904 18.7124
THP-1 CTRP2 3.3252 4.8653 3.2968 18.2114
KE-97 CTRP2 3.3963 5.4792 3.2868 18.0174
BL-70 CTRP2 3.4646 7.6953 2.6536 20.1505
OCI-AML-3 CTRP2 3.5095 5.0571 3.472 17.0146
Mino CTRP2 3.5273 6.3733 3.201 17.9237
HT CTRP2 3.5647 4.9586 3.5397 16.6042
DB CTRP2 3.592 7.6811 2.7939 19.2653
HD-MY-Z CTRP2 3.7769 7.0793 3.2263 17.1054
SEM CTRP2 3.8043 4.8947 3.7935 14.9599
KMS-18 CTRP2 3.8567 7.4259 3.1764 17.0724
RL CTRP2 4.1429 8.3079 3.1001 16.6012
MOLP-2 CTRP2 4.1692 5.9428 4.0247 12.9958
SR CTRP2 4.1704 6.8654 3.7283 14.0891
BV-173 CTRP2 4.2625 5.817 4.1568 12.2365
KMS-27 CTRP2 4.318 6.1841 4.1204 12.1976
K-562 CTRP2 4.6333 10.2131 2.6925 16.9923
KYO-1 CTRP2 4.6348 6.4841 4.367 10.3535
KMS-20 CTRP2 4.7782 7.962 3.3583 8.1615
KMS-12-BM CTRP2 4.8577 6.6705 4.5372 9.0764
KMS-28BM CTRP2 5.0279 8.1773 4.0459 10.5923
JeKo-1 CTRP2 5.1136 10.3875 3.0556 14.4379
NU-DHL-1 CTRP2 5.2255 8.0861 3.6717 5.8171
F-36P CTRP2 5.6777 18.4872 -1.1568 23.3983
MHH-CALL-3 CTRP2 5.8566 8.0557 4.8783 5.2765
SUP-T11 CTRP2 5.9313 8.3602 4.791 5.491
MOTN-1 CTRP2 5.9907 11.6977 3.1728 12.1197
M-07e CTRP2 6.1307 10.9351 2.9479 7.4023
PF-382 CTRP2 6.2342 8.2675 5.0868 3.6734
MV4-11 CTRP2 6.2598 8.6887 4.8972 4.4221
OCI-AML-5 CTRP2 6.2647 10.4783 3.265 5.809
Karpas-620 CTRP2 6.3549 8.2006 5.2129 2.9397
Hs 611.T CTRP2 6.4365 8.5962 5.0787 3.3624
TALL-1 [Human adult T-ALL] CTRP2 6.4384 9.2039 4.7798 4.6021
RPMI-8226 CTRP2 6.4472 11.8159 3.487 9.9673
HuNS1 CTRP2 6.5487 9.3999 4.7661 4.4745
Raji CTRP2 6.6057 8.1864 4.5058 0.555
Kasumi-2 CTRP2 6.647 10.8909 3.3246 4.9859
KO52 CTRP2 6.6781 10.8085 4.1676 6.744
A4/Fukuda CTRP2 6.6903 10.8186 4.1719 6.7056
SUP-B15 CTRP2 6.8459 12.5552 3.4305 9.4948
U266B1 CTRP2 6.8782 12.3632 2.7774 6.9504
Reh CTRP2 6.8891 8.6171 4.4625 0.5135
Ci-1 CTRP2 6.9541 8.006 5.6781 0.4444
MOLP-8 CTRP2 7.0214 12.3858 3.6465 8.3198
HEL 92.1.7 CTRP2 7.0573 9.4733 5.0827 2.4545
OCI-Ly19 CTRP2 7.097 9.4646 5.1116 2.2939
SUP-HD1 CTRP2 7.1255 9.4937 5.1158 2.2435
MJ CTRP2 7.1302 23.6781 -1.8847 25.6957
JJN-3 CTRP2 7.1908 12.5851 2.8776 6.0855
L-363 CTRP2 7.1939 13.2585 3.3447 9.2601
Granta-519 CTRP2 7.1992 10.7628 4.5644 4.313
SU-DHL-10 CTRP2 7.2179 8.3327 5.6682 0.3191
NB4 CTRP2 7.2574 8.1471 5.7537 0.1316
MC116 CTRP2 7.2629 8.245 5.7202 0.1888
Kasumi-1 CTRP2 7.2712 10.8495 4.5713 4.1852
LP-1 CTRP2 7.2755 14.4063 2.8399 11.1276
RPMI-6666 CTRP2 7.3023 13.1182 3.4932 8.4885
CMK CTRP2 7.4065 8.6141 5.6409 0.2949
OCI-Ly3 CTRP2 7.4514 26.1014 -2.837 27.0689
GDM-1 CTRP2 7.4622 12.224 4.0415 6.0367
OCI-AML-2 CTRP2 7.4903 8.7648 5.6188 0.3071
AMO1 CTRP2 7.4905 9.0907 5.4912 0.6242
HL-60 CTRP2 7.507 8.8196 5.6051 0.3299
MOLM-16 CTRP2 7.5166 9.4961 5.3361 1.0698
NOMO-1 CTRP2 7.6059 8.7964 5.6539 0.1968
OCI-M1 CTRP2 7.6179 9.0439 5.5665 0.3667
SU-DHL-1 CTRP2 7.6349 8.874 5.6369 0.2175
Ri-1 CTRP2 7.6437 13.7765 3.4165 8.2665
EJM CTRP2 7.656 14.319 3.1611 9.2563
HPB-ALL CTRP2 7.7143 10.5976 4.9628 2.1588
MOLT-16 CTRP2 7.727 9.2269 5.5428 0.3711
SKM-1 CTRP2 7.7625 9.0133 5.636 0.1811
SU-DHL-4 CTRP2 7.778 9.1332 5.5986 0.2401
Mono-Mac-1 CTRP2 7.8004 11.222 4.7314 2.9097
P31/FUJ CTRP2 7.8043 8.901 5.6911 0.0965
SET-2 CTRP2 7.8385 14.9048 3.0057 9.583
Karpas-422 CTRP2 7.8457 9.2256 5.5915 0.2312
MHH-CALL-4 CTRP2 7.857 9.7197 5.4082 0.6293
NU-DUL-1 CTRP2 7.8756 9.2984 5.5767 0.2479
Karpas-299 CTRP2 7.9487 9.2606 5.6183 0.1606
PL21 CTRP2 8.0096 9.6611 5.4964 0.3537
HEL CTRP2 8.0191 9.3799 5.6025 0.1667
KCL-22 CTRP2 8.0249 11.6854 4.6535 2.9505
REC-1 CTRP2 8.0303 10.8643 5.019 1.6696
P3HR-1 CTRP2 8.051 9.6244 5.5266 0.281
SU-DHL-8 CTRP2 8.0688 9.3391 5.635 0.1144
RPMI-8402 CTRP2 8.0953 9.4649 5.6008 0.1519
L-540 CTRP2 8.1613 9.6699 5.5529 0.2049
JVM-2 CTRP2 8.1661 11.0046 5.0296 1.5225
Ki-JK CTRP2 8.1782 9.5525 5.6006 0.1352
JVM-3 CTRP2 8.2902 9.8993 5.5199 0.2222
SUP-T1 CTRP2 8.4687 9.9867 5.5553 0.1357
MOLT-13 CTRP2 8.5194 10.1495 5.5171 0.1728
LAMA-84 CTRP2 8.5385 10.3629 5.4485 0.2678
ME1 CTRP2 8.5505 10.0389 5.5665 0.1103
KHM-1B CTRP2 8.6076 10.0811 5.5723 0.0967
RCH-ACV CTRP2 8.6235 10.3046 5.5011 0.1721
SU-DHL-6 CTRP2 8.6271 10.1206 5.5657 0.1002
HDLM-2 CTRP2 8.6338 10.6934 5.3655 0.3823
Jurkat CTRP2 8.67 9.8264 5.6778 0.0238
MOLM-6 CTRP2 8.7129 10.6244 5.4214 0.2637
KMM-1 CTRP2 8.738 10.9505 5.3123 0.447
EHEB CTRP2 8.8625 10.6692 5.4612 0.1751
SIG-M5 CTRP2 11.5011 24.2452 0.9901 11.6157
⏷ Show the Full List of 127 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 24 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE8 CTRP2 3.5527 5.7266 3.4048 17.1109
TE15 CTRP2 5.6239 10.626 3.3943 11.9534
KYSE-30 CTRP2 3.3468 6.2457 2.7666 14.4124
KYSE-410 CTRP2 3.4948 6.3451 3.1744 18.1181
TE-5 CTRP2 3.9509 6.4637 3.6329 15.0796
TE-4 CTRP2 4.0427 5.5224 3.977 13.5598
KYSE-140 CTRP2 5.0166 10.5702 2.8767 15.3744
TE-6 CTRP2 5.0724 6.621 1.5769 0.0896
KYSE-510 CTRP2 5.129 9.6322 2.8206 9.826
OE21 CTRP2 5.4948 9.3444 3.9167 10.0611
KYSE-180 CTRP2 5.6222 10.9994 3.2068 12.7262
KYSE-520 CTRP2 6.7206 14.8934 2.17 14.6638
TE-9 CTRP2 7.0201 11.4161 4.122 6.3765
COLO 680N CTRP2 7.4852 11.5135 4.3973 4.5846
KYSE-450 CTRP2 7.6512 10.4581 4.9892 2.1293
OE19 CTRP2 7.8522 9.2844 5.5725 0.2631
KYSE-70 CTRP2 8.1031 9.7678 5.4946 0.3228
TE-10 CTRP2 8.1432 10.8314 5.091 1.3482
TE-1 CTRP2 8.2207 10.0879 5.4231 0.4212
KYSE-150 CTRP2 8.3226 14.729 2.5846 5.799
TE-14 CTRP2 8.4248 19.4448 0.4295 13.6451
OE33 CTRP2 8.714 10.4113 5.4969 0.1599
EC-GI-10 CTRP2 9.3266 20.1976 1.4812 12.8878
TE-11 CTRP2 9.6903 18.6429 2.4626 9.0241
⏷ Show the Full List of 24 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 36 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
N2a-PK1 CTRP2 9.4508 14.6772 4.1274 3.3867
KP-4 CTRP2 0.582 2.2066 0.5811 36.3941
SU.86.86 CTRP2 3.7437 4.6801 3.7399 15.3401
KP-3 CTRP2 4.0556 7.7077 3.2698 16.1694
PSN1 CTRP2 4.1157 8.5249 2.9756 17.1595
BxPC-3 CTRP2 4.1174 8.6576 2.9177 17.3819
MIA PaCa-2 CTRP2 4.5217 7.5946 3.8018 12.847
Capan-2 CTRP2 4.5659 8.0685 3.1171 9.7201
PaTu 8988s CTRP2 6.0324 12.4007 2.8562 13.3154
Panc 10.05 CTRP2 6.367 11.9535 3.3542 10.6597
PaTu 8902 CTRP2 6.8326 12.479 3.458 9.4054
SW1990 CTRP2 7.0012 13.3179 3.1711 10.2781
DAN-G CTRP2 7.1444 11.5133 4.1636 6.0143
Panc 08.13 CTRP2 7.3048 18.8797 -0.0918 19.1856
SNU-213 CTRP2 7.3408 8.6019 5.6173 0.3801
PK-45H CTRP2 7.3452 9.9267 5.0504 2.235
AsPC-1 CTRP2 7.66 14.6213 3.0165 9.8165
SNU-410 CTRP2 7.7492 11.1565 4.7306 2.97
Panc 02.03 CTRP2 7.8759 11.6771 4.5685 3.4317
Panc 05.04 CTRP2 8.0089 9.3089 5.6237 0.1399
YAPC CTRP2 8.0101 9.0659 5.7073 0.0531
PaTu 8988t CTRP2 8.0159 9.1369 5.6854 0.0706
HPAF-II CTRP2 8.1886 10.1361 5.3914 0.5034
Hs 766T CTRP2 8.2625 21.304 -0.5846 17.1552
TCC-Pan2 CTRP2 8.2906 9.5734 5.6335 0.0821
SUIT-2 CTRP2 8.3036 15.4774 3.052 8.7187
QGP-1 CTRP2 8.5008 9.7659 5.6413 0.0535
HuP-T4 CTRP2 8.5903 10.0773 5.5675 0.1036
HuP-T3 CTRP2 8.9109 17.0088 2.7277 9.0909
PK-59 CTRP2 8.9766 10.4269 5.583 0.0514
Panc 03.27 CTRP2 9.1655 16.9705 2.9119 8.0776
Panc 04.03 CTRP2 9.3963 21.6594 0.8232 14.8993
L3.3 CTRP2 9.5124 17.2908 2.9815 7.3911
HPAC CTRP2 9.7973 25.6002 -0.8097 18.9199
CFPAC-1 CTRP2 11.3798 27.2506 -0.5095 15.9976
KP-2 CTRP2 12.6703 26.2961 0.7629 10.9577
⏷ Show the Full List of 36 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 47 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SH4 CTRP2 7.4487 10.0764 4.1379 1.0729
SK-MEL-1 CTRP2 0.9999 2.1533 0.9999 33.6072
WT2-iPS CTRP2 1.6924 2.1809 1.6924 28.9938
UACC-62 CTRP2 3.5088 5.0745 3.4693 17.0258
WM266-4 CTRP2 3.5781 6.1629 3.3196 17.3387
RPMI-7951 CTRP2 3.7267 6.191 3.4735 16.3315
MeWo CTRP2 4.3346 9.2666 2.8544 17.0802
WM88 CTRP2 4.3494 8.1418 3.3845 14.9449
WM115 CTRP2 4.6161 6.6827 4.2744 10.7566
Hs 940.T CTRP2 4.6373 6.196 4.4649 9.9836
HT-144 CTRP2 4.7701 9.9812 2.9342 15.7117
WM983B CTRP2 4.7818 9.5857 3.1362 14.8742
UACC-257 CTRP2 4.9976 8.4008 3.9106 11.2162
RVH-421 CTRP2 5.0122 8.896 3.6878 12.0917
SK-MEL-5 CTRP2 5.4633 9.2652 3.9274 10.0849
IGR-37 CTRP2 5.4637 9.5054 3.153 7.6843
CJM [Human melanoma] CTRP2 5.6858 7.9305 4.788 6.0164
SK-MEL-28 CTRP2 5.6981 16.5834 0.4836 22.3836
Mel Ho CTRP2 5.7738 9.0896 4.2908 7.91
Hs 688(A).T CTRP2 6.0347 7.8741 5.1215 3.898
LOX-IMVI CTRP2 6.262 7.5257 5.4764 1.9991
Hs 944.T CTRP2 6.5672 12.1002 3.4404 9.9419
COLO 829 CTRP2 6.7427 11.6506 3.7999 8.1563
SK-MEL-2 CTRP2 6.809 12.1338 3.6111 8.8202
Hs 839.T CTRP2 7.0318 13.3678 3.1695 10.2328
SK-MEL-31 CTRP2 7.1523 11.5696 4.1419 6.0907
SK-MEL-3 CTRP2 7.2046 11.211 4.3524 5.1584
A2058 CTRP2 7.2585 8.7917 5.502 0.7517
HMCB CTRP2 7.4096 9.7429 5.1708 1.7271
IGR-39 CTRP2 7.5424 11.5648 4.4106 4.4558
IGR-1 CTRP2 7.6221 9.4516 5.4069 0.7769
Hs 294T CTRP2 7.7092 9.54 5.4122 0.7059
Hs 895.T CTRP2 7.7875 9.2011 5.5774 0.2762
Hs 936.T CTRP2 7.901 9.1205 5.65 0.1281
SK-MEL-30 CTRP2 8.0424 9.5114 5.5643 0.2189
COLO 792 CTRP2 8.135 10.175 5.3532 0.6189
MDA-MB-435S CTRP2 8.1983 9.6191 5.5847 0.1513
Hs 852.T CTRP2 8.2211 9.5588 5.614 0.112
WM1799 CTRP2 8.2282 9.31 5.7002 0.0386
A-375 CTRP2 8.4088 9.9334 5.552 0.1507
COLO 800 CTRP2 8.4266 11.7493 4.8473 1.895
A101D CTRP2 8.4269 13.3605 4.1297 4.4392
WM793 CTRP2 8.462 9.9916 5.5511 0.1417
G-361 CTRP2 8.5652 10.0545 5.5664 0.1082
IPC-298 CTRP2 9.0832 15.9835 3.3213 6.6718
Mel JuSo CTRP2 9.9197 19.1487 2.3716 9.0546
K029AX CTRP2 10.4355 22.2716 1.2337 12.1843
⏷ Show the Full List of 47 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 CTRP2 3.1145 7.136 2.4942 21.7433
Cancer Drug Sensitivity Data Curated from 12 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SiMa CTRP2 2.0833 4.9523 1.9632 26.7968
SK-N-BE(2) CTRP2 3.1513 5.6434 2.9868 19.842
SK-N-FI CTRP2 6.0085 16.2256 0.9239 20.3793
SK-N-DZ CTRP2 6.9618 8.7518 5.3573 1.5244
NH-6 CTRP2 7.3272 12.1999 3.9591 6.5676
IMR-32 CTRP2 7.3322 8.5874 5.6192 0.3798
SK-N-SH CTRP2 7.7883 10.1518 5.1974 1.2924
NB1 CTRP2 7.8317 11.554 4.5983 3.3713
Kelly CTRP2 8.1151 9.5784 5.5681 0.1938
KP-N-SI9s CTRP2 8.2238 9.5336 5.6236 0.1013
KP-N-YN CTRP2 8.3108 10.2683 5.3926 0.4488
CHP-126 CTRP2 8.8371 10.233 5.6002 0.0518
⏷ Show the Full List of 12 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 7 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-478 CTRP2 2.4931 4.9135 2.4087 23.9457
SNU-308 CTRP2 3.6999 8.8912 2.3893 20.5091
HuCC-T1 CTRP2 4.4776 8.3282 3.4301 14.4358
SNU-245 CTRP2 5.851 8.4869 3.9402 3.5313
HuH-28 CTRP2 6.6675 9.7377 4.6878 4.6064
SNU-1196 CTRP2 9.7953 19.0073 2.3587 9.2555
SNU-869 CTRP2 11.0326 29.7553 -1.9551 19.9444
⏷ Show the Full List of 7 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 14 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SaOS-2 CTRP2 2.8872 5.084 2.8056 21.3113
Hs 888.T CTRP2 4.4616 6.6542 4.1192 11.7828
SJSA-1 CTRP2 4.5238 6.8417 4.1151 11.6228
Hs 822.T CTRP2 4.913 10.6596 2.7373 16.1644
MHH-ES-1 CTRP2 5.1651 8.8812 3.8399 11.113
CAL-78 CTRP2 5.6979 9.2552 4.1418 8.691
TC71 CTRP2 5.9558 10.2412 3.8717 9.2986
A-673 CTRP2 7.272 11.7388 4.144 5.9021
G-292 clone A141B1 CTRP2 7.2884 10.2287 3.9973 1.637
SK-N-MC CTRP2 7.7834 8.8031 5.7173 0.072
SW1353 CTRP2 7.9667 9.3143 5.6061 0.1741
MG-63 CTRP2 8.2226 13.7037 3.8422 5.783
U2OS CTRP2 8.7164 10.3486 5.5194 0.1338
HOS CTRP2 10.373 18.7372 2.8396 6.8981
⏷ Show the Full List of 14 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 69 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MDA-MB-157 CTRP2 2.8756 4.9953 2.6908 16.1713
MDA-MB-453 CTRP2 3.727 7.394 3.0516 17.9094
MDA-MB-415 CTRP2 3.8012 9.0438 2.4238 20.1106
DU4475 CTRP2 4.3207 6.6799 3.9582 12.7926
BT-20 CTRP2 4.8048 8.224 3.8046 12.1148
T-47D CTRP2 5.0905 10.0728 2.5685 11.022
MDA-MB-361 CTRP2 5.1283 7.902 3.6849 5.9508
KPL-1 CTRP2 5.709 6.0496 5.677 2.3466
Hs 578Bst CTRP2 5.8743 9.5415 4.1521 8.2869
HCC1419 CTRP2 5.986 7.9107 5.0622 4.2426
HMC-1-8 CTRP2 5.9994 11.6869 3.1855 12.0508
HCC1500 CTRP2 6.003 8.848 4.6079 6.1184
CAL-85-1 CTRP2 6.0762 8.3537 4.9162 4.6813
ZR-75-30 CTRP2 6.1537 11.9052 3.2046 11.6735
HDQ-P1 CTRP2 6.4804 12.6094 3.1178 11.4126
SK-BR-3 CTRP2 6.5704 11.1599 3.1459 5.8524
BT-474 CTRP2 6.7927 8.509 4.4624 0.5651
HCC1428 CTRP2 6.9452 12.6359 3.466 9.1819
EFM-192A CTRP2 7.0094 15.0128 2.3369 13.5179
HCC202 CTRP2 7.2752 11.2295 4.392 4.897
HCC38 CTRP2 7.5852 11.2607 4.5813 3.7337
MDA-MB-468 CTRP2 7.7052 11.6587 4.4712 4.0093
Hs 578T CTRP2 7.7197 11.4745 4.5661 3.6264
CAL-148 CTRP2 7.7966 9.0215 5.6461 0.1569
MCF-7 CTRP2 7.8209 9.9835 5.2844 0.9984
HCC1806 CTRP2 7.9335 9.9317 5.3587 0.7152
ZR-75-1 CTRP2 8.0289 9.5526 5.5442 0.2569
CAL-51 CTRP2 8.0511 10.5579 5.1594 1.2078
BT-549 CTRP2 8.1643 9.7641 5.5202 0.2569
HCC1937 CTRP2 8.191 10.9603 5.061 1.4046
AU565 CTRP2 8.277 16.0201 2.7723 9.8198
MDA-MB-231 CTRP2 8.3803 10.3467 5.3918 0.423
CAMA-1 CTRP2 8.4532 10.1215 5.5024 0.2076
HCC1954 CTRP2 8.4825 10.1402 5.5067 0.1947
HCC1395 CTRP2 8.8705 10.6103 5.4845 0.1466
HCC1143 CTRP2 9.435 11.4668 5.3917 0.1555
JIMT-1 CTRP2 9.942 21.8165 1.1224 13.1925
BT 172 CTRP2 2.0168 4.4916 1.9554 27.0393
BT 286 CTRP2 2.1506 4.2332 2.1199 26.044
BT 428 CTRP2 2.3165 3.9485 2.3067 24.8686
BT 228 CTRP2 3.5224 5.4109 3.2706 11.8276
BT 231 CTRP2 4.3399 8.32 2.7879 11.7105
BT 131 CTRP2 4.5116 6.956 4.0574 11.878
BT 239 CTRP2 4.6637 6.4087 4.0237 5.4494
BT 159 CTRP2 4.7912 7.7585 3.4709 7.6272
BT 444 CTRP2 4.8231 7.2034 4.2821 10.1611
BT147 CTRP2 4.9465 8.4356 3.8445 11.6081
BT 416 CTRP2 5.0949 8.3804 4.0143 10.561
BT 139 CTRP2 5.1117 7.4127 3.9159 4.9447
BT 187 CTRP2 5.1823 7.7337 3.8129 5.2671
BT 145 CTRP2 5.3733 9.915 3.5248 11.9479
BT 359 CTRP2 5.3965 8.8621 4.0649 9.6606
BT 245 CTRP2 5.4299 8.9576 4.0486 9.6541
BT 482 CTRP2 5.576 7.7415 4.7797 6.2948
BT 216 CTRP2 5.8547 8.7811 4.5149 6.8046
BT 340 CTRP2 6.0341 9.4931 4.3115 7.303
BT 422 CTRP2 6.2714 9.8034 4.3506 6.6926
BT 232 CTRP2 6.4802 10.4542 4.1913 6.9851
BT 320 CTRP2 6.8106 8.4275 5.4147 1.4821
BT164 CTRP2 6.8991 8.7418 5.3239 1.7218
BT 330 CTRP2 6.9166 8.5656 5.4152 1.3607
BT 504 CTRP2 7.1109 11.7202 4.0388 6.5746
BT 112 CTRP2 7.1662 11.6821 4.0969 6.2526
BT 440 CTRP2 7.2207 11.9733 3.9939 6.5882
BT 333 CTRP2 7.3752 10.7125 4.7044 3.5221
BT 328 CTRP2 7.3757 10.9408 4.597 3.9426
BT 498 CTRP2 7.7634 11.7015 4.4879 3.8727
BT 179 CTRP2 8.4983 16.3412 2.7697 9.5094
BT 224 CTRP2 8.5701 13.0461 4.3571 3.4472
⏷ Show the Full List of 69 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Tongue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
YD-38 CTRP2 8.671 15.4286 3.3191 7.2006
Cancer Drug Sensitivity Data Curated from 44 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SF268 CTRP2 1.822 4.1634 1.7232 23.361
SF539 CTRP2 2.2122 3.7754 2.1861 20.3092
SF126 CTRP2 2.3584 4.3844 2.3252 24.6683
SNU-466 CTRP2 2.4409 4.8312 2.3644 24.2662
GB-1 CTRP2 3.1107 6.1012 2.8271 20.537
Daoy CTRP2 3.5693 5.954 3.3674 17.1931
CAS-1 CTRP2 3.781 5.199 3.7434 15.206
KNS-60 CTRP2 3.8116 4.9036 3.8006 14.9119
SNU-738 CTRP2 4.0727 9.1195 2.6626 18.4904
U-251MG CTRP2 4.4819 7.5918 3.2761 9.2076
GaMG CTRP2 4.5151 7.2043 3.9605 12.2433
D283 Med CTRP2 4.7989 18.8048 -1.4013 29.1491
SW1088 CTRP2 4.8855 6.5857 4.5995 8.7609
KNS-81 CTRP2 4.8973 7.9313 4.0319 10.969
SW1783 CTRP2 5.4298 9.0728 3.9918 9.8903
KALS-1 CTRP2 5.5781 8.4927 4.4128 7.8143
SNU-626 CTRP2 5.715 11.4681 3.0534 13.1587
SF295 CTRP2 5.841 9.5313 4.1287 8.452
SNU-489 CTRP2 6.0378 9.7331 4.1945 7.7869
ONS-76 CTRP2 6.1435 7.3466 5.4739 2.2134
SNB-75 CTRP2 6.2611 11.359 3.5655 9.9871
42-MG-BA CTRP2 6.3517 8.6188 4.1932 1.8278
AM-38 CTRP2 6.7449 9.1844 5.0129 3.1559
KG-1-C CTRP2 6.822 8.1644 4.6045 0.2313
Hs 683 CTRP2 7.0271 11.9283 3.8758 7.3735
DK-MG CTRP2 7.1538 9.1737 5.279 1.6029
U-87MG ATCC CTRP2 7.3415 8.9592 5.4734 0.7774
SNU-1105 CTRP2 7.465 8.7155 5.6269 0.3002
CCF-STTG1 CTRP2 7.5508 8.6952 5.6691 0.1873
SNU-201 CTRP2 7.6207 8.9873 5.5891 0.3163
LN-18 CTRP2 7.6462 19.3152 0.6921 18.0725
TM-31 CTRP2 7.6713 8.941 5.6268 0.2239
A-172 CTRP2 7.6816 10.7013 4.8974 2.4291
YH-13 CTRP2 7.7753 9.2396 5.5581 0.319
DBTRG-05MG CTRP2 7.8979 10.3982 5.1492 1.3578
GMS-10 CTRP2 7.9718 9.4638 5.5541 0.2573
M059K CTRP2 7.9822 10.407 5.188 1.1715
NMC-G1 CTRP2 8.0685 9.5443 5.5626 0.2145
8-MG-BA CTRP2 8.1532 9.5954 5.5763 0.1726
U-118MG CTRP2 8.1908 9.6361 5.576 0.1646
Becker CTRP2 8.2985 9.8862 5.5277 0.2081
LN-229 CTRP2 8.3442 12.2503 4.5837 2.87
GOS-3 CTRP2 9.2483 15.9087 3.4577 5.9736
T98G CTRP2 11.6176 21.5651 2.2893 7.4089
⏷ Show the Full List of 44 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 21 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HEC-151 CTRP2 2.8282 4.4384 2.8102 21.4873
HEC-108 CTRP2 3.2951 7.9547 2.3698 21.6888
HEC-265 CTRP2 3.6332 7.9079 2.7443 19.3401
KLE CTRP2 3.6738 7.893 2.7931 19.0427
MFE-296 CTRP2 3.9285 7.9289 2.5921 13.5797
HEC-1-A CTRP2 4.7588 9.0645 2.7916 10.739
HEC-251 CTRP2 5.8757 11.8193 3.0152 12.9875
EFE-184 CTRP2 5.9153 10.8402 3.5381 10.7673
JHUEM-1 CTRP2 6.1159 10.8232 3.7143 9.6446
MFE-319 CTRP2 6.8985 11.8458 3.8211 7.8075
HEC-6 CTRP2 7.4931 12.7007 3.8326 6.8301
JHUEM-7 CTRP2 7.5106 11.6307 4.3583 4.7047
EN CTRP2 7.5725 11.9289 4.2575 5.0198
JHUEM-2 CTRP2 8.0328 10.1971 5.2983 0.8184
HEC-1-B CTRP2 8.3126 9.8126 5.559 0.1611
RL95-2 CTRP2 8.3757 9.9187 5.545 0.1662
HEC-59 CTRP2 8.5519 14.6969 3.5867 6.3393
ESS-1 CTRP2 8.9479 16.1053 3.1789 7.3695
AN3-CA CTRP2 8.9764 16.3962 3.0604 7.7733
HEC-50B CTRP2 11.6166 24.8104 0.7991 12.0495
Ishikawa (Heraklio) 02 ER- CTRP2 11.5479 25.8589 0.2626 13.6855
⏷ Show the Full List of 21 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 17 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
UO-31 CTRP2 2.5885 3.911 2.5685 17.6011
TUHR4TKB CTRP2 3.1881 6.2224 2.8769 20.1226
VMRC-RCZ CTRP2 3.6215 5.7059 3.4844 16.6148
SNU-1272 CTRP2 5.1444 9.7912 3.3766 13.0629
RCC10RGB CTRP2 5.4184 7.9409 4.5347 7.6672
KMRC-1 CTRP2 7.0505 10.1644 4.7505 3.7757
ACHN CTRP2 7.385 9.6375 5.2038 1.6348
KMRC-3 CTRP2 7.5843 9.1363 4.5452 0.1365
TUHR10TKB CTRP2 7.74 9.0228 5.6239 0.2075
KMRC-2 CTRP2 7.8438 9.2141 5.5949 0.2258
KMRC-20 CTRP2 7.9106 15.3674 2.8318 10.1431
769-P CTRP2 8.0136 12.9784 4.049 5.2527
VMRC-RCW CTRP2 8.1762 11.7061 4.7308 2.518
OS-RC-2 CTRP2 8.2666 9.7346 5.5694 0.1571
Caki-2 CTRP2 8.2979 9.9608 5.5008 0.2504
Caki-1 CTRP2 9.0774 15.2268 3.667 5.4044
786-O CTRP2 10.0667 17.1446 3.3798 5.3547
⏷ Show the Full List of 17 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 44 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 320 CTRP2 2.27 5.0397 2.1497 25.5546
HT115 CTRP2 2.8108 5.0022 2.7358 21.7971
C2BBe1 CTRP2 3.0288 8.7945 1.7406 24.7229
SW620 CTRP2 3.2181 5.9974 2.9727 19.6857
SNU-C5 CTRP2 3.4108 5.0663 3.3665 17.6952
KM12 CTRP2 3.8433 10.6273 1.7335 22.5475
HCT 8 CTRP2 4.5113 10.1146 2.0523 14.5269
LS123 CTRP2 4.6415 7.4782 3.9758 11.846
CL-11 CTRP2 4.8982 8.7977 3.6256 12.6148
RKO CTRP2 4.9505 8.8785 3.6373 12.4429
T84 CTRP2 4.9688 11.7444 1.6312 15.2891
DLD-1 CTRP2 5.0683 14.157 1.1485 21.6332
SNU-61 CTRP2 5.6456 9.1267 4.1595 8.7267
HCT 116 CTRP2 5.8389 14.4112 1.6885 18.1317
SK-CO-1 CTRP2 6.212 10.4689 3.9702 8.3955
GP2d CTRP2 6.4971 13.2789 2.7972 12.6635
SW948 CTRP2 6.6567 9.5223 4.7856 4.2201
SNU-C4 CTRP2 6.7046 10.5634 3.5153 4.1133
LS180 CTRP2 6.8621 12.3234 3.5576 8.9486
SW1463 CTRP2 6.9493 9.3985 5.0482 2.7289
HCC-56 CTRP2 6.9813 10.4018 4.5884 4.5304
SNU-407 CTRP2 7.0083 10.2288 4.6908 4.0761
HCT 15 CTRP2 7.0271 16.8842 1.4201 16.7877
COLO 678 CTRP2 7.113 11.9719 3.9171 7.0681
SNU-C1 CTRP2 7.1536 16.1203 1.8984 14.8818
SW1417 CTRP2 7.2764 9.5788 5.1677 1.8777
OUMS-23 CTRP2 7.3993 13.9861 3.1383 9.7509
LS513 CTRP2 7.4563 11.3656 4.4485 4.4212
SNU-503 CTRP2 7.496 10.0742 5.0721 1.9919
COLO205 CTRP2 7.6243 9.4663 5.402 0.7897
RCM-1 [Human ESC] CTRP2 7.6901 9.5696 5.3912 0.7768
SNU-1033 CTRP2 7.7077 26.3824 -3.4945 25.3051
LS1034 CTRP2 7.7203 10.3737 5.0653 1.7929
LS411N CTRP2 7.9772 17.5285 1.8227 13.7635
COLO201 CTRP2 8.0099 9.4064 5.5896 0.1879
NCI-H508 CTRP2 8.0356 12.3945 4.3355 4.1244
MDST8 CTRP2 8.1452 9.3552 5.6566 0.08
NCI-H716 CTRP2 8.3223 11.3044 4.9825 1.5476
CCK-81 CTRP2 8.5405 10.3656 5.4483 0.2675
CW-2 CTRP2 8.671 10.341 5.5057 0.1573
SNU-C2A CTRP2 8.7557 10.5656 5.4583 0.2004
LoVo CTRP2 8.9915 10.7504 5.4795 0.1326
HT-55 CTRP2 10.2327 23.8619 0.3383 15.1744
HT-29 CTRP2 12.2618 29.1205 -0.8145 15.6895
⏷ Show the Full List of 44 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 21 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-878 CTRP2 1.5098 3.5073 1.4975 30.2511
SNU-886 CTRP2 1.5608 4.7108 1.4404 30.2737
Li-7 CTRP2 2.3691 5.4998 2.1679 25.1759
SNU-761 CTRP2 2.4577 4.4208 1.2003 4.0455
HuH-6 CTRP2 3.3088 5.1885 3.2416 18.4531
SNU-182 CTRP2 3.6645 5.1742 3.6228 15.9961
JHH-2 CTRP2 3.8448 5.583 3.7523 14.9709
PLC/PRF/5 CTRP2 4.5831 20.0629 -2.217 31.2508
JHH-6 CTRP2 6.8616 11.4587 3.9844 7.1965
SNU-449 CTRP2 7.1286 13.6839 3.0863 10.4019
SK-HEP-1 CTRP2 7.4522 12.2852 4.0051 6.1974
HuH-1 CTRP2 7.6127 14.0542 3.2594 8.936
JHH-4 CTRP2 7.6622 11.4797 4.5277 3.8448
SNU-475 CTRP2 7.8023 11.9854 4.3799 4.2402
SNU-423 CTRP2 8.0154 15.8829 2.6553 10.6545
HLF CTRP2 8.1474 13.4547 3.911 5.6144
Hep 3B2.1-7 CTRP2 8.2786 9.8444 5.5351 0.2022
SNU-398 CTRP2 8.5679 10.5562 5.3897 0.3599
SNU-387 CTRP2 8.6356 16.5242 2.7749 9.2956
JHH-1 CTRP2 10.5612 18.9807 2.84 6.6921
Hep-G2 CTRP2 12.9123 29.4163 -0.5339 14.2179
⏷ Show the Full List of 21 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 134 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H1581 CTRP2 0.4131 2.1893 0.4116 37.5216
NCI-H2106 CTRP2 0.6895 2.4567 0.6874 35.6819
SBC-5 CTRP2 1.0799 3.757 1.0392 33.2088
SHP-77 CTRP2 1.0904 9.2115 -0.4657 37.1598
HOP-62 CTRP2 1.289 4.4684 1.0878 27.5392
NCI-H2030 CTRP2 1.3181 2.1656 1.3181 31.4874
RERF-LC-A1 CTRP2 1.6774 4.8398 1.5452 29.5381
NCI-H810 CTRP2 1.7162 3.7024 1.7012 28.8853
NCI-H1155 CTRP2 1.7306 3.9384 1.7035 28.8298
NCI-H2087 CTRP2 1.8033 4.1317 1.7652 28.3826
Lu-99 CTRP2 1.8259 4.3027 1.7737 28.2797
NCI-H1573 CTRP2 2.1191 4.7912 2.0263 26.4652
DMS 53 CTRP2 2.1412 4.7285 1.9564 21.4065
NCI-H838 CTRP2 2.1461 3.4089 2.1448 25.9756
HOP-92 CTRP2 2.4289 8.1244 1.0093 24.1931
DMS 454 CTRP2 2.537 5.1923 2.2662 18.917
NCI-H1563 CTRP2 2.5731 3.385 2.5722 17.6422
NCI-H1755 CTRP2 2.6474 5.6198 2.4439 23.3329
NCI-H1355 CTRP2 2.6839 6.1308 2.353 23.5419
NCI-H1666 CTRP2 2.7075 4.8066 2.6511 22.4217
Calu-3 CTRP2 2.807 5.7377 2.5901 22.3186
HCC44 CTRP2 2.8782 5.3008 2.76 21.4978
NCI-H2444 CTRP2 2.8928 8.3371 -0.4067 11.9574
NCI-H1105 CTRP2 3.1201 9.8776 1.3591 25.7777
T3M-10 CTRP2 3.3679 11.0027 1.0908 25.9815
EKVX CTRP2 3.4332 6.9438 2.5579 15.0418
NCI-H358 CTRP2 3.4361 5.3344 3.3556 17.6513
MOR/CPR CTRP2 3.4434 8.886 2.1292 22.17
NCI-H1341 CTRP2 3.4525 7.7325 2.6258 20.2892
HARA [Human squamous cell lung carcinoma] CTRP2 3.4873 7.1961 2.8722 19.2632
HCC1195 CTRP2 3.4987 5.6748 3.3577 17.4461
NCI-H1944 CTRP2 3.5205 7.1171 2.9374 18.9235
HCC1833 CTRP2 3.5257 6.7274 3.0829 18.3648
DV-90 CTRP2 3.5949 5.7884 3.4365 16.8672
NCI-H2228 CTRP2 3.6492 4.755 3.6407 15.9857
Sq-1 CTRP2 3.6564 5.8902 3.4788 16.5264
NCI-H522 CTRP2 3.7232 8.6804 2.5064 20.0033
HCC15 CTRP2 3.7365 8.8339 2.4521 20.1744
KNS-62 CTRP2 3.8678 5.4492 3.6308 9.3131
SW1271 CTRP2 3.9238 5.7049 3.8132 14.5088
ChaGo-K-1 CTRP2 3.9902 9.4123 2.4456 19.5369
NCI-H841 CTRP2 4.0325 8.5216 2.8926 17.7
NCI-H1694 CTRP2 4.0471 5.0567 4.0354 13.3453
NCI-H226 CTRP2 4.1563 6.8681 3.7122 14.1903
NCI-H647 CTRP2 4.2825 6.6186 3.939 12.9742
NCI-H526 CTRP2 4.3077 9.3912 2.7696 17.4804
LCLC-97TM1 CTRP2 4.4607 6.1477 4.2868 11.1628
LUDLU-1 CTRP2 4.525 9.7142 2.8284 16.7158
PC-14 CTRP2 4.6305 9.1501 3.1988 14.9838
HCC2935 CTRP2 4.8846 7.8672 3.4977 7.3028
NCI-H460 CTRP2 4.9464 15.994 0.1274 25.0334
NCI-H2170 CTRP2 4.9849 10.3472 2.9568 15.1259
HCC1438 CTRP2 5.0161 8.4332 3.3263 7.7945
VMRC-LCD CTRP2 5.0226 10.1413 3.0925 14.4935
Calu-1 CTRP2 5.086 7.9873 4.1921 9.857
COLO 668 CTRP2 5.2597 10.1945 3.2839 13.1858
HCC2279 CTRP2 5.2907 9.5031 3.6528 11.6014
NCI-H292 CTRP2 5.3661 10.6214 3.1687 13.4242
NCI-H1838 CTRP2 5.448 9.4209 3.8366 10.4954
HCC4006 CTRP2 5.4649 9.5628 3.7816 10.6868
DMS 79 CTRP2 5.5571 8.5636 4.3587 8.0856
NCI-H1651 CTRP2 5.5633 10.9899 2.4922 10.4155
NCI-H1650 CTRP2 6.0435 9.7165 4.2076 7.7209
DMS 114 CTRP2 6.0505 10.6251 3.0416 7.1288
NCI-H2141 CTRP2 6.1913 24.9347 -3.2786 30.0224
HCC366 CTRP2 6.2233 10.8886 3.7698 9.2103
EPLC-272H CTRP2 6.2536 11.4757 3.5011 10.2672
NCI-H1092 CTRP2 6.2679 12.5335 2.9841 12.3478
NCI-H446 CTRP2 6.3938 9.0251 4.8343 4.4507
NCI-H2110 CTRP2 6.4388 10.3638 4.2039 7.0055
NCI-H69 CTRP2 6.5289 9.2392 4.8306 4.2398
NCI-H1793 CTRP2 6.5452 10.9146 4.013 7.6142
NCI-H2029 CTRP2 6.5586 29.3886 -5.202 32.2727
HCC2108 CTRP2 6.6185 12.4076 3.3277 10.3109
HCC95 CTRP2 6.6436 10.8958 4.0982 7.0906
NCI-H2286 CTRP2 6.6774 8.6444 4.3544 0.9558
SK-MES-1 CTRP2 6.7613 8.91 5.156 2.556
NCI-H322 CTRP2 6.8252 10.128 4.6111 4.674
NCI-H1792 CTRP2 6.8777 11.724 3.8656 7.6592
HCC1588 CTRP2 6.9422 12.0354 3.7602 7.9853
NCI-H520 CTRP2 6.9439 12.151 3.7045 8.2109
NCI-H1915 CTRP2 7.1206 11.669 4.0707 6.4296
COR-L95 CTRP2 7.1679 12.1999 3.8454 7.2742
NCI-H2081 CTRP2 7.2427 14.8287 2.6065 12.0868
DMS 273 CTRP2 7.3182 12.5255 3.7943 7.2482
Lu-65 CTRP2 7.3195 14.0405 3.0529 10.2182
NCI-H2196 CTRP2 7.3538 12.2037 3.976 6.4598
RERF-LC-Ad1 CTRP2 7.3672 8.3147 5.7356 0.1306
LOU-NH91 CTRP2 7.3952 13.4222 3.4117 8.6687
NCI-H196 CTRP2 7.4423 12.3791 3.9528 6.4219
NCI-H23 CTRP2 7.547 14.1215 3.1793 9.3543
NCI-H2342 CTRP2 7.6086 13.8359 3.3627 8.533
A-549 CTRP2 7.6701 13.0663 3.7786 6.7872
NCI-H1869 CTRP2 7.7318 10.8346 4.8666 2.4878
RERF-LC-MS CTRP2 7.7325 10.5704 4.9852 2.061
HCC78 CTRP2 7.8315 10.7119 4.9779 1.9894
NCI-H1339 CTRP2 7.9097 12.1089 4.3898 4.0694
NCI-H727 CTRP2 7.9374 9.8654 5.3869 0.6397
NCI-H889 CTRP2 7.9471 9.7457 5.4379 0.5091
RERF-LC-Ad2 CTRP2 7.9625 11.6815 4.6185 3.1472
NCI-H1623 CTRP2 7.9667 12.7179 4.1413 4.9552
LCLC-103H CTRP2 7.9676 9.3496 5.5938 0.1925
NCI-H1435 CTRP2 7.993 9.448 5.5681 0.2267
LC-1/sq-SF CTRP2 8.0094 13.3009 3.894 5.8614
NCI-H2172 CTRP2 8.0264 9.6906 5.4922 0.3557
NCI-H2126 CTRP2 8.0378 9.529 5.5562 0.2335
NCI-H2405 CTRP2 8.1266 13.6141 3.8223 5.985
COLO 699 CTRP2 8.1534 9.6181 5.5684 0.1838
NCI-H1734 CTRP2 8.1948 10.1118 5.4033 0.4744
NCI-H441 CTRP2 8.232 10.3081 5.3439 0.5929
EBC-1 CTRP2 8.2881 10.6762 5.2242 0.8651
NCI-H2009 CTRP2 8.3276 9.9292 5.5234 0.2073
NCI-H1184 CTRP2 8.341 10.155 5.447 0.3304
CAL-12T CTRP2 8.3707 25.3587 -1.7492 23.3353
LXF 289 CTRP2 8.3726 10.1271 5.4696 0.2806
NCI-H650 CTRP2 8.3835 10.4434 5.3567 0.4951
NCI-H2023 CTRP2 8.3969 10.4455 5.3615 0.4792
NCI-H2085 CTRP2 8.4773 10.2316 5.4723 0.2467
COR-L105 CTRP2 8.4998 14.8289 3.4911 6.7709
NCI-H2291 CTRP2 8.5184 10.423 5.419 0.3234
NCI-H1568 CTRP2 8.5726 17.6421 2.1935 11.5193
SK-LU-1 CTRP2 8.5938 10.4556 5.4364 0.272
LK2 CTRP2 8.5978 16.518 2.7524 9.4327
NCI-H1703 CTRP2 8.7263 17.5894 2.3252 10.8193
HCC1171 CTRP2 8.797 10.6282 5.4515 0.2006
HCC827 CTRP2 8.8292 10.4473 5.5256 0.1106
Calu-6 CTRP2 9.0374 17.6241 2.5188 9.6819
NCI-H1373 CTRP2 9.0778 10.887 5.4634 0.1361
NCI-H1299 CTRP2 9.1115 11.6504 5.2035 0.5233
NCI-H661 CTRP2 9.3523 18.5284 2.2972 10.0493
BEN CTRP2 9.5016 25.7145 -1.0794 20.0271
NCI-H2122 CTRP2 9.6964 19.0583 2.2712 9.6878
NCI-H1395 CTRP2 10.483 30.6893 -2.8032 22.4697
Hs 888.Lu CTRP2 8.2259 9.9634 5.4716 0.3237
⏷ Show the Full List of 134 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Thigh Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
H-STS CTRP2 7.1002 12.2504 3.7713 7.6835
SYO-1 CTRP2 7.8069 9.3645 5.5241 0.3775
P-STS CTRP2 7.8154 9.2176 5.5825 0.2571
Cancer Drug Sensitivity Data Curated from 20 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Yamato-SS CTRP2 7.9435 9.273 5.612 0.171
GCT CTRP2 2.5932 4.0968 2.5561 17.6298
A-204 CTRP2 2.8092 6.0496 2.5124 22.5884
Rh18 CTRP2 3.5882 5.1104 3.5493 16.495
MES-SA CTRP2 4.1904 7.4798 3.5059 14.8886
TE 441.T CTRP2 4.5993 7.1652 4.0649 11.6094
KYM-1 CTRP2 4.6044 5.1331 4.5374 3.396
TE 617.T CTRP2 5.9118 7.4616 5.2224 3.7198
HT-1080 CTRP2 6.111 8.6184 4.8124 5.0513
SK-UT-1 CTRP2 7.0025 14.3647 2.6533 12.3192
BT-16 CTRP2 7.2675 14.5289 2.7733 11.4003
G-402 CTRP2 7.4881 12.2261 4.0583 5.9318
G-401 CTRP2 7.8521 12.4732 4.1828 4.9417
RKN CTRP2 8.0249 9.2634 5.6454 0.1102
Hs 729.T CTRP2 8.0703 16.1069 2.5853 10.8344
TTC-709 CTRP2 8.1106 10.2406 5.3166 0.7242
Tm87-16 CTRP2 8.1934 9.6983 5.555 0.1938
RD CTRP2 8.2988 14.3101 3.6055 6.5962
SK-LMS-1 CTRP2 9.162 20.4459 1.2472 13.8943
BT-12 CTRP2 10.123 27.1491 -1.3322 19.7464
⏷ Show the Full List of 20 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 40 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
2004 CTRP2 8.5046 10.4009 5.4216 0.3232
A2780 CTRP2 1.7842 3.9322 1.7594 28.4651
JHOM-1 CTRP2 1.7867 4.5308 1.7067 28.6346
TYK-nu CTRP2 2.6099 4.5507 2.5744 23.0005
SNU-119 CTRP2 3.0528 5.2826 2.9516 20.276
OC 314 CTRP2 3.5279 7.8733 2.2286 16.1843
OVCAR-5 CTRP2 3.6797 5.4031 3.4437 10.646
ONCO-DG-1 CTRP2 4.1746 9.117 2.7654 17.8312
EFO-27 CTRP2 4.7827 9.9914 2.9412 15.6545
COV362 CTRP2 5.0029 8.4101 3.9113 11.2004
OAW42 CTRP2 5.2962 8.2688 4.2603 9.0799
TOV-112D CTRP2 5.6553 11.0162 3.2273 12.574
MCAS CTRP2 5.8829 14.8785 1.4921 18.7329
IGROV-1 CTRP2 6.034 13.0531 2.5314 14.593
OV7 CTRP2 6.0729 18.8153 -0.3173 23.8991
COV434 CTRP2 6.1059 8.9284 3.8998 3.3281
SNU-840 CTRP2 6.8191 10.3577 4.4943 5.1633
JHOC-5 CTRP2 6.9183 12.2906 3.6163 8.6138
OVTOKO CTRP2 6.9565 9.156 5.1672 2.2537
Kuramochi CTRP2 6.9615 11.9836 3.8002 7.7899
Caov-3 CTRP2 7.3912 13.3887 3.4253 8.6207
TOV-21G CTRP2 7.4204 11.4788 4.3708 4.7785
SNU-8 CTRP2 7.4417 8.9577 5.5221 0.5697
ES2 CTRP2 7.6802 11.6571 4.456 4.0995
DOV13 CTRP2 7.9445 10.4685 5.1433 1.3393
JHOS-2 CTRP2 7.9841 11.2499 4.8252 2.3758
FU-OV-1 CTRP2 8.0442 9.9618 5.3964 0.5601
OVSAHO CTRP2 8.0542 9.3107 5.6396 0.1117
COV644 CTRP2 8.1165 13.5588 3.8419 5.9224
OVCAR-4 CTRP2 8.2393 10.7525 5.1706 1.0435
HEY A8 CTRP2 8.2591 11.3766 4.9193 1.8013
SK-OV-3 CTRP2 8.4038 9.8343 5.5845 0.1142
OV56 CTRP2 8.4142 14.6077 3.54 6.6957
OVK18 CTRP2 8.4638 9.926 5.5744 0.1154
OV-90 CTRP2 8.5909 16.2204 2.8902 8.9267
RMG-I CTRP2 8.8504 10.6915 5.449 0.1927
OAW28 CTRP2 8.883 11.0412 5.3366 0.3539
EFO-21 CTRP2 9.466 18.3584 2.4521 9.3494
OVCAR-8 CTRP2 10.5359 19.5662 2.5587 7.6795
OVISE CTRP2 13.7495 28.1456 0.563 10.3955
⏷ Show the Full List of 40 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 7 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H28 CTRP2 2.0097 4.195 1.9758 26.9934
NCI-H2452 CTRP2 3.6552 6.9627 3.1391 17.7806
MSTO-211H CTRP2 7.5702 14.5496 2.9867 10.0745
IST-Mes1 CTRP2 7.7231 11.582 4.5182 3.8059
ACC-MESO-1 CTRP2 7.9019 10.1654 5.2488 1.047
JL-1 CTRP2 8.5598 14.2981 3.778 5.6039
NCI-H2052 CTRP2 8.5658 10.4869 5.4142 0.3169
⏷ Show the Full List of 7 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
DU145 CTRP2 4.3492 8.3159 3.3061 15.2556
PaCa-3 CTRP2 4.7846 8.1546 3.8167 12.1161
VCaP CTRP2 6.9914 9.7747 4.8972 3.2713
LNCaP clone FGC CTRP2 7.4866 13.7379 3.3233 8.8783
22Rv1 CTRP2 8.6126 10.5912 5.3946 0.3367
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 CTRP2 5.1063 10.4396 3.0232 14.5848
YD-15 CTRP2 7.1735 8.8293 5.4422 1.0127
Cancer Drug Sensitivity Data Curated from 30 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HGC-27 CTRP2 1.8142 5.4173 1.5827 28.9652
SNU-16 CTRP2 1.9193 2.7863 1.9193 27.4819
ECC10 CTRP2 3.2393 4.9385 3.1992 18.8233
MKN1 CTRP2 3.6294 5.9373 3.4373 16.7584
SNU-1 CTRP2 3.7556 8.1384 2.775 18.8896
NUGC-4 CTRP2 3.9322 7.7607 3.1187 17.0881
OCUM-1 CTRP2 4.0086 5.5712 3.9316 13.8263
MKN74 CTRP2 5.0816 11.5871 2.4348 16.9682
HuG1-N CTRP2 5.2616 11.9433 2.4197 16.63
SNU-216 CTRP2 5.3132 8.8926 3.3395 7.1382
Hs 746.T CTRP2 5.6491 8.7699 4.3397 7.9665
SNU-601 CTRP2 5.9462 10.5821 2.9864 7.5486
MKN7 CTRP2 6.0179 13.9783 2.0554 16.4355
AGS CTRP2 6.2002 14.6137 1.8888 16.6876
KE-39 CTRP2 6.5778 12.3604 3.3192 10.4186
GSU CTRP2 6.8225 7.5107 5.8145 0.1671
Fu97 CTRP2 6.8764 10.7347 4.3514 5.661
ECC12 CTRP2 7.0184 8.7428 5.3944 1.3277
IM95 CTRP2 7.0476 12.2131 3.7509 7.8513
SNU-719 CTRP2 7.1202 10.0783 4.8381 3.331
SNU-668 CTRP2 7.3635 9.8858 5.0798 2.1054
23132/87 CTRP2 7.5056 10.1092 5.0619 2.0186
SNU-620 CTRP2 7.5858 8.9531 5.5874 0.3344
NUGC-3 CTRP2 7.9326 10.9078 4.9476 1.9983
LMSU CTRP2 8.5213 15.1715 3.3432 7.3064
SH-10-TC CTRP2 8.585 17.2617 2.3859 10.8039
MKN45 CTRP2 11.5288 27.801 -0.6726 16.2312
SNU-1077 CTRP2 2.8682 5.7766 2.6475 21.9249
SNU-685 CTRP2 7.2448 13.0199 3.4994 8.5549
SNG-M CTRP2 10.9512 34.4424 -4.3018 24.6077
⏷ Show the Full List of 30 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 12 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
8505C CTRP2 2.1827 5.0148 2.0598 26.1448
TT CTRP2 3.0463 8.2106 2.0033 23.7364
CAL-62 CTRP2 3.3425 6.6503 2.9106 19.539
ML-1 [Human leukemia] CTRP2 4.6852 6.6695 4.3534 10.2614
TT2609-C02 CTRP2 7.2142 14.0744 2.9577 10.7675
CGTH-W-1 CTRP2 7.4048 13.5645 3.349 8.9044
B-CPAP CTRP2 7.6152 12.9225 3.8101 6.7411
8305C CTRP2 7.8284 9.4029 5.5186 0.3805
SW579 CTRP2 7.8881 13.3951 3.7688 6.517
BHT-101 CTRP2 8.0764 10.253 5.296 0.7982
FTC-238 CTRP2 8.2211 14.6817 3.3774 7.5832
FTC-133 CTRP2 9.0999 15.7765 3.4277 6.2585
⏷ Show the Full List of 12 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 29 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HSC-2 CTRP2 3.2491 5.09 3.1916 18.8174
HSC-4 CTRP2 4.1027 5.334 4.0688 13.0505
PE/CA-PJ15 CTRP2 4.6115 10.1436 2.7054 16.9934
SCC-4 CTRP2 4.682 9.0115 3.3145 14.3936
SCC-25 CTRP2 4.9985 7.1671 4.4788 8.9244
CAL-33 CTRP2 5.2476 7.3794 4.0416 4.1128
FaDu CTRP2 6.3864 8.9894 4.8463 4.4133
YD-8 CTRP2 6.5934 8.6443 5.1687 2.7466
PE/CA-PJ34 (clone C12) CTRP2 6.6263 11.0822 3.9925 7.5587
BICR 56 CTRP2 7.0869 13.1689 2.5324 7.6609
PE/CA-PJ41 (clone D2) CTRP2 7.1673 13.3856 3.2624 9.634
SNU-1214 CTRP2 7.3002 11.1295 4.4569 4.6017
PE/CA-PJ49 CTRP2 7.4834 9.1746 5.4537 0.7353
BICR 22 CTRP2 7.7174 10.6219 4.9537 2.1882
CAL-27 CTRP2 7.7344 9.2847 5.5239 0.4101
SNU-1066 CTRP2 8.0113 9.5106 5.5526 0.2477
BICR 18 CTRP2 8.1841 10.3751 5.2965 0.7349
HSC-3 CTRP2 8.2238 9.7346 5.5535 0.1886
YD-10B CTRP2 8.2638 9.6179 5.6089 0.1105
BHY CTRP2 8.2726 10.0565 5.4559 0.337
SNU-46 CTRP2 8.4797 10.0973 5.5208 0.1763
SNU-899 CTRP2 8.4946 12.6658 4.4839 3.0722
SCC-9 CTRP2 8.5626 16.227 2.868 9.0496
Detroit 562 CTRP2 8.6306 10.1665 5.5513 0.1137
BICR 6 CTRP2 8.9007 17.6136 2.4322 10.1844
SNU-1041 CTRP2 8.984 10.5753 5.5361 0.0826
BICR 31 CTRP2 10.1788 17.9233 3.0942 6.2281
BICR 16 CTRP2 11.501 37.2976 -6.0695 24.6615
SNU-1076 CTRP2 11.7739 25.3186 0.661 12.2687
⏷ Show the Full List of 29 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 20 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KMBC-2 CTRP2 2.6818 5.9505 2.3999 23.3814
5637 CTRP2 3.48 6.6709 3.0527 18.6105
TCCSUP CTRP2 3.5168 5.7298 3.365 17.3637
U-BLC1 CTRP2 3.6939 5.4915 3.6063 15.9589
VM-CUB-1 CTRP2 3.8415 7.1095 3.284 16.7042
UM-UC-1 CTRP2 3.8572 7.6017 3.1057 17.3425
UM-UC-3 CTRP2 3.887 4.7245 3.8844 14.3814
HT-1197 CTRP2 4.4297 11.0868 2.0772 19.8369
639V CTRP2 4.6106 10.693 2.4387 18.0349
BC-3C CTRP2 5.8928 10.2542 3.8118 9.6736
SW1710 CTRP2 6.6079 21.788 -1.3629 25.471
T24 CTRP2 6.7408 12.483 3.3855 9.8598
HT-1376 CTRP2 7.4228 14.2301 3.0358 10.1176
JMSU-1 CTRP2 7.5378 12.1424 4.1322 5.5657
RT-112 CTRP2 7.8312 10.6724 4.9952 1.93
SCaBER CTRP2 7.9242 9.3721 5.5689 0.2462
RT-4 CTRP2 8.4164 10.0891 5.5 0.2201
647V CTRP2 8.5462 9.6637 5.69 0.0247
KU-19-19 CTRP2 9.4326 24.9895 -0.7743 19.3625
J82 CTRP2 11.1692 21.8138 1.9109 9.1172
⏷ Show the Full List of 20 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HeLa CTRP2 12.3226 27.145 0.1546 13.0632

References

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