Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM32FKD)

Drug Name
PF-228 Drug Info
Synonyms
869288-64-2; PF-573228; PF 573228; PF573228; PF-228; CHEMBL514554; 3,4-Dihydro-6-[[4-[[[3-(methylsulfonyl)phenyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]-2(1H)-quinolinone; 6-((4-((3-(Methylsulfonyl)benzyl)amino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)-3,4-dihydroquinolin-2(1H)-one; 6-(4-(3-(methylsulfonyl)benzylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-3,4-dihydroquinolin-2(1H)-one; 6-[4-(3-Methanesulfonyl-benzylamino)-5-trifluoromethyl-pyrimidin-2-ylamino]-3,4-dihydro-1H-quinolin-2-one
Cross-matching ID
PubChem CID
11612883
ChEBI ID
CHEMBL91446
CAS Number
CAS 869288-64-2
TTD Drug ID
D02QAZ

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Oxidative phosphorylation 2.34 0.00e+0 93/133 (69.92%) NDUFV1;NDUFA7;NDUFS8;...
Valine, leucine and isoleucine degradation 2.22 0.00e+0 42/48 (87.5%) HMGCS1;PCCB;ECHS1;...
Other glycan degradation 2.09 0.00e+0 13/18 (72.22%) NEU1;FUCA1;MAN2B1;...
Peroxisome 2.05 2.37e-3 72/82 (87.8%) PXMP2;ACOX2;ECI2;...
Pentose and glucuronate interconversions 2.05 1.90e-3 17/34 (50%) AKR1B10;SORD;DCXR;...
Glycolysis / Gluconeogenesis 2.02 1.58e-3 56/67 (83.58%) ALDOC;PGAM1;PFKL;...
Pentose phosphate pathway 1.93 5.42e-3 25/30 (83.33%) ALDOC;PFKL;GPI;...
Fatty acid elongation 1.93 4.75e-3 19/27 (70.37%) HACD3;TECR;ECHS1;...
Pyruvate metabolism 1.90 4.22e-3 41/47 (87.23%) GLO1;PKM;MDH1;...
Propanoate metabolism 1.89 4.75e-3 30/34 (88.24%) PCCB;ECHS1;ALDH6A1;...
Steroid biosynthesis 1.88 5.18e-3 19/20 (95%) MSMO1;DHCR24;TM7SF2;...
Glycosaminoglycan degradation 1.86 6.33e-3 19/19 (100%) GNS;GLB1;IDS;...
Citrate cycle (TCA cycle) 1.79 1.24e-2 30/30 (100%) ACLY;MDH1;IDH2;...
Lysosome 1.79 1.22e-2 115/128 (89.84%) NEU1;LITAF;SLC17A5;...
Fructose and mannose metabolism 1.77 1.39e-2 30/33 (90.91%) ALDOC;AKR1B10;PFKL;...
Fatty acid degradation 1.74 1.96e-2 40/43 (93.02%) ECHS1;ECI2;ALDH3A2;...
Terpenoid backbone biosynthesis 1.74 1.84e-2 18/22 (81.82%) PCYOX1;HMGCS1;IDI1;...
Galactose metabolism 1.74 1.74e-2 26/31 (83.87%) AKR1B10;PFKL;PGM1;...
Sulfur metabolism 1.74 1.75e-2 9/10 (90%) SELENBP1;PAPSS1;ETHE1;...
Tyrosine metabolism 1.71 2.09e-2 30/36 (83.33%) ALDH3A1;TYRP1;DDC;...
Synaptic vesicle cycle 1.70 1.99e-2 63/78 (80.77%) SNAP25;SLC1A1;UNC13B;...
Glyoxylate and dicarboxylate metabolism 1.66 2.72e-2 23/30 (76.67%) PCCB;MDH1;CAT;...
Biosynthesis of unsaturated fatty acids 1.66 2.68e-2 21/27 (77.78%) HACD3;TECR;SCD;...
Metabolism of xenobiotics by cytochrome P450 1.64 2.93e-2 49/77 (63.64%) AKR7A2;MGST3;GSTM3;...
Butanoate metabolism 1.63 3.00e-2 23/28 (82.14%) HMGCS1;ALDH5A1;BDH2;...
Proximal tubule bicarbonate reclamation 1.58 4.64e-2 21/23 (91.3%) ATP1A1;AQP1;MDH1;...
Glutathione metabolism 1.58 4.51e-2 43/57 (75.44%) MGST3;GSTM3;GPX4;...
Cardiac muscle contraction 1.58 4.42e-2 64/87 (73.56%) CACNA2D2;ATP1A1;FXYD2;...
Steroid hormone biosynthesis 1.57 4.62e-2 43/61 (70.49%) AKR1C3;AKR1C2;AKR1C1;...
HIF-1 signaling pathway 1.57 4.72e-2 105/109 (96.33%) ALDOC;PFKL;ENO2;...
Systemic lupus erythematosus -1.76 4.02e-2 45/135 (33.33%) ACTN4;HLA-DQB1;TRIM21;...
Transcriptional misregulation in cancer -1.76 4.83e-2 158/192 (82.29%) MPO;SP1;ETV6;...
Asthma -1.80 3.67e-2 25/31 (80.65%) HLA-DOB;HLA-DMB;CCL11;...
Proteasome -1.98 3.50e-3 44/46 (95.65%) PSMC2;PSME4;PSMB6;...
Ribosome biogenesis in eukaryotes -2.09 5.25e-3 52/108 (48.15%) TBL3;PWP2;NOP10;...
Spliceosome -2.20 0.00e+0 101/150 (67.33%) RBMX;SNRNP40;PPIH;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SK-ES-1 CVCL_0627 Homo sapiens 1.11uM - 10uM 24H
Bone marrow
Neuroblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SH-SY5Y CVCL_0019 Homo sapiens 0.04uM - 10uM 24H
Brain
Glioma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
GI-1 CVCL_1230 Homo sapiens 1.11uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.04uM - 10uM 24H
MDA-MB-468 CVCL_0419 Homo sapiens 1.11uM - 10uM 24H
Breast ductal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
T-47D CVCL_0553 Homo sapiens 1.11uM - 10uM 24H
Normal (Epithelial)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HME1 CVCL_2950 Homo sapiens 0.04uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.04uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.04uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.04uM - 10uM 24H
SNU-407 CVCL_5004 Homo sapiens 1.11uM - 10uM 24H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 1.11uM - 10uM 24H
HEC-1-A CVCL_0293 Homo sapiens 1.11uM - 10uM 24H
HEC-251 CVCL_2928 Homo sapiens 1.11uM - 10uM 24H
HEC-265 CVCL_2929 Homo sapiens 1.11uM - 10uM 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 0.04uM - 10uM 24H
CJM CVCL_U797 Homo sapiens 1.11uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.04uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.04uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 10uM 24H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHH-5 CVCL_1320 Homo sapiens 1.11uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.04uM - 10uM 24H
A549/Asc-1 CVCL_YA87 Homo sapiens 0.04uM - 10uM 24H
NCI-H1573 CVCL_1483 Homo sapiens 1.11uM - 10uM 24H
NCI-H838 CVCL_1594 Homo sapiens 1.11uM - 10uM 24H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BEN CVCL_1081 Homo sapiens 1.11uM - 10uM 24H
HCC95 CVCL_1276 Homo sapiens 1.11uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 0.04uM - 10uM 24H
NCI-H2110 CVCL_1529 Homo sapiens 1.11uM - 10uM 24H
Muscle
Rhabdomyosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-204 CVCL_0134 Homo sapiens 1.11uM - 10uM 24H
Ovary
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OVTOKO CVCL_3114 Homo sapiens 1.11uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.04uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.04uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
22Rv1 CVCL_1045 Homo sapiens 1.11uM - 10uM 24H
PC-3 CVCL_0035 Homo sapiens 0.04uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.04uM - 10uM 24H
IGR-37 CVCL_1303 Homo sapiens 1.11uM - 10uM 24H
Mel-HO CVCL_1402 Homo sapiens 1.11uM - 10uM 24H
SH-4 CVCL_1692 Homo sapiens 1.11uM - 10uM 24H
SK-L CVCL_1699 Homo sapiens 0.04uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.04uM - 10uM 24H
Urinary bladder
Bladder carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BC-3C CVCL_1079 Homo sapiens 1.11uM - 10uM 24H
Bladder transitional cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CAL-29 CVCL_1109 Homo sapiens 1.11uM - 10uM 24H