Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM36PKZ)

Drug Name
PF-3758309 Drug Info
Synonyms PF-309
Cross-matching ID
PubChem CID
25227462
ChEBI ID
CHEMBL3128043
CAS Number
CAS 898044-15-0
TTD Drug ID
D08MHM

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Oxidative phosphorylation 2.02 1.48e-2 93/133 (69.92%) ATP6V1D;ATP6V0D1;ATP6V1G1;...
Butanoate metabolism -1.68 2.79e-2 23/28 (82.14%) ACSM5;GAD2;EHHADH;...
Spliceosome -1.71 2.20e-2 101/150 (67.33%) PRPF8;HSPA2;CDC5L;...
Mismatch repair -1.72 1.92e-2 22/23 (95.65%) POLD3;RFC5;RPA3;...
Nucleotide excision repair -1.74 1.65e-2 40/47 (85.11%) POLD3;RFC5;GTF2H5;...
Synthesis and degradation of ketone bodies -1.84 5.43e-3 9/10 (90%) BDH2;HMGCS1;BDH1;...
Glycine, serine and threonine metabolism -1.88 3.54e-3 31/40 (77.5%) GCAT;SHMT1;GAMT;...
Cysteine and methionine metabolism -1.88 4.13e-3 43/50 (86%) MPST;MTR;CDO1;...
Glyoxylate and dicarboxylate metabolism -1.89 2.48e-3 23/30 (76.67%) ACO1;CAT;MMUT;...
One carbon pool by folate -1.95 0.00e+0 15/20 (75%) MTHFD1;TYMS;DHFR;...
Base excision repair -1.97 0.00e+0 29/33 (87.88%) FEN1;POLD2;NEIL3;...
Cell cycle -2.02 0.00e+0 110/124 (88.71%) PTTG1;PKMYT1;CREBBP;...
DNA replication -2.61 0.00e+0 34/36 (94.44%) FEN1;POLD2;POLA2;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone marrow
Neuroblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SH-SY5Y CVCL_0019 Homo sapiens 0.04uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 3.33uM 24H
Normal (Epithelial)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HME1 CVCL_2950 Homo sapiens 0.04uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 0.04uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 3.33uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 3.33uM 24H
A549/Asc-1 CVCL_YA87 Homo sapiens 0.04uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 0.04uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.04uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H
SK-L CVCL_1699 Homo sapiens 0.04uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.04uM - 10uM 24H