Details of the Drug

General Information of Drug (ID: DM36PKZ)

Drug Name
PF-3758309
Synonyms PF-309
Indication
Disease Entry ICD 11 Status REF
Solid tumour/cancer 2A00-2F9Z Phase 1 [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 490.6
Logarithm of the Partition Coefficient (xlogp) 3.1
Rotatable Bond Count (rotbonds) 6
Hydrogen Bond Donor Count (hbonddonor) 3
Hydrogen Bond Acceptor Count (hbondacc) 7
Chemical Identifiers
Formula
C25H30N8OS
IUPAC Name
N-[(1S)-2-(dimethylamino)-1-phenylethyl]-6,6-dimethyl-3-[(2-methylthieno[3,2-d]pyrimidin-4-yl)amino]-1,4-dihydropyrrolo[3,4-c]pyrazole-5-carboxamide
Canonical SMILES
CC1=NC2=C(C(=N1)NC3=NNC4=C3CN(C4(C)C)C(=O)N[C@H](CN(C)C)C5=CC=CC=C5)SC=C2
InChI
InChI=1S/C25H30N8OS/c1-15-26-18-11-12-35-20(18)23(27-15)29-22-17-13-33(25(2,3)21(17)30-31-22)24(34)28-19(14-32(4)5)16-9-7-6-8-10-16/h6-12,19H,13-14H2,1-5H3,(H,28,34)(H2,26,27,29,30,31)/t19-/m1/s1
InChIKey
AYCPARAPKDAOEN-LJQANCHMSA-N
Cross-matching ID
PubChem CID
25227462
ChEBI ID
CHEBI:93751
CAS Number
898044-15-0
UNII
PK459EA5I2
DrugBank ID
DB11775
TTD ID
D08MHM
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
PAK-4 protein kinase (PAK4) TT7Y3BZ PAK4_HUMAN Inhibitor [1]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Alpha-crystallin B chain (CRYAB) OTY4JGYU CRYAB_HUMAN Gene/Protein Processing [2]
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Gene/Protein Processing [2]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Gene/Protein Processing [2]
Azurocidin (AZU1) OTHXU264 CAP7_HUMAN Gene/Protein Processing [2]
B-cell lymphoma 6 protein (BCL6) OTQAWWO1 BCL6_HUMAN Gene/Protein Processing [2]
Baculoviral IAP repeat-containing protein 3 (BIRC3) OT3E95KB BIRC3_HUMAN Gene/Protein Processing [2]
Bcl-2 homologous antagonist/killer (BAK1) OTDP6ILW BAK_HUMAN Gene/Protein Processing [2]
Bcl-2-associated transcription factor 1 (BCLAF1) OT7T8H6A BCLF1_HUMAN Gene/Protein Processing [2]
Bcl-2-interacting killer (BIK) OTTH1T3D BIK_HUMAN Gene/Protein Processing [2]
Bcl-2-like protein 1 (BCL2L1) OTRC5K9O B2CL1_HUMAN Gene/Protein Processing [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 66 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MEC1 CTRP2 -6.6401 2.4195 -7.004 73.3733
JM1 CTRP2 -6.431 3.7169 -7.0128 71.0835
OCI-Ly3 CTRP2 -10.9201 0.616 -11.3194 83.018
OCI-AML-3 CTRP2 -10.3218 -3.75 -10.3468 90.2811
SUP-M2 CTRP2 -10.2174 -3.0799 -10.2606 88.9138
MOLP-8 CTRP2 -10.1888 1.3985 -10.6533 81.067
Pfeiffer CTRP2 -9.7224 1.3087 -10.139 80.6583
EoL-1 CTRP2 -9.6452 -6.4131 -9.6453 95.2115
DB CTRP2 -9.59 3.4948 -10.3955 77.2986
OCI-Ly19 CTRP2 -9.3823 1.4133 -9.7903 80.0565
OCI-Ly10 CTRP2 -9.3084 4.8129 -10.391 75.2057
GA-10 CTRP2 -9.1932 -2.1777 -9.2467 86.1789
JJN-3 CTRP2 -9.0293 -0.1956 -9.2143 82.2683
A4/Fukuda CTRP2 -8.9157 0.7976 -9.2058 80.4006
SIG-M5 CTRP2 -8.7202 -6.3088 -8.7202 94.0682
OPM-2 CTRP2 -8.414 -1.0831 -8.5005 82.9687
697 CTRP2 -8.2067 -1.1547 -8.2816 82.752
Granta-519 CTRP2 -7.9335 5.8518 -9.1579 71.7251
Mino CTRP2 -7.4546 1.9664 -7.8077 75.9255
Daudi CTRP2 -7.4528 2.0018 -7.8112 75.8676
Karpas-422 CTRP2 -7.2881 4.3412 -8.0785 72.2607
OCI-AML-5 CTRP2 -7.2778 0.0719 -7.4002 78.6401
HuT 78 CTRP2 -7.2238 6.6861 -8.6158 69.4566
Hs 611.T CTRP2 -7.0754 2.8922 -7.5526 73.7344
CA46 CTRP2 -6.9494 1.4488 -7.1965 75.5935
A3/Kawakami CTRP2 -6.8302 -4.1422 -6.8303 84.4617
HH [Human lymphoma] CTRP2 -6.8166 4.2163 -7.5376 71.3809
NU-DHL-1 CTRP2 -6.5485 0.9088 -6.7107 75.4173
SEM CTRP2 -6.3344 0.099 -6.4186 76.0898
M-07e CTRP2 -6.3137 3.649 -6.8719 70.8704
ST486 CTRP2 -6.3088 1.7472 -6.5529 73.4754
SUP-HD1 CTRP2 -6.3011 0.6114 -6.423 75.18
Namalwa CTRP2 -6.2986 3.5274 -6.8316 70.9872
MOLT-3 CTRP2 -6.0796 2.8463 -6.4709 71.2887
RPMI-6666 CTRP2 -6.0295 1.4546 -6.2207 73.09
BL-70 CTRP2 -6.0277 0.7876 -6.1518 74.0712
EJM CTRP2 -5.9831 4.8673 -6.7799 68.5435
LP-1 CTRP2 -5.9381 4.4715 -6.639 68.8734
HuNS1 CTRP2 -5.7848 4.9104 -6.5741 67.9607
KMS-20 CTRP2 -5.7461 0.8497 -5.8621 73.055
Kasumi-1 CTRP2 -5.5679 -0.1145 -5.6136 73.7686
RL CTRP2 -5.5199 11.5918 -8.43 61.8927
DND-41 CTRP2 -5.0317 2.4787 -5.2894 68.406
HL-60 CTRP2 -4.5133 3.7366 -4.9394 65.1284
U266B1 CTRP2 -4.3424 6.8344 -5.5162 61.8591
EB1 CTRP2 -4.2109 7.6521 -5.6245 60.8652
BCP-1 CTRP2 -4.2082 3.9881 -4.6577 63.725
JeKo-1 CTRP2 -4.0231 2.72 -4.2456 64.1019
Kasumi-2 CTRP2 -3.72 5.0085 -4.3479 60.9628
SUP-B15 CTRP2 -3.243 4.023 -3.6195 59.57
MOTN-1 CTRP2 -3.0547 7.5269 -4.3269 56.8905
MJ CTRP2 -2.6968 9.9936 -4.8041 54.6942
F-36P CTRP2 -2.6862 5.5746 -3.3595 56.1886
Ci-1 CTRP2 -2.2359 6.3974 -3.091 53.827
K-562 CTRP2 -1.997 7.6376 -3.213 52.4782
CMK CTRP2 -1.8141 5.1247 -2.2994 51.9539
HD-MY-Z CTRP2 -1.6481 6.7435 -2.5515 50.9415
HEL 92.1.7 CTRP2 -0.7877 6.4792 -1.5348 46.3608
SET-2 CTRP2 -0.6998 7.1964 -1.6597 46.0539
AML-193 CTRP2 -0.6515 7.4654 -1.6952 45.8656
TF-1 CTRP2 -0.3937 6.8397 -1.214 44.2282
L-428 CTRP2 0.6297 5.4501 0.2862 37.0791
KO52 CTRP2 1.3509 6.3758 0.828 32.9435
OCI-M1 CTRP2 1.4254 8.7441 0.0754 34.7628
BL-41 CTRP2 7.7433 22.0965 -0.6135 21.6264
Toledo CTRP2 9.4929 24.9871 -0.7293 19.1579
⏷ Show the Full List of 66 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 13 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE15 CTRP2 -1.7176 4.6408 -2.0887 51.4732
OE21 CTRP2 -6.1021 4.52 -6.8285 69.2546
TE-11 CTRP2 -3.8431 3.2886 -4.1379 62.8197
TE-5 CTRP2 -3.4371 7.304 -4.6725 58.4327
KYSE-450 CTRP2 -0.8253 6.4516 -1.5677 46.5658
OE33 CTRP2 -0.1567 7.046 -1.2812 39.9388
TE-14 CTRP2 0.6043 6.3749 0.014 37.8678
EC-GI-10 CTRP2 1.1105 5.3915 0.8231 33.7894
KYSE-520 CTRP2 1.8256 6.8021 1.2131 30.1558
KYSE-510 CTRP2 2.3488 2.986 2.3488 24.6203
KYSE-30 CTRP2 2.3637 11.2889 -0.0423 32.0913
KYSE-150 CTRP2 2.4033 5.5594 2.1919 24.9841
OE19 CTRP2 2.7676 6.2298 2.1589 18.625
⏷ Show the Full List of 13 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 19 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
N2a-PK1 CTRP2 0.6769 9.4145 -1.355 36.935
PaTu 8988s CTRP2 -5.3846 7.4433 -6.8367 64.4465
MIA PaCa-2 CTRP2 -4.8617 0.4426 -4.9138 70.134
Panc 08.13 CTRP2 -4.3684 3.4876 -4.7373 64.8187
PSN1 CTRP2 -1.8728 4.8383 -2.299 52.3112
Panc 03.27 CTRP2 -0.8654 5.1693 -1.2768 46.5219
Hs 766T CTRP2 -0.5449 7.8739 -1.718 45.4165
Panc 02.03 CTRP2 -0.3337 9.5556 -2.1129 44.89
SW1990 CTRP2 -0.3281 9.7326 -2.1764 44.9224
HuP-T3 CTRP2 -0.0969 7.7063 -1.1754 42.907
Panc 10.05 CTRP2 -0.0624 10.4902 -2.2006 43.9372
PaTu 8988t CTRP2 0.5629 4.512 0.4002 37.0133
Capan-1 CTRP2 0.7543 10.7143 -1.4398 40.0823
Capan-2 CTRP2 1.5891 6.4754 1.058 31.4281
DAN-G CTRP2 1.8952 5.4202 1.6702 28.406
PK-45H CTRP2 2.2323 10.2759 -0.1704 28.8305
KP-2 CTRP2 2.2434 4.7394 2.166 25.5847
Panc 04.03 CTRP2 3.0214 11.807 0.3736 29.0968
AsPC-1 CTRP2 4.0678 13.423 0.6014 25.7049
⏷ Show the Full List of 19 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 33 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SH4 CTRP2 -3.1158 3.5018 -3.4923 56.7503
LOX-IMVI CTRP2 -4.6755 4.1353 -5.1941 65.3216
Hs 294T CTRP2 -2.2576 3.9144 -2.5358 54.6151
A2058 CTRP2 -2.0397 3.4428 -2.2279 53.4917
IGR-1 CTRP2 -1.8425 7.7232 -3.0735 51.7731
WM88 CTRP2 -1.2203 7.664 -2.3785 48.8313
Hs 940.T CTRP2 -0.6186 8.1587 -1.8973 45.884
WM115 CTRP2 -0.3092 10.122 -2.3113 44.9613
COLO 792 CTRP2 -0.2427 7.7036 -1.3323 43.7193
COLO 800 CTRP2 0.2519 6.4929 -0.4051 40.182
Hs 934.T CTRP2 0.3043 6.6911 -0.4077 39.976
UACC-257 CTRP2 0.3237 11.1796 -2.0852 42.4311
Malme-3M CTRP2 0.3413 9.9028 -1.5358 41.6881
HT-144 CTRP2 0.9275 5.7294 0.5429 35.2702
WM983B CTRP2 1.1247 6.6775 0.49 34.7147
MeWo CTRP2 1.2193 9.9061 -0.6145 37.0253
Hs 895.T CTRP2 1.4783 8.5022 0.2264 34.1993
A101D CTRP2 1.6896 3.5484 1.6799 29.0446
HMCB CTRP2 1.7833 8.1162 0.7005 31.876
UACC-62 CTRP2 1.8613 3.8072 1.8457 27.9207
Hs 688(A).T CTRP2 1.9109 9.5801 0.2444 32.7368
WT2-iPS CTRP2 2.1451 6.2707 1.7251 27.4214
RVH-421 CTRP2 2.2635 3.7018 2.2594 25.2026
COLO 829 CTRP2 2.3234 4.0782 2.3084 24.8398
IGR-37 CTRP2 2.4093 3.0096 2.4093 24.2178
SK-MEL-3 CTRP2 2.446 14.6279 -1.5206 35.0628
Hs 839.T CTRP2 2.573 3.9671 2.5677 23.1446
SK-MEL-2 CTRP2 2.8177 4.1143 2.8128 21.513
WM266-4 CTRP2 2.9387 16.9676 -2.1809 34.9465
CJM [Human melanoma] CTRP2 3.1001 4.5045 3.0874 19.6579
SK-MEL-24 CTRP2 4.0211 6.4269 3.7211 14.5469
K029AX CTRP2 5.917 28.4274 -5.9282 32.2669
IGR-39 CTRP2 6.0977 11.3082 3.4568 10.7469
⏷ Show the Full List of 33 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 CTRP2 -4.378 9.813 -6.5433 60.0487
Cancer Drug Sensitivity Data Curated from 9 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
IMR-32 CTRP2 -8.9335 0.0391 -9.1369 81.7207
SK-N-AS CTRP2 -3.0756 4.8242 -3.6038 58.3294
CHP-212 CTRP2 -2.9406 5.4365 -3.6022 57.4028
NH-6 CTRP2 -2.2691 5.3981 -2.8604 54.2554
SK-N-DZ CTRP2 -1.1253 7.7153 -2.2927 48.365
SK-N-BE(2) CTRP2 -0.7403 8.7191 -2.2305 46.6337
SK-N-SH CTRP2 0.4793 11.7242 -2.158 41.9801
SK-N-FI CTRP2 0.8091 5.0639 0.5657 35.6318
KP-N-YN CTRP2 6.8441 12.6143 3.3998 9.6225
⏷ Show the Full List of 9 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-869 CTRP2 1.9183 13.6294 -1.5647 36.6212
Cancer Drug Sensitivity Data Curated from 10 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-673 CTRP2 -8.2192 3.2509 -8.8578 75.5102
SK-ES-1 CTRP2 -3.9931 4.4066 -4.51 62.5173
SK-N-MC CTRP2 -3.0651 4.2275 -3.4665 58.6134
TC71 CTRP2 -1.8655 4.826 -2.2883 52.2731
G-292 clone A141B1 CTRP2 -0.8548 6.9916 -1.7633 46.8457
SaOS-2 CTRP2 0.6 4.4901 0.4436 36.7507
HOS CTRP2 1.8434 6.645 1.2826 29.872
Hs 888.T CTRP2 3.6115 21.1403 -3.616 35.5741
Hs 822.T CTRP2 3.7289 7.1086 3.1639 17.4774
MG-63 CTRP2 6.3807 20.2332 -0.7718 24.4787
⏷ Show the Full List of 10 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 56 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
DU4475 CTRP2 -6.0654 0.6368 -6.1784 74.4176
MDA-MB-468 CTRP2 -2.2149 3.3619 -2.4037 54.5219
UACC-812 CTRP2 -1.6818 6.1079 -2.4049 51.1565
CAL-85-1 CTRP2 -1.518 5.7666 -2.1345 50.3098
HCC1500 CTRP2 -1.292 4.2256 -1.5489 48.9839
Hs 578T CTRP2 -1.0042 3.0149 -1.0802 47.0584
MDA-MB-453 CTRP2 -0.1346 5.6556 -0.5969 42.168
BT-549 CTRP2 0.3937 6.4539 -0.2389 39.2664
MDA-MB-361 CTRP2 0.5114 10.6882 -1.6818 41.274
AU565 CTRP2 0.7329 3.4423 0.7002 35.4924
HCC202 CTRP2 1.1333 4.7363 0.8562 28.9221
HCC2218 CTRP2 1.3107 4.7633 1.1634 32.0237
SK-BR-3 CTRP2 1.6994 7.092 0.9802 31.3071
HCC38 CTRP2 1.7307 5.8964 1.3763 29.9293
HCC1428 CTRP2 1.7313 5.6062 1.4494 29.6837
Hs 578Bst CTRP2 1.7904 22.3166 -5.8614 41.8098
MDA-MB-157 CTRP2 1.8184 4.9905 1.6715 28.6503
BT-474 CTRP2 2.1982 3.5363 2.196 25.6314
EFM-192A CTRP2 2.4732 3.5617 2.4724 23.7946
HCC1419 CTRP2 2.5162 4.2055 2.5008 23.5568
BT-20 CTRP2 2.7932 4.6386 2.7589 21.7753
ZR-75-30 CTRP2 2.8495 4.6525 2.8167 21.3954
MDA-MB-415 CTRP2 3.041 4.927 2.9907 20.179
T-47D CTRP2 4.7649 13.1348 1.3836 21.5278
BT 112 CTRP2 -0.8908 8.1664 -2.194 47.2633
BT164 CTRP2 -0.5647 5.7057 -1.0787 44.8443
BT 271 CTRP2 -0.5301 6.0184 -1.1234 44.737
BT147 CTRP2 -0.5161 8.5252 -1.9185 45.4657
BT 179 CTRP2 -0.4965 9.2194 -2.1566 45.5744
BT 286 CTRP2 -0.1793 6.7462 -0.9515 42.9381
BT 145 CTRP2 -0.055 4.9687 -0.3522 41.3513
BT 231 CTRP2 0.1414 6.2792 -0.4634 40.7491
BT 239 CTRP2 0.2743 9.321 -1.3744 41.7154
BT 172 CTRP2 0.4915 7.6782 -0.5291 39.4809
BT 228 CTRP2 0.5544 5.1582 0.2697 37.4081
BT 330 CTRP2 0.7781 7.9843 -0.3289 37.9901
BT 333 CTRP2 0.7811 5.1441 0.5188 35.8701
BT 504 CTRP2 0.8892 7.6729 -0.0976 37.0651
BT 482 CTRP2 0.8995 4.9304 0.6899 34.9379
BT 440 CTRP2 0.9719 10.2409 -1.0132 38.6312
BT 245 CTRP2 1.4464 5.1478 1.2398 31.3186
BT 159 CTRP2 1.5953 4.1347 1.5471 29.8021
BT 232 CTRP2 1.6958 9.2384 0.1616 33.6458
BT 248 CTRP2 1.721 2.9536 1.7205 28.8048
BT 416 CTRP2 1.7683 5.2543 1.5673 29.1668
BT 422 CTRP2 1.9601 4.0589 1.9339 27.2982
BT 498 CTRP2 1.9684 2.855 1.9684 27.1549
BT 131 CTRP2 2.1982 3.0951 2.1982 25.6239
BT 139 CTRP2 2.412 2.9274 2.412 24.1998
BT 359 CTRP2 2.4839 3.8144 2.4805 23.7318
BT 444 CTRP2 2.5205 3.0792 2.5205 23.4766
BT 340 CTRP2 2.6998 9.3355 1.1677 27.6077
BT 224 CTRP2 2.7988 7.5466 1.6427 20.6332
BT 328 CTRP2 2.8507 3.3585 2.8507 21.2768
BT 216 CTRP2 3.1982 6.778 2.7109 20.6999
BT 320 CTRP2 4.2799 5.7211 4.1964 12.0422
⏷ Show the Full List of 56 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 23 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
D283 Med CTRP2 -6.721 -0.9989 -6.7594 79.061
A-172 CTRP2 -3.0998 20.3322 -9.6516 53.6849
42-MG-BA CTRP2 -0.2303 12.3896 -3.1784 45.3075
Hs 683 CTRP2 0.1391 6.2035 -0.4443 40.721
YH-13 CTRP2 0.498 5.2952 0.1783 37.8653
SF268 CTRP2 0.5461 5.6513 0.1465 37.7627
DK-MG CTRP2 1.0524 5.814 0.6576 34.4913
SNB-75 CTRP2 1.2011 4.7108 1.0541 32.7494
KG-1-C CTRP2 1.2344 14.7988 -2.785 40.3654
SF539 CTRP2 1.5305 4.547 1.4317 30.403
M059K CTRP2 1.5982 7.1819 0.8399 32.0718
U-251MG CTRP2 2.1119 14.9207 -1.9832 36.776
KNS-42 CTRP2 2.2368 5.5136 2.021 26.1063
U-118MG CTRP2 2.4537 5.4577 2.269 24.5554
GMS-10 CTRP2 2.8273 13.1927 -0.4691 31.8138
GOS-3 CTRP2 2.8962 14.9484 -1.2425 33.3222
T98G CTRP2 2.9253 7.9185 1.9935 24.1191
Becker CTRP2 3.0466 13.7974 -0.5457 31.4016
CCF-STTG1 CTRP2 3.1696 5.5387 3.0292 19.6351
YKG-1 CTRP2 3.2 16.6015 -1.7585 33.5516
8-MG-BA CTRP2 3.4961 6.3306 3.1803 18.0927
TM-31 CTRP2 4.8216 14.5632 0.7274 23.5378
SW1783 CTRP2 6.258 11.0775 3.7036 9.4207
⏷ Show the Full List of 23 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 9 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JHUEM-7 CTRP2 -8.1303 1.5084 -8.4639 77.9597
ESS-1 CTRP2 -3.3456 4.8098 -3.8944 59.5363
JHUEM-1 CTRP2 -2.7047 3.705 -2.9819 57.084
MFE-296 CTRP2 -2.2707 8.1389 -3.6776 53.5545
AN3-CA CTRP2 -1.3674 5.1753 -1.8247 49.4712
EN CTRP2 -0.487 3.9225 -0.6362 43.8252
HEC-1-A CTRP2 0.6351 11.726 -1.9984 41.2627
JHUEM-3 CTRP2 1.2822 6.3558 0.759 33.3869
MFE-319 CTRP2 2.2339 3.6623 2.2302 25.3981
⏷ Show the Full List of 9 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 12 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CAL-54 CTRP2 -1.6405 11.2156 -4.1586 50.6779
KMRC-2 CTRP2 0.5814 8.5236 -0.7397 39.538
UO-31 CTRP2 1.2702 5.1131 1.0558 32.5091
KMRC-3 CTRP2 1.594 3.9816 1.5584 29.7684
KMRC-1 CTRP2 2.3296 3.7959 2.3245 24.7657
786-O CTRP2 3.6765 6.5686 3.3003 17.1171
Caki-2 CTRP2 3.8108 6.677 3.4088 16.3219
VMRC-RCZ CTRP2 4.3076 8.3854 3.2328 15.6527
RCC10RGB CTRP2 4.552 7.5466 3.8538 12.5625
ACHN CTRP2 4.6253 12.8608 1.3917 21.8243
TUHR14TKB CTRP2 4.8634 12.2087 1.93 34.5959
Caki-1 CTRP2 11.6696 32.0364 -2.6145 20.5367
⏷ Show the Full List of 12 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 18 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-1033 CTRP2 -4.4025 14.7479 -8.5164 57.8903
SNU-C1 CTRP2 -2.0549 3.7995 -2.2983 53.5086
NCI-H747 CTRP2 -0.96 10.2612 -3.0559 47.9127
T84 CTRP2 -0.2521 6.0701 -0.8342 43.0794
SW948 CTRP2 -0.0234 10.3775 -2.1133 43.7078
COLO 678 CTRP2 0.226 12.6085 -2.805 43.4895
NCI-H716 CTRP2 0.2691 5.3281 -0.2472 35.7349
SW1417 CTRP2 0.5109 9.963 -1.3815 40.8533
SNU-503 CTRP2 0.6814 21.3646 -6.4422 44.6142
C2BBe1 CTRP2 1.109 15.9932 -3.4675 41.457
RCM-1 [Human ESC] CTRP2 1.6102 8.3998 0.4066 33.2776
GP2d CTRP2 2.0341 9.5743 0.3751 31.9962
HCT 15 CTRP2 2.7848 6.0444 2.4871 22.7538
COLO 320 CTRP2 3.0728 11.2685 0.6754 28.0785
HCC-56 CTRP2 3.57 6.6796 3.1472 17.9965
LS1034 CTRP2 3.6179 7.9915 2.6935 19.5754
SNU-C4 CTRP2 4.8201 8.068 3.892 11.7245
HCT 8 CTRP2 5.0408 7.1804 4.5163 8.6656
⏷ Show the Full List of 18 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 13 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HLF CTRP2 -1.7845 3.3007 -1.9365 51.9944
JHH-5 CTRP2 0.4998 10.1013 -1.4499 40.9929
JHH-1 CTRP2 1.0527 7.1219 0.2686 35.5688
SNU-423 CTRP2 1.5785 4.5936 1.4764 30.0948
HuH-1 CTRP2 1.8974 8.9948 0.4736 32.1564
SK-HEP-1 CTRP2 2.1322 3.6876 2.1265 26.0827
JHH-2 CTRP2 2.1778 5.3814 1.9854 26.4171
SNU-387 CTRP2 2.2799 5.6129 2.0454 25.885
JHH-4 CTRP2 2.3768 6.459 1.9214 26.0163
SNU-475 CTRP2 2.4438 10.0647 0.5866 30.1472
PLC/PRF/5 CTRP2 3.1034 6.0735 2.8268 20.5605
JHH-6 CTRP2 3.2329 3.9812 3.2327 18.7311
SNU-449 CTRP2 5.1011 8.8936 3.7735 11.5337
⏷ Show the Full List of 13 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 66 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
DV-90 CTRP2 -8.9472 5.0521 -10.0564 74.3716
NCI-H1694 CTRP2 -8.0432 3.3275 -8.6824 75.0872
SCLC-21H CTRP2 -7.8378 4.0929 -8.6209 73.6759
DMS 273 CTRP2 -5.7892 5.2029 -6.6503 67.6561
NCI-H23 CTRP2 -5.3913 4.2303 -5.9913 67.5735
NCI-H2081 CTRP2 -4.7643 6.4647 -5.8688 63.4837
NCI-H520 CTRP2 -4.731 4.7655 -5.3922 64.8963
NCI-H1341 CTRP2 -4.6465 1.4189 -4.759 68.11
Lu-65 CTRP2 -4.1937 7.9713 -5.7087 60.6034
COR-L279 CTRP2 -3.4928 2.9011 -3.7045 61.5051
NCI-H2141 CTRP2 -3.4821 6.9864 -4.6239 58.7737
NCI-H2171 CTRP2 -3.2452 7.1283 -4.4091 57.8074
NCI-H810 CTRP2 -2.8313 6.7433 -3.8415 56.3363
LK2 CTRP2 -2.5471 5.0252 -3.0744 55.7473
HOP-92 CTRP2 -2.5334 14.5828 -6.5049 53.195
NCI-H522 CTRP2 -2.3452 6.6956 -3.2972 54.2473
SK-MES-1 CTRP2 -2.1626 5.9954 -2.8988 53.5777
DMS 114 CTRP2 -2.1564 9.2709 -3.9553 52.8609
COR-L47 CTRP2 -2.0247 9.4808 -3.8916 52.3089
COR-L51 CTRP2 -1.8872 4.3345 -2.2119 52.4654
NCI-H1623 CTRP2 -1.2273 7.4986 -2.3313 48.8534
NCI-H1915 CTRP2 -1.1707 7.5855 -2.2986 48.5782
VMRC-LCD CTRP2 -1.1228 11.962 -3.9227 48.7436
NCI-H841 CTRP2 -0.8366 5.3355 -1.284 46.3835
COR-L88 CTRP2 -0.7083 7.5015 -1.7688 46.179
RERF-LC-MS CTRP2 -0.5796 4.6375 -0.8548 44.6172
NCI-H1703 CTRP2 -0.5771 6.5147 -1.3156 45.1717
NCI-H647 CTRP2 -0.5559 5.7511 -1.0807 44.8052
DMS 53 CTRP2 -0.4827 12.1052 -3.3171 46.2593
NCI-H2029 CTRP2 -0.418 5.8529 -0.9569 44.0049
NCI-H1105 CTRP2 -0.1748 3.4766 -0.2518 41.637
NCI-H146 CTRP2 -0.0976 3.7458 -0.1991 41.1889
LUDLU-1 CTRP2 -0.0701 7.4057 -1.0443 42.6109
HCC1438 CTRP2 -0.0602 9.0211 -1.6148 43.3117
NCI-H1651 CTRP2 -0.0254 8.1382 -1.2501 42.7155
NCI-H1339 CTRP2 0.0698 8.6696 -1.3426 42.4597
RERF-LC-Ad2 CTRP2 0.2486 6.457 -0.3981 40.1812
NCI-H1944 CTRP2 0.2826 11.6003 -2.3077 42.8162
NCI-H1869 CTRP2 0.2909 7.4158 -0.6562 40.5057
COR-L95 CTRP2 0.3012 5.7276 -0.1397 39.4148
COR-L105 CTRP2 0.5856 16.9551 -4.4324 43.6915
COLO 668 CTRP2 0.6972 8.4759 -0.5977 38.8385
NCI-H2110 CTRP2 0.9012 5.3496 0.6047 35.1857
NCI-H838 CTRP2 0.9825 4.2105 0.8917 34.0191
HOP-62 CTRP2 1.0266 5.0977 0.7947 34.1697
NCI-H1092 CTRP2 1.0453 5.5921 0.7052 34.3752
NCI-H1693 CTRP2 1.119 7.8574 0.0841 35.8018
ChaGo-K-1 CTRP2 1.1868 5.5283 0.8747 33.3656
HCC4006 CTRP2 1.308 5.7727 0.947 32.7246
EKVX CTRP2 1.3953 6.8647 0.7251 33.0989
LC-1/sq-SF CTRP2 1.4311 9.1786 -0.0926 35.1542
KNS-62 CTRP2 1.4719 5.0089 1.2941 31.055
NCI-H2170 CTRP2 1.6539 4.8005 1.5262 29.679
NCI-H322 CTRP2 1.7273 4.8463 1.5978 29.1971
NCI-H1568 CTRP2 1.9774 2.9004 1.9773 27.0953
NCI-H2196 CTRP2 1.9857 4.1729 1.9525 27.1509
NCI-H1563 CTRP2 2.2238 3.4097 2.2229 25.4562
NCI-H1395 CTRP2 2.5945 12.9799 -0.5957 32.7537
T3M-10 CTRP2 3.3966 6.2676 3.0909 18.7169
NCI-H2342 CTRP2 3.4719 12.1079 0.6709 27.0139
HCC2935 CTRP2 3.7521 6.3228 3.4615 16.2994
DMS 454 CTRP2 4.0022 9.2877 2.5149 19.2405
IA-LM CTRP2 4.3805 9.8507 2.6237 17.8709
Calu-1 CTRP2 4.7928 9.967 2.9625 15.5459
NCI-H1793 CTRP2 6.0824 16.1772 1.0097 19.9537
Hs 888.Lu CTRP2 0.3268 14.5853 -3.5902 43.8195
⏷ Show the Full List of 66 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 17 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
2004 CTRP2 -5.7246 7.2988 -7.1628 65.4549
COV434 CTRP2 -6.6091 3.6489 -7.1922 71.6133
COV644 CTRP2 -3.3267 3.3119 -3.587 60.4224
OC 314 CTRP2 -3.1108 2.064 -3.2054 60.0572
TOV-21G CTRP2 -0.7684 8.346 -2.1256 46.6898
COV362 CTRP2 0.2346 8.9224 -1.2621 41.707
OVCAR-5 CTRP2 0.4762 8.9852 -1.0285 40.4325
TOV-112D CTRP2 0.6978 5.6919 0.3019 36.7817
OV7 CTRP2 1.0284 6.6602 0.3905 35.3316
EFO-21 CTRP2 1.3154 10.0675 -0.5819 36.6347
OAW28 CTRP2 1.4803 2.6317 1.4802 30.407
OV-90 CTRP2 2.0703 4.8139 1.9708 26.8127
JHOS-2 CTRP2 2.3783 6.1867 2.0037 25.7225
JHOM-1 CTRP2 2.6834 4.1077 2.6762 22.4153
OAW42 CTRP2 3.4414 5.2072 3.3807 17.5476
EFO-27 CTRP2 3.7068 12.5596 0.6801 26.3746
OV56 CTRP2 4.6376 7.8424 3.8111 12.5095
⏷ Show the Full List of 17 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Thigh Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SYO-1 CTRP2 -3.5618 7.8767 -4.9912 58.5704
P-STS CTRP2 -2.3396 7.6061 -3.5749 53.9747
H-STS CTRP2 -0.985 6.0788 -1.8447 44.4672
Cancer Drug Sensitivity Data Curated from 20 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Yamato-SS CTRP2 0.0926 7.6751 -0.9595 41.8142
Aska-SS CTRP2 1.2893 6.8851 0.6033 33.8178
TE 441.T CTRP2 -6.6583 0.6741 -6.8035 76.089
TTC-709 CTRP2 -6.5943 8.4798 -8.483 66.4632
G-401 CTRP2 -5.7098 2.6278 -6.0379 70.4891
TE 617.T CTRP2 -5.0869 5.2185 -5.8884 65.6055
A-204 CTRP2 -4.3661 5.4572 -5.1621 63.0236
G-402 CTRP2 -3.6665 7.0018 -4.8295 59.437
HT-1080 CTRP2 -3.5252 5.3577 -4.22 59.9358
RD CTRP2 -3.4302 5.4314 -4.1348 59.5006
Tm87-16 CTRP2 -3.2499 4.4461 -3.7113 59.3397
KYM-1 CTRP2 -1.8942 6.5 -2.7478 52.1768
MES-SA CTRP2 -1.8366 3.2805 -1.9894 52.3117
GCT CTRP2 -1.0943 3.4542 -1.2219 47.6861
BT-16 CTRP2 -0.7679 4.9432 -1.1209 45.8763
BT-12 CTRP2 -0.2737 2.1072 -0.2801 42.1111
SW982 CTRP2 -0.1157 6.5595 -0.8257 42.4722
Hs 729.T CTRP2 0.9061 4.6403 0.7483 34.736
SK-LMS-1 CTRP2 3.3697 7.7797 2.5194 20.9207
SK-UT-1 CTRP2 4.0329 16.0514 -0.7206 29.3353
⏷ Show the Full List of 20 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Clivus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
U-CH1 CTRP2 5.9253 15.9404 0.9969 20.3114
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JL-1 CTRP2 0.7769 8.9165 -0.6817 38.7089
MPP 89 CTRP2 1.7607 4.652 1.6629 28.8681
IST-Mes1 CTRP2 1.9155 5.8878 1.5802 28.6465
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
LNCaP clone FGC CTRP2 -3.876 5.9097 -4.7455 60.9154
VCaP CTRP2 -1.8713 5.9717 -2.5744 52.1388
PaCa-3 CTRP2 1.7089 9.067 0.2456 33.3842
NCI-H660 CTRP2 2.2157 13.579 -1.2484 35.1907
DU145 CTRP2 3.9911 10.7893 1.8005 21.9314
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 CTRP2 0.4989 7.7919 -0.561 39.5146
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-16 CTRP2 -5.7385 2.4988 -6.0488 70.7472
SNU-1 CTRP2 -4.8317 5.4235 -5.6614 64.6076
HGC-27 CTRP2 -4.5827 3.8275 -5.032 65.295
IM95 CTRP2 -3.6566 4.8153 -4.234 60.8448
SNU-216 CTRP2 -0.8682 7.8808 -2.0704 47.0962
Hs 746.T CTRP2 -0.7515 7.4537 -1.7998 46.3964
NCC-StC-K140 CTRP2 -0.5633 3.9908 -0.7276 44.3421
HuG1-N CTRP2 -0.087 8.3766 -1.4026 43.1628
SH-10-TC CTRP2 0.1573 3.6678 0.079 39.4494
KATO III CTRP2 0.4063 8.7849 -1.0262 40.6918
SNU-601 CTRP2 0.5432 9.8661 -1.308 40.6268
LMSU CTRP2 1.5541 4.9362 1.396 30.4439
MKN74 CTRP2 1.866 5.8257 1.5421 28.935
MKN7 CTRP2 3.2469 9.7962 1.5242 24.8662
KE-39 CTRP2 3.4252 18.8157 -2.6368 34.5347
SNU-685 CTRP2 2.1981 3.5868 2.1952 25.6344
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 4 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
FTC-238 CTRP2 -1.5623 9.5083 -3.4063 50.4279
SW579 CTRP2 -1.3725 4.5843 -1.703 49.4816
TT2609-C02 CTRP2 -0.525 8.0896 -1.7718 45.3783
FTC-133 CTRP2 3.5415 5.7342 3.3909 17.1954
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CAL-27 CTRP2 -4.5114 5.9377 -5.4465 63.1147
BICR 22 CTRP2 -4.1507 2.1598 -4.3111 65.1826
BICR 6 CTRP2 -1.9557 4.2135 -2.2633 52.87
PE/CA-PJ34 (clone C12) CTRP2 -1.93 3.8569 -2.1735 52.7832
BICR 31 CTRP2 -1.711 5.2698 -2.221 51.38
SCC-9 CTRP2 -1.6627 6.8776 -2.6081 51.0048
BICR 18 CTRP2 -1.2816 5.6935 -1.8577 49.0123
PE/CA-PJ15 CTRP2 -0.8967 7.3189 -1.9134 47.1351
PE/CA-PJ49 CTRP2 -0.8382 4.7054 -1.1482 46.2595
CAL-33 CTRP2 -0.6772 4.8758 -1.0083 45.2971
BICR 16 CTRP2 -0.5031 4.7504 -0.7939 44.1629
FaDu CTRP2 0.1764 5.7598 -0.2841 40.2395
PE/CA-PJ41 (clone D2) CTRP2 0.5892 7.897 -0.5009 39.0523
SCC-4 CTRP2 0.7358 2.9776 0.7247 35.4031
HSC-2 CTRP2 1.3001 3.9746 1.2517 31.7682
BICR 56 CTRP2 1.8198 3.9685 1.7942 28.2305
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 9 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
647V CTRP2 -6.0672 0.5239 -6.1712 74.5946
UM-UC-1 CTRP2 -1.5751 7.5625 -2.7302 50.547
U-BLC1 CTRP2 0.0483 4.7374 -0.1944 40.5716
SCaBER CTRP2 1.0218 14.6672 -2.9342 41.1514
HT-1197 CTRP2 2.3442 35.8319 -12.0352 43.9116
KMBC-2 CTRP2 2.4569 4.6968 2.3982 24.0989
BC-3C CTRP2 2.8688 4.7496 2.8279 21.2944
J82 CTRP2 3.4351 8.0653 2.4714 20.9186
T24 CTRP2 3.6378 12.037 0.8647 25.9851
⏷ Show the Full List of 9 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HeLa CTRP2 1.5822 2.254 1.5822 29.7278

References

1 Small-molecule p21-activated kinase inhibitor PF-3758309 is a potent inhibitor of oncogenic signaling and tumor growth. Proc Natl Acad Sci U S A. 2010 May 18;107(20):9446-51.
2 Inhibition of neuroblastoma proliferation by PF-3758309, a small-molecule inhibitor that targets p21-activated kinase 4. Oncol Rep. 2017 Nov;38(5):2705-2716. doi: 10.3892/or.2017.5989. Epub 2017 Sep 22.