Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM3827C)

Drug Name
AZD4547 Drug Info
Synonyms
AZD4547; 1035270-39-3; AZD-4547; AZD 4547; UNII-2167OG1EKJ; 2167OG1EKJ; CHEBI:63453; KB-74810; N-(5-(3,5-Dimethoxyphenethyl)-1H-pyrazol-3-yl)-4-((3R,5S)-rel-3,5-dimethylpiperazin-1-yl)benzamide; N-{5-[2-(3,5-dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl}-4-(cis-3,5-dimethylpiperazin-1-yl)benzamide; rel-N-[5-[2-(3,5-Dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]-4-[(3R,5S)-3,5-dimethyl-1-piperazinyl]benzamide; N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]-4-[(3R,5S)-3,5-dimethylpiperazin-1-yl]benzamide
Cross-matching ID
PubChem CID
51039095
ChEBI ID
CHEMBL3348846
CAS Number
CAS 1035270-39-3
TTD Drug ID
D0NU0U

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Steroid biosynthesis 2.57 0.00e+0 19/20 (95%) MSMO1;SQLE;SC5D;...
Terpenoid backbone biosynthesis 2.44 0.00e+0 18/22 (81.82%) HMGCS1;ACAT2;IDI1;...
Steroid hormone biosynthesis 2.27 0.00e+0 43/61 (70.49%) HSD17B7;AKR1C2;HSD11B1;...
Metabolism of xenobiotics by cytochrome P450 2.11 0.00e+0 49/77 (63.64%) GSTA1;HSD11B1;GSTM3;...
PPAR signaling pathway 2.01 4.18e-3 66/74 (89.19%) HMGCS1;SCD;FADS2;...
Synthesis and degradation of ketone bodies 1.99 3.49e-3 9/10 (90%) HMGCS1;ACAT2;ACAT1;...
Butanoate metabolism 1.96 4.48e-3 23/28 (82.14%) HMGCS1;ACAT2;ABAT;...
Arginine biosynthesis 1.92 5.23e-3 17/22 (77.27%) ASS1;GLUL;CPS1;...
Valine, leucine and isoleucine degradation 1.87 1.05e-2 42/48 (87.5%) HMGCS1;ACAT2;AOX1;...
Glutathione metabolism 1.86 1.05e-2 43/57 (75.44%) IDH1;GSTA1;GSTM3;...
Glyoxylate and dicarboxylate metabolism 1.84 1.05e-2 23/30 (76.67%) ACAT2;SHMT1;GLUL;...
Ovarian steroidogenesis 1.84 9.59e-3 41/51 (80.39%) HSD17B7;LDLR;STAR;...
Propanoate metabolism 1.83 8.85e-3 30/34 (88.24%) ACAT2;ABAT;MMUT;...
Cholesterol metabolism 1.83 8.22e-3 44/50 (88%) LDLR;APOA1;STAR;...
Pyruvate metabolism 1.81 1.12e-2 41/47 (87.23%) ACAT2;ME1;GLO1;...
Bile secretion 1.80 1.31e-2 68/90 (75.56%) LDLR;HMGCR;ABCC4;...
Ascorbate and aldarate metabolism 1.78 1.54e-2 15/30 (50%) UGT2B4;UGT2A3;KL;...
Primary bile acid biosynthesis 1.77 1.51e-2 15/17 (88.24%) AMACR;ACOX2;CH25H;...
Cardiac muscle contraction 1.77 1.43e-2 64/87 (73.56%) ATP2A3;FXYD2;TNNC1;...
Retinol metabolism 1.75 1.73e-2 41/68 (60.29%) RDH11;AOX1;UGT2B4;...
Arachidonic acid metabolism 1.67 3.83e-2 48/61 (78.69%) PTGIS;GPX2;AKR1C3;...
Aldosterone synthesis and secretion 1.66 3.90e-2 85/98 (86.73%) LDLR;AGT;NPR1;...
Tryptophan metabolism 1.63 4.82e-2 35/42 (83.33%) ACAT2;AOX1;ALDH8A1;...
Fatty acid degradation 1.63 4.75e-2 40/43 (93.02%) ACAT2;ACAA2;CPT1A;...
Nicotine addiction -1.87 1.90e-2 32/40 (80%) CACNA1A;GABRA1;GABRA5;...
Proteasome -2.04 0.00e+0 44/46 (95.65%) PSMB9;PSMB5;PSME2;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone marrow
Neuroblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SH-SY5Y CVCL_0019 Homo sapiens 0.04uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Normal (Epithelial)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HME1 CVCL_2950 Homo sapiens 0.04uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Embryonic stem cell
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUES 3 CVCL_B062 Homo sapiens 0.04uM - 10uM 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 0.04uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
A549/Asc-1 CVCL_YA87 Homo sapiens 0.04uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 0.04uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H
SK-L CVCL_1699 Homo sapiens 0.04uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.04uM - 10uM 24H