Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM3BH1Y)

Drug Name
Lapatinib Drug Info
Synonyms
FMM; Tycerb; Lapatinib Ditosylate; Lapatinib [INN]; Lapatinib tosilate hydrate; GSK 572016; GSK572016; GW 572016; GW 572016X; GW572016; Lapatinib (INN); Tykerb (TN); Lapatinib, Tykerb, GW572016; N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfonylethylamino)methyl]furan-2-yl]quinazolin-4-amine; N-{3-CHLORO-4-[(3-FLUOROBENZYL)OXY]PHENYL}-6-[5-({[2-(METHYLSULFONYL)ETHYL]AMINO}METHYL)-2-FURYL]-4-QUINAZOLINAMINE; N-(3-Chloro-4-((3-fluorophenyl)methoxy)phenyl)-6-(5-((2-methylsulfonylethylamino)methyl)-2-furyl)quinazolin-4-amine; N-(3-Chloro-4-{[(3-fluorophenyl)methyl]oxy}phenyl)-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furanyl]-4-quinazolinamine; 4-[[3-Chloro-4-(3-fluorobenzyloxy)phenyl]amino]-6-[5-[[(2-methanesulfonylethyl)amino]methyl]furan-2-yl]quinazoline; Lapatinib (ERBB2 inhibitor)
Therapeutic ClassAnticancer Agents
Cross-matching ID
PubChem CID
208908
ChEBI ID
CHEMBL554
CAS Number
CAS 231277-92-2
TTD Drug ID
D08CDI
VARIDT Drug ID
DR00120
INTEDE Drug ID
DR0917
ACDINA Drug ID
D00351

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Steroid biosynthesis 2.50 0.00e+0 19/20 (95%) SQLE;MSMO1;CYP51A1;...
Glycine, serine and threonine metabolism 2.38 0.00e+0 31/40 (77.5%) PHGDH;GATM;PIPOX;...
DNA replication 2.24 0.00e+0 34/36 (94.44%) POLE2;MCM6;PRIM1;...
Glyoxylate and dicarboxylate metabolism 2.20 0.00e+0 23/30 (76.67%) ACAT2;GLUL;DLD;...
Homologous recombination 2.19 0.00e+0 35/41 (85.37%) BRCA1;BARD1;BRIP1;...
Fanconi anemia pathway 2.14 0.00e+0 36/54 (66.67%) USP1;BRCA1;FANCI;...
Base excision repair 2.11 0.00e+0 29/33 (87.88%) POLE2;PARP2;APEX1;...
Biosynthesis of unsaturated fatty acids 2.11 0.00e+0 21/27 (77.78%) SCD;FADS1;ELOVL6;...
Terpenoid backbone biosynthesis 2.09 0.00e+0 18/22 (81.82%) ACAT2;HMGCS1;IDI1;...
Butanoate metabolism 2.07 0.00e+0 23/28 (82.14%) ACAT2;HMGCS1;HADH;...
Valine, leucine and isoleucine degradation 2.05 0.00e+0 42/48 (87.5%) ACAT2;HMGCS1;ALDH9A1;...
PPAR signaling pathway 1.99 1.26e-3 66/74 (89.19%) SCD;HMGCS1;FADS2;...
beta-Alanine metabolism 1.92 4.08e-3 25/30 (83.33%) ALDH9A1;DPYD;ALDH3A1;...
Peroxisome 1.90 3.79e-3 72/82 (87.8%) IDH1;FAR2;SLC27A2;...
Synthesis and degradation of ketone bodies 1.88 5.06e-3 9/10 (90%) ACAT2;HMGCS1;BDH1;...
Propanoate metabolism 1.86 5.69e-3 30/34 (88.24%) ACAT2;DLD;ALDH6A1;...
Pyruvate metabolism 1.86 5.35e-3 41/47 (87.23%) ACAT2;PCK2;ALDH9A1;...
Histidine metabolism 1.85 5.48e-3 16/22 (72.73%) ALDH9A1;HNMT;HAL;...
Lysine degradation 1.84 5.19e-3 51/63 (80.95%) ACAT2;BBOX1;ALDH9A1;...
Mismatch repair 1.84 4.93e-3 22/23 (95.65%) EXO1;RFC5;LIG1;...
One carbon pool by folate 1.82 5.42e-3 15/20 (75%) DHFR;SHMT1;SHMT2;...
Fatty acid degradation 1.81 6.55e-3 40/43 (93.02%) ACAT2;ALDH9A1;ACSL1;...
Citrate cycle (TCA cycle) 1.80 7.25e-3 30/30 (100%) PCK2;IDH1;IDH2;...
Fatty acid biosynthesis 1.73 1.17e-2 16/18 (88.89%) ACSL1;FASN;ACACA;...
Sulfur metabolism 1.66 2.06e-2 9/10 (90%) SUOX;MPST;SELENBP1;...
Fatty acid elongation 1.65 2.22e-2 19/27 (70.37%) ELOVL6;HADH;ELOVL5;...
Tryptophan metabolism 1.65 2.22e-2 35/42 (83.33%) ACAT2;ALDH9A1;HADH;...
Glutathione metabolism 1.64 2.33e-2 43/57 (75.44%) PGD;IDH1;GGCT;...
Ascorbate and aldarate metabolism 1.64 2.30e-2 15/30 (50%) ALDH9A1;AKR1A1;UGT2A3;...
Nucleotide excision repair 1.60 3.03e-2 40/47 (85.11%) POLE2;CETN2;RFC5;...
PI3K-Akt signaling pathway -1.72 4.06e-2 317/354 (89.55%) COL9A2;THBS4;RBL2;...
Human papillomavirus infection -1.78 2.26e-2 284/331 (85.8%) COL9A1;TNXB;WNT7A;...
Hypertrophic cardiomyopathy -1.80 2.22e-2 81/90 (90%) ITGA10;TGFB3;ITGA9;...
Cell adhesion molecules -1.81 2.18e-2 118/148 (79.73%) PDCD1LG2;HLA-DQB1;PVR;...
Dilated cardiomyopathy -1.87 8.46e-3 86/96 (89.58%) CACNB2;ITGB5;MYL2;...
Small cell lung cancer -1.91 5.08e-3 90/92 (97.83%) AKT1;LAMB2;MYC;...
Mineral absorption -1.97 0.00e+0 48/60 (80%) SLC26A3;FTH1;SLC34A2;...
Proteoglycans in cancer -1.99 0.00e+0 172/205 (83.9%) TGFB2;ARHGEF12;SDC2;...
Focal adhesion -2.21 0.00e+0 180/201 (89.55%) TLN1;COL9A2;PPP1CA;...
ECM-receptor interaction -2.50 0.00e+0 80/88 (90.91%) LAMA5;COL6A1;COL6A2;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SK-ES-1 CVCL_0627 Homo sapiens 0.12uM - 10uM 24H
TC-32 CVCL_7141 Homo sapiens 0.12uM - 10uM 24H
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 0.12uM - 10uM 6H, 24H, 48H
Bone marrow
Chronic myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
K-562 CVCL_0004 Homo sapiens 0.01uM - 10uM 24H
Multiple myeloma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
KMS-34 CVCL_1333 Homo sapiens 0.01uM - 10uM 24H
Brain
Glioblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
LN-229 CVCL_0393 Homo sapiens 0.01uM - 10uM 24H
U-251 MG CVCL_0021 Homo sapiens 0.12uM - 10uM 24H
YH-13 CVCL_1800 Homo sapiens 0.12uM - 10uM 24H
Glioma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
GI-1 CVCL_1230 Homo sapiens 0.12uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 3H, 6H, 24H, 48H
MDA-MB-231 CVCL_0062 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
MDA-MB-468 CVCL_0419 Homo sapiens 0.12uM - 10uM 24H
SK-BR-3 CVCL_0033 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H, XH
Breast carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BT-20 CVCL_0178 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
Hs 578T CVCL_0332 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
Breast ductal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BT-474 CVCL_0179 Homo sapiens 0.01uM - 10uM 24H
T-47D CVCL_0553 Homo sapiens 0.12uM - 10uM 24H
ZR-75-1 CVCL_0588 Homo sapiens 0.12uM - 10uM 24H
Normal (Epithelial)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HME1 CVCL_2950 Homo sapiens 0.04uM - 10uM 3H, 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 3H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CW-2 CVCL_1155 Homo sapiens 0.01uM - 10uM 24H
GP2d CVCL_1234 Homo sapiens 0.12uM - 10uM 24H
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H, XH
NCI-H508 CVCL_1561 Homo sapiens 0.66uM - 10uM XH
SNU-1040 CVCL_5001 Homo sapiens 0.01uM - 10uM 24H
SNU-407 CVCL_5004 Homo sapiens 0.12uM - 10uM 24H
Embryonic stem cell
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
WA09 (H9) Derived CVCL_9773 (WA09) Homo sapiens 0.12uM - 10uM 24H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
AN3 CA CVCL_0146 Homo sapiens 0.01uM - 10uM 24H
HEC-108 CVCL_2926 Homo sapiens 0.12uM - 10uM 24H
HEC-151 CVCL_2927 Homo sapiens 0.12uM - 10uM 24H
HEC-1-A CVCL_0293 Homo sapiens 0.12uM - 10uM 24H
HEC-251 CVCL_2928 Homo sapiens 0.12uM - 10uM 24H
HEC-265 CVCL_2929 Homo sapiens 0.12uM - 10uM 24H
MFE-319 CVCL_1409 Homo sapiens 0.01uM - 10uM 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
CJM CVCL_U797 Homo sapiens 0.12uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.04uM - 10uM 24H
Renal cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
RCC10RGB CVCL_1656 Homo sapiens 0.12uM - 10uM 24H
Rhabdoid tumor
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
G-401 CVCL_0270 Homo sapiens 0.12uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 10uM 6H, 24H, XH
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HuH-7 CVCL_0336 Homo sapiens 6.66uM 72H
JHH-5 CVCL_1320 Homo sapiens 0.12uM - 10uM 24H
JHH-7 CVCL_1322 Homo sapiens 0.12uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H, 48H, XH
DV-90 CVCL_1184 Homo sapiens 0.01uM - 10uM 24H
NCI-H1563 CVCL_1478 Homo sapiens 0.01uM - 10uM 24H
NCI-H1781 CVCL_1499 Homo sapiens 0.01uM - 10uM 24H
NCI-H1975 CVCL_1511 Homo sapiens 0.66uM - 10uM XH
HCC827 CVCL_2063 Homo sapiens 0.01uM - 10uM 24H
NCI-H1437 CVCL_1472 Homo sapiens 0.12uM - 10uM 24H
NCI-H1573 CVCL_1483 Homo sapiens 0.12uM - 10uM 24H
NCI-H1975 CVCL_1511 Homo sapiens 0.66uM - 10uM XH
NCI-H838 CVCL_1594 Homo sapiens 0.12uM - 10uM 24H
Lung adenosquamous carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H596 CVCL_1571 Homo sapiens 0.66uM - 10uM XH
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BEN CVCL_1081 Homo sapiens 0.12uM - 10uM 24H
HCC1588 CVCL_1263 Homo sapiens 0.12uM - 10uM 24H
HCC95 CVCL_1276 Homo sapiens 0.12uM - 1.11uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H2110 CVCL_1529 Homo sapiens 0.01uM - 10uM 24H
HCC515 CVCL_5134 Homo sapiens 0.04uM - 10uM 6H, 24H
NCI-H2073 CVCL_1523 Homo sapiens 0.66uM - 10uM XH
NCI-H2110 CVCL_1529 Homo sapiens 0.12uM - 10uM 24H
NCI-H2172 CVCL_1534 Homo sapiens 0.12uM - 10uM 24H
Small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H841 CVCL_1595 Homo sapiens 0.12uM - 10uM 24H
Lymph node
Burkitt lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BJAB CVCL_5711 Homo sapiens 0.01uM - 10uM 3H, 6H, 24H
Diffuse large B-cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HBL-1 CVCL_4213 Homo sapiens 0.01uM - 10uM 24H
OCI-Ly10 CVCL_8795 Homo sapiens 0.01uM - 10uM 24H
OCI-Ly19 CVCL_8797 Homo sapiens 0.01uM - 10uM 24H
OCI-Ly3 CVCL_8796 Homo sapiens 0.01uM - 10uM 24H
SU-DHL-4 CVCL_0539 Homo sapiens 0.66uM - 10uM XH
TMD8 CVCL_A440 Homo sapiens 0.01uM - 10uM 3H, 6H, 24H
Mantle cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MINO CVCL_4965 Homo sapiens 0.01uM - 10uM 3H, 6H, 24H
Muscle
Rhabdomyosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-204 CVCL_0134 Homo sapiens 0.12uM - 10uM 24H
Oral cavity
Oral squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BICR 6 CVCL_1086 Homo sapiens 0.12uM - 10uM 24H
Ovary
Ovarian carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OC 314 CVCL_1614 Homo sapiens 0.01uM - 10uM 24H
OVCAR-8 CVCL_1625 Homo sapiens 0.01uM - 10uM 24H
OVK18 CVCL_1629 Homo sapiens 0.12uM - 10uM 24H
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ES-2 CVCL_3509 Homo sapiens 0.12uM - 10uM 24H
OVTOKO CVCL_3114 Homo sapiens 0.12uM - 10uM 24H
Ovarian cystadenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OAW 28 CVCL_1611 Homo sapiens 0.12uM - 10uM 24H
OC 316 CVCL_1615 Homo sapiens 0.12uM - 10uM 24H
Ovarian endometrioid carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
TOV-112D CVCL_3612 Homo sapiens 0.12uM - 10uM 24H
Ovarian granulosa cell tumor
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COV434 CVCL_2010 Homo sapiens 0.12uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute B-lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NALM-6 CVCL_0092 Homo sapiens 0.01uM - 10uM 24H
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 3H, 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
22Rv1 CVCL_1045 Homo sapiens 0.12uM - 10uM 24H
LNCaP CVCL_0395 Homo sapiens 0.04uM - 10uM 3H, 24H
LNCaP clone FGC CVCL_1379 Homo sapiens 0.12uM - 10uM 24H
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H, XH
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H, XH
IGR-37 CVCL_1303 Homo sapiens 0.12uM - 10uM 24H
Mel-HO CVCL_1402 Homo sapiens 0.12uM - 10uM 24H
SH-4 CVCL_1692 Homo sapiens 0.12uM - 10uM 24H
SK-MEL-3 CVCL_0525 Homo sapiens 0.12uM - 10uM 24H
SK-MEL-5 CVCL_0527 Homo sapiens 0.01uM - 10uM 24H
Stomach
Gastric adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
AGS CVCL_0139 Homo sapiens 0.12uM - 10uM 24H
MKN45 CVCL_0434 Homo sapiens 0.12uM - 10uM 24H
Gastric carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
IM95 CVCL_1305 Homo sapiens 0.12uM - 10uM 24H
Unclear
Rat sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
XC CVCL_1891 Rattus norvegicus (Rat) 0.01uM - 10uM 24H
Urinary bladder
Bladder carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
5637 CVCL_0126 Homo sapiens 0.01uM - 10uM 24H
BC-3C CVCL_1079 Homo sapiens 0.12uM - 10uM 24H
Bladder transitional cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CAL-29 CVCL_1109 Homo sapiens 0.12uM - 10uM 24H
J82 CVCL_0359 Homo sapiens 0.01uM - 10uM 24H
VM-CUB-1 CVCL_1786 Homo sapiens 0.01uM - 10uM 24H