Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM3EP8N)

Drug Name
Dothiepin Drug Info
Synonyms
Dothiepin; cis-dothiepin; Dosulepin; Prothiaden; UNII-CZ377VWX9P; Dosulepin [INN]; 113-53-1; CZ377VWX9P; CHEBI:36802; Dosulepin (INN); Dosulepin chloride; 3-Dibenzo[b,e]thiepin-11(6H)-ylidene-N,N-dimethyl-1-propanamine; Dosulepine [INN-French]; Dosulepinum [INN-Latin]; Dosulepina [INN-Spanish]; Dothep; HSDB 7181; N,N-dimethyldibenzo[b,e]thiepin-Delta(11(6H),gamma)-propylamine; 3-dibenzo[b,e]thiepin-11(6H)-ylidene-N,N-dimethylpropan-1-amine; Dothiepin;; EINECS 204-031-2; Prothiadiene; Depresym
Cross-matching ID
PubChem CID
5282426
ChEBI ID
CHEMBL36802
CAS Number
CAS 25627-38-7
TTD Drug ID
D0Q2MN

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Neutrophil extracellular trap formation 2.36 0.00e+0 101/189 (53.44%) PLCB3;PLCB1;PIK3R1;...
GnRH secretion 1.99 6.91e-3 60/64 (93.75%) SPP1;PLCB3;PLCB1;...
Steroid biosynthesis 1.97 4.61e-3 19/20 (95%) SQLE;LBR;HSD17B7;...
Amoebiasis 1.97 3.45e-3 99/102 (97.06%) GNAS;PLCB3;PLCB1;...
Diabetic cardiomyopathy 1.89 1.11e-2 162/203 (79.8%) GAPDH;PLCB3;PLCB1;...
Phagosome 1.86 2.30e-2 118/152 (77.63%) THBS2;FCGR2B;TLR4;...
Carbohydrate digestion and absorption 1.80 2.57e-2 37/47 (78.72%) PLCB3;PLCB1;PIK3R1;...
Fc epsilon RI signaling pathway 1.76 3.28e-2 57/68 (83.82%) PIK3R1;ALOX5;PIK3R3;...
DNA replication 1.76 3.07e-2 34/36 (94.44%) PCNA;MCM6;FEN1;...
Thyroid hormone signaling pathway 1.76 3.04e-2 112/121 (92.56%) PLCB3;PLCB1;PIK3R1;...
Notch signaling pathway 1.74 3.89e-2 49/59 (83.05%) NOTCH1;NOTCH3;JAG1;...
Chagas disease 1.72 4.84e-2 93/102 (91.18%) GNAS;PLCB3;PLCB1;...
AGE-RAGE signaling pathway in diabetic complications 1.71 4.68e-2 97/100 (97%) PLCB3;PLCB1;FN1;...
Retinol metabolism -2.22 0.00e+0 41/68 (60.29%) RETSAT;DHRS3;UGT2A3;...
Mineral absorption -2.28 0.00e+0 48/60 (80%) STEAP1;ATP1A2;SLC39A4;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 6.66uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H