Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM3JBLK)

Drug Name
PIK-93 Drug Info
Synonyms PIK93; PIK 93
Cross-matching ID
PubChem CID
6852167
ChEBI ID
CHEMBL1229535
CAS Number
CAS 593960-11-3
TTD Drug ID
D0S5YV

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Glutathione metabolism -1.70 4.67e-2 43/57 (75.44%) MGST3;SMS;HPGDS;...
Cholesterol metabolism -1.73 3.98e-2 44/50 (88%) LIPG;ANGPTL3;APOC1;...
mTOR signaling pathway -1.73 4.01e-2 114/154 (74.03%) PIK3CA;ATP6V1H;GSK3B;...
Cysteine and methionine metabolism -1.75 3.82e-2 43/50 (86%) DNMT3A;CBS;AMD1;...
Collecting duct acid secretion -1.80 3.31e-2 22/27 (81.48%) ATP6V0E1;CA2;SLC12A7;...
Ferroptosis -1.86 2.23e-2 36/41 (87.8%) CP;ACSL1;ACSL4;...
Terpenoid backbone biosynthesis -2.07 0.00e+0 18/22 (81.82%) MVD;FDPS;ACAT2;...
Proteasome -2.09 0.00e+0 44/46 (95.65%) PSMC6;PSMD4;PSMA1;...
Steroid biosynthesis -2.42 0.00e+0 19/20 (95%) HSD17B7;EBP;NSDHL;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.04uM - 10uM 3H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.04uM - 10uM 3H, 24H
SK-BR-3 CVCL_0033 Homo sapiens 0.04uM - 10uM 3H, 24H
Breast carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BT-20 CVCL_0178 Homo sapiens 0.04uM - 10uM 3H, 24H
Hs 578T CVCL_0332 Homo sapiens 0.04uM - 10uM 3H, 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.04uM - 10uM 3H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.04uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.04uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.04uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.04uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.04uM - 10uM 24H