Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM4A1KJ)

Drug Name
UNC0638 Drug Info
Synonyms
UNC0638; 1255580-76-7; UNC-0638; UNC 0638; UNII-26A103L2FO; 2-Cyclohexyl-N-(1-isopropylpiperidin-4-yl)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazolin-4-amine; CHEMBL1231795; 26A103L2FO; 2-Cyclohexyl-6-methoxy-N-[1-(1-methylethyl)-4-piperidinyl]-7-[3-(1-pyrrolidinyl)propoxy]-4-quinazolinamine; 1255517-77-1; 2-cyclohexyl-6-methoxy-N-[1-(propan-2-yl)piperidin-4-yl]-7-[3-(pyrrolidin-1-yl)propoxy]quinazolin-4-amine; 2-Cyclohexyl-N-(1-isopropyl-4-piperidinyl)-6-methoxy-7-[3-(1-pyrrolidinyl)propoxy]-4-quinazolinamine
Cross-matching ID
PubChem CID
46224516
ChEBI ID
CHEMBL1231795
CAS Number
CAS 1255580-76-7
TTD Drug ID
D0GK7A

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Steroid biosynthesis 2.45 0.00e+0 19/20 (95%) MSMO1;SQLE;DHCR24;...
Terpenoid backbone biosynthesis 2.34 0.00e+0 18/22 (81.82%) HMGCS1;IDI1;FDPS;...
PPAR signaling pathway 2.29 0.00e+0 66/74 (89.19%) SCD;HMGCS1;FADS2;...
Lysosome 2.04 1.88e-3 115/128 (89.84%) NPC1;NEU1;MCOLN1;...
Rheumatoid arthritis 2.01 3.01e-3 78/93 (83.87%) CXCL8;CCL2;CXCL3;...
Collecting duct acid secretion 2.01 2.51e-3 22/27 (81.48%) ATP6V1C1;ATP6V1D;ATP6V1E1;...
Viral protein interaction with cytokine and cytokine re... 2.00 2.15e-3 84/100 (84%) CXCL8;CCL2;CXCL3;...
Synthesis and degradation of ketone bodies 1.96 2.83e-3 9/10 (90%) HMGCS1;ACAT2;HMGCS2
Butanoate metabolism 1.96 2.51e-3 23/28 (82.14%) HMGCS1;ACAT2;HMGCS2
Phagosome 1.94 2.26e-3 118/152 (77.63%) TFRC;THBS2;ATP6V1C1;...
Synaptic vesicle cycle 1.94 2.06e-3 63/78 (80.77%) ATP6V1C1;ATP6V0B;ATP6V1D;...
Biosynthesis of unsaturated fatty acids 1.92 1.88e-3 21/27 (77.78%) SCD;FADS1;FADS2;...
NF-kappa B signaling pathway 1.89 2.32e-3 90/104 (86.54%) CXCL8;LY96;CXCL3;...
Vibrio cholerae infection 1.85 8.07e-3 44/50 (88%) KDELR3;ATP6V1C1;ATP6V0B;...
Amino sugar and nucleotide sugar metabolism 1.81 1.51e-2 38/48 (79.17%) GNPDA1;AMDHD2;HEXB;...
IL-17 signaling pathway 1.81 1.55e-2 84/94 (89.36%) CXCL8;CCL2;S100A7;...
Cholesterol metabolism 1.80 1.55e-2 44/50 (88%) NPC1;LDLR;NPC2;...
Epithelial cell signaling in Helicobacter pylori infect... 1.79 1.84e-2 62/70 (88.57%) CXCL8;CXCL3;ATP6V1C1;...
Ferroptosis 1.78 1.78e-2 36/41 (87.8%) HMOX1;TFRC;FTH1;...
Thyroid hormone synthesis -1.84 4.08e-2 66/75 (88%) GSR;DUOX1;TG;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone marrow
Neuroblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SH-SY5Y CVCL_0019 Homo sapiens 0.04uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.04uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.12uM - 10uM 24H
Normal (Epithelial)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HME1 CVCL_2950 Homo sapiens 0.04uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.04uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.04uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.04uM - 10uM 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 0.04uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.04uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.04uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.04uM - 10uM 24H
A549/Asc-1 CVCL_YA87 Homo sapiens 0.04uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 0.04uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.04uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.04uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.04uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.04uM - 10uM 24H
SK-L CVCL_1699 Homo sapiens 0.04uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.04uM - 10uM 24H