General Information of Drug (ID: DM4G09S)

Drug Name
SB-505124 Drug Info
Synonyms
SB-505124; 694433-59-5; SB505124; SB 505124; 2-(4-(benzo[d][1,3]dioxol-5-yl)-2-tert-butyl-1H-imidazol-5-yl)-6-methylpyridine; CHEMBL226838; 2-[4-(1,3-Benzodioxol-5-yl)-2-(tert-butyl)-1H-imidazol-5-yl]-6-methylpyridine; 2-[5-(1,3-Benzodioxol-5-yl)-2-(1,1-dimethylethyl)-1H-imidazol-4-yl]-6-methylpyridine; 2-[4-(2H-1,3-benzodioxol-5-yl)-2-tert-butyl-1H-imidazol-5-yl]-6-methylpyridine; MLS006010969; SCHEMBL373422; GTPL6049; CTK8E3615; KS-00000XPS; EX-A217; DTXSID50431926; AOB1766; AOB5688; MolPort-021-804-897; CHEBI:100922
Cross-matching ID
PubChem CID
9858940
ChEBI ID
CHEMBL100922
CAS Number
CAS 694433-59-5
TTD Drug ID
D0Q5UH

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name NES FDR q-val Tag % Leading Edge Genes
Alanine, aspartate and glutamate metabolism 2.29 0.00e+0 27/37 (72.97%) ASNS;ASS1;CPS1;...
Glycine, serine and threonine metabolism 2.24 0.00e+0 31/40 (77.5%) PSAT1;CTH;SHMT2;...
beta-Alanine metabolism 2.20 0.00e+0 25/30 (83.33%) ALDH2;ALDH6A1;ALDH3A1;...
Cysteine and methionine metabolism 2.01 2.13e-3 43/50 (86%) PSAT1;CTH;TST;...
Tryptophan metabolism 1.96 1.70e-3 35/42 (83.33%) ALDH2;IDO1;ACAT1;...
Mineral absorption 1.89 5.67e-3 48/60 (80%) MT1E;MT1M;STEAP1;...
Histidine metabolism 1.88 6.08e-3 16/22 (72.73%) ALDH2;ALDH3A1;ALDH3B1;...
Arginine biosynthesis 1.87 8.51e-3 17/22 (77.27%) ASS1;CPS1;ARG1;...
One carbon pool by folate 1.86 8.51e-3 15/20 (75%) SHMT2;MTHFD2;MTHFD2L;...
Selenocompound metabolism 1.83 1.45e-2 11/17 (64.71%) CTH;KYAT3;TXNRD1;...
Ribosome 1.80 1.70e-2 113/158 (71.52%) MRPS16;RPS5;FAU;...
Drug metabolism 1.79 1.77e-2 78/151 (51.66%) ALDH3A1;ALDH3B1;CES2;...
Arginine and proline metabolism 1.78 1.64e-2 39/50 (78%) PYCR1;ALDH2;ODC1;...
Sulfur relay system 1.74 2.01e-2 5/8 (62.5%) TST;MPST
Mismatch repair 1.73 2.16e-2 22/23 (95.65%) PCNA;RFC4;RFC5;...
Pentose and glucuronate interconversions 1.70 2.87e-2 17/34 (50%) UGP2;AKR1B10;DCXR;...
Collecting duct acid secretion 1.69 2.90e-2 22/27 (81.48%) ATP6V1D;SLC4A1;ATP6V1F;...
Fatty acid degradation 1.69 2.74e-2 40/43 (93.02%) ALDH2;ACAT1;ALDH9A1;...
Glyoxylate and dicarboxylate metabolism 1.68 2.78e-2 23/30 (76.67%) SHMT2;ACAT1;DLD;...
Propanoate metabolism 1.66 3.19e-2 30/34 (88.24%) ALDH6A1;ACAT1;SUCLG1;...
Phenylalanine metabolism 1.64 4.01e-2 14/17 (82.35%) ALDH3A1;ALDH3B1;GOT1;...
Adipocytokine signaling pathway 1.63 3.99e-2 64/69 (92.75%) PCK2;IRS2;LEPR;...
Lysine degradation 1.63 4.00e-2 51/63 (80.95%) ALDH2;ACAT1;AASS;...
Citrate cycle (TCA cycle) 1.62 4.18e-2 30/30 (100%) PCK2;SUCLG1;PCK1;...
Tyrosine metabolism 1.59 4.94e-2 30/36 (83.33%) ALDH3A1;ALDH3B1;ADH1B;...
Epithelial cell signaling in Helicobacter pylori infect... 1.58 4.91e-2 62/70 (88.57%) ATP6V1D;CXCL2;PAK1;...
Pyruvate metabolism 1.58 4.76e-2 41/47 (87.23%) ALDH2;PCK2;ACAT1;...
Valine, leucine and isoleucine degradation 1.58 4.68e-2 42/48 (87.5%) ALDH2;ALDH6A1;ACAT1;...
DNA replication 1.58 4.52e-2 34/36 (94.44%) PCNA;RFC4;RFC5;...
Sulfur metabolism 1.57 4.51e-2 9/10 (90%) TST;MPST;PAPSS1;...
Focal adhesion -1.69 4.22e-2 180/201 (89.55%) COL2A1;ITGB6;FLNB;...
Cholesterol metabolism -1.73 2.35e-2 44/50 (88%) APOC2;CYP27A1;ABCA1;...
HIF-1 signaling pathway -1.79 1.35e-2 105/109 (96.33%) CREBBP;PRKCA;CDKN1B;...
Cell adhesion molecules -1.80 1.50e-2 118/148 (79.73%) SIGLEC1;ITGB8;HLA-DPA1;...
AGE-RAGE signaling pathway in diabetic complications -1.85 7.04e-3 97/100 (97%) PRKCA;CDKN1B;MAPK1;...
Hypertrophic cardiomyopathy -1.88 8.04e-3 81/90 (90%) ITGB6;TTN;TGFB3;...
Proteoglycans in cancer -1.89 9.38e-3 172/205 (83.9%) FZD10;ERBB4;KRAS;...
ECM-receptor interaction -1.91 6.75e-3 80/88 (90.91%) LAMA5;COL6A3;SV2A;...
Leishmaniasis -1.91 8.44e-3 67/77 (87.01%) HLA-DPA1;ITGAM;PRKCB;...
Dilated cardiomyopathy -1.92 1.13e-2 86/96 (89.58%) CACNA2D2;ITGA10;CACNB4;...
Arrhythmogenic right ventricular cardiomyopathy -1.93 1.69e-2 70/77 (90.91%) CTNNA2;CACNA2D2;ITGA10;...
Steroid biosynthesis -2.09 0.00e+0 19/20 (95%) CYP51A1;SOAT2;FDFT1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 1.11uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 1.11uM - 10uM 24H