Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM4HYMS)

Drug Name
ABT-888 Drug Info
Synonyms
Veliparib; 912444-00-9; ABT-888; ABT 888; ABT-888 (Veliparib); Veliparib (ABT-888); ABT888; UNII-01O4K0631N; 2-[(2R)-2-Methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide; CHEBI:62880; 2-[(R)-2-methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide; (R)-2-(2-methylpyrrolidin-2-yl)-1H-benzo[d]imidazole-4-carboxamide; 01O4K0631N; 2-[(2R)-2-Methylpyrrolidin-2-yl]-1H-benimidazole-4-; (2r)-2-(7-Carbamoyl-1h-Benzimidazol-2-Yl)-2-Methylpyrrolidinium; Veliparib dihydrochloride
Cross-matching ID
PubChem CID
45480520
ChEBI ID
CHEMBL5723363
CAS Number
CAS 912445-05-7
TTD Drug ID
D0Q7UD

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Ribosome 2.16 0.00e+0 113/158 (71.52%) RPS4Y1;MRPS2;MRPL15;...
Ribosome biogenesis in eukaryotes 2.10 0.00e+0 52/108 (48.15%) NXT1;RAN;IMP3;...
Proteasome 1.82 2.60e-2 44/46 (95.65%) PSMA4;PSMA6;PSMA3;...
Steroid biosynthesis 1.80 2.31e-2 19/20 (95%) SQLE;MSMO1;DHCR24;...
Spliceosome 1.76 2.70e-2 101/150 (67.33%) SNRPE;SNRPG;LSM5;...
RNA transport 1.74 3.55e-2 128/186 (68.82%) EIF1AY;NXT1;RAN;...
Shigellosis -1.66 3.03e-2 180/246 (73.17%) MAPK3;DIAPH1;HK1;...
TNF signaling pathway -1.66 3.13e-2 103/112 (91.96%) VEGFC;PIK3R1;MAP2K6;...
Amino sugar and nucleotide sugar metabolism -1.67 3.02e-2 38/48 (79.17%) GFPT1;CYB5R1;RENBP;...
Staphylococcus aureus infection -1.69 2.91e-2 72/95 (75.79%) C3;C1S;DEFB4A;...
Primary immunodeficiency -1.69 2.88e-2 33/38 (86.84%) CD19;LCK;CD3D;...
Protein processing in endoplasmic reticulum -1.69 2.99e-2 127/171 (74.27%) CALR;SKP1;HSP90AB1;...
Epithelial cell signaling in Helicobacter pylori infect... -1.70 2.76e-2 62/70 (88.57%) ATP6V1H;ADAM17;TCIRG1;...
T cell receptor signaling pathway -1.70 2.88e-2 93/104 (89.42%) GSK3B;GRAP2;MAP2K7;...
NOD-like receptor signaling pathway -1.70 2.95e-2 145/181 (80.11%) IL6;RNASEL;MAPK13;...
Antigen processing and presentation -1.71 2.98e-2 60/78 (76.92%) HLA-G;HLA-A;HSPA5;...
Th17 cell differentiation -1.72 2.88e-2 95/107 (88.79%) IRF4;STAT3;NFKBIB;...
Pertussis -1.74 2.65e-2 64/76 (84.21%) MAPK3;IL6;MAPK13;...
Ferroptosis -1.75 2.04e-2 36/41 (87.8%) SLC39A14;CYBB;GPX4;...
Osteoclast differentiation -1.75 2.09e-2 117/127 (92.13%) PIK3R1;IL1R1;MAP2K6;...
IL-17 signaling pathway -1.75 2.15e-2 84/94 (89.36%) IL6;MUC5B;MAPK13;...
Graft-versus-host disease -1.75 2.29e-2 32/42 (76.19%) FASLG;HLA-DQB1;HLA-DRA;...
Fluid shear stress and atherosclerosis -1.77 2.01e-2 123/139 (88.49%) GSTM4;MAPK13;IKBKB;...
Mitophagy -1.77 1.98e-2 56/68 (82.35%) RHOT2;CSNK2B;NBR1;...
Th1 and Th2 cell differentiation -1.78 2.04e-2 80/92 (86.96%) MAPK3;HLA-DPA1;PPP3CC;...
Apoptosis -1.80 1.67e-2 126/168 (75%) PIK3CB;CAPN2;TRADD;...
Neutrophil extracellular trap formation -1.82 1.47e-2 101/189 (53.44%) AGER;PIK3R1;RAC2;...
PD-L1 expression and PD-1 checkpoint pathway in cancer -1.82 1.64e-2 79/89 (88.76%) STAT3;PDCD1;NFKBIB;...
Legionellosis -1.84 1.07e-2 51/57 (89.47%) TLR5;CASP9;CXCL2;...
NF-kappa B signaling pathway -1.85 8.76e-3 90/104 (86.54%) IKBKB;CYLD;CXCL12;...
Autophagy -1.86 8.18e-3 113/169 (66.86%) PRKACB;PIK3R1;STK11;...
Phagosome -1.89 0.00e+0 118/152 (77.63%) TUBB1;HLA-G;MRC2;...
Rheumatoid arthritis -1.90 0.00e+0 78/93 (83.87%) TCIRG1;HLA-DPA1;ATP6V1F;...
Lysosome -1.99 0.00e+0 115/128 (89.84%) GALNS;TCIRG1;HEXA;...
Mineral absorption -2.10 0.00e+0 48/60 (80%) TRPV6;ATP1B1;ATP1A2;...
Complement and coagulation cascades -2.11 0.00e+0 76/85 (89.41%) SERPINE1;FGB;C1QB;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-673 CVCL_0080 Homo sapiens 10uM 6H
Bone marrow
Neuroblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SH-SY5Y CVCL_0019 Homo sapiens 0.04uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.002uM - 10uM 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 6H, 24H
SK-BR-3 CVCL_0033 Homo sapiens 0.08uM - 10uM 6H, 24H
Breast carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BT-20 CVCL_0178 Homo sapiens 0.08uM - 10uM 6H, 24H
Hs 578T CVCL_0332 Homo sapiens 0.08uM - 10uM 6H, 24H
Fibrocystic breast disease
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A (Parent) CVCL_0598 Homo sapiens 1.11uM - 10uM 3H, 6H, 12H, 24H
Normal (Epithelial)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HME1 CVCL_2950 Homo sapiens 0.04uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 6H, 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CL-34 CVCL_1123 Homo sapiens 10uM 6H
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
LoVo CVCL_0399 Homo sapiens 10uM 6H
MDST8 CVCL_1400 Homo sapiens 10uM 6H
NCI-H508 CVCL_1561 Homo sapiens 10uM 6H
SNU-1040 CVCL_5001 Homo sapiens 10uM 6H
SNU-C4 CVCL_5008 Homo sapiens 10uM 6H
SNU-C5 CVCL_5009 Homo sapiens 10uM 6H
SW480 CVCL_0546 Homo sapiens 10uM 6H
SW620 CVCL_0547 Homo sapiens 10uM 6H
SW948 CVCL_0550 Homo sapiens 10uM 6H
Colorectal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCT 116 CVCL_0291 Homo sapiens 10uM 6H
HT115 CVCL_1294 Homo sapiens 10uM 6H
RKO CVCL_0504 Homo sapiens 10uM 6H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 10uM 6H
SNG-M CVCL_1707 Homo sapiens 10uM 6H
Endometrial carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHUEM-2 CVCL_1327 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 0.04uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
1HAEo- CVCL_0128 Homo sapiens 10uM 24H
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
NL20 CVCL_0461 Homo sapiens 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 10uM 6H, 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.002uM - 10uM 6H, 24H
A549/Asc-1 CVCL_YA87 Homo sapiens 0.04uM - 10uM 24H
DV-90 CVCL_1184 Homo sapiens 10uM 6H
SK-LU-1 CVCL_0624 Homo sapiens 10uM 6H
Lung adenosquamous carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H596 CVCL_1571 Homo sapiens 10uM 6H
Lung large cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COR-L23 CVCL_1133 Homo sapiens 10uM 6H
T3M-10 CVCL_1729 Homo sapiens 10uM 6H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC15 CVCL_1253 Homo sapiens 10uM 6H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1299 CVCL_0060 Homo sapiens 10uM 6H
HCC515 CVCL_5134 Homo sapiens 0.04uM - 10uM 6H, 24H
NCI-H2073 CVCL_1523 Homo sapiens 10uM 6H
Normal (Fibroblast)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HFL1 CVCL_4295 Homo sapiens 10uM 24H
IMR-90 CVCL_0347 Homo sapiens 10uM 24H
WI-38 CVCL_0579 Homo sapiens 10uM 24H
Small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1694 CVCL_1495 Homo sapiens 10uM 6H
NCI-H1836 CVCL_1502 Homo sapiens 10uM 6H
Lymph node
Diffuse large B-cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
WSU-DLCL2 CVCL_1787 Homo sapiens 10uM 6H
Ovary
Ovarian carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
EFO-27 CVCL_1194 Homo sapiens 10uM 6H
OV7 CVCL_1623 Homo sapiens 10uM 6H
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
RMG-I CVCL_1663 Homo sapiens 10uM 6H
Ovarian mucinous cystadenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COV644 CVCL_2011 Homo sapiens 10uM 6H
RMUG-S CVCL_1666 Homo sapiens 10uM 6H
Ovarian undifferentiated carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
TYK-nu CVCL_1774 Homo sapiens 10uM 6H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 6H, 24H
Acute myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NOMO-1 CVCL_1609 Homo sapiens 10uM 6H
PL-21 CVCL_2161 Homo sapiens 10uM 6H
SKM-1 CVCL_0010 Homo sapiens 10uM 6H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Pleural effusion
Histiocytic lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-937 CVCL_0007 Homo sapiens 10uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H
SK-L CVCL_1699 Homo sapiens 0.04uM - 10uM 24H
SK-MEL-1 CVCL_0523 Homo sapiens 10uM 6H
SK-MEL-28 CVCL_0526 Homo sapiens 10uM 6H
Stomach
Gastric adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
AGS CVCL_0139 Homo sapiens 10uM 6H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.04uM - 10uM 24H