Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM4TGY0)

Drug Name
CGP-60474 Drug Info
Synonyms
CGP60474; 164658-13-3; CGP-60474; UNII-16IP6G5MLC; CGP 60474; GNF-Pf-88; 16IP6G5MLC; 3-[[4-[2-[(3-Chlorophenyl)amino]-4-pyrimidinyl]-2-pyridinyl]amino]-1-propanol; MLS000911536; SMR000463552; 3-[[4-[2-(3-chloroanilino)pyrimidin-4-yl]-2-pyridyl]amino]propan-1-ol; 3-[[4-[2-(3-chloroanilino)pyrimidin-4-yl]pyridin-2-yl]amino]propan-1-ol; 1-Propanol, 3-((4-(2-((3-chlorophenyl)amino)-4-pyrimidinyl)-2-pyridinyl)amino)-; 1-propanol, 3-[[4-[2-[(3-chlorophenyl)amino]-4-pyrimidinyl]-2-pyridinyl]amino]-; AC1LD8S6; MLS003105942
Cross-matching ID
PubChem CID
644215
ChEBI ID
CHEMBL91339
CAS Number
CAS 164658-13-3
TTD Drug ID
D0U2TQ

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Lysosome 2.41 0.00e+0 115/128 (89.84%) CTSC;MAN2B1;CTSZ;...
Valine, leucine and isoleucine degradation 2.39 0.00e+0 42/48 (87.5%) ALDH6A1;OXCT1;ACADM;...
Oxidative phosphorylation 2.18 0.00e+0 93/133 (69.92%) ATP6AP1;ATP6V0B;ATP6V0E2;...
Complement and coagulation cascades 2.15 0.00e+0 76/85 (89.41%) SERPING1;CLU;CFI;...
Pentose phosphate pathway 2.14 0.00e+0 25/30 (83.33%) RPIA;GPI;FBP1;...
Rheumatoid arthritis 2.09 0.00e+0 78/93 (83.87%) HLA-DQA1;ATP6AP1;ATP6V0B;...
Glycine, serine and threonine metabolism 2.03 0.00e+0 31/40 (77.5%) MAOA;SHMT2;ALDH7A1;...
Graft-versus-host disease 2.03 0.00e+0 32/42 (76.19%) HLA-DQA1;HLA-DPB1;IL1A;...
Tryptophan metabolism 2.01 0.00e+0 35/42 (83.33%) MAOA;AOX1;ECHS1;...
Glycosaminoglycan degradation 2.00 0.00e+0 19/19 (100%) HEXA;GUSB;IDS;...
beta-Alanine metabolism 2.00 0.00e+0 25/30 (83.33%) ALDH6A1;ECHS1;GAD1;...
Various types of N-glycan biosynthesis 1.99 0.00e+0 26/39 (66.67%) DDOST;HEXA;DAD1;...
Phagosome 1.96 0.00e+0 118/152 (77.63%) HLA-DQA1;ITGB5;ATP6AP1;...
Glycolysis / Gluconeogenesis 1.96 0.00e+0 56/67 (83.58%) ADH1B;GPI;FBP1;...
ECM-receptor interaction 1.95 0.00e+0 80/88 (90.91%) COL6A3;ITGB5;COL6A2;...
Retrograde endocannabinoid signaling 1.90 2.47e-3 118/148 (79.73%) ADCY7;NDUFA7;NDUFA1;...
Cell adhesion molecules 1.89 3.10e-3 118/148 (79.73%) HLA-DQA1;SDC2;HLA-DPB1;...
Arginine and proline metabolism 1.88 3.65e-3 39/50 (78%) MAOA;P4HA1;PYCR1;...
Type I diabetes mellitus 1.85 5.54e-3 38/43 (88.37%) HLA-DQA1;HLA-DPB1;GAD1;...
Butanoate metabolism 1.83 7.23e-3 23/28 (82.14%) ALDH5A1;OXCT1;ECHS1;...
Allograft rejection 1.81 8.14e-3 32/38 (84.21%) HLA-DQA1;HLA-DPB1;HLA-C;...
Viral myocarditis 1.80 8.97e-3 53/60 (88.33%) HLA-DQA1;EIF4G3;CYCS;...
Fatty acid elongation 1.80 8.58e-3 19/27 (70.37%) PPT1;ACOT7;ECHS1;...
Other glycan degradation 1.79 8.22e-3 13/18 (72.22%) MAN2B1;MAN2B2;HEXA;...
Propanoate metabolism 1.77 8.94e-3 30/34 (88.24%) ALDH6A1;SUCLG2;ECHS1;...
Thermogenesis 1.76 9.11e-3 173/232 (74.57%) ADCY7;NDUFA7;NDUFA1;...
Alanine, aspartate and glutamate metabolism 1.75 1.02e-2 27/37 (72.97%) ALDH5A1;GLUD2;GAD1;...
Tyrosine metabolism 1.74 1.04e-2 30/36 (83.33%) MAOA;ADH1B;AOX1;...
N-Glycan biosynthesis 1.74 1.01e-2 38/50 (76%) DDOST;GANAB;DAD1;...
Diabetic cardiomyopathy 1.74 1.02e-2 162/203 (79.8%) COL1A2;NDUFA7;NDUFA1;...
Terpenoid backbone biosynthesis -1.76 2.09e-2 18/22 (81.82%) MVD;GGPS1;HMGCR;...
MicroRNAs in cancer -1.87 7.30e-3 146/310 (47.1%) ITGA5;PIK3R3;NFKB1;...
Cell cycle -2.00 2.92e-3 110/124 (88.71%) YWHAH;TP53;SKP2;...
RNA transport -2.00 3.65e-3 128/186 (68.82%) EIF3B;EIF2B2;PRMT5;...
mRNA surveillance pathway -2.04 2.43e-3 71/98 (72.45%) CSTF3;PPP1CA;FUS;...
Ribosome biogenesis in eukaryotes -2.19 0.00e+0 52/108 (48.15%) RCL1;GNL3;XPO1;...
Spliceosome -2.38 0.00e+0 101/150 (67.33%) HSPA6;PQBP1;HSPA1L;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone marrow
Neuroblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SH-SY5Y CVCL_0019 Homo sapiens 0.04uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
SK-BR-3 CVCL_0033 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
Breast carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BT-20 CVCL_0178 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
Hs 578T CVCL_0332 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
Normal (Epithelial)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HME1 CVCL_2950 Homo sapiens 0.04uM - 10uM 3H, 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.04uM - 0.12uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.04uM - 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 0.04uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.04uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.04uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 10uM 6H, 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.04uM - 10uM 6H, 24H
A549/Asc-1 CVCL_YA87 Homo sapiens 0.04uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 0.04uM - 10uM 6H, 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.04uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.04uM - 3.33uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 3.33uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
LNCaP CVCL_0395 Homo sapiens 0.04uM - 10uM 3H, 24H
PC-3 CVCL_0035 Homo sapiens 0.04uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.04uM - 10uM 6H, 24H
SK-L CVCL_1699 Homo sapiens 0.04uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.04uM - 10uM 24H