Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM4ZBK6)

Drug Name
Fedratinib Drug Info
Synonyms TG101348
Cross-matching ID
PubChem CID
16722836
ChEBI ID
CHEMBL1287853
CAS Number
CAS 936091-26-8
TTD Drug ID
D0G8BM
ACDINA Drug ID
D01069

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Steroid biosynthesis 2.22 0.00e+0 19/20 (95%) MSMO1;DHCR7;LSS;...
Synaptic vesicle cycle 2.15 0.00e+0 63/78 (80.77%) STXBP1;SYT1;UNC13B;...
mTOR signaling pathway 2.14 0.00e+0 114/154 (74.03%) DDIT4;RRAGC;PDPK1;...
Autophagy 2.13 0.00e+0 113/169 (66.86%) DDIT4;RRAGC;CTSB;...
Inositol phosphate metabolism 2.10 0.00e+0 66/73 (90.41%) PIP5K1B;CDIPT;ALDH6A1;...
Valine, leucine and isoleucine degradation 2.09 0.00e+0 42/48 (87.5%) ABAT;AACS;HMGCS1;...
Lysosome 2.06 0.00e+0 115/128 (89.84%) NEU1;CTSB;CTSK;...
Insulin signaling pathway 2.05 0.00e+0 121/137 (88.32%) PRKAR2B;PDPK1;PPP1CC;...
Pyruvate metabolism 2.04 1.48e-3 41/47 (87.23%) HAGH;ACAT2;PCK2;...
Vibrio cholerae infection 2.02 1.33e-3 44/50 (88%) ADCY9;ATP6V1G1;ATP6V1A;...
Collecting duct acid secretion 2.02 1.21e-3 22/27 (81.48%) CA2;ATP6V1G1;ATP6V1A;...
Biosynthesis of unsaturated fatty acids 1.96 1.11e-3 21/27 (77.78%) SCD;ACOT7;ACAA1;...
Phosphatidylinositol signaling system 1.93 1.02e-3 82/97 (84.54%) PIP5K1B;CDIPT;IP6K2;...
Oxidative phosphorylation 1.91 9.51e-4 93/133 (69.92%) ATP6V1G1;ATP6V1A;COX6A1;...
Glycine, serine and threonine metabolism 1.89 8.87e-4 31/40 (77.5%) PSAT1;CTH;ALDH7A1;...
Insulin resistance 1.85 1.66e-3 96/108 (88.89%) PDPK1;PPP1CC;INSR;...
Endocrine and other factor-regulated calcium reabsorpti... 1.85 1.57e-3 49/53 (92.45%) ADCY9;ATP1B3;ATP2B1;...
Thyroid hormone signaling pathway 1.83 2.96e-3 112/121 (92.56%) NCOA3;PDPK1;ATP1B3;...
Bacterial invasion of epithelial cells 1.82 4.20e-3 59/77 (76.62%) ACTB;CRK;ACTR2;...
Terpenoid backbone biosynthesis 1.82 4.66e-3 18/22 (81.82%) IDI1;PCYOX1;FDPS;...
Proximal tubule bicarbonate reclamation 1.79 8.24e-3 21/23 (91.3%) CA2;ATP1B3;PCK2;...
Sphingolipid metabolism 1.77 9.68e-3 32/49 (65.31%) NEU1;ASAH1;PSAP;...
Mitophagy 1.76 1.22e-2 56/68 (82.35%) BNIP3L;FOXO3;PINK1;...
Cushing syndrome 1.75 1.39e-2 125/155 (80.65%) CDKN1A;ADCY9;GNAI2;...
Diabetic cardiomyopathy 1.73 1.49e-2 162/203 (79.8%) PPP1CC;INSR;SLC25A4;...
AMPK signaling pathway 1.72 1.43e-2 106/120 (88.33%) SCD;PDPK1;INSR;...
Citrate cycle (TCA cycle) 1.72 1.53e-2 30/30 (100%) PCK2;IDH1;IDH3A;...
Cardiac muscle contraction 1.69 2.28e-2 64/87 (73.56%) CACNA2D2;COX6A1;ATP1B3;...
Glyoxylate and dicarboxylate metabolism 1.67 2.98e-2 23/30 (76.67%) ACAT2;GRHPR;ACO1;...
Melanogenesis 1.66 3.11e-2 74/101 (73.27%) ADCY9;GNAI2;GSK3B;...
Cytosolic DNA-sensing pathway -1.61 2.55e-2 52/63 (82.54%) POLR1D;NFKB1;POLR3C;...
Chagas disease -1.64 1.66e-2 93/102 (91.18%) C1QA;CD247;PPP2R2B;...
Measles -1.65 1.60e-2 133/139 (95.68%) TLR2;CASP8;NFKB1;...
Graft-versus-host disease -1.67 1.58e-2 32/42 (76.19%) KIR3DL1;TNF;HLA-DPB1;...
RIG-I-like receptor signaling pathway -1.68 1.43e-2 64/70 (91.43%) IKBKG;NFKBIB;MAPK10;...
Mismatch repair -1.70 1.41e-2 22/23 (95.65%) POLD1;POLD3;RFC5;...
Proteasome -1.73 7.75e-3 44/46 (95.65%) POMP;PSMC4;PSMA6;...
Malaria -1.74 7.49e-3 44/50 (88%) IL6;ACKR1;TGFB2;...
TNF signaling pathway -1.75 7.83e-3 103/112 (91.96%) CXCL5;IL15;TRAF2;...
Type I diabetes mellitus -1.75 7.22e-3 38/43 (88.37%) HLA-DOB;GAD1;FASLG;...
Fanconi anemia pathway -1.77 6.55e-3 36/54 (66.67%) TOP3A;TELO2;FANCA;...
Drug metabolism -1.77 6.89e-3 78/151 (51.66%) NME1;GSTM5;CYP1A2;...
Pertussis -1.78 6.13e-3 64/76 (84.21%) SFTPA2;TICAM1;TLR4;...
NF-kappa B signaling pathway -1.79 6.49e-3 90/104 (86.54%) TNFSF14;PLAU;CXCL2;...
Influenza A -1.81 6.03e-3 156/172 (90.7%) PRKCA;RAE1;CXCL10;...
Hematopoietic cell lineage -1.86 2.76e-3 90/99 (90.91%) FCER2;IL9R;HLA-DRA;...
Inflammatory bowel disease -1.86 2.46e-3 58/65 (89.23%) TNF;IL13;HLA-DPB1;...
Complement and coagulation cascades -1.87 2.12e-3 76/85 (89.41%) C7;PROCR;TFPI;...
Primary immunodeficiency -1.90 5.74e-4 33/38 (86.84%) TNFRSF13B;CD79A;PTPRC;...
Asthma -1.92 6.26e-4 25/31 (80.65%) CD40;HLA-DRA;EPX;...
Ribosome biogenesis in eukaryotes -1.96 6.89e-4 52/108 (48.15%) NOP10;POP4;MDN1;...
IL-17 signaling pathway -1.99 7.66e-4 84/94 (89.36%) CXCL3;IL6;MMP13;...
Homologous recombination -1.99 8.61e-4 35/41 (85.37%) TOP3A;SEM1;RAD54B;...
Intestinal immune network for IgA production -2.00 0.00e+0 38/48 (79.17%) MADCAM1;TGFB1;CD28;...
Pyrimidine metabolism -2.00 0.00e+0 40/56 (71.43%) NT5C;NME1;ENTPD6;...
Cytokine-cytokine receptor interaction -2.11 0.00e+0 246/295 (83.39%) IL26;TNFSF8;IFNA4;...
Systemic lupus erythematosus -2.11 0.00e+0 45/135 (33.33%) GRIN2A;CD28;C2;...
Staphylococcus aureus infection -2.34 0.00e+0 72/95 (75.79%) KRT9;ITGAL;HLA-DPB1;...
DNA replication -2.35 0.00e+0 34/36 (94.44%) MCM4;RNASEH2B;POLD1;...
Viral protein interaction with cytokine and cytokine re... -2.37 0.00e+0 84/100 (84%) CCL1;CXCL3;IL6;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-673 CVCL_0080 Homo sapiens 12uM 6H
Bone marrow
Chronic myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
K-562 CVCL_0004 Homo sapiens 0.01uM - 10uM 4H, 24H
HAP1 CVCL_Y019 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 BRD4 (-) 1 CVCL_SF59 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 CDK4 (-) 1 CVCL_SI36 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 HDAC5 (-) 1 CVCL_SR11 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 ITGA4 (-) 1 CVCL_ST27 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 MAPK8 (-) 1 CVCL_SW99 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 PIK3CA (-) 1 CVCL_TD60 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 PRKACA (-) 1 CVCL_TG70 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 PRKCQ (-) CVCL_TG92 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 RELA (-) 1 CVCL_TI75 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 SRC (-) 1 CVCL_TQ36 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 TP53 (-) 1 CVCL_RJ70 Homo sapiens 0.66uM - 3.33uM 24H
Multiple myeloma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
KMS-34 CVCL_1333 Homo sapiens 0.01uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.04uM - 12uM 3H, 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
SK-BR-3 CVCL_0033 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
Breast carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BT-20 CVCL_0178 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
Hs 578T CVCL_0332 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
Colon
Colon carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCT 116 TP53(-/-) CVCL_HD97 Homo sapiens 0.04uM - 10uM 24H
HCT 116 CVCL_0291 Homo sapiens 0.04uM - 10uM 24H
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CL-34 CVCL_1123 Homo sapiens 12uM 6H
HT-29 CVCL_0320 Homo sapiens 0.04uM - 12uM 6H, 24H
LoVo CVCL_0399 Homo sapiens 12uM 6H
MDST8 CVCL_1400 Homo sapiens 12uM 6H
NCI-H508 CVCL_1561 Homo sapiens 12uM 6H
SNU-1040 CVCL_5001 Homo sapiens 12uM 6H
SNU-C4 CVCL_5008 Homo sapiens 12uM 6H
SNU-C5 CVCL_5009 Homo sapiens 12uM 6H
SW480 CVCL_0546 Homo sapiens 12uM 6H
SW620 CVCL_0547 Homo sapiens 12uM 6H
SW948 CVCL_0550 Homo sapiens 12uM 6H
Colorectal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCT 116 CVCL_0291 Homo sapiens 12uM 6H
HCT 116 (Parent) CVCL_0291 Homo sapiens 0.04uM - 10uM 24H
HT115 CVCL_1294 Homo sapiens 12uM 6H
RKO CVCL_0504 Homo sapiens 12uM 6H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 12uM 6H
SNG-M CVCL_1707 Homo sapiens 12uM 6H
Endometrial carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHUEM-2 CVCL_1327 Homo sapiens 12uM 6H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.04uM - 12uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 12uM 6H, 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.04uM - 12uM 6H, 24H
DV-90 CVCL_1184 Homo sapiens 12uM 6H
SK-LU-1 CVCL_0624 Homo sapiens 12uM 6H
Lung adenosquamous carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H596 CVCL_1571 Homo sapiens 12uM 6H
Lung large cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COR-L23 CVCL_1133 Homo sapiens 12uM 6H
T3M-10 CVCL_1729 Homo sapiens 12uM 6H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC15 CVCL_1253 Homo sapiens 12uM 6H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1299 CVCL_0060 Homo sapiens 12uM 6H
HCC515 CVCL_5134 Homo sapiens 0.04uM - 12uM 6H, 24H
NCI-H2073 CVCL_1523 Homo sapiens 12uM 6H
Small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1694 CVCL_1495 Homo sapiens 12uM 6H
NCI-H1836 CVCL_1502 Homo sapiens 12uM 6H
Lymph node
Burkitt lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BJAB CVCL_5711 Homo sapiens 0.01uM - 10uM 24H
Diffuse large B-cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HBL-1 CVCL_4213 Homo sapiens 0.01uM - 10uM 4H, 24H
OCI-Ly19 CVCL_8797 Homo sapiens 0.01uM - 10uM 4H, 24H
OCI-Ly3 CVCL_8796 Homo sapiens 0.01uM - 10uM 4H, 24H
TMD8 CVCL_A440 Homo sapiens 0.01uM - 10uM 4H, 24H
WSU-DLCL2 CVCL_1787 Homo sapiens 12uM 6H
Mantle cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MINO CVCL_4965 Homo sapiens 0.01uM - 10uM 24H
Ovary
Ovarian carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
EFO-27 CVCL_1194 Homo sapiens 12uM 6H
OV7 CVCL_1623 Homo sapiens 12uM 6H
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
RMG-I CVCL_1663 Homo sapiens 12uM 6H
Ovarian mucinous cystadenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COV644 CVCL_2011 Homo sapiens 12uM 6H
RMUG-S CVCL_1666 Homo sapiens 12uM 6H
Ovarian undifferentiated carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
TYK-nu CVCL_1774 Homo sapiens 12uM 6H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 8uM 6H
Peripheral blood
Acute B-lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NALM-6 CVCL_0092 Homo sapiens 0.01uM - 10uM 24H
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 12uM 6H, 24H
Acute myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NOMO-1 CVCL_1609 Homo sapiens 12uM 6H
PL-21 CVCL_2161 Homo sapiens 12uM 6H
SKM-1 CVCL_0010 Homo sapiens 12uM 6H
Pleural effusion
Histiocytic lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-937 CVCL_0007 Homo sapiens 12uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.04uM - 12uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 0.04uM - 12uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.04uM - 12uM 6H, 24H
SK-MEL-1 CVCL_0523 Homo sapiens 12uM 6H
SK-MEL-28 CVCL_0526 Homo sapiens 12uM 6H
SK-MEL-5 CVCL_0527 Homo sapiens 0.01uM - 10uM 24H
Stomach
Gastric adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
AGS CVCL_0139 Homo sapiens 12uM 6H