Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM5CBNY)

Drug Name
BIX-01294 Drug Info
Synonyms BIX01294; BIX 01294
Cross-matching ID
PubChem CID
25150857
ChEBI ID
CHEMBL569864
CAS Number
CAS 935693-62-2
TTD Drug ID
D06PPL

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
IL-17 signaling pathway 2.52 0.00e+0 84/94 (89.36%) CXCL8;NFKBIA;FOSL1;...
Steroid biosynthesis 2.47 0.00e+0 19/20 (95%) MSMO1;SQLE;DHCR7;...
Terpenoid backbone biosynthesis 2.30 0.00e+0 18/22 (81.82%) HMGCS1;IDI1;ACAT2;...
Epithelial cell signaling in Helicobacter pylori infect... 2.19 0.00e+0 62/70 (88.57%) CXCL8;NFKBIA;CXCL2;...
TNF signaling pathway 2.18 0.00e+0 103/112 (91.96%) NFKBIA;TNFAIP3;CXCL2;...
Rheumatoid arthritis 2.14 0.00e+0 78/93 (83.87%) CXCL8;CXCL2;CXCL3;...
NF-kappa B signaling pathway 2.02 0.00e+0 90/104 (86.54%) CXCL8;NFKBIA;TNFAIP3;...
C-type lectin receptor signaling pathway 1.98 0.00e+0 93/104 (89.42%) NFKBIA;RELB;PTGS2;...
Biosynthesis of unsaturated fatty acids 1.94 1.18e-3 21/27 (77.78%) SCD;ELOVL6;FADS2;...
Synthesis and degradation of ketone bodies 1.92 1.06e-3 9/10 (90%) HMGCS1;ACAT2
Cholesterol metabolism 1.92 9.63e-4 44/50 (88%) LDLR;NPC2;NPC1;...
PPAR signaling pathway 1.89 2.65e-3 66/74 (89.19%) HMGCS1;SCD;FADS2;...
Osteoclast differentiation 1.83 8.15e-3 117/127 (92.13%) SQSTM1;NFKBIA;FOSL1;...
Kaposi sarcoma-associated herpesvirus infection 1.81 9.08e-3 172/193 (89.12%) CXCL8;NFKBIA;CXCL2;...
Circadian rhythm 1.78 1.34e-2 26/31 (83.87%) BHLHE40;BHLHE41;RORA;...
NOD-like receptor signaling pathway 1.78 1.26e-2 145/181 (80.11%) CXCL8;NFKBIA;TNFAIP3;...
Viral protein interaction with cytokine and cytokine re... 1.77 1.25e-2 84/100 (84%) CXCL8;CXCL2;CXCL3;...
Lipid and atherosclerosis 1.76 1.35e-2 190/215 (88.37%) CXCL8;NFKBIA;LDLR;...
Viral carcinogenesis 1.72 2.18e-2 149/203 (73.4%) NFKBIA;ACTN1;EGR3;...
Butanoate metabolism 1.69 3.55e-2 23/28 (82.14%) HMGCS1;ACAT2;OXCT1;...
Legionellosis 1.69 3.43e-2 51/57 (89.47%) CXCL8;NFKBIA;CXCL2;...
Influenza A 1.68 3.37e-2 156/172 (90.7%) CXCL8;NFKBIA;FDPS;...
Collecting duct acid secretion 1.66 4.19e-2 22/27 (81.48%) ATP6V1B2;ATP6V1C1;ATP6V1G1;...
ErbB signaling pathway 1.65 4.28e-2 79/85 (92.94%) CRK;CDKN1B;ERBB4;...
B cell receptor signaling pathway 1.65 4.11e-2 71/81 (87.65%) NFKBIA;LILRA2;NFKB1;...
T cell receptor signaling pathway 1.64 4.12e-2 93/104 (89.42%) NFKBIA;NFKB1;KRAS;...
Transcriptional misregulation in cancer 1.64 4.16e-2 158/192 (82.29%) CXCL8;DUSP6;PLAT;...
Measles 1.63 4.66e-2 133/139 (95.68%) NFKBIA;TNFAIP3;FADD;...
Dilated cardiomyopathy -1.81 3.72e-2 86/96 (89.58%) ITGA9;LAMA1;ITGA1;...
Cardiac muscle contraction -1.90 9.29e-3 64/87 (73.56%) COX7A2L;HRC;MYH7;...
Hypertrophic cardiomyopathy -1.93 4.64e-3 81/90 (90%) ITGA9;LAMA1;ITGA1;...
Cysteine and methionine metabolism -2.02 0.00e+0 43/50 (86%) SDS;GCLM;MAT2A;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SK-ES-1 CVCL_0627 Homo sapiens 1.11uM 24H
Bone marrow
Neuroblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SH-SY5Y CVCL_0019 Homo sapiens 0.04uM - 10uM 24H
Brain
Glioma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
GI-1 CVCL_1230 Homo sapiens 1.11uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.04uM - 10uM 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.04uM - 10uM 24H
MDA-MB-468 CVCL_0419 Homo sapiens 1.11uM - 10uM 24H
Breast ductal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
T-47D CVCL_0553 Homo sapiens 1.11uM - 10uM 24H
Normal (Epithelial)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HME1 CVCL_2950 Homo sapiens 0.04uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.04uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.04uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.04uM - 10uM 6H, 24H
SNU-407 CVCL_5004 Homo sapiens 1.11uM - 3.33uM 24H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 1.11uM 24H
HEC-1-A CVCL_0293 Homo sapiens 1.11uM - 3.33uM 24H
HEC-251 CVCL_2928 Homo sapiens 1.11uM - 10uM 24H
HEC-265 CVCL_2929 Homo sapiens 1.11uM 24H
Fibroblast
Nasopharyngeal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
FIBRNPC CVCL_UK07 Homo sapiens 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 0.04uM - 10uM 24H
CJM CVCL_U797 Homo sapiens 1.11uM - 3.33uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.04uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.04uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 10uM 24H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHH-5 CVCL_1320 Homo sapiens 1.11uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.04uM - 10uM 6H, 24H
A549/Asc-1 CVCL_YA87 Homo sapiens 0.04uM - 10uM 24H
NCI-H1573 CVCL_1483 Homo sapiens 1.11uM - 10uM 24H
NCI-H838 CVCL_1594 Homo sapiens 1.11uM - 3.33uM 24H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BEN CVCL_1081 Homo sapiens 1.11uM - 3.33uM 24H
HCC95 CVCL_1276 Homo sapiens 1.11uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 0.04uM - 10uM 6H, 24H
NCI-H2110 CVCL_1529 Homo sapiens 1.11uM - 3.33uM 24H
Ovary
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OVTOKO CVCL_3114 Homo sapiens 1.11uM - 3.33uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.04uM - 10uM 6H, 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.04uM - 3.33uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
22Rv1 CVCL_1045 Homo sapiens 1.11uM 24H
PC-3 CVCL_0035 Homo sapiens 0.04uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.04uM - 10uM 6H, 24H
IGR-37 CVCL_1303 Homo sapiens 1.11uM 24H
Mel-HO CVCL_1402 Homo sapiens 1.11uM - 3.33uM 24H
SH-4 CVCL_1692 Homo sapiens 1.11uM 24H
SK-L CVCL_1699 Homo sapiens 0.04uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.04uM - 10uM 24H
Urinary bladder
Bladder transitional cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CAL-29 CVCL_1109 Homo sapiens 1.11uM - 3.33uM 24H