Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM5I2HL)

Drug Name
GSK269962A Drug Info
Synonyms GSK-269962A; GSK269962; GSK 269962; GSK-269962; aminofurazanyl-azabenzimidazole 6n
Cross-matching ID
PubChem CID
16095342
ChEBI ID
CHEMBL220241
CAS Number
CAS 925213-63-4
TTD Drug ID
D02ZQS

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Steroid hormone biosynthesis 2.15 0.00e+0 43/61 (70.49%) AKR1C3;AKR1C1;AKR1C2;...
Metabolism of xenobiotics by cytochrome P450 1.96 1.68e-2 49/77 (63.64%) AKR1C1;UGT2B15;ADH1B;...
Retinol metabolism 1.87 1.68e-2 41/68 (60.29%) UGT2B15;ADH1B;ADH1C;...
Pentose and glucuronate interconversions 1.86 1.26e-2 17/34 (50%) UGT2B15;AKR1B1;UGDH;...
Tyrosine metabolism 1.83 1.68e-2 30/36 (83.33%) ADH1B;FAH;HGD;...
Fructose and mannose metabolism 1.79 3.22e-2 30/33 (90.91%) PFKL;TKFC;ALDOB;...
Asthma 1.77 3.36e-2 25/31 (80.65%) CD40;PRG2;HLA-DPA1;...
Porphyrin and chlorophyll metabolism 1.77 2.94e-2 23/43 (53.49%) UGT2B15;PPOX;CPOX;...
N-Glycan biosynthesis 1.75 3.08e-2 38/50 (76%) ST6GAL1;MAN1C1;MGAT4B;...
Pentose phosphate pathway 1.73 3.70e-2 25/30 (83.33%) PFKL;RPIA;PGLS;...
Terpenoid backbone biosynthesis -1.92 1.60e-2 18/22 (81.82%) MVK;GGPS1;MVD;...
Cardiac muscle contraction -2.00 5.99e-3 64/87 (73.56%) TPM2;ATP1B2;COX7A2;...
Steroid biosynthesis -2.12 0.00e+0 19/20 (95%) NSDHL;CYP51A1;DHCR7;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.04uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.04uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.04uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.04uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.04uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.04uM - 10uM 24H