Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM5IXKQ)

Drug Name
Vismodegib Drug Info
Synonyms
879085-55-9; GDC-0449; Erivedge; 2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonyl)benzamide; Vismodegib (GDC-0449); HhAntag691; GDC0449; GDC 0449; UNII-25X868M3DS; CHEMBL473417; CHEBI:66903; 25X868M3DS; NSC755986; AK-77261; 2-chloro-N-[4-chloro-3-(pyridin-2-yl)phenyl]-4-(methylsulfonyl)benzamide; C19H14Cl2N2O3S; 2-chloro-N-(4-chloro-3-pyridin-2-ylphenyl)-4-methylsulfonylbenzamide; 2-chloro-n-(4-chloro-3-(2-pyridinyl)phenyl)-4-(methylsulfonyl)benzamide; Erivedge (TN); Vismodegib (SHH inhibitor); Gdc-0449
Cross-matching ID
PubChem CID
24776445
ChEBI ID
CHEMBL473417
CAS Number
CAS 879085-55-9
TTD Drug ID
D03EDQ
VARIDT Drug ID
DR00234
INTEDE Drug ID
DR1698
ACDINA Drug ID
D00730

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Fructose and mannose metabolism 2.02 0.00e+0 30/33 (90.91%) PFKL;TPI1;AKR1B10;...
Allograft rejection 1.96 0.00e+0 32/38 (84.21%) CD40;HLA-DPA1;HLA-DPB1;...
Central carbon metabolism in cancer 1.92 7.56e-3 67/70 (95.71%) FGFR3;PGAM1;PFKL;...
Ferroptosis 1.90 1.13e-2 36/41 (87.8%) SLC39A14;SLC39A8;ACSL5;...
DNA replication 1.89 1.36e-2 34/36 (94.44%) PCNA;MCM6;MCM2;...
Ribosome biogenesis in eukaryotes 1.88 1.13e-2 52/108 (48.15%) NOP56;NXT1;CSNK2A1;...
Toxoplasmosis 1.88 9.72e-3 103/112 (91.96%) HSPA8;CD40;BIRC3;...
Proteasome 1.87 8.50e-3 44/46 (95.65%) PSMF1;PSMA2;ADRM1;...
Proximal tubule bicarbonate reclamation 1.82 2.02e-2 21/23 (91.3%) CA2;PCK1;ATP1B3;...
Glycolysis / Gluconeogenesis 1.81 2.15e-2 56/67 (83.58%) PGAM1;PFKL;ADH1C;...
Antigen processing and presentation 1.81 1.96e-2 60/78 (76.92%) HSPA8;HSPA4;HLA-DPA1;...
Arginine biosynthesis 1.81 1.98e-2 17/22 (77.27%) ARG2;GLUD2;GLUD1;...
Viral myocarditis 1.80 1.83e-2 53/60 (88.33%) CD40;HLA-DPA1;HLA-DPB1;...
Intestinal immune network for IgA production 1.77 2.11e-2 38/48 (79.17%) CD40;HLA-DPA1;TGFB1;...
Cell cycle 1.77 1.97e-2 110/124 (88.71%) PCNA;ORC1;TGFB1;...
RNA transport 1.74 2.48e-2 128/186 (68.82%) NUP85;NXT1;EIF2S2;...
Vitamin digestion and absorption 1.71 3.47e-2 17/24 (70.83%) APOB;APOA1;ABCC1;...
Graft-versus-host disease 1.70 3.28e-2 32/42 (76.19%) HLA-DPA1;HLA-DPB1;HLA-C;...
Spliceosome 1.68 3.82e-2 101/150 (67.33%) HSPA8;SNRPB;SNRPB2;...
Non-homologous end-joining 1.66 4.87e-2 11/13 (84.62%) XRCC5;FEN1;DCLRE1C;...
Alanine, aspartate and glutamate metabolism 1.65 4.91e-2 27/37 (72.97%) GLUD2;GLUD1;GOT1;...
Purine metabolism 1.65 5.00e-2 102/129 (79.07%) PRPS2;HPRT1;GUCY1A1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 0.04uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H