Details of the Drug

General Information of Drug (ID: DM5IXKQ)

Drug Name
Vismodegib
Synonyms
879085-55-9; GDC-0449; Erivedge; 2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonyl)benzamide; Vismodegib (GDC-0449); HhAntag691; GDC0449; GDC 0449; UNII-25X868M3DS; CHEMBL473417; CHEBI:66903; 25X868M3DS; NSC755986; AK-77261; 2-chloro-N-[4-chloro-3-(pyridin-2-yl)phenyl]-4-(methylsulfonyl)benzamide; C19H14Cl2N2O3S; 2-chloro-N-(4-chloro-3-pyridin-2-ylphenyl)-4-methylsulfonylbenzamide; 2-chloro-n-(4-chloro-3-(2-pyridinyl)phenyl)-4-(methylsulfonyl)benzamide; Erivedge (TN); Vismodegib (SHH inhibitor); Gdc-0449
Indication
Disease Entry ICD 11 Status REF
Basal cell carcinoma 2C32 Approved [1]
Primitive neuroectodermal tumour medulloblastoma 2A00.11 Phase 2 [2]
Affected Organisms
Humans and other mammals
ATC Code
L01XJ01: Vismodegib
L01XJ: Hedgehog pathway inhibitors
L01X: OTHER ANTINEOPLASTIC AGENTS
L01: ANTINEOPLASTIC AGENTS
L: ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 421.3
Logarithm of the Partition Coefficient (xlogp) 3.8
Rotatable Bond Count (rotbonds) 4
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 4
ADMET Property
BDDCS Class
Biopharmaceutics Drug Disposition Classification System (BDDCS) Class 4: low solubility and low permeability [3]
Bioavailability
The bioavailability of drug is 31.8% []
Clearance
The drug present in the plasma can be removed from the body at the rate of 0.01 mL/min/kg [4]
Half-life
The concentration or amount of drug in body reduced by one-half in 12 days [4]
Metabolism
The drug is not metabolised []
Unbound Fraction
The unbound fraction of drug in plasma is 0.01% [4]
Vd
The volume of distribution (Vd) of drug is 16.4-26.6 L []
Chemical Identifiers
Formula
C19H14Cl2N2O3S
IUPAC Name
2-chloro-N-(4-chloro-3-pyridin-2-ylphenyl)-4-methylsulfonylbenzamide
Canonical SMILES
CS(=O)(=O)C1=CC(=C(C=C1)C(=O)NC2=CC(=C(C=C2)Cl)C3=CC=CC=N3)Cl
InChI
InChI=1S/C19H14Cl2N2O3S/c1-27(25,26)13-6-7-14(17(21)11-13)19(24)23-12-5-8-16(20)15(10-12)18-4-2-3-9-22-18/h2-11H,1H3,(H,23,24)
InChIKey
BPQMGSKTAYIVFO-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
24776445
ChEBI ID
CHEBI:66903
CAS Number
879085-55-9
UNII
25X868M3DS
DrugBank ID
DB08828
TTD ID
D03EDQ
VARIDT ID
DR00234
INTEDE ID
DR1698
ACDINA ID
D00730
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug
Repurposed Drugs (RPD) Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Smoothened homolog (SMO) TT8J1S3 SMO_HUMAN Modulator [5]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4)
Main DME 		DE4LYSA CP3A4_HUMAN Substrate [6]
Cytochrome P450 2C9 (CYP2C9)
Main DME 		DE5IED8 CP2C9_HUMAN Substrate [6]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Gene/Protein Processing [7]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Protein Interaction/Cellular Processes [7]
N-myc proto-oncogene protein (MYCN) OTWD33K1 MYCN_HUMAN Drug Response [8]
Platelet-derived growth factor receptor alpha (PDGFRA) OTDJXUCN PGFRA_HUMAN Gene/Protein Processing [7]
Protein patched homolog 1 (PTCH1) OTMG07H5 PTC1_HUMAN Gene/Protein Processing [7]
Protein patched homolog 2 (PTCH2) OTOQ0K9V PTC2_HUMAN Gene/Protein Processing [7]
Protein smoothened (SMO) OTXXE208 SMO_HUMAN Gene/Protein Processing [7]
Suppressor of fused homolog (SUFU) OT0IRYG1 SUFU_HUMAN Drug Response [8]
Tumor necrosis factor receptor superfamily member 10A (TNFRSF10A) OTBPCU2O TR10A_HUMAN Gene/Protein Processing [7]
Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B) OTA1CPBV TR10B_HUMAN Gene/Protein Processing [7]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Basal cell carcinoma
ICD Disease Classification 2C32
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Smoothened homolog (SMO) DTT SMO 4.01E-06 -0.18 -0.35
Cytochrome P450 2C9 (CYP2C9) DME CYP2C9 4.91E-03 -1.59E-01 -3.84E-01
Cytochrome P450 3A4 (CYP3A4) DME CYP3A4 1.29E-36 -3.75E-01 -1.06E+00
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 40 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RPMI-3460/CS1 GDSC1; GDSC2 4.4069 6.2756 2.6212 2.1019
CAL-72 GDSC1; GDSC2 3.7976 6.8599 1.9321 7.5022
HuO-3N1 GDSC1; GDSC2 3.8145 5.9457 2.3945 4.5856
EW-7 GDSC1; GDSC2 4.2057 7.746 1.7962 7.3545
MG-63 GDSC1; GDSC2 4.2346 7.8137 1.7837 7.3638
SaOS-2 GDSC1; GDSC2 4.3913 6.7055 2.4165 3.2673
ES1 GDSC1; GDSC2 4.5023 7.3683 2.1775 4.4447
EW-24 GDSC1; GDSC2 4.59 7.5463 2.1498 4.4396
HOS GDSC1; GDSC2 4.6062 8.1657 1.8685 6.0539
ES7 GDSC1; GDSC2 4.6955 7.7674 2.1129 4.4575
A-673 GDSC1; GDSC2 4.6981 6.3607 2.7384 1.1417
TC-71 GDSC1; GDSC2 4.7218 6.2569 2.792 0.887
ES8 GDSC1; GDSC2 4.7454 6.9861 2.4961 2.2638
EW-18 GDSC1; GDSC2 4.822 6.9398 2.5572 1.8511
EW-3 GDSC1; GDSC2 4.8222 7.9538 2.1048 4.2772
CAL-78 GDSC1; GDSC2 4.9286 6.769 2.682 1.1519
EW-11 GDSC1; GDSC2 4.9643 7.5958 2.3487 2.7173
MHH-ES-1 GDSC1; GDSC2 4.9848 7.0012 2.6138 1.3931
EW-1 GDSC1; GDSC2 5.0281 7.1481 2.5742 1.5251
U-CH2 GDSC2 5.0585 7.0518 2.6286 1.2521
NY GDSC1; GDSC2 5.1897 8.4355 2.1029 3.6825
EW-13 GDSC1; GDSC2 5.2543 7.9877 2.3346 2.3946
ES4 GDSC1; GDSC2 5.2916 8.1219 2.2965 2.5347
SK-ES-1 GDSC1; GDSC2 5.4062 10.2867 1.3854 7.2624
NOS-1 [Human HNSCC] GDSC1; GDSC2 5.4355 8.2303 2.3249 2.2178
ES5 GDSC1; GDSC2 5.4553 9.3985 1.8236 4.7673
CHSA8926 GDSC1; GDSC2 5.5551 6.9945 2.8571 0.214
CADO-ES1 GDSC1; GDSC2 5.579 7.1609 2.8074 0.3077
SJSA-1 GDSC1; GDSC2 5.606 7.018 2.8673 0.1819
HuO9 GDSC1; GDSC2 5.6514 9.3368 1.9623 3.7361
ES6 GDSC1; GDSC2 5.6939 7.6775 2.6642 0.632
SK-PN-DW GDSC1; GDSC2 5.7113 7.4789 2.7439 0.4039
EW-12 GDSC2 5.7514 7.6605 2.6936 0.5166
CHSA0108 GDSC1; GDSC2 5.7943 8.001 2.5838 0.8249
EW-16 GDSC1; GDSC2 6.0868 8.2576 2.6075 0.5861
H-EMC-SS GDSC1; GDSC2 6.101 8.1992 2.6344 0.5082
CHSA0011 GDSC1; GDSC2 6.1164 8.3021 2.6029 0.584
G-292 clone A141B1 GDSC1; GDSC2 6.2555 8.0597 2.7413 0.2282
EW-22 GDSC1; GDSC2 6.4534 8.1325 2.7859 0.1263
U2OS GDSC1; GDSC2; CTRP1 7.1765 9.1811 4.3828 0.73
⏷ Show the Full List of 40 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 174 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JM1 GDSC1; GDSC2 5.0648 7.2915 2.5326 1.6753
SIG-M5 GDSC2 0.2475 1.3898 0.2447 30.8663
BL-41 GDSC1; GDSC2 3.5024 5.176 2.5407 4.4458
DoHH2 GDSC1; GDSC2 3.5858 6.3733 2.0102 7.5649
NB4 GDSC1; GDSC2 3.6134 4.8937 2.7637 2.7715
OCI-Ly7 GDSC1; GDSC2 3.6377 5.1227 2.6692 3.3
SU-DHL-6 GDSC1; GDSC2 3.6562 5.0779 2.7045 3.0375
EoL-1 GDSC1; GDSC2 3.6718 6.7361 1.8969 8.0466
MV4-11 GDSC1; GDSC2 3.6938 6.6713 1.9462 7.6809
CCRF-CEM GDSC1; GDSC2 3.6944 6.1128 2.2234 5.9436
Karpas-231 GDSC1; GDSC2 3.7021 5.7499 2.4084 4.7684
SCC-3 GDSC2 3.7739 5.2736 2.6923 2.8485
DEL GDSC1; GDSC2 3.7775 5.6743 2.5004 4.0168
Ramos.2G6.4C10 GDSC1; GDSC2 3.797 7.1168 1.8044 8.2975
GR-ST GDSC1; GDSC2 3.8007 7.0487 1.841 8.0609
BV-173 GDSC1; GDSC2 3.8041 6.3212 2.2027 5.8004
WSU-NHL GDSC1 3.808 6.5281 2.1037 7.9688
Karpas-1106P GDSC1; GDSC2 3.8404 5.8497 2.4597 4.1234
RPMI-6666 GDSC1; GDSC2 3.9016 6.0826 2.3898 4.414
KOPN-8 GDSC1; GDSC2 3.9041 5.5785 2.6342 2.9242
ST486 GDSC1 3.9223 5.5206 2.6736 3.3035
Reh GDSC1; GDSC2 3.9491 6.0441 2.4414 3.9938
JVM-3 GDSC1; GDSC2 3.9514 5.7014 2.607 2.9902
MEG-01 GDSC1; GDSC2 3.9813 6.0974 2.4378 3.9461
Karpas-422 GDSC1; GDSC2 3.9945 6.4655 2.2692 4.9446
697 GDSC1; GDSC2 3.9947 6.0226 2.4828 3.6457
OCI-AML-5 GDSC1; GDSC2 3.9962 5.2716 2.8352 1.5861
SUP-M2 GDSC1; GDSC2 4.0508 5.3443 2.8342 1.5041
DB GDSC1; GDSC2 4.0869 7.3342 1.9121 6.9227
SU-DHL-10 GDSC2 4.0869 5.2751 2.885 1.1809
L-363 GDSC1; GDSC2 4.0904 7.1029 2.0273 6.2091
KMS-12-BM GDSC1; GDSC2 4.1121 7.4857 1.8562 7.2057
Namalwa GDSC1; GDSC2 4.1164 5.9964 2.5746 2.8589
JJN-3 GDSC1; GDSC2 4.1227 6.3735 2.4008 3.8734
ALL-PO GDSC1; GDSC2 4.1231 7.1034 2.0501 5.9951
KG-1 GDSC1; GDSC2 4.136 6.3352 2.4278 3.6855
CML-T1 GDSC1; GDSC2 4.1372 5.7995 2.6786 2.2241
U-698-M GDSC1; GDSC2 4.1436 7.2402 1.9981 6.2664
Karpas-299 GDSC1; GDSC2 4.1506 5.8246 2.6752 2.2206
A4/Fukuda GDSC1; GDSC2 4.1584 7.2966 1.9812 6.3358
YT GDSC1; GDSC2 4.1662 7.6819 1.7992 7.4275
RPMI-8866 GDSC1; GDSC2 4.168 7.9279 1.6803 8.1463
SUP-B15 GDSC1; GDSC2 4.1705 6.4492 2.3963 3.8033
P32/ISH GDSC1; GDSC2 4.173 5.3916 2.8807 1.0866
GA-10 GDSC1; GDSC2 4.1781 6.7983 2.2351 4.7527
RPMI-8402 GDSC1; GDSC2 4.1938 6.1674 2.5436 2.8952
MN-60 GDSC1; GDSC2 4.1989 6.4601 2.4097 3.6681
JURL-MK1 GDSC1; GDSC2 4.2263 7.5303 1.9155 6.5831
MOLT-4 GDSC1; GDSC2 4.2273 6.3949 2.4585 3.3267
BE-13 GDSC1; GDSC2 4.2386 7.3998 1.9871 6.1214
IM-9 GDSC1; GDSC2 4.2432 5.7061 2.7818 1.4943
SR GDSC1; GDSC2 4.268 7.7455 1.8404 6.9449
NCI-H929 GDSC1; GDSC2 4.2691 6.6088 2.3849 3.6776
HH [Human lymphoma] GDSC1; GDSC2 4.2807 6.6086 2.3924 3.6116
SU-DHL-16 GDSC1; GDSC2 4.2809 5.6959 2.8067 1.3146
K-562 GDSC1; GDSC2 4.3085 6.2677 2.5674 2.5567
HAL-01 GDSC1; GDSC2 4.3143 6.9891 2.2348 4.4747
DND-41 GDSC1; GDSC2 4.3181 6.7061 2.3705 3.6682
BC-3 GDSC2 4.3222 7.337 2.0744 5.4154
OPM-2 GDSC1; GDSC2 4.3379 5.9594 2.7227 1.667
Karpas-620 GDSC1; GDSC2 4.3507 6.095 2.6699 1.927
BC-1 GDSC1; GDSC2 4.3554 6.4839 2.4966 2.8749
Raji GDSC1; GDSC2 4.3598 8.6672 1.4571 9.0381
P12-Ichikawa GDSC1 4.3717 8.0646 1.7582 8.9132
MOLT-13 GDSC1; GDSC2 4.3794 8.9697 1.3235 9.7829
BALL-1 GDSC1; GDSC2 4.3811 7.5822 1.9967 5.7574
MHH-PREB-1 GDSC1; GDSC2 4.3991 6.4189 2.5524 2.4895
SUP-T1 GDSC1; GDSC2 4.4001 7.3378 2.1258 4.9491
ALL-SIL GDSC1; GDSC2 4.4115 6.0917 2.7051 1.654
LAMA-84 GDSC1; GDSC2 4.4118 7.8045 1.911 6.2055
DG-75 GDSC1; GDSC2 4.4201 7.3342 2.1406 4.8214
LC4-1 GDSC1; GDSC2 4.4223 6.811 2.3868 3.3818
OCI-Ly19 GDSC1; GDSC2 4.4409 6.6531 2.4707 2.8745
A3/Kawakami GDSC1; GDSC2 4.4528 5.625 2.921 0.607
KY821 GDSC1; GDSC2 4.4568 7.8546 1.9174 6.0722
Jurkat GDSC1; GDSC2 4.4802 6.267 2.6658 1.76
SUP-B8 GDSC1; GDSC2 4.4842 6.4383 2.5926 2.1376
CTB-1 GDSC1; GDSC2 4.4968 8.9745 1.4048 9.0321
Loucy GDSC1; GDSC2 4.5038 8.1132 1.8253 6.5219
OCI-M1 GDSC1; GDSC2 4.5044 6.4672 2.5911 2.1155
KE-37 GDSC1; GDSC2 4.5241 6.0814 2.7685 1.1975
MOLT-16 GDSC1; GDSC2 4.5365 8.0119 1.8956 6.0366
H9 GDSC1; GDSC2 4.5529 6.8797 2.434 2.8915
WIL2 NS GDSC1; GDSC2 4.5631 6.8895 2.4356 2.8659
Hs 445 GDSC2 4.5766 6.1641 2.7601 1.1762
Karpas-45 GDSC1; GDSC2 4.5984 6.2338 2.7419 1.2362
HDLM-2 GDSC1; GDSC2 4.632 6.9981 2.4267 2.8038
ME1 GDSC1; GDSC2 4.6342 5.9885 2.8591 0.6953
CTV-1 GDSC1; GDSC2 4.6546 7.8649 2.0418 4.9447
Kasumi-1 GDSC1; GDSC2 4.6626 7.6889 2.1289 4.4257
TK [Human B-cell lymphoma] GDSC1; GDSC2 4.6716 6.1036 2.8304 0.7764
HL-60 GDSC1; GDSC2 4.699 6.6964 2.597 1.8129
RS4;11 GDSC1; GDSC2 4.7154 8.5069 1.7785 6.3617
CRO-AP2 GDSC1; GDSC2 4.7392 7.3918 2.3116 3.2625
MLMA GDSC1; GDSC2 4.7435 6.7969 2.5773 1.8529
ARH-77 GDSC1; GDSC2 4.749 6.6509 2.6425 1.5278
RCH-ACV GDSC1; GDSC2 4.7713 7.1948 2.4183 2.6343
PF-382 GDSC1; GDSC2 4.7714 7.0421 2.4858 2.2803
OCI-AML-2 GDSC1; GDSC2 4.786 6.1422 2.866 0.5524
KMOE-2 GDSC1; GDSC2 4.8578 7.6644 2.2578 3.3661
HC-1 GDSC1; GDSC2 4.8588 6.6344 2.7036 1.1284
KM-H2 GDSC1; GDSC2 4.8592 6.6027 2.7167 1.0717
ATN-1 GDSC1; GDSC2 4.8602 6.9773 2.5611 1.7839
NALM-6 GDSC1; GDSC2 4.8659 8.0643 2.0805 4.3375
L-540 GDSC1; GDSC2 4.8673 9.4092 1.4499 7.9623
MOLM-13 GDSC1; GDSC2 4.8815 7.2696 2.4463 2.3295
L-1236 GDSC1; GDSC2 4.892 7.5845 2.3132 3.0122
NKM-1 GDSC1; GDSC2 4.8962 9.1447 1.5948 7.0664
EM-2 GDSC1; GDSC2 4.9001 6.394 2.818 0.639
ML-2 GDSC1; GDSC2 4.9124 7.2643 2.4652 2.1912
CMK GDSC1 4.9138 7.1423 2.5185 2.3964
Farage GDSC1; GDSC2 4.9147 6.7654 2.6768 1.1881
Daudi GDSC1; GDSC2 4.9284 6.8438 2.6513 1.286
Jiyoye GDSC1; GDSC2 4.9355 7.1139 2.5418 1.7842
P31/FUJ GDSC1; GDSC2 4.9453 6.2318 2.898 0.3563
JSC-1 GDSC1; GDSC2 4.972 7.4153 2.4317 2.2805
SUP-HD1 GDSC1; GDSC2 4.9721 7.3976 2.4394 2.2416
JVM-2 GDSC1; GDSC2 5.0102 7.4689 2.4289 2.2435
RL GDSC1; GDSC2 5.0256 6.4512 2.8491 0.4551
MM1.S GDSC1; GDSC2 5.0715 6.7991 2.7356 0.8095
NK-92MI GDSC2 5.0822 7.2854 2.5438 1.6041
TUR GDSC1; GDSC2 5.0895 9.2771 1.6569 6.334
Mono-Mac-6 GDSC1; GDSC2 5.1128 8.8812 1.8551 5.1724
MOLP-8 GDSC1; GDSC2 5.123 6.8057 2.7555 0.6988
JeKo-1 GDSC1; GDSC2 5.1456 9.8959 1.4022 7.6701
U266B1 GDSC1; GDSC2 5.1918 8.1218 2.2429 2.9419
TALL-1 [Human adult T-ALL] GDSC2 5.21 8.649 2.0187 4.1045
HEL GDSC1; GDSC2 5.2124 6.4079 2.9364 0.1665
P30/OHK GDSC1; GDSC2 5.2355 6.9863 2.7343 0.6933
Sc-1 GDSC1 5.265 6.721 2.8452 0.43
VAL GDSC1; GDSC2 5.2673 7.32 2.6179 1.1014
ROS-50 GDSC1; GDSC2 5.3965 8.2081 2.3144 2.3148
CESS GDSC1; GDSC2 5.4124 7.1185 2.7578 0.5107
L-428 GDSC1; GDSC2 5.4396 7.3316 2.689 0.7088
PL21 CTRP1 5.4849 8.6126 3.6234 11.1692
GDM-1 GDSC1; GDSC2; CTRP1 5.4994 7.698 4.086 4.2505
SU-DHL-8 GDSC2 5.5018 6.6676 2.9498 0.0868
PL-21 GDSC1; GDSC2 5.5139 7.8456 2.5211 1.2708
SK-MM-2 GDSC1; GDSC2 5.5167 6.9656 2.8531 0.2331
MHH-CALL-2 GDSC1 5.5189 7.3558 2.7128 0.7287
WSU-DLCL2 GDSC1; GDSC2; CTRP1 5.5515 7.6665 4.1393 3.8634
Granta-519 GDSC1; GDSC2 5.5526 7.3136 2.742 0.4826
EB2 GDSC1; GDSC2 5.6263 7.0252 2.8722 0.1689
RC-K8 GDSC1 5.6419 7.1112 2.8481 0.2563
MY-M12 GDSC1; GDSC2 5.645 8.2098 2.4357 1.5002
BL-70 CTRP1 5.6539 6.9363 4.5575 2.5687
KCL-22 GDSC1; GDSC2 5.6699 7.601 2.6829 0.5896
THP-1 GDSC1; GDSC2; CTRP1 5.6889 7.791 4.1755 3.4103
MHH-CALL-4 GDSC2 5.6952 7.6858 2.6616 0.639
BONNA-12 GDSC2 5.7676 8.7883 2.2576 2.1505
CA46 GDSC1; GDSC2 5.8102 7.8152 2.66 0.5803
VL51 GDSC1; GDSC2 5.872 7.9466 2.6363 0.6158
EHEB GDSC1 5.89 8.1641 2.5622 1.0386
KMS-11 GDSC1; GDSC2; CTRP1 6.0402 9.2718 3.7036 5.2032
QIMR-WIL GDSC1; GDSC2 6.1035 14.155 0.0113 13.0021
MC116 GDSC1; GDSC2; CTRP1 6.1352 7.1264 4.7259 0.3393
Ku812 GDSC1; GDSC2; CTRP1 6.2717 10.4758 3.2825 6.9401
SU-DHL-4 GDSC1; GDSC2; CTRP1 6.2725 9.362 3.8151 4.228
NU-DUL-1 GDSC1; GDSC2; CTRP1 6.375 8.1904 4.4062 1.3068
KE-97 CTRP1 6.3857 8.4424 4.303 2.8994
SU-DHL-5 GDSC1; GDSC2; CTRP1 6.4385 7.4655 4.7229 0.2034
SKM-1 GDSC1; GDSC2; CTRP1 6.4487 7.7681 4.6137 0.4835
LP-1 GDSC1; GDSC2; CTRP1 6.4556 8.6354 4.2567 1.8554
SU-DHL-1 GDSC2 6.5417 20.7953 -2.8984 22.9374
OCI-AML-3 GDSC1; GDSC2; CTRP1 6.6952 12.2975 2.6959 9.0979
EJM GDSC1; GDSC2; CTRP1 6.7374 8.227 4.561 0.4679
HT GDSC1; GDSC2; CTRP1 6.8067 8.2147 4.5941 0.3469
NOMO-1 GDSC1; GDSC2; CTRP1 6.8099 8.6804 4.416 0.8753
P3HR-1 CTRP1 6.9253 8.5967 4.4996 0.8963
MOLM-16 GDSC1; GDSC2; CTRP1 6.9545 12.4617 2.7931 8.149
AMO1 GDSC1; GDSC2; CTRP1 7.1428 8.4291 4.6448 0.1403
U-937 CTRP1 7.1835 8.7834 4.5348 0.5475
RPMI-8226 GDSC1; GDSC2; CTRP1 7.6787 15.0468 2.0432 10.4047
OCI-Ly10 CTRP1 8.1126 17.5284 1.1488 18.8303
⏷ Show the Full List of 174 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 11 Cell Line(s) in Aero Dig Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ESO-51 GDSC1; GDSC2 3.9683 6.8858 2.0458 6.3791
OACP4 C GDSC1; GDSC2 4.2441 6.2907 2.5176 2.953
FLO-1 GDSC1; GDSC2 4.6052 7.4136 2.221 4.0023
ESO-26 GDSC1; GDSC2 4.6736 6.7058 2.5794 1.9356
KYAE-1 GDSC1; GDSC2 4.7126 6.4897 2.6919 1.3377
KYSE-50 GDSC1; GDSC2 5.4182 7.0986 2.7675 0.4798
TE-12 GDSC1; GDSC2 5.4508 11.4234 0.8785 9.9486
SK-GT-4 GDSC1; GDSC2 5.4801 7.6188 2.5956 1.0097
HCE-4 GDSC1; GDSC2 5.5763 8.3592 2.3415 1.9802
OACM5.1 C GDSC1; GDSC2 5.7037 7.9716 2.5564 0.9825
KYSE-220 GDSC1; GDSC2 5.8701 7.9124 2.6482 0.5827
⏷ Show the Full List of 11 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 GDSC1; GDSC2 4.8549 9.2543 1.5155 7.6085
Cancer Drug Sensitivity Data Curated from 31 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SK-N-MC-IXC GDSC1; GDSC2 4.0584 6.0107 2.5306 3.23
GOTO GDSC1; GDSC2 4.0815 6.4897 2.3176 4.4592
TGW GDSC1; GDSC2 4.2028 5.777 2.7276 1.8442
SJNB-13 GDSC1; GDSC2 4.257 6.8632 2.2568 4.4596
SK-N-FI GDSC1; GDSC2 4.2775 5.8105 2.7548 1.586
SJNB-12 GDSC1; GDSC2 4.373 6.1653 2.6511 1.9933
CHP-126 GDSC1; GDSC2 4.495 6.7808 2.4447 2.9285
Kelly GDSC1; GDSC2 4.5441 7.5411 2.1232 4.6816
SJNB-14 GDSC1; GDSC2 4.5764 6.1036 2.7852 1.0623
SK-N-BE(2)-M17 GDSC1; GDSC2 4.7385 6.4556 2.7189 1.1857
KP-N-YS GDSC1; GDSC2 4.7432 6.8534 2.5527 1.9767
IMR-5 GDSC1; GDSC2 4.7862 6.7668 2.6124 1.6269
CHP-212 GDSC1; GDSC2 4.8056 6.6662 2.6646 1.3588
MHH-NB-11 GDSC1; GDSC2 4.9808 11.8682 0.34 13.8065
SJNB-5 GDSC1; GDSC2 4.982 6.8468 2.6756 1.1267
SK-N-DZ GDSC1; GDSC2 4.9826 6.1627 2.9376 0.2394
NH-12 GDSC1; GDSC2 5.1126 7.0173 2.6678 1.0381
SJNB-6 GDSC1; GDSC2 5.152 6.9816 2.6997 0.8801
SK-N-AS GDSC1; GDSC2 5.2193 7.08 2.691 0.8593
SK-N-SH GDSC1; GDSC2 5.231 7.3224 2.6002 1.206
SJNB-7 GDSC1; GDSC2 5.2965 8.949 1.9339 4.4264
KP-N-RT-BM-1 GDSC2 5.3372 7.4755 2.5879 1.1597
NB(TU)1 GDSC1; GDSC2 5.3545 12.133 0.4737 12.2832
SJNB-17 GDSC1; GDSC2 5.3811 7.1826 2.721 0.6419
NB1 GDSC1; GDSC2 5.6179 7.91 2.5427 1.0989
NB69 GDSC1; GDSC2 5.6388 7.3329 2.7687 0.374
KP-N-YN GDSC1; GDSC2 5.7234 7.8154 2.6245 0.7377
LA-N-6 GDSC1; GDSC2 5.7305 7.1215 2.8761 0.1399
SJNB-10 GDSC1; GDSC2 5.8731 7.3626 2.8442 0.1561
SiMa GDSC1; GDSC2 5.9891 7.9573 2.6785 0.4464
GI-ME-N GDSC1; GDSC2 6.4069 8.6265 2.5982 0.4673
⏷ Show the Full List of 31 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuCC-T1 GDSC1; GDSC2 5.182 6.7215 2.8121 0.4777
Cancer Drug Sensitivity Data Curated from 52 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HCC202 GDSC1 3.8753 6.0789 2.373 5.6993
HCC1419 GDSC1; GDSC2 4.0367 5.6479 2.6869 2.3559
BT-20 GDSC1; GDSC2 4.0506 6.2248 2.4237 3.8848
DU4475 GDSC1; GDSC2 4.0949 5.5492 2.7675 1.7986
CAL-51 GDSC1; GDSC2 4.1512 5.6607 2.75 1.8037
HCC2157 GDSC1; GDSC2 4.167 5.8874 2.6563 2.2984
HCC1500 GDSC1; GDSC2 4.348 6.8576 2.3185 3.9151
MFM-223 GDSC1; GDSC2 4.4358 6.1822 2.6787 1.7559
JIMT-1 GDSC1; GDSC2 4.443 5.9687 2.7747 1.2648
MDA-MB-468 GDSC1; GDSC2 4.4748 6.3456 2.6284 1.9625
UACC-812 GDSC2 4.5246 7.0361 2.3457 3.435
CAMA-1 GDSC1; GDSC2 4.5621 11.5984 0.1663 15.6942
Hs 578T GDSC1; GDSC2 4.6713 6.6802 2.5892 1.8889
EFM-19 GDSC1; GDSC2 4.7175 6.9157 2.5116 2.2226
MDA-MB-157 GDSC1; GDSC2 4.7256 10.2964 0.924 11.2693
MDA-MB-231 GDSC1; GDSC2 4.7268 7.9647 2.0408 4.8148
MRK-nu-1 GDSC1; GDSC2 4.8644 6.5916 2.7237 1.0374
HDQ-P1 GDSC1; GDSC2 4.9291 6.6314 2.7377 0.9201
BT-483 GDSC1; GDSC2 4.9458 6.8578 2.6539 1.2564
MDA-MB-436 GDSC1; GDSC2 4.9879 6.5528 2.7947 0.6579
CAL-148 GDSC2 5.0317 6.4998 2.8334 0.4998
HCC2218 GDSC1; GDSC2 5.063 9.1134 1.7167 6.0445
HCC70 GDSC1; GDSC2 5.116 7.5733 2.4396 2.0555
ZR-75-30 GDSC1; GDSC2 5.1215 6.8136 2.7518 0.7128
HCC1954 GDSC1; GDSC2 5.1319 6.9504 2.7031 0.8837
CAL-120 GDSC1; GDSC2 5.1816 6.5395 2.8785 0.2986
HCC1428 GDSC1; GDSC2 5.2036 6.5948 2.867 0.3173
MDA-MB-330 GDSC1; GDSC2 5.2236 7.0902 2.689 0.8636
HCC1187 GDSC1; GDSC2 5.2534 6.9509 2.7554 0.6114
HCC38 GDSC1; GDSC2 5.2552 7.1433 2.6822 0.8642
BT-549 GDSC1; GDSC2 5.2751 7.0917 2.7108 0.747
Evsa-T GDSC1; GDSC2 5.2809 6.9835 2.7545 0.5971
CAL-85-1 GDSC1; GDSC2 5.3002 8.0851 2.3169 2.4231
MDA-MB-415 GDSC1; GDSC2 5.3396 6.8742 2.8187 0.3794
HCC1569 GDSC1; GDSC2 5.3458 11.7157 0.6684 11.2863
T-47D GDSC1; GDSC2 5.3653 7.3564 2.6475 0.9071
HCC1937 GDSC1; GDSC2 5.3733 7.6998 2.5144 1.43
EFM-192A GDSC1; GDSC2 5.3756 7.0545 2.7667 0.5047
COLO 824 GDSC1; GDSC2 5.38 7.6118 2.553 1.2623
BT-474 GDSC1; GDSC2 5.407 6.86 2.8496 0.2777
YMB-1-E GDSC2 5.6243 8.0415 2.4935 1.2838
HCC1395 GDSC1; GDSC2 5.6297 8.2699 2.404 1.6485
HCC1599 GDSC2 5.7603 7.4061 2.7884 0.2844
MDA-MB-361 GDSC1; GDSC2 5.791 7.5659 2.7432 0.3727
HCC1806 GDSC1; GDSC2 5.8108 7.3084 2.8407 0.1752
MDA-MB-453 GDSC1; GDSC2 5.8376 7.7605 2.691 0.4821
UACC-893 GDSC1; GDSC2 5.8637 9.5248 1.995 3.2817
MDA-MB-175-VII GDSC1; GDSC2 5.8847 7.4644 2.8135 0.2014
HCC1143 GDSC1; GDSC2 5.9177 7.9894 2.6388 0.5846
MCF-7 GDSC1; GDSC2; CTRP1 6.0412 8.4653 4.0881 3.2429
OCUB-M GDSC1; GDSC2 6.1604 7.8837 2.7679 0.2082
AU565 GDSC1; GDSC2 7.076 8.9918 2.7117 0.1173
⏷ Show the Full List of 52 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 55 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MOG-G-CCM GDSC1; GDSC2 3.935 5.9746 2.4652 3.8793
ONS-76 GDSC1; GDSC2 4.0306 6.0412 2.4979 3.481
Becker GDSC1; GDSC2 4.0638 5.9471 2.5642 3.0209
Hs 683 GDSC1; GDSC2 4.0742 5.6435 2.7121 2.1442
D-566MG GDSC1; GDSC2 4.0787 6.1364 2.4844 3.4639
D-423MG GDSC1; GDSC2 4.1573 8.6828 1.3018 10.448
GB-1 GDSC1; GDSC2 4.3311 6.0934 2.6594 2.0132
GI-1 GDSC1; GDSC2 4.3907 6.4268 2.5438 2.5506
H4 GDSC1; GDSC2 4.4038 6.5582 2.4918 2.8187
LNZTA3WT4 GDSC1; GDSC2 4.4166 6.709 2.4305 3.1431
D-263MG GDSC1; GDSC2 4.4564 6.478 2.559 2.3612
SF539 GDSC1; GDSC2 4.4947 6.1291 2.7332 1.4022
YH-13 GDSC1; GDSC2 4.5108 6.4662 2.5952 2.0845
D-247MG GDSC1; GDSC2 4.5276 6.3405 2.6595 1.7271
YKG-1 GDSC1; GDSC2 4.5389 8.0479 1.88 6.1241
CAS-1 GDSC1; GDSC2 4.6439 6.6413 2.5914 1.9147
D283 Med GDSC1; GDSC2 4.6842 6.265 2.771 1.0125
M059J GDSC1; GDSC2 4.7697 6.5805 2.6825 1.3169
KNS-81-FD GDSC1; GDSC2 4.8306 7.4393 2.3431 2.9465
NMC-G1 GDSC1; GDSC2 4.8822 6.7036 2.6865 1.1791
DBTRG-05MG GDSC1; GDSC2 4.8852 6.8453 2.6294 1.4312
LN-18 GDSC1; GDSC2 4.8976 5.924 2.9902 0.158
PFSK-1 GDSC1 4.9394 7.0215 2.5828 1.9742
KALS-1 GDSC1; GDSC2 4.9909 7.8945 2.2311 3.301
MOG-G-UVW GDSC1; GDSC2 5.0415 8.3779 2.0426 4.2493
8-MG-BA GDSC1; GDSC2 5.0673 8.1422 2.1641 3.5433
KINGS-1 GDSC1; GDSC2 5.0971 7.5446 2.4421 2.0673
T98G GDSC1; GDSC2 5.1262 7.2406 2.5838 1.3778
LN-405 GDSC1; GDSC2 5.1549 6.7593 2.7867 0.5723
A-172 GDSC1; GDSC2 5.1891 12.9279 -0.0278 15.1498
U-87MG ATCC GDSC1 5.253 6.4728 2.9286 0.2109
AM-38 GDSC1; GDSC2 5.2612 7.4473 2.5639 1.329
KNS-42 GDSC1; GDSC2 5.2664 6.744 2.8374 0.3645
D-336MG GDSC1; GDSC2 5.3084 8.6609 2.0698 3.6777
DK-MG GDSC1; GDSC2 5.3348 6.6411 2.8999 0.1986
Onda 11 GDSC1; GDSC2 5.3859 7.5987 2.561 1.2245
D-245MG GDSC2 5.4127 10.5777 1.2533 7.9808
U-251MG GDSC1; GDSC2 5.4499 10.4197 1.3509 7.3719
Daoy GDSC1; GDSC2 5.5924 7.2466 2.7819 0.3614
SW1088 GDSC1; GDSC2 5.6339 7.2804 2.7856 0.3362
SW1783 GDSC1; GDSC2 5.6799 7.3616 2.774 0.3448
42-MG-BA GDSC1; GDSC2 5.721 7.5074 2.7374 0.4159
D-542MG GDSC1; GDSC2 5.8276 7.3679 2.8263 0.1945
Onda 10 GDSC1; GDSC2 5.8693 13.1018 0.3573 11.798
D-502MG GDSC1; GDSC2 5.8892 8.0427 2.6075 0.6916
SK-MG-1 GDSC1; GDSC2 5.9276 7.6302 2.7715 0.2649
SF126 GDSC1; GDSC2 6.0299 7.5855 2.8235 0.1533
U-118MG GDSC1; GDSC2 6.0922 7.5111 2.8699 0.0882
SF268 GDSC1; GDSC2 6.1787 8.06 2.7134 0.3002
KS-1 [Human Krukenberg tumour] GDSC1; GDSC2 6.3015 8.5521 2.5844 0.5457
D-392MG GDSC1; GDSC2 6.6121 8.6669 2.6599 0.2743
SNB-75 GDSC1; GDSC2 6.6283 8.3873 2.7606 0.1282
GaMG GDSC1; GDSC2; CTRP1 6.7698 8.532 4.4568 0.7673
SF295 GDSC1; GDSC2; CTRP1 6.9444 8.3583 4.5959 0.2861
LN-229 GDSC1; GDSC2; CTRP1 7.2303 8.9947 4.4758 0.4447
⏷ Show the Full List of 55 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Digestive System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ETK-1 GDSC1; GDSC2 5.0246 7.3604 2.483 1.9587
TGBC1TKB GDSC1; GDSC2 5.4026 7.0801 2.7681 0.4864
TGBC24TKB GDSC1; GDSC2 6.037 7.9054 2.7152 0.3433
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
EN GDSC1; GDSC2 5.0885 6.6083 2.8161 0.5199
RL95-2 GDSC1; GDSC2 5.1806 6.9663 2.7183 0.7889
ESS-1 GDSC1; GDSC2 5.6184 7.0304 2.8675 0.1785
MFE-296 GDSC1; GDSC2 5.6561 7.4236 2.7425 0.4317
HEC-265 CTRP1 5.7332 7.5778 4.3073 4.4371
HEC-6 CTRP1 5.8023 8.2384 4.0379 6.5274
HEC-108 CTRP1 5.8782 7.6332 4.3735 3.4957
MFE-280 GDSC1; GDSC2 5.9547 8.1857 2.5809 0.7349
AN3-CA GDSC1; GDSC2 6.129 12.7747 0.6799 9.6693
KLE GDSC1; GDSC2; CTRP1 6.4996 8.7076 4.2491 1.8364
HEC-151 CTRP1 6.6367 13.9941 1.8283 19.6462
HEC-251 CTRP1 6.9132 8.5548 4.5104 0.8567
HEC-59 CTRP1 6.9234 8.5343 4.5224 0.7924
MFE-319 GDSC1; GDSC2; CTRP1 7.1371 8.7216 4.5391 0.3359
JHUEM-2 CTRP1 7.5161 9.1906 4.5156 0.4247
Ishikawa (Heraklio) 02 ER- CTRP1 6.5061 7.5314 4.725 0.2934
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 33 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
LB2241-RCC GDSC1; GDSC2 3.6425 5.6109 2.4323 4.7663
BFTC-909 GDSC1; GDSC2 4.1039 5.8651 2.6279 2.5733
KMRC-20 GDSC1; GDSC2 4.2397 7.5069 1.9361 6.428
769-P GDSC1; GDSC2 4.4915 7.0573 2.3156 3.665
A-498 GDSC1; GDSC2 4.5118 6.4838 2.5879 2.1215
KTCTL-26A GDSC1; GDSC2 4.7479 6.544 2.6869 1.3209
NCC021 GDSC1; GDSC2 4.792 7.5765 2.259 3.4661
A-704 GDSC1; GDSC2 4.864 7.1858 2.4733 2.2155
HA7-RCC GDSC1; GDSC2 4.8896 6.9834 2.5736 1.6875
LB996-RCC GDSC2 4.9812 7.2873 2.4916 1.9709
SN12C GDSC1; GDSC2 5.0273 9.5489 1.4892 7.4105
TK-10 GDSC1; GDSC2 5.0414 7.4077 2.4716 1.9933
KTCTL-1M GDSC1; GDSC2 5.195 7.0362 2.6974 0.8545
KTCTL-140 GDSC1; GDSC2 5.234 7.3514 2.5899 1.246
KTCTL-21 GDSC1; GDSC2 5.2939 16.1087 -1.5117 21.1401
KTCTL-195 GDSC1; GDSC2 5.4776 7.0744 2.7997 0.3663
OS-RC-2 GDSC1; GDSC2 5.4791 7.5469 2.6232 0.9092
KTCTL-13 GDSC1; GDSC2 5.4861 7.113 2.789 0.3893
SW13 GDSC1; GDSC2 5.4975 7.1992 2.7621 0.4549
RXF 393L GDSC1; GDSC2 5.5421 7.7552 2.5697 1.0578
KMRC-1 GDSC1; GDSC2 5.6954 7.0929 2.8735 0.1511
NCC010 GDSC1; GDSC2 5.7053 7.8517 2.6031 0.8194
BB65-RCC GDSC1; GDSC2 5.7431 8.548 2.3447 1.7904
UO-31 GDSC1; GDSC2 5.8368 7.6253 2.7394 0.3637
VMRC-RCZ GDSC1; GDSC2 5.9428 7.9408 2.6665 0.4973
SW156 GDSC1; GDSC2 5.9673 7.8028 2.7255 0.346
786-O GDSC1; GDSC2 6.0726 7.9379 2.7171 0.3272
CAL-54 GDSC1; GDSC2 6.1849 8.3208 2.6229 0.4999
RCC10RGB GDSC1; GDSC2; CTRP1 6.315 8.3351 4.3113 1.7849
VMRC-RCW GDSC1; GDSC2; CTRP1 6.3227 9.5948 3.7379 4.5318
LB1047-RCC GDSC1; GDSC2 6.4012 8.6212 2.5979 0.4702
Caki-1 GDSC1; GDSC2 6.4491 17.2155 -1.223 17.5684
ACHN GDSC1; GDSC2 6.5343 13.4037 0.6402 9.1386
⏷ Show the Full List of 33 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 58 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H716 GDSC1; GDSC2 4.0219 9.9948 0.5494 15.0875
HCC2998 GDSC1; GDSC2 4.343 6.7455 2.3678 3.6369
LS1034 GDSC1; GDSC2 4.5677 8.2789 1.789 6.6032
CaR-1 GDSC1; GDSC2 4.5696 7.3507 2.228 4.0263
HCT 15 GDSC1; GDSC2 4.6119 5.8631 2.8984 0.5643
CL-11 GDSC1; GDSC2 4.6734 6.9232 2.4838 2.4328
COLO 320HSR GDSC1; GDSC2 4.8038 7.8288 2.151 4.0486
SW1417 GDSC1; GDSC2 4.859 6.9647 2.5658 1.7623
CCK-81 GDSC1; GDSC2 4.8812 7.1624 2.4927 2.0945
SW1463 GDSC1; GDSC2 5.1233 6.676 2.805 0.5336
SNU-C1 GDSC1; GDSC2 5.292 7.0536 2.7326 0.6612
SW1116 GDSC1; GDSC2 5.3766 7.0171 2.7809 0.4635
SW626 GDSC1; GDSC2 5.4626 7.3962 2.6741 0.7433
SNU-283 GDSC2 5.6565 7.1325 2.846 0.2055
SW837 GDSC1; GDSC2 5.6846 8.0024 2.536 1.071
NCI-H747 GDSC1; GDSC2 5.8001 7.5534 2.7511 0.3509
SNU-81 GDSC1; GDSC2; CTRP1 5.9506 8.6452 3.9434 4.1317
SNU-C2B GDSC1; GDSC2 5.9932 9.4828 2.0798 2.7135
GP5d GDSC1; GDSC2 5.9934 7.5407 2.8259 0.1573
GP2d CTRP1 6.0533 10.2658 3.2305 12.3711
SNU-C5 GDSC1; GDSC2; CTRP1 6.0744 8.5639 4.0631 3.3135
SNU-407 GDSC1; GDSC2 6.1115 7.7597 2.7929 0.1805
T84 GDSC1; GDSC2 6.158 7.8808 2.768 0.2086
HT115 GDSC1; GDSC2; CTRP1 6.1609 7.812 4.456 1.333
LS513 GDSC1; GDSC2; CTRP1 6.1642 7.9944 4.3778 1.6749
SNU-61 GDSC1; GDSC2; CTRP1 6.2365 8.4729 4.2047 2.3781
SW48 GDSC1; GDSC2; CTRP1 6.2404 8.9222 4.0006 3.3578
HCT 8 CTRP1 6.2861 7.727 4.5557 1.3409
CW-2 GDSC1; GDSC2; CTRP1 6.463 8.6398 4.2588 1.8374
RCM-1 [Human ESC] GDSC1; GDSC2; CTRP1 6.5128 8.8069 4.2129 1.9799
SK-CO-1 GDSC1; GDSC2; CTRP1 6.5431 7.9411 4.5877 0.5035
HT-55 GDSC1; GDSC2; CTRP1 6.5432 7.8563 4.6202 0.4093
DLD-1 CTRP1 6.5905 8.1564 4.5245 1.1225
LS180 GDSC1; GDSC2; CTRP1 6.5941 8.1244 4.5387 0.6229
SNU-1040 CTRP1 6.6036 8.0918 4.5556 0.9419
LS123 GDSC1; GDSC2; CTRP1 6.6388 10.1359 3.6851 4.2845
COLO 678 GDSC1; GDSC2; CTRP1 6.672 9.9428 3.7944 3.7057
SW480 CTRP1 6.6983 9.9902 3.7885 6.1135
COLO 320 CTRP1 6.7166 10.7881 3.4298 8.8262
SW948 GDSC1; GDSC2; CTRP1 6.718 8.0401 4.623 0.3164
SW403 CTRP1 6.7871 8.6596 4.4139 1.5047
HCT 116 GDSC1; GDSC2; CTRP1 6.8021 10.1522 3.7765 3.6033
LS411N GDSC1; GDSC2; CTRP1 6.8567 8.5111 4.5031 0.5655
HT-29 GDSC1; GDSC2; CTRP1 6.8639 11.596 3.1444 6.5803
SNU-C4 CTRP1 6.8698 7.8938 4.7311 0.1353
COLO205 GDSC1; GDSC2; CTRP1 7.0193 8.1808 4.6861 0.1094
MDST8 GDSC1; GDSC2; CTRP1 7.0461 9.8825 4.0326 2.1436
CL-40 CTRP1 7.0677 8.4379 4.6143 0.3486
CL-34 CTRP1 7.081 8.5501 4.5794 0.4531
SW620 GDSC1; GDSC2; CTRP1 7.128 10.8427 3.6551 3.7206
RKO GDSC1; GDSC2; CTRP1 7.1874 9.652 4.2003 1.3391
DiFi GDSC1; GDSC2 7.1987 9.0858 2.7219 0.0939
KM12 GDSC1; GDSC2; CTRP1 7.2056 8.5392 4.6294 0.1488
NCI-H508 GDSC1; GDSC2; CTRP1 7.2427 14.825 1.8543 12.039
C2BBe1 GDSC1; GDSC2; CTRP1 7.2906 14.2064 2.1848 10.4448
LoVo GDSC1; GDSC2; CTRP1 7.4478 9.9738 4.1922 1.1586
SNU-175 GDSC2; CTRP1 7.7304 9.5011 4.4858 0.2458
SNU-C2A CTRP1 7.8007 10.5336 4.13 1.8522
⏷ Show the Full List of 58 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Leukemia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MO-T GDSC1; GDSC2 4.0912 6.3951 2.3696 4.1255
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Hep 3B2.1-7 GDSC1; GDSC2 3.95 5.9609 2.4821 3.7447
HuH-1 GDSC1; GDSC2 4.3753 6.5087 2.4973 2.8367
HLE GDSC1; GDSC2 4.7656 6.5027 2.7127 1.1845
JHH-2 GDSC1; GDSC2 4.8949 6.4643 2.7884 0.7516
JHH-4 GDSC1; GDSC2 5.0111 7.8005 2.2844 2.9866
Hep-G2/C3A GDSC1; GDSC2 5.276 6.5327 2.9162 0.1854
Huh-7 GDSC1; GDSC2 5.3585 6.8124 2.8482 0.299
SK-HEP-1 GDSC1; GDSC2 5.5176 6.7084 2.9416 0.0938
SNU-423 GDSC1; GDSC2 5.5852 7.0267 2.8569 0.2058
JHH-1 GDSC1; GDSC2 5.5901 7.011 2.8641 0.1916
JHH-7 GDSC1; GDSC2 5.8375 7.873 2.6496 0.5958
SNU-387 GDSC1; GDSC2 5.8672 7.3734 2.8385 0.1659
JHH-6 GDSC1; GDSC2; CTRP1 6.1456 7.3709 4.634 0.6347
SNU-398 GDSC1; GDSC2; CTRP1 6.7844 9.3515 4.1227 2.0534
Hep-G2 CTRP1 7.2182 9.0769 4.4402 0.906
SNU-449 GDSC1; GDSC2; CTRP1 7.3711 8.8951 4.5659 0.2077
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 205 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H292 GDSC1; GDSC2 3.7938 5.7301 2.4849 4.0753
NCI-H290 GDSC1; GDSC2 3.8896 5.9419 2.4496 4.0747
NCI-H1930 CTRP1 3.9232 7.977 2.5714 26.5327
NCI-H524 GDSC1; GDSC2 3.9902 6.9401 2.035 6.3934
NCI-H526 GDSC1; GDSC2 4.0223 6.2581 2.3885 4.1567
NCI-H1155 GDSC1; GDSC2 4.0533 6.7793 2.1583 5.4909
IA-LM GDSC1; GDSC2 4.0552 5.714 2.6677 2.4325
NCI-H847 GDSC1; GDSC2 4.0963 5.7555 2.674 2.3225
Lu-165 GDSC1; GDSC2 4.1261 5.4504 2.8296 1.4141
CPC-N GDSC1; GDSC2 4.1652 7.8011 1.7403 7.7885
Ms-1 GDSC1; GDSC2 4.1952 5.8913 2.6715 2.1657
SBC-5 GDSC1; GDSC2 4.1956 5.2514 2.9513 0.7254
NCI-H1703 GDSC1; GDSC2 4.2691 6.0307 2.6518 2.1532
NCI-H69 GDSC1; GDSC2 4.3462 6.4365 2.5129 2.7991
NCI-H740 GDSC2 4.3686 8.4918 1.5489 8.4707
NCI-H446 GDSC1; GDSC2 4.3925 6.0927 2.6942 1.7372
Lu-135 GDSC1; GDSC2 4.4149 7.0057 2.2917 3.9444
NCI-H2795 GDSC1; GDSC2 4.4317 6.9613 2.323 3.7318
NCI-H1341 GDSC1; GDSC2 4.46 6.2813 2.6485 1.8784
NCI-H345 GDSC1; GDSC2 4.479 5.6706 2.9148 0.6091
COR-L105 GDSC1; GDSC2 4.5079 6.7457 2.4683 2.7761
COR-L321 GDSC1; GDSC2 4.5219 7.3735 2.1875 4.3491
NCI-H2170 GDSC1; GDSC2 4.5483 6.4981 2.6019 1.9949
NCI-H2803 GDSC1; GDSC2 4.5494 7.3117 2.2336 4.0312
COR-L311 GDSC2 4.5811 6.7311 2.5171 2.3944
NCI-H187 GDSC1 4.5963 6.0893 2.8008 1.2113
SK-MES-1 GDSC1; GDSC2 4.622 6.3998 2.6838 1.4839
SW1573 GDSC1; GDSC2 4.6497 6.6629 2.5852 1.9388
NCI-H2804 GDSC1; GDSC2 4.7296 7.6764 2.176 4.0368
NCI-H2444 GDSC1; GDSC2 4.733 5.8931 2.938 0.3539
NCI-H1693 GDSC1; GDSC2 4.7877 6.6036 2.6817 1.3003
NCI-H2595 GDSC1; GDSC2 4.7879 7.329 2.368 2.8778
Lu-134-A GDSC1; GDSC2 4.7881 8.1013 2.0156 4.8459
SBC-1 GDSC1; GDSC2 4.8002 6.6695 2.6605 1.3837
NCI-H2171 GDSC2 4.8199 7.8996 2.1283 4.1486
COR-L303 GDSC2 4.8467 6.3822 2.7992 0.7497
NCI-H2135 GDSC1; GDSC2 4.8895 6.3435 2.833 0.594
LB647-SCLC GDSC1; GDSC2 4.8912 6.9803 2.5758 1.6752
PC-14 GDSC1; GDSC2 4.8991 6.4365 2.8011 0.7009
LOU-NH91 GDSC1; GDSC2 4.905 6.681 2.7066 1.0704
HCC366 GDSC1; GDSC2 4.9076 6.5955 2.7422 0.9212
Lu-139 GDSC1; GDSC2 4.9138 7.0235 2.569 1.6806
NCI-H1838 GDSC1; GDSC2 4.9161 7.8458 2.2099 3.5343
LK-2 GDSC1; GDSC2 4.9588 6.535 2.789 0.6999
NCI-H1092 GDSC1; GDSC2 4.9726 6.8803 2.6576 1.2129
NCI-H720 GDSC1; GDSC2 5.081 6.4935 2.8558 0.4051
NCI-H835 GDSC1; GDSC2 5.0876 8.227 2.1377 3.6538
NCI-H1304 GDSC1 5.0946 6.7397 2.7687 0.8383
NCI-H209 GDSC1; GDSC2 5.1182 7.2155 2.5902 1.3579
NCI-H510A GDSC1; GDSC2 5.1384 6.7054 2.8002 0.5397
EKVX GDSC1; GDSC2 5.1861 7.7251 2.4112 2.1064
NCI-H2196 GDSC2 5.1991 6.681 2.8339 0.4061
SW1271 GDSC1; GDSC2 5.2146 7.1939 2.6441 1.0431
NCI-H211 GDSC1; GDSC2 5.2148 7.8507 2.3726 2.2583
NCI-H2369 GDSC1; GDSC2 5.2223 6.504 2.9065 0.2209
DMS 114 GDSC1; GDSC2 5.2395 7.1414 2.676 0.8996
NCI-H196 GDSC1; GDSC2 5.2402 6.5786 2.8868 0.2567
DMS 79 GDSC1; GDSC2 5.2569 7.3701 2.593 1.2113
SBC-3 GDSC1; GDSC2 5.2755 6.8852 2.7891 0.4939
NCI-H250 GDSC2 5.284 7.3528 2.6125 1.1082
NCI-H1770 GDSC1; GDSC2 5.2931 6.9849 2.7591 0.5752
NCI-H748 GDSC2 5.2941 7.3836 2.6048 1.1299
NCI-H64 GDSC1; GDSC2 5.3102 6.4951 2.9414 0.1339
NCI-H2291 GDSC1; GDSC2 5.3169 7.2348 2.6736 0.8486
NCI-H513 GDSC1; GDSC2 5.3227 7.2248 2.68 0.8211
A-427 GDSC1; GDSC2 5.3348 10.3113 1.3286 7.7135
NCI-H322M GDSC1; GDSC2 5.3351 9.8979 1.5219 6.6362
NCI-H838 GDSC1; GDSC2 5.4074 6.7132 2.9012 0.1758
NCI-H226 GDSC1; GDSC2 5.4144 6.8187 2.8669 0.2383
COR-L51 CTRP1 5.4193 9.8256 2.9689 16.6778
NCI-H2818 GDSC1; GDSC2 5.4218 7.2643 2.7071 0.6611
NCI-H1836 GDSC1; GDSC2; CTRP1 5.4542 7.0656 4.3629 2.8797
COR-L95 GDSC1; GDSC2 5.4859 6.8021 2.8987 0.1601
NCI-H1993 GDSC1; GDSC2 5.5124 9.2642 1.9167 4.1792
NCI-H1650 GDSC1; GDSC2 5.5126 10.0466 1.5625 6.094
NCI-H2126 CTRP1 5.5134 7.82 4.0364 7.4846
NCI-H2085 GDSC1; GDSC2 5.5163 7.734 2.5665 1.0908
VMRC-LCD GDSC1; GDSC2; CTRP1 5.5185 6.9508 4.4631 2.2368
DMS 53 GDSC1; GDSC2 5.5356 7.2138 2.7718 0.4111
NCI-H1688 GDSC1; GDSC2 5.5419 7.1582 2.7942 0.3526
NCI-H2110 GDSC1; GDSC2; CTRP1 5.555 8.0361 3.9608 4.7995
NCI-H146 GDSC1; GDSC2 5.5645 7.1248 2.8148 0.2967
NCI-H1651 GDSC1; GDSC2 5.5843 8.7453 2.1827 2.7192
NCI-H647 GDSC1; GDSC2 5.5885 7.7138 2.6061 0.8897
NCI-H1963 GDSC1; GDSC2; CTRP1 5.601 7.9166 4.0528 4.2205
NCI-H2066 GDSC1; GDSC2 5.6369 7.1563 2.8306 0.2398
UMC-11 GDSC1; GDSC2 5.659 7.319 2.7813 0.3362
EMC-BAC-1 GDSC1; GDSC2 5.6639 8.7933 2.2034 2.5215
BEN GDSC1; GDSC2; CTRP1 5.6698 7.523 4.2912 2.8483
NCI-H810 GDSC1; GDSC2; CTRP1 5.6779 8.0961 4.0201 4.241
NCI-H2810 GDSC1; GDSC2 5.7164 7.6881 2.6693 0.604
NCI-H2347 GDSC1; GDSC2 5.7212 7.627 2.6939 0.531
EMC-BAC-2 GDSC1; GDSC2 5.7406 7.8102 2.6336 0.6985
HOP-62 GDSC1; GDSC2 5.7682 7.3063 2.8262 0.2101
NCI-H2373 GDSC1; GDSC2 5.7687 7.4205 2.7865 0.2857
NCI-H2029 GDSC1; GDSC2; CTRP1 5.7778 8.3137 3.9847 4.235
Lu-99A GDSC1; GDSC2 5.809 7.7262 2.6922 0.4922
NCI-H2722 GDSC1; GDSC2 5.8321 7.4079 2.8141 0.2141
NCI-H1563 GDSC1; GDSC2 5.8361 7.4706 2.7937 0.25
NCI-H2461 GDSC1; GDSC2 5.8393 7.8228 2.6689 0.5406
IST-SL2 GDSC1; GDSC2 5.8521 7.8376 2.6685 0.5354
NCI-H1436 GDSC1; GDSC2 5.8983 7.3648 2.8523 0.1396
NCI-H1734 GDSC1; GDSC2 5.9073 7.4062 2.8414 0.153
NCI-H3255 GDSC1; GDSC2; CTRP1 5.9177 8.3024 4.0849 3.4669
ABC-1 GDSC1; GDSC2 5.9212 8.282 2.5304 0.9191
NCI-H1105 GDSC1; GDSC2; CTRP1 5.9215 9.9379 3.2956 7.5565
RERF-LC-MS GDSC1; GDSC2 5.9236 7.5271 2.8058 0.2044
NCI-H2227 GDSC1; GDSC2 5.9267 7.2704 2.8937 0.0861
NCI-H1648 GDSC1; GDSC2 5.9268 8.2063 2.5615 0.8128
NCI-H3122 GDSC1; GDSC2 5.9409 7.9001 2.6805 0.4623
SHP-77 GDSC1; GDSC2; CTRP1 5.9488 8.0716 4.2139 2.7664
IST-SL1 GDSC1; GDSC2 5.9579 7.5619 2.8061 0.1954
LC-2/ad GDSC1; GDSC2 5.9624 7.9803 2.6598 0.5058
NCI-H1437 GDSC1; GDSC2; CTRP1 5.9721 7.7855 4.3605 2.0152
NCI-H2591 GDSC1; GDSC2 5.9834 8.679 2.4034 1.3312
NCI-H2228 GDSC1; GDSC2 6.0105 7.917 2.7011 0.3842
NCI-H1581 GDSC1; GDSC2 6.0285 7.2861 2.9227 0.0505
RERF-LC-Sq1 GDSC1; GDSC2 6.0327 9.6216 2.0414 2.8472
NCI-H522 GDSC2; CTRP1 6.0739 9.4032 3.6634 5.3481
NCI-H520 GDSC1; GDSC2 6.0756 7.8031 2.7652 0.2342
HARA [Human squamous cell lung carcinoma] GDSC1; GDSC2; CTRP1 6.093 7.8842 4.3865 1.7267
LC-1/sq GDSC1; GDSC2 6.099 9.6019 2.083 2.577
COLO 668 GDSC1; GDSC2; CTRP1 6.1199 8.3157 4.2068 2.5367
NCI-H1048 GDSC1; GDSC2; CTRP1 6.1259 8.734 4.0163 3.4634
NCI-H1435 GDSC1; GDSC2; CTRP1 6.1414 8.854 3.9698 3.6698
PaCa-3 GDSC1; GDSC2 6.1483 8.3222 2.6081 0.5547
SCLC-21H CTRP1 6.1652 8.711 4.0519 5.3744
NCI-H1793 GDSC1; GDSC2; CTRP1 6.181 8.1566 4.3151 1.939
NCI-H2087 GDSC1; GDSC2 6.1822 8.1809 2.672 0.3851
NCI-H1869 GDSC1 6.1973 8.0168 2.7352 0.3165
NCI-H1792 GDSC1; GDSC2; CTRP1 6.2485 9.1113 3.9175 3.7562
HCC4006 CTRP1 6.263 8.0731 4.3975 2.4535
LC-1/sq-SF CTRP1 6.2731 9.6149 3.696 7.9756
COR-L279 GDSC1; GDSC2; CTRP1 6.2741 8.0509 4.4131 1.3882
NCI-H1944 GDSC1; GDSC2; CTRP1 6.2806 8.7552 4.1024 2.802
NCI-H2172 GDSC1; GDSC2; CTRP1 6.2931 7.8966 4.4887 1.0548
NCI-H1876 GDSC1; GDSC2; CTRP1 6.2989 9.3404 3.8422 4.049
NCI-H1623 GDSC1; GDSC2 6.3134 8.0973 2.749 0.202
KNS-62 GDSC1; GDSC2; CTRP1 6.3163 8.9076 4.0541 2.9818
HCC1833 CTRP1 6.3502 10.0944 3.5189 9.1709
Calu-3 GDSC1; GDSC2; CTRP1 6.39 8.7379 4.1746 2.3092
NCI-H2869 GDSC1; GDSC2 6.401 8.222 2.7374 0.2001
NCI-H2731 GDSC1; GDSC2 6.4184 8.1861 2.7558 0.1702
HOP-92 GDSC1; GDSC2 6.4226 8.2837 2.724 0.2158
NCI-H82 GDSC1; GDSC2; CTRP1 6.4253 10.6761 3.2913 6.6118
NCI-H1694 GDSC1; GDSC2; CTRP1 6.4288 9.0068 4.076 2.7159
COLO 699 CTRP1 6.4296 8.7653 4.1849 3.6889
NCI-H358 GDSC1; GDSC2; CTRP1 6.4308 8.637 4.2424 1.9493
Calu-6 GDSC1; GDSC2; CTRP1 6.436 9.3727 3.913 3.4852
Lu-65 GDSC1; GDSC2; CTRP1 6.4374 8.7315 4.2043 2.1118
HCC44 GDSC1; GDSC2; CTRP1 6.4421 9.6465 3.7898 4.0787
RERF-LC-KJ GDSC1; GDSC2; CTRP1 6.4548 8.1604 4.4591 1.0163
COR-L32 GDSC2 6.4686 8.5327 2.6545 0.3251
HCC1359 CTRP1 6.4764 7.4474 4.7437 0.2504
HCC1195 CTRP1 6.5205 8.1014 4.5145 1.2665
LCLC-103H GDSC1; GDSC2; CTRP1 6.5403 7.6879 4.6817 0.2544
NCI-H1299 GDSC1; GDSC2; CTRP1 6.5454 9.6385 3.8574 3.5899
NCI-H2122 GDSC1; GDSC2; CTRP1 6.5498 8.0625 4.5433 0.6388
EPLC-272H GDSC1; GDSC2; CTRP1 6.5746 8.4849 4.3834 1.1976
NCI-H1781 GDSC1; GDSC2; CTRP1 6.6033 8.6326 4.3358 1.3586
HCC78 GDSC1; GDSC2; CTRP1 6.6058 11.5741 2.9829 7.8382
NCI-H650 GDSC1; GDSC2; CTRP1 6.6183 9.0638 4.1582 2.0941
HCC827 GDSC1; GDSC2; CTRP1 6.6268 9.0757 4.1576 2.0866
ChaGo-K-1 GDSC1; GDSC2; CTRP1 6.6341 11.5258 3.0253 7.5744
SK-LU-1 GDSC1; CTRP1 6.6352 9.1016 4.1508 2.5307
NCI-H2286 CTRP1 6.6485 8.2582 4.5104 1.1314
HCC2108 CTRP1 6.6705 9.8621 3.8304 5.8581
NCI-H1975 GDSC1; GDSC2; CTRP1 6.6781 8.7124 4.3399 1.269
LXF 289 GDSC1; GDSC2; CTRP1 6.6895 9.6075 3.9569 2.915
NCI-H1568 GDSC1; GDSC2; CTRP1 6.7098 11.6854 3 7.5644
NCI-H596 GDSC1; GDSC2; CTRP1 6.769 8.5744 4.4396 0.8256
NCI-H441 GDSC1; GDSC2; CTRP1 6.7763 8.8268 4.3407 1.1751
NCI-H661 GDSC1; GDSC2; CTRP1 6.8108 8.7972 4.3694 1.0394
Lu-99 CTRP1 6.8309 8.275 4.5815 0.6129
COR-L23 GDSC1; GDSC2; CTRP1 6.8578 8.2584 4.5984 0.3147
NCI-H460 GDSC1; GDSC2; CTRP1 6.8614 8.9763 4.3204 1.1762
NCI-H2405 GDSC1; GDSC2; CTRP1 6.8775 9.2737 4.2046 1.6109
NCI-H1573 GDSC1; GDSC2; CTRP1 6.889 11.4575 3.2259 6.1377
NCI-H727 GDSC1; GDSC2; CTRP1 6.8926 9.2712 4.2134 1.5608
CAL-12T GDSC1; GDSC2; CTRP1 6.9127 9.0363 4.3204 1.1321
NCI-H1373 CTRP1 6.922 11.5989 3.1806 10.1229
NCI-H2081 GDSC1; GDSC2; CTRP1 6.9261 9.6794 4.0565 2.176
A-549 GDSC1; GDSC2; CTRP1 6.9548 8.62 4.5031 0.51
T3M-10 CTRP1 6.9657 9.3128 4.2324 2.3633
NCI-H2141 GDSC1; GDSC2; CTRP1 6.9927 8.612 4.5218 0.4409
NCI-H841 GDSC1; GDSC2; CTRP1 7.0082 12.0759 3.0115 6.9896
DV-90 CTRP1 7.0573 8.6884 4.5196 0.695
NCI-H23 GDSC1; GDSC2; CTRP1 7.1153 9.0717 4.3985 0.7205
NCI-H2030 GDSC1; GDSC2; CTRP1 7.1157 11.2978 3.4413 4.7408
Sq-1 CTRP1 7.1301 8.7247 4.5352 0.5807
HCC2935 CTRP1 7.1501 9.2214 4.3555 1.3899
EBC-1 GDSC1; GDSC2; CTRP1 7.1842 9.3199 4.332 0.8841
LCLC-97TM1 GDSC1; GDSC2; CTRP1 7.2417 12.1146 3.1417 5.9817
NCI-H2009 GDSC1; GDSC2; CTRP1 7.3509 9.4355 4.3598 0.6934
NCI-H1915 GDSC1; GDSC2; CTRP1 7.3547 8.9014 4.5576 0.2263
NCI-H2073 CTRP1 7.3571 9.1779 4.459 0.717
COR-L88 GDSC1; GDSC2; CTRP1 7.3667 9.2003 4.4546 0.4353
HCC33 GDSC2; CTRP1 7.3668 14.3473 2.1688 10.3817
DMS 273 GDSC1; GDSC2; CTRP1 7.3834 13.5782 2.5458 8.5938
NCI-H1755 GDSC1; GDSC2; CTRP1 7.3938 9.0484 4.5201 0.2834
NCI-H2023 GDSC1; GDSC2; CTRP1 7.6127 13.4714 2.7426 7.2926
NCI-H2342 GDSC1; GDSC2; CTRP1 7.6691 9.5423 4.4482 0.3332
NCI-H1355 GDSC1; GDSC2; CTRP1 7.8419 9.9326 4.3741 0.4251
HCC15 GDSC1; GDSC2; CTRP1 8.9263 15.5158 2.5932 6.092
NCI-H1666 GDSC1; GDSC2; CTRP1 9.3599 18.5425 1.4751 10.143
⏷ Show the Full List of 205 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Lymphoma Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CBTCi002-A GDSC1; GDSC2 5.8427 7.7783 2.6865 0.4915
Cancer Drug Sensitivity Data Curated from 24 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KYSE-510 GDSC1; GDSC2 2.2618 5.1212 1.4365 15.4115
TE-8 GDSC1; GDSC2 4.3894 6.5687 2.4784 2.9191
TE-5 GDSC1; GDSC2 4.3902 6.4876 2.5159 2.7067
TE-4 GDSC1; GDSC2 4.624 6.8251 2.4995 2.4233
EC-GI-10 GDSC1; GDSC2 4.6716 6.5183 2.659 1.5428
TE-9 GDSC1; GDSC2 4.8033 6.3073 2.8093 0.7468
OE21 GDSC1; GDSC2 4.8148 7.9732 2.0914 4.3661
T.T GDSC1; GDSC2 4.8428 6.743 2.651 1.3794
OE33 GDSC1; GDSC2 5.0283 7.4903 2.4293 2.2179
OE19 GDSC1; GDSC2 5.0954 6.4516 2.8769 0.3405
COLO 680N GDSC1; GDSC2 5.1097 7.3586 2.5269 1.6507
KYSE-150 GDSC1; GDSC2 5.2979 13.577 -0.2667 16.0228
TE-11 GDSC1; GDSC2 5.458 7.1514 2.764 0.4693
TE-1 GDSC1; GDSC2 5.4682 7.3197 2.7055 0.6376
TE-15 GDSC1; GDSC2 5.7282 7.6845 2.6755 0.5796
TE-6 GDSC1; GDSC2 5.8132 7.6375 2.726 0.4046
KYSE-180 GDSC1; GDSC2 5.9725 11.8836 0.9967 8.3177
KYSE-70 GDSC1; GDSC2 6.1123 8.0308 2.699 0.3515
TE-10 GDSC1; GDSC2 6.1149 7.8554 2.7613 0.2305
KYSE-270 GDSC1; GDSC2 6.3052 8.3077 2.6731 0.34
KYSE-520 GDSC1; GDSC2 6.5983 8.4813 2.7186 0.186
KYSE-450 GDSC1; GDSC2; CTRP1 7.1198 8.4399 4.6328 0.1636
KYSE-410 GDSC1; GDSC2; CTRP1 7.2625 9.025 4.4776 0.426
KYSE-140 GDSC1; GDSC2; CTRP1 7.304 9.5793 4.2835 0.9584
⏷ Show the Full List of 24 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 41 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
OV56 GDSC1; GDSC2 4.0236 5.6077 2.6974 2.3192
OC 314 GDSC1; GDSC2 4.148 5.7735 2.697 2.1024
TOV-21G GDSC1; GDSC2 4.2893 7.324 2.0584 5.581
OVISE GDSC1; GDSC2 4.6351 7.869 2.0274 5.0653
DOV13 GDSC1; GDSC2 4.6846 6.1325 2.8248 0.7874
FU-OV-1 GDSC1; GDSC2 5.0288 8.1589 2.1343 3.766
OVTOKO GDSC1; GDSC2 5.1414 7.5189 2.4757 1.8529
ES-2 GDSC1; GDSC2 5.312 6.7102 2.867 0.274
TOV-112D GDSC1; GDSC2 5.3955 7.9926 2.4045 1.8925
OVKATE GDSC1; GDSC2; CTRP1 5.5946 7.3735 4.3119 2.8785
OVCAR-3 GDSC1; GDSC2 5.6273 7.7872 2.5946 0.9026
JHOS-2 GDSC1; GDSC2 5.7481 7.2648 2.8333 0.203
OVCAR-5 GDSC1; GDSC2 5.8996 7.8544 2.681 0.4794
Caov-4 GDSC1; GDSC2 6.006 8.0451 2.6533 0.5025
OV-90 GDSC1; GDSC2; CTRP1 6.1328 8.5276 4.1169 2.9544
Kuramochi GDSC1; GDSC2 6.1433 7.9233 2.748 0.2461
SNU-840 CTRP1 6.2826 8.4935 4.2224 3.7274
JHOS-4 GDSC1; GDSC2; CTRP1 6.3233 8.7045 4.1509 2.5104
COV644 CTRP1 6.3351 8.2383 4.3645 2.552
RMG-I GDSC1; GDSC2; CTRP1 6.4485 9.0048 4.0884 2.6301
IGROV-1 GDSC1; GDSC2; CTRP1 6.4698 8.7705 4.2052 2.0672
RMUG-S CTRP1 6.5324 11.9058 2.7721 14.1769
OAW28 GDSC1; GDSC2 6.5639 8.8574 2.5753 0.4589
OAW42 GDSC1; CTRP1 6.6968 7.9391 4.6516 0.3119
TYK-nu GDSC1; GDSC2; CTRP1 6.7035 9.9344 3.8171 3.5516
HEY A8 CTRP1 6.7806 8.2179 4.5824 0.6489
OVK18 GDSC1; GDSC2; CTRP1 6.8175 10.3402 3.7001 3.9441
OV7 CTRP1 6.8274 8.6087 4.4524 1.2386
OVCAR-4 GDSC1; GDSC2; CTRP1 6.8619 10.5163 3.6462 4.1366
JHOM-1 CTRP1 6.8802 8.3975 4.556 0.6816
COV318 CTRP1 6.9772 7.8852 4.7705 0.0566
JHOC-5 CTRP1 7.1997 8.6847 4.5763 0.3982
SK-OV-3 GDSC1; GDSC2; CTRP1 7.3146 8.7565 4.5936 0.1774
COV434 CTRP1 7.3528 9.9123 4.1729 2.1685
EFO-21 GDSC1; GDSC2; CTRP1 7.3846 9.6851 4.2779 0.9212
OVCAR-8 GDSC1; GDSC2; CTRP1 7.3942 14.1103 2.3002 9.7251
OVMANA CTRP1 7.4335 8.5411 4.7072 0.0645
COV362 CTRP1 7.5328 9.3868 4.4518 0.6257
A2780 GDSC1; GDSC2; CTRP1 7.9005 9.5156 4.5417 0.1302
EFO-27 GDSC1; GDSC2; CTRP1 8.1774 9.873 4.5172 0.1149
Caov-3 GDSC2; CTRP1 8.2799 16.0486 1.9604 9.7712
⏷ Show the Full List of 41 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 31 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KP-4 GDSC1; GDSC2 2.4132 4.4233 1.9061 12.0115
PL4 GDSC1; GDSC2 4.2495 6.4373 2.4527 3.3185
PSN1 GDSC1; GDSC2 4.4964 6.6463 2.5065 2.5844
PaTu 8988t GDSC1; GDSC2 4.8285 6.0047 2.9351 0.3127
MIA PaCa-2 GDSC1; GDSC2 4.8795 7.2734 2.4436 2.3463
Hs 766T GDSC1; GDSC2 5.0456 6.7835 2.7302 0.8505
SU.86.86 GDSC1; GDSC2 5.1528 6.3916 2.9203 0.2158
KP-2 GDSC1; GDSC2 5.2841 6.7294 2.8495 0.3261
AsPC-1 GDSC1; GDSC2 5.2915 10.6004 1.1642 8.7115
Panc 04.03 GDSC1; GDSC2 5.3839 7.0573 2.769 0.4936
DAN-G GDSC1; GDSC2 5.4355 7.0127 2.8057 0.3695
Panc 08.13 GDSC1; GDSC2 5.4926 7.7496 2.5496 1.1761
YAPC GDSC1; GDSC2 5.57 6.8719 2.9046 0.1323
Panc 02.03 GDSC1; GDSC2 5.6252 7.0373 2.8676 0.1767
KP-1N GDSC1; GDSC2 5.7078 8.1001 2.508 1.1576
Capan-1 GDSC1; GDSC2 5.73 7.409 2.7761 0.3214
HuP-T3 GDSC1; GDSC2 5.8773 7.3868 2.8374 0.1652
BxPC-3 GDSC1; GDSC2 5.9245 8.0928 2.6032 0.6843
HPAF-II GDSC1 6.0688 8.0474 2.6767 0.5206
HuP-T4 GDSC1; GDSC2; CTRP1 6.0785 8.3045 4.1866 2.697
SW1990 GDSC1; GDSC2 6.1643 8.0472 2.7125 0.3064
MZ-PC-1 GDSC1; GDSC2 6.3505 8.8039 2.5115 0.7201
PaTu 8902 GDSC1; GDSC2; CTRP1 6.431 7.7624 4.6082 0.5118
CFPAC-1 GDSC1; GDSC2; CTRP1 6.4653 8.9232 4.1347 2.3928
Panc 03.27 GDSC1; GDSC2; CTRP1 6.5154 9.3683 3.963 3.1277
KP-3 GDSC1; GDSC2; CTRP1 6.5909 9.8564 3.7848 3.873
Capan-2 GDSC1; CTRP1 6.7627 9.1486 4.1986 2.1094
HPAC GDSC1; GDSC2; CTRP1 6.9456 8.5707 4.5179 0.4748
QGP-1 GDSC1; GDSC2; CTRP1 7.2229 8.5487 4.6324 0.1408
SUIT-2 GDSC1; GDSC2; CTRP1 7.2858 8.5511 4.6537 0.1019
Panc 10.05 GDSC1; GDSC2; CTRP1 7.3637 9.4825 4.3473 0.7225
⏷ Show the Full List of 31 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MPP 89 GDSC1; GDSC2 5.0931 7.6356 2.401 2.2741
IST-Mes1 GDSC1; GDSC2 5.6695 8.1835 2.4576 1.3878
NCI-H2452 GDSC1; GDSC2 6.345 8.257 2.7054 0.2666
NCI-H2052 GDSC1; GDSC2; CTRP1 7.3313 8.9281 4.5394 0.2666
MSTO-211H GDSC1; GDSC2; CTRP1 7.4905 9.474 4.4031 0.5049
NCI-H28 GDSC1; GDSC2; CTRP1 7.6159 9.3309 4.5032 0.2474
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 7 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
DU145 GDSC1; GDSC2 4.2329 6.9235 2.2121 4.7761
22Rv1 GDSC1; GDSC2 4.5827 7.0307 2.3831 3.125
VCaP GDSC1; GDSC2 5.1314 6.4314 2.8981 0.2726
NCI-H660 GDSC2 5.175 6.7347 2.8043 0.5051
PaCa-3 CTRP1 5.9479 8.3376 4.0881 5.671
PC-3 GDSC1; GDSC2 6.322 8.477 2.6194 0.4515
LNCaP clone FGC GDSC1; GDSC2 6.803 8.6082 2.7465 0.1183
⏷ Show the Full List of 7 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 GDSC1; GDSC2 4.9413 7.8436 2.2255 3.4089
Cancer Drug Sensitivity Data Curated from 61 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
G-mel GDSC1; GDSC2 3.5301 5.0624 2.6185 3.8841
Mel Ho GDSC1; GDSC2 3.8475 5.4965 2.6353 3.0357
A2058 GDSC1; GDSC2 3.91 5.5635 2.6452 2.8461
GAK GDSC1; GDSC2 4.0281 5.2427 2.8667 1.3638
RPMI-7951 GDSC1; GDSC2 4.0316 6.1639 2.44 3.8266
A101D GDSC1; GDSC2 4.1585 7.2792 1.9897 6.2841
451Lu GDSC1; GDSC2 4.1695 6.2838 2.4738 3.3479
COLO 783 GDSC1; GDSC2 4.186 5.5876 2.8023 1.4698
WM793 GDSC1; GDSC2 4.1898 7.4682 1.9199 6.6382
IGR-1 GDSC1; GDSC2 4.1899 5.9195 2.6554 2.2645
WM35 GDSC1; GDSC2 4.2085 7.7717 1.7856 7.412
COLO 829 GDSC1; GDSC2 4.229 6.5882 2.3687 3.8511
UACC-62 GDSC1; GDSC2 4.376 5.6146 2.8893 0.8109
WM278 GDSC1; GDSC2 4.4729 6.7407 2.4498 2.9369
WT2-iPS GDSC1; GDSC2 4.557 6.5903 2.5661 2.17
SK-MEL-2 GDSC1; GDSC2 4.5687 5.8768 2.8737 0.694
A-388 GDSC1; GDSC2 4.6784 7.7676 2.1022 4.5507
DJM-1 GDSC1; GDSC2 4.7181 7.1982 2.3866 2.8864
CHL-1 GDSC1; GDSC2 4.7229 6.9619 2.4943 2.3053
WM115 GDSC1; GDSC2 4.7383 9.0932 1.5143 7.8596
Hs 938.T GDSC1; GDSC2 4.7608 5.9853 2.9149 0.4078
A-431 GDSC1; GDSC2 4.8329 6.6141 2.6995 1.1729
HT-144 GDSC1; GDSC2 4.8364 6.6985 2.6664 1.3167
MZ-MEL-7 GDSC1; GDSC2 4.886 6.9022 2.606 1.5386
IPC-298 GDSC1; GDSC2 4.9451 8.4901 1.9327 5.0334
SK-MEL-30 GDSC1; GDSC2 4.9544 15.8203 -1.6244 22.3388
WM1552C GDSC1; GDSC2 5.0578 6.7023 2.7672 0.7045
CP50-MEL-B GDSC1; GDSC2 5.0676 6.6677 2.7848 0.6363
LB373-MEL-D GDSC1; GDSC2 5.0719 6.1045 2.9906 0.1125
IGR-37 GDSC1; GDSC2 5.1256 6.262 2.9556 0.1563
MZ-MEL-2 GDSC1; GDSC2 5.1874 7.2212 2.6207 1.1619
LB2518-MEL GDSC1; GDSC2 5.2 7.0736 2.685 0.8971
SK-MEL-3 GDSC1; GDSC2 5.2001 6.6157 2.8582 0.3411
Hs 940.T GDSC1; GDSC2 5.3388 7.0917 2.7377 0.6148
VMRC-MELG GDSC1; GDSC2 5.3865 6.6831 2.9041 0.1764
IST-MEL1 GDSC1; GDSC2 5.3873 7.5253 2.5909 1.1042
SK-MEL-24 GDSC1; GDSC2 5.4081 7.6643 2.545 1.2695
UACC-257 GDSC1; GDSC2 5.4324 6.8472 2.8636 0.2393
M14 GDSC1 5.4328 7.3077 2.6953 0.8627
Mel JuSo GDSC1; GDSC2 5.4479 6.9563 2.8308 0.3045
RVH-421 GDSC1; GDSC2 5.4748 6.8665 2.8724 0.2088
SK-MEL-31 GDSC1; GDSC2 5.493 6.9233 2.8592 0.2286
SH-4 GDSC1; GDSC2 5.4997 7.1267 2.7894 0.3824
MMAc-SF GDSC1; GDSC2 5.525 14.2183 -0.4173 16.1937
CP66-MEL GDSC1; GDSC2 5.6143 6.8117 2.9402 0.0809
COLO 792 GDSC1; GDSC2 5.624 9.1542 2.0272 3.4427
COLO 679 GDSC1; GDSC2 5.6299 7.2191 2.8059 0.2925
SK-MEL-28 GDSC1; GDSC2; CTRP1 5.8076 11.3898 2.4937 11.9232
LOX-IMVI GDSC1; GDSC2 5.8146 7.2474 2.8628 0.1416
MeWo GDSC1; GDSC2 5.858 7.2432 2.8793 0.1122
G-361 GDSC1; GDSC2; CTRP1 6.0569 7.9932 4.3164 2.1033
Hs 852.T CTRP1 6.0664 9.413 3.6535 8.9405
SK-MEL-1 GDSC1; GDSC2; CTRP1 6.1266 8.0599 4.3271 1.9564
COLO 741 CTRP1 6.2097 9.1958 3.8529 6.8791
HMV-II GDSC1; GDSC2 6.3507 8.1624 2.74 0.2074
SK-MEL-5 GDSC1; GDSC2; CTRP1 6.7242 7.9702 4.6509 0.2505
Hs 936.T CTRP1 6.9975 11.9916 3.0444 10.8959
Hs 944.T CTRP1 7.264 8.8142 4.5545 0.4332
A-375 GDSC1; GDSC2; CTRP1 7.4185 9.0847 4.5165 0.2823
COLO 800 GDSC1; GDSC2 8.4268 22.4326 -2.3873 17.9727
EquiPSC Line K2 GDSC1; GDSC2 5.9009 8.3021 2.514 0.9895
⏷ Show the Full List of 61 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Small Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuTu 80 GDSC1; GDSC2 4.6276 6.7288 2.5442 2.1817
Cancer Drug Sensitivity Data Curated from 23 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE 441.T GDSC2 4.1464 7.2379 2.0012 6.2407
SW684 GDSC1; GDSC2 4.4811 9.4596 1.1573 10.5133
GCT GDSC1; GDSC2 4.4968 7.8255 1.958 5.7481
G-402 GDSC1; GDSC2 4.5208 7.1397 2.2956 3.727
SW982 GDSC1; GDSC2 4.6194 5.9305 2.8753 0.6448
MES-SA GDSC1; GDSC2 4.8266 6.0971 2.9001 0.4149
Hs 633.T GDSC1; GDSC2 4.866 8.4952 1.8809 5.4745
VA-ES-BJ GDSC1; GDSC2 5.0137 9.2097 1.6403 6.5735
Rh41 GDSC1; GDSC2 5.1524 8.483 2.0601 3.9722
Rh30 GDSC1; GDSC2 5.1864 6.8204 2.7768 0.5846
EW-8 GDSC1; GDSC2 5.2541 6.8781 2.7831 0.5241
SW872 GDSC1; GDSC2 5.2856 7.0066 2.7477 0.6159
Rh18 GDSC1 5.3152 7.2236 2.6772 1.0421
KYM-1 GDSC1; GDSC2 5.3855 6.9175 2.8208 0.3537
RD GDSC1; GDSC2 5.5274 7.2059 2.7714 0.4158
SK-UT-1 GDSC1; GDSC2 5.8193 7.2521 2.8629 0.1405
A-204 GDSC1; GDSC2 5.8298 8.94 2.2253 2.2287
MFH-ino GDSC1; GDSC2 5.859 7.4502 2.8092 0.2155
SK-LMS-1 GDSC1; GDSC2 5.9531 7.718 2.7501 0.299
STS-0421 GDSC1; GDSC2 6.8339 9.125 2.5814 0.3544
RKN GDSC1; GDSC2; CTRP1 6.9202 8.1914 4.6464 0.1942
G-401 GDSC1; GDSC2; CTRP1 6.989 10.1741 3.8743 2.9021
HT-1080 GDSC1; GDSC2; CTRP1 7.3855 8.8859 4.5743 0.1902
⏷ Show the Full List of 23 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 31 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-16 GDSC1; GDSC2 3.6938 5.5252 2.5128 4.1379
Hs 746.T GDSC1; GDSC2 3.7924 5.1242 2.7763 2.3026
HSC-39 GDSC1; GDSC2 3.8572 6.1042 2.3478 4.7745
IM95 GDSC1; GDSC2 3.9894 6.4205 2.2875 4.844
ECC10 GDSC1; GDSC2 4.0257 6.0827 2.4748 3.6293
SNU-1 GDSC1; GDSC2 4.1051 6.7314 2.2175 5.0154
MKN1 GDSC1; GDSC2 4.1099 6.1522 2.4973 3.3256
NUGC-3 GDSC1; GDSC2 4.2079 5.7606 2.7378 1.7807
RERF-GC-1B GDSC1; GDSC2 4.362 7.3826 2.0793 5.3034
HGC-27 GDSC1; GDSC2 4.3802 6.8231 2.3551 3.6415
KATO III GDSC1; GDSC2 4.5582 6.5348 2.5912 2.0364
MKN45 GDSC1; GDSC2 4.9036 7.0118 2.5687 1.6939
ECC12 GDSC2 5.0452 6.2413 2.9333 0.2257
SCH GDSC1; GDSC2 5.1277 6.3611 2.9217 0.2214
SNU-5 GDSC1; GDSC2 5.1425 6.8069 2.7634 0.6579
TMK-1 GDSC1; GDSC2 5.1708 7.7502 2.3926 2.2163
TGBC11TKB GDSC1; GDSC2 5.2373 6.7915 2.8084 0.4583
GCIY GDSC1; GDSC2 5.2611 6.8368 2.8013 0.4661
SK-GT-2 GDSC1; GDSC2 5.3183 7.7058 2.4855 1.6112
23132/87 GDSC1; GDSC2 5.4271 7.2414 2.718 0.6231
NCI-N87 GDSC1 5.7223 7.5654 2.7169 0.5829
OCUM-1 GDSC1; GDSC2 5.7772 7.8186 2.6454 0.641
RF-48 GDSC1; GDSC2 5.946 7.6649 2.7661 0.2695
MKN28 GDSC1; GDSC2 6.1598 8.545 2.5305 0.7697
SH-10-TC CTRP1 6.1617 7.7776 4.4713 2.1165
NUGC-4 GDSC1; GDSC2; CTRP1 6.1713 7.957 4.3982 1.5745
Fu97 GDSC1; GDSC2; CTRP1 6.3402 9.7892 3.6574 4.9073
MKN74 CTRP1 6.7028 8.8938 4.2762 2.5029
AGS GDSC1; GDSC2; CTRP1 7.2432 8.5824 4.628 0.1427
MKN7 GDSC1; GDSC2; CTRP1 7.2677 10.065 4.0688 1.7672
SNG-M GDSC1; GDSC2; CTRP1 7.4727 9.0102 4.5628 0.1869
⏷ Show the Full List of 31 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
IHH-4 GDSC1; GDSC2 3.8359 5.5115 2.6203 3.1518
8305C GDSC1; GDSC2 4.0709 6.0716 2.5099 3.3278
CGTH-W-1 GDSC1; GDSC2 4.0857 5.6728 2.7056 2.161
BHT-101 GDSC1; GDSC2 4.1692 7.2269 2.0225 6.0603
ML-1 [Human leukemia] GDSC1; GDSC2 4.2959 6.3832 2.5068 2.9219
FTC-133 GDSC1; GDSC2 4.4824 6.8428 2.4089 3.1506
8505C GDSC1; GDSC2 4.6362 7.4622 2.2176 3.9662
B-CPAP GDSC1; GDSC2 4.9145 7.2953 2.4529 2.2507
CAL-62 GDSC1; GDSC2 5.4605 6.9058 2.8534 0.2508
TT GDSC1; GDSC2 5.4806 6.8151 2.8923 0.1719
KMH-2 GDSC1; GDSC2 5.7457 7.1101 2.8853 0.1245
ASH-3 GDSC1; GDSC2 5.7954 7.1262 2.897 0.1015
WRO GDSC1; GDSC2 5.8107 7.2625 2.8563 0.1516
K5 GDSC1; GDSC2 5.8483 7.4483 2.8059 0.2241
TT2609-C02 GDSC1; GDSC2 6.2617 8.0597 2.7435 0.2231
HTC-C3 GDSC1; GDSC2 6.4411 8.5512 2.6378 0.3673
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 41 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HSC-3 GDSC1; GDSC2 3.7815 5.3183 2.6759 2.9316
CAL-27 GDSC1; GDSC2 3.7873 5.7663 2.4626 4.2279
HO-1-u-1 GDSC1; GDSC2 3.8674 5.5249 2.6352 2.9945
PCI-04B GDSC1; GDSC2 4.1486 6.3324 2.4373 3.6037
DOK GDSC1; GDSC2 4.2111 8.8608 1.254 10.5983
PCI-06A GDSC1; GDSC2 4.3849 7.3471 2.1113 5.0656
BICR 22 GDSC1; GDSC2 4.4322 6.6912 2.448 3.0166
PCI-15A GDSC1; GDSC2 4.4786 6.3062 2.6478 1.8553
NCI-H3118 GDSC1; GDSC2 4.6111 7.0567 2.3881 3.0502
KOSC-2 GDSC1; GDSC2 4.6503 7.2517 2.3227 3.3482
CAL-33 GDSC1; GDSC2 4.6738 6.2826 2.7588 1.0765
SAT [Human HNSCC] GDSC1; GDSC2 4.688 8.0355 1.9831 5.2218
BB30-HNC GDSC1; GDSC2 4.8481 6.7495 2.6509 1.3742
Detroit 562 GDSC1; GDSC2 4.8741 6.9143 2.5949 1.6046
KON GDSC1; GDSC2 4.9706 7.5837 2.3575 2.6626
HSC-4 GDSC1; GDSC2 4.9779 9.7075 1.3814 8.1264
JHU-022 GDSC1; GDSC2 5.1122 7.3482 2.5325 1.6222
SAS GDSC1; GDSC2 5.1266 8.4704 2.0508 4.0644
BICR 78 GDSC1; GDSC2 5.1396 8.3399 2.1169 3.6847
BICR 10 GDSC1 5.1439 6.6672 2.8168 0.6043
SCC-4 GDSC1; GDSC2 5.174 6.7915 2.7825 0.5738
LB771-HNC GDSC1; GDSC2 5.2301 7.5867 2.4916 1.6785
Ca9-22 GDSC1; GDSC2 5.3728 7.1904 2.7146 0.6681
PCI-30 GDSC1; GDSC2 5.4233 7.9001 2.4564 1.6301
SKN-3 GDSC1; GDSC2 5.5251 10.7865 1.2271 7.9106
JHU-029 GDSC1; GDSC2 5.6199 8.2148 2.4218 1.5825
SCC-25 GDSC1; GDSC2 5.6625 7.7537 2.6224 0.7834
JHU-011 GDSC1; GDSC2 5.7791 13.0901 0.3027 12.2528
BHY GDSC1; GDSC2 5.8123 7.5862 2.7441 0.3624
BB49-HNC GDSC1 5.814 7.9315 2.6183 0.8747
PCI-38 GDSC1 5.8399 7.6167 2.7436 0.4394
UPCI-SCC-090 GDSC1; GDSC2 5.8472 7.8529 2.661 0.5586
BICR 31 GDSC2 5.9366 7.8556 2.6949 0.4284
PE/CA-PJ15 GDSC1; GDSC2 5.9549 7.7192 2.7504 0.2979
HO-1-N-1 GDSC1; GDSC2 6.0596 7.6615 2.8081 0.1692
OSC-20 GDSC1; GDSC2 6.0962 7.869 2.7498 0.2559
HSC-2 GDSC1; GDSC2; CTRP1 6.1098 7.7634 4.4495 1.4219
FaDu GDSC1; GDSC2 6.2011 7.5336 2.899 0.0526
SCC-15 GDSC1; GDSC2 6.84 15.861 -0.3141 13.0613
OSC-19 GDSC1; GDSC2 7.0604 16.9167 -0.6694 14.1714
SCC-9 GDSC1; GDSC2; CTRP1 7.3139 9.1796 4.441 0.4926
⏷ Show the Full List of 41 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 17 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
BFTC-905 GDSC1; GDSC2 3.6851 5.5096 2.514 4.1515
J82 GDSC1; GDSC2 4.1972 6.7304 2.2804 4.4408
639V GDSC1; GDSC2 4.3321 6.8338 2.3195 3.9399
KU-19-19 GDSC1; GDSC2 4.7216 6.0766 2.8634 0.6086
CAL-29 GDSC1; GDSC2 4.9049 6.7784 2.6668 1.2419
HT-1197 GDSC1; GDSC2 5.5489 6.8944 2.8894 0.1598
647V GDSC1; GDSC2 5.6193 7.1943 2.8107 0.286
SW780 GDSC1; GDSC2 5.6847 7.3742 2.7714 0.3491
RT-112 GDSC1; GDSC2 5.7023 7.2064 2.8369 0.209
T24 GDSC1; GDSC2 5.7685 7.9772 2.5821 0.8478
RT-4 GDSC1; GDSC2; CTRP1 5.9422 8.5376 3.9892 3.912
SW1710 GDSC1; GDSC2 5.9632 7.6791 2.7674 0.2619
TCCSUP GDSC1; GDSC2 6.049 7.4438 2.8776 0.0862
UM-UC-3 GDSC1; GDSC2; CTRP1 6.3405 8.3626 4.3133 1.7448
HT-1376 GDSC1; GDSC2; CTRP1 6.4691 8.6697 4.2491 1.8731
5637 GDSC1; GDSC2; CTRP1 6.8682 10.1474 3.8174 3.3202
KMBC-2 CTRP1 7.3454 9.7603 4.2305 1.844
⏷ Show the Full List of 17 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 39 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NEC8 GDSC1; GDSC2 4.2838 6.2874 2.5435 2.7341
ME-180 GDSC1; GDSC2 4.3788 6.9231 2.3074 3.9213
HeLa GDSC1; GDSC2 4.699 5.731 2.984 0.2447
ACC-OV7 GDSC1; GDSC2 4.701 9.7246 1.1843 9.8518
SW954 GDSC1; GDSC2 4.8448 7.2341 2.4418 2.404
SW756 GDSC1; GDSC2 4.8793 6.5977 2.7282 1.0042
TC-YIK GDSC1; GDSC2 4.9516 7.0894 2.5604 1.6764
Ca Ski GDSC1; GDSC2 5.0208 7.2524 2.5268 1.7533
C-33 A GDSC1; GDSC2 5.0244 6.9025 2.673 1.0972
DoTc2 4510 GDSC1; GDSC2 5.0264 6.7752 2.7248 0.887
UWB1.289 GDSC1; GDSC2 5.0305 7.1523 2.5736 1.5252
JAR GDSC1; GDSC2 5.0373 6.6796 2.7671 0.72
C-4-I GDSC1; GDSC2 5.0509 6.6703 2.7766 0.6763
OV17R GDSC1; GDSC2 5.0686 7.3308 2.518 1.7391
SW962 GDSC1; GDSC2 5.0712 7.0795 2.6233 1.262
SiHa GDSC1; GDSC2 5.1364 6.4467 2.8945 0.2789
KGN GDSC1; GDSC2 5.3074 7.2858 2.6495 0.9449
PWR-1E GDSC1; GDSC2 5.3082 7.1001 2.7217 0.6868
PA-1 GDSC1; GDSC2 5.3354 7.0557 2.7499 0.5786
NT2-D1 GDSC1; GDSC2 5.3517 7.2451 2.6847 0.7836
JEG-3 GDSC1; GDSC2 5.3873 6.7174 2.8924 0.1971
SKN GDSC1; GDSC2 5.3943 7.6374 2.5494 1.264
DSH1 GDSC1; GDSC2 5.3959 6.8638 2.844 0.2942
OVCA420 GDSC1; GDSC2 5.3987 7.2928 2.6865 0.7445
HEC-1 GDSC1; GDSC2 5.4475 6.9692 2.826 0.3157
CAL-39 GDSC1; GDSC2 5.4955 7.4733 2.6586 0.7734
HEY GDSC1; GDSC2 5.7216 8.2363 2.4604 1.3305
SiSo GDSC1; GDSC2 5.7776 7.3922 2.7997 0.2564
SKG-IIIa GDSC1; GDSC2 5.781 7.4963 2.7642 0.3288
OMC-1 [Human cervical carcinoma] GDSC1; GDSC2 5.7811 7.4296 2.7879 0.2787
MS751 GDSC1; GDSC2 5.8626 7.3641 2.84 0.1645
NCC-IT GDSC2 5.9395 7.7026 2.7505 0.3027
HT-3 GDSC1; GDSC2 6.0054 7.8403 2.7264 0.3305
JHOS-3 GDSC1; GDSC2 6.0087 7.7853 2.747 0.2873
OVMIU GDSC1; GDSC2 6.0896 8.4516 2.5366 0.7919
LB831-BLC GDSC1; GDSC2 6.1013 7.9314 2.7299 0.2919
PEO1 GDSC1; GDSC2 6.2 8.3815 2.6068 0.5343
OVCA433 GDSC1; GDSC2 6.2896 8.099 2.74 0.2219
BPH-1 GDSC1; GDSC2 6.2937 8.4141 2.6311 0.4353
⏷ Show the Full List of 39 Cancer Drug Sensitivity Data of This Drug

Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Disease Different from Vismodegib (Comorbidity)
DDI Drug Name DDI Drug ID Severity Mechanism Comorbidity REF
Tucatinib DMBESUA Moderate Decreased metabolism of Vismodegib caused by Tucatinib mediated inhibition of CYP450 enzyme. Breast cancer [2C60-2C6Y] [9]
SODIUM CITRATE DMHPD2Y Minor Decreased absorption of Vismodegib due to altered gastric pH caused by SODIUM CITRATE. Discovery agent [N.A.] [10]

Drug Inactive Ingredient(s) (DIG) and Formulation(s) of This Drug

DIG
DIG Name DIG ID PubChem CID Functional Classification
Sodium lauryl sulfate E00464 3423265 Emulsifying agent; Modified-release agent; Penetration agent; Solubilizing agent; Surfactant; lubricant
Eisenoxyd E00585 56841934 Colorant
Ferrosoferric oxide E00231 14789 Colorant
Lactose monohydrate E00393 104938 Binding agent; Diluent; Dry powder inhaler carrier; Lyophilization aid
Magnesium stearate E00208 11177 lubricant
Talc E00520 16211421 Anticaking agent; Diluent; Glidant; lubricant
Titanium dioxide E00322 26042 Coating agent; Colorant; Opacifying agent
Vinylpyrrolidone E00668 Not Available Binding agent; Coating agent; Disintegrant; Film/membrane-forming agent; Solubilizing agent; Suspending agent
⏷ Show the Full List of 8 Pharmaceutical Excipients of This Drug
Pharmaceutical Formulation
Formulation Name Drug Dosage Dosage Form Route
Vismodegib 150 mg capsule 150 mg Oral Capsule Oral
Jump to Detail Pharmaceutical Formulation Page of This Drug

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6975).
2 A phase II, multicenter, open-label, 3-cohort trial evaluating the efficacy and safety of vismodegib in operable basal cell carcinoma. J Am Acad Dermatol. 2015 Jul;73(1):99-105.e1.
3 BDDCS predictions, self-correcting aspects of BDDCS assignments, BDDCS assignment corrections, and classification for more than 175 additional drugs
4 Trend Analysis of a Database of Intravenous Pharmacokinetic Parameters in Humans for 1352 Drug Compounds
5 Nat Rev Drug Discov. 2013 Feb;12(2):87-90.
6 The dawn of hedgehog inhibitors: Vismodegib. J Pharmacol Pharmacother. 2013 Jan;4(1):4-7.
7 Hedgehog signaling antagonist GDC-0449 (Vismodegib) inhibits pancreatic cancer stem cell characteristics: molecular mechanisms. PLoS One. 2011;6(11):e27306. doi: 10.1371/journal.pone.0027306. Epub 2011 Nov 8.
8 Epigenetic targeting of Hedgehog pathway transcriptional output through BET bromodomain inhibition. Nat Med. 2014 Jul;20(7):732-40. doi: 10.1038/nm.3613. Epub 2014 Jun 29.
9 Product Information. Tukysa (tucatinib). Seattle Genetics Inc, Bothell, WA.
10 Cerner Multum, Inc. "Australian Product Information.".