Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM5NW1E)

Drug Name
Beclomethasone dipropionate Drug Info
Synonyms
BECLOMETHASONE DIPROPIONATE; Beclometasone dipropionate; Beconase; Beclovent; Vancenase; Beclorhinol; Becloforte; Sanasthmyl; Beclazone; Sanasthmax; Propaderm; Beclomet; Vanceril; Aerobec; Becloturmant; Beclacin; Respocort; Entyderma; Korbutone; Viarox; Rino-clenil; Clenil-A; Beclometasone 17,21-dipropionate; Becotide; Aldecin; Turbinal; Aldecina; Rhinosol; Beclate; Atomase; Alanase; Benconase; Aldecine; Clenil; Spir; Beclocort Nasel; Beclomet Nasal; Propaderm Forte; Rhino Clenil; Inalone O; Inalone R; Qvar; QNASL; Beconase AQ; Qvar 80
Cross-matching ID
PubChem CID
21700
ChEBI ID
CHEMBL3002
CAS Number
CAS 5534-09-8
VARIDT Drug ID
DR01665

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 2.04 0.00e+0 34/36 (94.44%) PCNA;MCM5;MCM2;...
Tyrosine metabolism 2.04 0.00e+0 30/36 (83.33%) MAOA;ADH1B;AOX1;...
Drug metabolism 1.94 8.76e-3 78/151 (51.66%) MAOA;ADH1B;UGT2B28;...
PPAR signaling pathway 1.89 8.76e-3 66/74 (89.19%) ACSL1;LPL;PLIN2;...
Starch and sucrose metabolism 1.85 1.58e-2 25/36 (69.44%) HK1;GYS1;PYGM;...
Pyruvate metabolism 1.81 2.63e-2 41/47 (87.23%) ADH1B;PCK2;DLAT;...
Homologous recombination 1.77 3.75e-2 35/41 (85.37%) BRCA1;BLM;NBN;...
Complement and coagulation cascades 1.77 3.28e-2 76/85 (89.41%) CFD;SERPINE1;F3;...
Glyoxylate and dicarboxylate metabolism 1.76 3.21e-2 23/30 (76.67%) GLUL;SHMT1;GLDC;...
Caffeine metabolism 1.75 3.15e-2 5/6 (83.33%) NAT1;CYP2A6;CYP1A2
Phenylalanine metabolism 1.73 3.10e-2 14/17 (82.35%) MAOA;AOC3;GLYAT;...
Proximal tubule bicarbonate reclamation 1.70 3.94e-2 21/23 (91.3%) CA4;ATP1A2;PCK2;...
Fatty acid elongation 1.70 3.84e-2 19/27 (70.37%) ELOVL2;HACD2;ELOVL4;...
Folate biosynthesis 1.69 3.88e-2 23/26 (88.46%) AKR1C3;ALPL;AKR1B1;...
Tryptophan metabolism 1.67 4.03e-2 35/42 (83.33%) MAOA;AOX1;DHTKD1;...
p53 signaling pathway 1.67 3.83e-2 63/73 (86.3%) SERPINE1;GADD45B;IGF1;...
Mismatch repair 1.67 3.61e-2 22/23 (95.65%) PCNA;RFC2;RFC4;...
Propanoate metabolism 1.66 4.28e-2 30/34 (88.24%) ACAT1;EHHADH;ACACB;...
Cytokine-cytokine receptor interaction -1.78 4.40e-2 246/295 (83.39%) IL21;CCR9;ACKR4;...
Viral protein interaction with cytokine and cytokine re... -1.79 4.86e-2 84/100 (84%) CCL22;CXCR3;CCL7;...
Primary immunodeficiency -2.07 5.68e-3 33/38 (86.84%) CD79A;TAP1;CD40LG;...
Antigen processing and presentation -2.12 0.00e+0 60/78 (76.92%) PSME1;IFNG;HSPA1L;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 3H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H