Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM63OD7)

Drug Name
Pifithrin-alpha Drug Info
Synonyms P53 inhibitor, Univ of Illinois; PFT-alpha; PFT-beta; Pifithrin compounds, Quark; Pifithrin-beta
Cross-matching ID
PubChem CID
9929138
ChEBI ID
CHEMBL556353
CAS Number
CAS 63208-82-2
TTD Drug ID
D02NYK

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Cell cycle 2.07 1.20e-2 110/124 (88.71%) CCNA2;CDC20;CCND3;...
ECM-receptor interaction 1.97 1.20e-2 80/88 (90.91%) THBS1;TNC;ITGA2;...
Oocyte meiosis 1.88 2.00e-2 90/129 (69.77%) CDC20;PRKACA;SMC1A;...
DNA replication 1.85 2.10e-2 34/36 (94.44%) POLD1;MCM4;RPA2;...
Cellular senescence 1.85 1.92e-2 139/156 (89.1%) CCNA2;NFATC4;CCND3;...
Fanconi anemia pathway 1.85 1.60e-2 36/54 (66.67%) RPA2;USP1;FANCG;...
TGF-beta signaling pathway 1.81 1.88e-2 81/94 (86.17%) ID2;THBS1;FST;...
Malaria 1.76 3.44e-2 44/50 (88%) THBS1;SDC2;CCL2;...
Progesterone-mediated oocyte maturation 1.75 3.46e-2 75/100 (75%) CCNA2;CDC25B;PRKACA;...
Viral protein interaction with cytokine and cytokine re... -1.61 4.84e-2 84/100 (84%) IL10RA;CCL21;PF4;...
Parkinson disease -1.62 4.83e-2 176/249 (70.68%) NDUFA9;NDUFB5;ATP5PB;...
Amino sugar and nucleotide sugar metabolism -1.63 4.77e-2 38/48 (79.17%) GALE;CYB5R4;NAGK;...
Neutrophil extracellular trap formation -1.64 4.56e-2 101/189 (53.44%) NCF4;FGA;SELP;...
Legionellosis -1.71 2.66e-2 51/57 (89.47%) IL12A;CASP8;CXCL2;...
Ferroptosis -1.73 2.22e-2 36/41 (87.8%) ATG7;PRNP;NCOA4;...
Huntington disease -1.73 2.38e-2 233/306 (76.14%) TFAM;GPX5;COX5B;...
Phagosome -1.74 2.57e-2 118/152 (77.63%) ITGAM;TUBA1A;RAB7A;...
Biosynthesis of unsaturated fatty acids -1.74 2.78e-2 21/27 (77.78%) SCD5;ACAA1;HSD17B4;...
Prion disease -1.77 2.27e-2 209/273 (76.56%) HSPA1L;ATP5PD;NDUFA2;...
PPAR signaling pathway -1.78 2.25e-2 66/74 (89.19%) SCD5;FABP2;FABP1;...
Proteasome -1.79 2.13e-2 44/46 (95.65%) PSMB1;PSMA3;PSMB7;...
Synthesis and degradation of ketone bodies -1.83 1.46e-2 9/10 (90%) HMGCL;ACAT1;HMGCS1
Mineral absorption -1.84 1.67e-2 48/60 (80%) MT1HL1;SLC39A4;SLC5A1;...
Systemic lupus erythematosus -1.84 1.95e-2 45/135 (33.33%) TRIM21;SNRPB;HLA-DQB1;...
Staphylococcus aureus infection -2.02 0.00e+0 72/95 (75.79%) ITGAM;PTAFR;DSG1;...
Terpenoid backbone biosynthesis -2.03 0.00e+0 18/22 (81.82%) MVD;ACAT1;HMGCR;...
Oxidative phosphorylation -2.26 0.00e+0 93/133 (69.92%) NDUFA9;NDUFB5;ATP5PB;...
Complement and coagulation cascades -2.30 0.00e+0 76/85 (89.41%) ITGAM;C7;FGA;...
Steroid biosynthesis -2.46 0.00e+0 19/20 (95%) LBR;EBP;LIPA;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-673 CVCL_0080 Homo sapiens 70uM 6H
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 15uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM - 70uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CL-34 CVCL_1123 Homo sapiens 70uM 6H
HT-29 CVCL_0320 Homo sapiens 10uM - 70uM 6H, 24H
LoVo CVCL_0399 Homo sapiens 70uM 6H
MDST8 CVCL_1400 Homo sapiens 70uM 6H
NCI-H508 CVCL_1561 Homo sapiens 70uM 6H
SNU-1040 CVCL_5001 Homo sapiens 70uM 6H
SNU-C4 CVCL_5008 Homo sapiens 70uM 6H
SNU-C5 CVCL_5009 Homo sapiens 70uM 6H
SW480 CVCL_0546 Homo sapiens 70uM 6H
SW620 CVCL_0547 Homo sapiens 70uM 6H
SW948 CVCL_0550 Homo sapiens 70uM 6H
Colorectal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCT 116 CVCL_0291 Homo sapiens 70uM 6H
HT115 CVCL_1294 Homo sapiens 70uM 6H
RKO CVCL_0504 Homo sapiens 70uM 6H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 70uM 6H
SNG-M CVCL_1707 Homo sapiens 70uM 6H
Endometrial carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHUEM-2 CVCL_1327 Homo sapiens 70uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM - 70uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM - 70uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM - 70uM 6H, 24H
DV-90 CVCL_1184 Homo sapiens 70uM 6H
SK-LU-1 CVCL_0624 Homo sapiens 70uM 6H
Lung adenosquamous carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H596 CVCL_1571 Homo sapiens 70uM 6H
Lung large cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COR-L23 CVCL_1133 Homo sapiens 70uM 6H
T3M-10 CVCL_1729 Homo sapiens 70uM 6H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC15 CVCL_1253 Homo sapiens 70uM 6H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1299 CVCL_0060 Homo sapiens 70uM 6H
HCC515 CVCL_5134 Homo sapiens 10uM - 70uM 6H, 24H
NCI-H2073 CVCL_1523 Homo sapiens 70uM 6H
Small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1694 CVCL_1495 Homo sapiens 70uM 6H
NCI-H1836 CVCL_1502 Homo sapiens 70uM 6H
Lymph node
Diffuse large B-cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
WSU-DLCL2 CVCL_1787 Homo sapiens 70uM 6H
Ovary
Ovarian carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
EFO-27 CVCL_1194 Homo sapiens 70uM 6H
OV7 CVCL_1623 Homo sapiens 70uM 6H
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
RMG-I CVCL_1663 Homo sapiens 70uM 6H
Ovarian mucinous cystadenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COV644 CVCL_2011 Homo sapiens 70uM 6H
RMUG-S CVCL_1666 Homo sapiens 70uM 6H
Ovarian undifferentiated carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
TYK-nu CVCL_1774 Homo sapiens 70uM 6H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 70uM 6H
Acute myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NOMO-1 CVCL_1609 Homo sapiens 70uM 6H
PL-21 CVCL_2161 Homo sapiens 70uM 6H
SKM-1 CVCL_0010 Homo sapiens 70uM 6H
Pleural effusion
Histiocytic lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-937 CVCL_0007 Homo sapiens 70uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM - 70uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM - 70uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM - 70uM 6H, 24H
SK-MEL-1 CVCL_0523 Homo sapiens 70uM 6H
SK-MEL-28 CVCL_0526 Homo sapiens 70uM 6H
Stomach
Gastric adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
AGS CVCL_0139 Homo sapiens 70uM 6H