Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM67EMK)

Drug Name
SCH-900776 Drug Info
Synonyms
CHEMBL1643208; MK-8776; 6-bromo-3-(1-methyl-1H-pyrazol-4-yl)-5-(piperidin-3-yl)pyrazolo[1,5-a]pyrimidin-7-amine; GTPL7943; SCHEMBL10380123; CHEBI:131165; HMS3656J19; BCP02883; BDBM50334854; AKOS026750519; MK 8776; NCGC00387868-02; DA-40779; 4CA-1150; BCP0726000317; J3.517.083I; 891494-63-6 pound not SCH900776 pound not SCH-900776; 6-bromo-3-(1-methylpyrazol-4-yl)-5-piperidin-3-ylpyrazolo[5,1-b]pyrimidin-7-amine; 6-bromo-3-(1-methylpyrazol-4-yl)-5-[(3S)-piperidin-3-yl]pyrazolo[1,5-a]pyrimidin-7-amine
Cross-matching ID
PubChem CID
46239015
ChEBI ID
CHEMBL2386889
CAS Number
CAS 891494-63-6
TTD Drug ID
D05FWH

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
beta-Alanine metabolism 1.94 3.26e-2 25/30 (83.33%) ALDH3A1;DPYD;ALDH3A2;...
Epithelial cell signaling in Helicobacter pylori infect... -1.67 4.46e-2 62/70 (88.57%) GIT1;ATP6V0E1;F11R;...
Lipid and atherosclerosis -1.69 3.89e-2 190/215 (88.37%) MAP2K6;PIK3R1;HSP90B1;...
Fluid shear stress and atherosclerosis -1.70 3.66e-2 123/139 (88.49%) CAV1;MAPK14;GSTT2;...
Salmonella infection -1.71 3.75e-2 198/249 (79.52%) KPNA4;S100A10;DCTN4;...
Chagas disease -1.71 3.86e-2 93/102 (91.18%) NOS2;AKT1;TGFBR1;...
Amino sugar and nucleotide sugar metabolism -1.74 3.40e-2 38/48 (79.17%) UGDH;MPI;NAGK;...
AGE-RAGE signaling pathway in diabetic complications -1.74 3.82e-2 97/100 (97%) AKT1;COL1A1;TGFBR1;...
Bacterial invasion of epithelial cells -1.77 2.66e-2 59/77 (76.62%) RAC1;SHC1;DNM1;...
Hippo signaling pathway -1.81 1.99e-2 120/186 (64.52%) PARD3;ITGB2;TGFB1;...
Glutathione metabolism -1.83 1.06e-2 43/57 (75.44%) GSTT2;SRM;RRM2;...
Pertussis -1.85 1.33e-2 64/76 (84.21%) C2;MAPK14;MAPK3;...
IL-17 signaling pathway -1.92 4.43e-3 84/94 (89.36%) FADD;MAPK14;MAPK3;...
TNF signaling pathway -1.93 0.00e+0 103/112 (91.96%) CX3CL1;PIK3R2;LTA;...
TGF-beta signaling pathway -2.02 0.00e+0 81/94 (86.17%) BMP7;ID3;TGFBR1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SK-ES-1 CVCL_0627 Homo sapiens 1.11uM - 3.33uM 24H
Brain
Glioma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
GI-1 CVCL_1230 Homo sapiens 1.11uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MDA-MB-468 CVCL_0419 Homo sapiens 1.11uM - 3.33uM 24H
Breast ductal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
T-47D CVCL_0553 Homo sapiens 1.11uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SNU-407 CVCL_5004 Homo sapiens 1.11uM - 10uM 24H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 1.11uM - 10uM 24H
HEC-1-A CVCL_0293 Homo sapiens 1.11uM - 10uM 24H
HEC-251 CVCL_2928 Homo sapiens 1.11uM - 10uM 24H
HEC-265 CVCL_2929 Homo sapiens 1.11uM - 10uM 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CJM CVCL_U797 Homo sapiens 1.11uM - 10uM 24H
Liver
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHH-5 CVCL_1320 Homo sapiens 1.11uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1573 CVCL_1483 Homo sapiens 1.11uM - 10uM 24H
NCI-H838 CVCL_1594 Homo sapiens 1.11uM - 10uM 24H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BEN CVCL_1081 Homo sapiens 1.11uM - 10uM 24H
HCC95 CVCL_1276 Homo sapiens 1.11uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H2110 CVCL_1529 Homo sapiens 1.11uM - 10uM 24H
Muscle
Rhabdomyosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-204 CVCL_0134 Homo sapiens 1.11uM - 10uM 24H
Ovary
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OVTOKO CVCL_3114 Homo sapiens 1.11uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
22Rv1 CVCL_1045 Homo sapiens 1.11uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
IGR-37 CVCL_1303 Homo sapiens 1.11uM - 10uM 24H
Mel-HO CVCL_1402 Homo sapiens 1.11uM - 10uM 24H
SH-4 CVCL_1692 Homo sapiens 1.11uM - 10uM 24H
Urinary bladder
Bladder transitional cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CAL-29 CVCL_1109 Homo sapiens 1.11uM - 10uM 24H