Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM6CHNJ)

Drug Name
Camptothecin Drug Info
Synonyms
camptothecin; Camptothecine; 7689-03-4; (S)-(+)-Camptothecin; Campathecin; d-Camptothecin; (+)-Camptothecine; (+)-Camptothecin; 20(S)-Camptothecine; 21,22-Secocamptothecin-21-oic acid lactone; NSC94600; (S)-Camptothecin; Camptothecine (8CI); 20(S)-Camptothecin; Camptothecine (S,+); CHEMBL65; UNII-XT3Z54Z28A; MLS000766223; (4S)-4-ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; XT3Z54Z28A; CHEBI:27656; VSJKWCGYPAHWDS-FQEVSTJZSA-N; Camptothecin, Camptotheca acuminata; NSC-94600; Camptothecin derivat
Cross-matching ID
PubChem CID
24360
ChEBI ID
CHEMBL27656
CAS Number
CAS 7689-03-4
TTD Drug ID
D09YDM
VARIDT Drug ID
DR01383

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
p53 signaling pathway 2.48 0.00e+0 63/73 (86.3%) CDKN1A;SESN1;PMAIP1;...
Allograft rejection 2.46 0.00e+0 32/38 (84.21%) HLA-B;HLA-F;HLA-C;...
Graft-versus-host disease 2.26 0.00e+0 32/42 (76.19%) HLA-B;HLA-F;HLA-C;...
Autoimmune thyroid disease 2.24 0.00e+0 46/53 (86.79%) HLA-B;HLA-F;HLA-C;...
DNA replication 2.09 0.00e+0 34/36 (94.44%) FEN1;POLE3;PCNA;...
Epstein-Barr virus infection 2.08 0.00e+0 189/202 (93.56%) CDKN1A;DDB2;HLA-B;...
Type I diabetes mellitus 2.08 0.00e+0 38/43 (88.37%) HLA-B;HLA-F;HLA-C;...
Herpes simplex virus 1 infection 2.03 0.00e+0 165/498 (33.13%) HLA-B;HLA-F;IRF9;...
Staphylococcus aureus infection 2.00 9.22e-4 72/95 (75.79%) KRT14;KRT17;CFB;...
Viral myocarditis 1.97 1.66e-3 53/60 (88.33%) CXADR;HLA-B;HLA-F;...
Measles 1.95 2.26e-3 133/139 (95.68%) IRF9;TP53;BCL2L1;...
Base excision repair 1.91 2.07e-3 29/33 (87.88%) FEN1;POLE3;PCNA;...
Antigen processing and presentation 1.87 3.19e-3 60/78 (76.92%) HLA-B;HLA-F;IFI30;...
Influenza A 1.83 5.33e-3 156/172 (90.7%) TNFRSF10B;SLC25A4;IRF9;...
Cytosolic DNA-sensing pathway 1.81 6.08e-3 52/63 (82.54%) POLR2H;NFKBIA;IRF7;...
Hepatitis C 1.75 9.85e-3 139/157 (88.54%) CDKN1A;IRF9;TP53;...
RNA polymerase 1.73 1.02e-2 23/31 (74.19%) POLR2H;POLR1C;POLR2K;...
Apoptosis 1.64 2.63e-2 126/168 (75%) PMAIP1;GADD45A;TNFRSF10B;...
Ribosome 1.62 3.19e-2 113/158 (71.52%) MRPS2;RPS27L;MRPL34;...
Toll-like receptor signaling pathway 1.60 3.77e-2 94/104 (90.38%) NFKBIA;CD14;LY96;...
Taurine and hypotaurine metabolism 1.58 4.27e-2 8/11 (72.73%) ADO;CSAD
Other glycan degradation 1.56 4.90e-2 13/18 (72.22%) FUCA1;NEU1;ENGASE;...
Hepatitis B 1.56 4.91e-2 151/162 (93.21%) CDKN1A;DDB2;EGR2;...
Viral protein interaction with cytokine and cytokine re... 1.56 4.84e-2 84/100 (84%) TNFRSF10B;CXCL13;CXCL8;...
GnRH secretion -1.69 1.80e-2 60/64 (93.75%) KCNJ3;GABBR1;RAF1;...
GnRH signaling pathway -1.71 1.65e-2 80/93 (86.02%) RAF1;SOS1;MMP2;...
Insulin secretion -1.73 1.34e-2 75/86 (87.21%) STX1A;SLC2A2;CACNA1D;...
Oocyte meiosis -1.73 1.35e-2 90/129 (69.77%) PPP1CC;PPP3R1;PTTG1;...
Progesterone-mediated oocyte maturation -1.74 1.23e-2 75/100 (75%) ADCY7;STK10;CDC25C;...
Endocrine and other factor-regulated calcium reabsorpti... -1.74 1.05e-2 49/53 (92.45%) CALB1;AP2A2;ATP1A1;...
Sphingolipid signaling pathway -1.75 9.98e-3 106/119 (89.08%) PPP2R2A;RAF1;GNA13;...
Rap1 signaling pathway -1.78 6.94e-3 184/210 (87.62%) GNAI3;BRAF;CALML5;...
Cholinergic synapse -1.79 6.22e-3 99/113 (87.61%) BCL2;GNAI3;KRAS;...
Salivary secretion -1.80 5.43e-3 76/93 (81.72%) CHRM3;AQP5;CST4;...
Wnt signaling pathway -1.81 5.13e-3 124/166 (74.7%) CSNK1A1;FZD4;RAC3;...
Proteoglycans in cancer -1.82 4.80e-3 172/205 (83.9%) SOS1;MMP2;PPP1CB;...
Gastric acid secretion -1.86 4.43e-3 63/76 (82.89%) CHRM3;MYLK;KCNK2;...
Axon guidance -1.87 2.68e-3 151/182 (82.97%) BMPR2;PAK4;SEMA5A;...
Dopaminergic synapse -1.87 2.85e-3 115/132 (87.12%) GNAI3;CALML5;PPP2R5A;...
Thyroid hormone signaling pathway -1.90 1.52e-3 112/121 (92.56%) HIF1A;ITGB3;ATP2A2;...
Platelet activation -1.91 1.63e-3 106/124 (85.48%) PRKG1;GUCY1B1;GNA13;...
Bacterial invasion of epithelial cells -1.92 1.75e-3 59/77 (76.62%) CDC42;ARPC2;CTNNA1;...
African trypanosomiasis -1.92 9.50e-4 32/37 (86.49%) F2RL1;SELE;GNAQ;...
Pancreatic secretion -1.94 1.04e-3 87/102 (85.29%) CLCA1;RAB27B;CHRM3;...
ECM-receptor interaction -1.96 0.00e+0 80/88 (90.91%) ITGB1;LAMA3;ITGB3;...
Long-term potentiation -1.96 0.00e+0 61/67 (91.04%) PPP1CC;PPP3R1;BRAF;...
Aldosterone synthesis and secretion -1.96 0.00e+0 85/98 (86.73%) CACNA1G;CACNA1D;AGT;...
Gap junction -1.99 0.00e+0 72/88 (81.82%) KRAS;PRKACB;ITPR3;...
Cortisol synthesis and secretion -2.00 0.00e+0 58/65 (89.23%) CACNA1G;CACNA1D;AGT;...
Melanogenesis -2.02 0.00e+0 74/101 (73.27%) LEF1;GNAI3;CALML5;...
PPAR signaling pathway -2.02 0.00e+0 66/74 (89.19%) SLC27A2;ACOX1;SLC27A6;...
Adherens junction -2.07 0.00e+0 63/71 (88.73%) ACTN4;AFDN;PTPRB;...
Regulation of actin cytoskeleton -2.13 0.00e+0 185/218 (84.86%) IQGAP1;ITGA9;FGF5;...
Focal adhesion -2.48 0.00e+0 180/201 (89.55%) RAF1;ITGA10;SOS1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SK-ES-1 CVCL_0627 Homo sapiens 0.12uM - 10uM 24H
TC-32 CVCL_7141 Homo sapiens 0.12uM - 10uM 24H
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 0.12uM - 10uM 6H, 24H, 48H
Brain
Glioblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-251 MG CVCL_0021 Homo sapiens 0.12uM - 10uM 24H
YH-13 CVCL_1800 Homo sapiens 0.12uM - 10uM 24H
Glioma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
GI-1 CVCL_1230 Homo sapiens 0.12uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.002uM - 10uM 6H, 24H, 48H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-468 CVCL_0419 Homo sapiens 0.12uM - 10uM 24H
Breast ductal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BT-474 CVCL_0179 Homo sapiens 0.12uM - 10uM 24H
T-47D CVCL_0553 Homo sapiens 0.12uM - 10uM 24H
ZR-75-1 CVCL_0588 Homo sapiens 0.12uM - 10uM 24H
Fibrocystic breast disease
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A (Parent) CVCL_0598 Homo sapiens 1.11uM - 10uM 3H, 6H, 12H, 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
GP2d CVCL_1234 Homo sapiens 0.12uM - 10uM 24H
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
SNU-407 CVCL_5004 Homo sapiens 0.12uM - 10uM 24H
Embryonic stem cell
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
WA09 (H9) Derived CVCL_9773 (WA09) Homo sapiens 0.12uM - 10uM 24H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 0.12uM - 10uM 24H
HEC-151 CVCL_2927 Homo sapiens 0.12uM - 10uM 24H
HEC-1-A CVCL_0293 Homo sapiens 0.12uM - 10uM 24H
HEC-251 CVCL_2928 Homo sapiens 0.12uM - 10uM 24H
HEC-265 CVCL_2929 Homo sapiens 0.12uM - 10uM 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
CJM CVCL_U797 Homo sapiens 0.12uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Renal cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
RCC10RGB CVCL_1656 Homo sapiens 0.12uM - 10uM 24H
Rhabdoid tumor
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
G-401 CVCL_0270 Homo sapiens 0.12uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HuH-7 CVCL_0336 Homo sapiens 10uM 72H
JHH-5 CVCL_1320 Homo sapiens 0.12uM - 10uM 24H
JHH-7 CVCL_1322 Homo sapiens 0.12uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.002uM - 10uM 6H, 24H, 48H
NCI-H1437 CVCL_1472 Homo sapiens 0.12uM - 10uM 24H
NCI-H1573 CVCL_1483 Homo sapiens 0.12uM - 10uM 24H
NCI-H838 CVCL_1594 Homo sapiens 0.12uM - 10uM 24H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BEN CVCL_1081 Homo sapiens 0.12uM - 10uM 24H
HCC1588 CVCL_1263 Homo sapiens 0.12uM - 10uM 24H
HCC95 CVCL_1276 Homo sapiens 0.12uM - 1.11uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 0.002uM - 10uM 6H, 24H
NCI-H2110 CVCL_1529 Homo sapiens 0.12uM - 10uM 24H
NCI-H2172 CVCL_1534 Homo sapiens 0.12uM - 10uM 24H
Small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H841 CVCL_1595 Homo sapiens 0.12uM - 10uM 24H
Muscle
Rhabdomyosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-204 CVCL_0134 Homo sapiens 0.12uM - 10uM 24H
Oral cavity
Oral squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BICR 6 CVCL_1086 Homo sapiens 0.12uM - 10uM 24H
Ovary
Ovarian carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OVK18 CVCL_1629 Homo sapiens 0.12uM - 10uM 24H
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ES-2 CVCL_3509 Homo sapiens 0.12uM - 10uM 24H
OVTOKO CVCL_3114 Homo sapiens 0.12uM - 10uM 24H
Ovarian cystadenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OAW 28 CVCL_1611 Homo sapiens 0.12uM - 10uM 24H
OC 316 CVCL_1615 Homo sapiens 0.12uM - 10uM 24H
Ovarian endometrioid carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
TOV-112D CVCL_3612 Homo sapiens 0.12uM - 10uM 24H
Ovarian granulosa cell tumor
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COV434 CVCL_2010 Homo sapiens 0.12uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
22Rv1 CVCL_1045 Homo sapiens 0.12uM - 10uM 24H
LNCaP clone FGC CVCL_1379 Homo sapiens 0.12uM - 10uM 24H
PC-3 CVCL_0035 Homo sapiens 0.002uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 0.37uM - 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H
IGR-37 CVCL_1303 Homo sapiens 0.12uM - 10uM 24H
Mel-HO CVCL_1402 Homo sapiens 0.12uM - 10uM 24H
SH-4 CVCL_1692 Homo sapiens 0.12uM - 10uM 24H
SK-MEL-3 CVCL_0525 Homo sapiens 0.12uM - 10uM 24H
Stomach
Gastric adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
AGS CVCL_0139 Homo sapiens 0.12uM - 10uM 24H
MKN45 CVCL_0434 Homo sapiens 0.12uM - 10uM 24H
Gastric carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
IM95 CVCL_1305 Homo sapiens 0.12uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.01uM - 10uM 24H
Urinary bladder
Bladder carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BC-3C CVCL_1079 Homo sapiens 0.12uM - 10uM 24H
Bladder transitional cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CAL-29 CVCL_1109 Homo sapiens 0.12uM - 10uM 24H