Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM6QOVN)

Drug Name
HKI-272 Drug Info
Synonyms Neratinib (ERBB2 inhibitor)
Therapeutic ClassAnticancer Agents
Cross-matching ID
PubChem CID
9915743
ChEBI ID
CHEMBL61397
CAS Number
CAS 698387-09-6
TTD Drug ID
D0Q9CY
INTEDE Drug ID
DR1887
ACDINA Drug ID
D00463

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Glycine, serine and threonine metabolism 2.17 0.00e+0 31/40 (77.5%) PSAT1;PHGDH;CBS;...
Ferroptosis 2.12 0.00e+0 36/41 (87.8%) HMOX1;SLC7A11;SLC3A2;...
Cysteine and methionine metabolism 2.07 0.00e+0 43/50 (86%) PSAT1;PHGDH;CBS;...
mTOR signaling pathway 1.96 2.59e-3 114/154 (74.03%) DDIT4;EIF4EBP1;SLC3A2;...
Mineral absorption 1.91 4.14e-3 48/60 (80%) HMOX1;FTH1;ATP1A2;...
Folate biosynthesis 1.90 6.90e-3 23/26 (88.46%) AKR1C3;AKR1B10;AKR1B1;...
Pantothenate and CoA biosynthesis 1.81 2.96e-2 14/21 (66.67%) ALDH2;BCAT1;ALDH3A2;...
One carbon pool by folate 1.81 2.59e-2 15/20 (75%) MTHFD2;SHMT2;SHMT1
Arginine biosynthesis 1.80 2.53e-2 17/22 (77.27%) ASS1;GOT1;ARG2;...
Steroid biosynthesis 1.80 2.28e-2 19/20 (95%) MSMO1;CYP51A1;FDFT1;...
Alanine, aspartate and glutamate metabolism 1.78 2.54e-2 27/37 (72.97%) ASNS;ASS1;GOT1;...
Terpenoid backbone biosynthesis 1.77 2.59e-2 18/22 (81.82%) HMGCS1;HMGCR;IDI1;...
Mitophagy 1.75 2.95e-2 56/68 (82.35%) ATF4;OPTN;SQSTM1;...
Histidine metabolism 1.73 3.62e-2 16/22 (72.73%) ALDH3A1;ALDH2;ALDH3B1;...
Porphyrin and chlorophyll metabolism 1.70 4.55e-2 23/43 (53.49%) HMOX1;BLVRB
Epstein-Barr virus infection -1.60 4.98e-2 189/202 (93.56%) RELA;DDX58;MYC;...
Rheumatoid arthritis -1.66 4.24e-2 78/93 (83.87%) IL6;TNFSF11;LTB;...
RNA transport -1.70 3.09e-2 128/186 (68.82%) EIF1AY;EIF2B3;ACIN1;...
Malaria -1.70 3.27e-2 44/50 (88%) TGFB2;ITGB2;IL1B;...
Protein export -1.75 2.52e-2 17/23 (73.91%) SPCS3;SRP72;SEC61G;...
AGE-RAGE signaling pathway in diabetic complications -1.77 2.30e-2 97/100 (97%) FN1;TGFB2;COL1A1;...
RNA polymerase -1.80 1.91e-2 23/31 (74.19%) POLR3F;POLR2A;POLR2D;...
TNF signaling pathway -1.83 1.79e-2 103/112 (91.96%) MAP2K7;IL1B;MAPK13;...
Amoebiasis -1.91 4.10e-3 99/102 (97.06%) LAMB3;PLCB3;IFNG;...
Proteasome -1.92 4.78e-3 44/46 (95.65%) PSMC3;IFNG;PSMB7;...
Viral protein interaction with cytokine and cytokine re... -1.99 1.91e-3 84/100 (84%) CXCR3;CXCL2;CCL22;...
ECM-receptor interaction -1.99 0.00e+0 80/88 (90.91%) ITGB6;FN1;COL1A1;...
IL-17 signaling pathway -2.09 0.00e+0 84/94 (89.36%) IL5;TRAF3;ELAVL1;...
Ribosome biogenesis in eukaryotes -2.27 0.00e+0 52/108 (48.15%) NVL;NHP2;TCOF1;...
Spliceosome -2.34 0.00e+0 101/150 (67.33%) PRPF38B;TRA2A;SNRNP40;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-673 CVCL_0080 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 3H, 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 3H, 6H, 24H
SK-BR-3 CVCL_0033 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H, XH
Breast carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BT-20 CVCL_0178 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
Hs 578T CVCL_0332 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 3H, 6H, 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CL-34 CVCL_1123 Homo sapiens 10uM 6H
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H, XH
LoVo CVCL_0399 Homo sapiens 10uM 6H
MDST8 CVCL_1400 Homo sapiens 10uM 6H
NCI-H508 CVCL_1561 Homo sapiens 0.66uM - 10uM 6H, XH
SNU-1040 CVCL_5001 Homo sapiens 10uM 6H
SNU-C4 CVCL_5008 Homo sapiens 10uM 6H
SNU-C5 CVCL_5009 Homo sapiens 10uM 6H
SW480 CVCL_0546 Homo sapiens 10uM 6H
SW620 CVCL_0547 Homo sapiens 10uM 6H
SW948 CVCL_0550 Homo sapiens 10uM 6H
Colorectal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCT 116 CVCL_0291 Homo sapiens 10uM 6H
HT115 CVCL_1294 Homo sapiens 10uM 6H
RKO CVCL_0504 Homo sapiens 10uM 6H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 10uM 6H
SNG-M CVCL_1707 Homo sapiens 10uM 6H
Endometrial carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHUEM-2 CVCL_1327 Homo sapiens 10uM 6H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 10uM 6H, 24H, XH
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H, XH
DV-90 CVCL_1184 Homo sapiens 10uM 6H
NCI-H1975 CVCL_1511 Homo sapiens 0.66uM - 10uM XH
NCI-H1975 CVCL_1511 Homo sapiens 0.66uM - 10uM XH
SK-LU-1 CVCL_0624 Homo sapiens 10uM 6H
Lung adenosquamous carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H596 CVCL_1571 Homo sapiens 0.66uM - 10uM 6H, XH
Lung large cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COR-L23 CVCL_1133 Homo sapiens 10uM 6H
T3M-10 CVCL_1729 Homo sapiens 10uM 6H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC15 CVCL_1253 Homo sapiens 10uM 6H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1299 CVCL_0060 Homo sapiens 10uM 6H
HCC515 CVCL_5134 Homo sapiens 0.04uM - 10uM 6H, 24H
NCI-H2073 CVCL_1523 Homo sapiens 0.66uM - 10uM 6H, XH
Small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1694 CVCL_1495 Homo sapiens 10uM 6H
NCI-H1836 CVCL_1502 Homo sapiens 10uM 6H
Lymph node
Diffuse large B-cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SU-DHL-4 CVCL_0539 Homo sapiens 0.66uM - 10uM XH
WSU-DLCL2 CVCL_1787 Homo sapiens 10uM 6H
Ovary
Ovarian carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
EFO-27 CVCL_1194 Homo sapiens 10uM 6H
OV7 CVCL_1623 Homo sapiens 10uM 6H
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
RMG-I CVCL_1663 Homo sapiens 10uM 6H
Ovarian mucinous cystadenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COV644 CVCL_2011 Homo sapiens 10uM 6H
RMUG-S CVCL_1666 Homo sapiens 10uM 6H
Ovarian undifferentiated carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
TYK-nu CVCL_1774 Homo sapiens 10uM 6H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.04uM - 10uM 6H, 24H
Acute myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NOMO-1 CVCL_1609 Homo sapiens 10uM 6H
PL-21 CVCL_2161 Homo sapiens 10uM 6H
SKM-1 CVCL_0010 Homo sapiens 10uM 6H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Pleural effusion
Histiocytic lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-937 CVCL_0007 Homo sapiens 10uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H, XH
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H, XH
SK-MEL-1 CVCL_0523 Homo sapiens 10uM 6H
SK-MEL-28 CVCL_0526 Homo sapiens 10uM 6H
Stomach
Gastric adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
AGS CVCL_0139 Homo sapiens 10uM 6H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.01uM - 10uM 24H