Details of the Drug

General Information of Drug (ID: DM6QOVN)

Drug Name
HKI-272
Synonyms Neratinib (ERBB2 inhibitor)
Indication
Disease Entry ICD 11 Status REF
Breast cancer 2C60-2C65 Phase 3 [1]
Therapeutic Class
Anticancer Agents
Affected Organisms
Humans and other mammals
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 2 Molecular Weight (mw) 557
Logarithm of the Partition Coefficient (xlogp) 4.9
Rotatable Bond Count (rotbonds) 11
Hydrogen Bond Donor Count (hbonddonor) 2
Hydrogen Bond Acceptor Count (hbondacc) 8
ADMET Property
Clearance
The total clearance of drug is 216 L/h []
Elimination
97.1% of the total dose is excreted in the feces and 1.13% in the urine []
Half-life
The concentration or amount of drug in body reduced by one-half in 7 - 17 hours []
Metabolism
The drug is metabolized via the CYP3A4 []
Vd
The volume of distribution (Vd) of drug is 6433 L []
Chemical Identifiers
Formula
C30H29ClN6O3
IUPAC Name
(E)-N-[4-[3-chloro-4-(pyridin-2-ylmethoxy)anilino]-3-cyano-7-ethoxyquinolin-6-yl]-4-(dimethylamino)but-2-enamide
Canonical SMILES
CCOC1=C(C=C2C(=C1)N=CC(=C2NC3=CC(=C(C=C3)OCC4=CC=CC=N4)Cl)C#N)NC(=O)/C=C/CN(C)C
InChI
InChI=1S/C30H29ClN6O3/c1-4-39-28-16-25-23(15-26(28)36-29(38)9-7-13-37(2)3)30(20(17-32)18-34-25)35-21-10-11-27(24(31)14-21)40-19-22-8-5-6-12-33-22/h5-12,14-16,18H,4,13,19H2,1-3H3,(H,34,35)(H,36,38)/b9-7+
InChIKey
JWNPDZNEKVCWMY-VQHVLOKHSA-N
Cross-matching ID
PubChem CID
9915743
ChEBI ID
CHEBI:61397
CAS Number
698387-09-6
UNII
JJH94R3PWB
DrugBank ID
DB11828
TTD ID
D0Q9CY
INTEDE ID
DR1887
ACDINA ID
D00463
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Epidermal growth factor receptor (EGFR) TTGKNB4 EGFR_HUMAN Inhibitor [2]
ERBB2 messenger RNA (HER2 mRNA) TTR5TV4 ERBB2_HUMAN Inhibitor [3]
Erbb2 tyrosine kinase receptor (HER2) TT6EO5L ERBB2_HUMAN Inhibitor [4]
Vascular endothelial growth factor receptor 2 (KDR) TTUTJGQ VGFR2_HUMAN Inhibitor [2]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4)
Main DME 		DE4LYSA CP3A4_HUMAN Substrate [5]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Bile salt export pump (ABCB11) OTRU7THO ABCBB_HUMAN Gene/Protein Processing [6]
Epidermal growth factor receptor (EGFR) OTAPLO1S EGFR_HUMAN Gene/Protein Processing [7]
Inhibitor of nuclear factor kappa-B kinase subunit beta (IKBKB) OT9RDS3H IKKB_HUMAN Gene/Protein Processing [8]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Breast cancer
ICD Disease Classification 2C60-2C65
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Vascular endothelial growth factor receptor 2 (KDR) DTT KDR 1.98E-01 0.11 0.2
Cytochrome P450 3A4 (CYP3A4) DME CYP3A4 1.04E-02 6.29E-02 3.54E-01
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 154 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MEC1 CTRP2 0.5681 2.4447 0.5591 29.8517
JM1 CTRP2 1.1798 4.1358 1.0357 26.2372
SEM CTRP2 -3.2928 0.302 -3.3127 55.4272
KMS-26 CTRP2 -3.0445 1.5278 -3.1754 50.6998
MOLM-16 CTRP2; CTRP1 -2.4415 -0.6758 -2.4417 49.9206
BL-70 CTRP2; CTRP1 -2.2006 -1.6158 -2.2006 48.3171
JVM-2 CTRP2 -2.1559 0.2676 -2.4309 23.0892
HuT 78 CTRP2 -1.8898 7.1437 -3.185 47.2546
Mono-Mac-1 CTRP2 -1.763 1.8736 -1.8163 45.4533
697 CTRP2 -1.6453 0.6323 -1.6485 44.5761
Ri-1 CTRP2 -1.5969 2.8808 -1.7478 44.5357
Pfeiffer CTRP2 -1.5359 1.1087 -1.546 43.8653
KE-37 CTRP2 -1.4829 1.0316 -1.4905 43.5068
MV4-11 CTRP2 -1.4216 0.1802 -1.4224 39.2041
SKM-1 CTRP2; CTRP1 -1.3334 1.18 -1.3419 42.5694
JVM-3 CTRP2 -1.2019 2.1873 -1.2547 41.7561
P31/FUJ CTRP2 -1.1387 1.4564 -1.1513 41.2303
A4/Fukuda CTRP2 -0.9191 2.7369 -1.009 39.9848
Mino CTRP2 -0.8371 2.1238 -0.8709 39.2863
HDLM-2 CTRP2 -0.7541 4.4511 -1.2999 36.1632
MOLT-13 CTRP2 -0.5853 0.9939 -0.5859 37.5077
NU-DUL-1 CTRP2; CTRP1 -0.5851 1.2905 -0.5874 37.5726
NALM-6 CTRP2 -0.5534 1.9962 -0.5951 33.1707
Hs 611.T CTRP2 -0.5487 1.995 -0.567 37.3208
GDM-1 CTRP2; CTRP1 -0.5252 2.3552 -0.5617 37.2819
KMS-12-BM CTRP2 -0.5189 1.3721 -0.5216 37.0725
RS4;11 CTRP2 -0.4401 3.0947 -0.5431 36.8584
MOLT-16 CTRP2 -0.4048 1.4099 -0.4071 36.3108
Kasumi-2 CTRP2 -0.3826 2.236 -0.4075 36.2363
OCI-Ly19 CTRP2 -0.3502 3.3217 -0.4777 36.337
KE-97 CTRP2 -0.3307 3.6737 -0.6278 32.4732
Peer CTRP2 -0.2133 2.6426 -0.258 35.1731
Ki-JK CTRP2 -0.1544 2.8751 -0.2165 34.8367
SU-DHL-6 CTRP2 -0.1216 3.0608 -0.2012 34.6746
EoL-1 CTRP2 -0.0253 0.9887 -0.0253 33.7752
EB1 CTRP2 -0.0133 3.0809 -0.0888 33.9419
BDCM CTRP2 -0.0107 1.7632 -0.0138 33.688
Jurkat CTRP2 0.0385 3.4016 -1.6688 10.4317
AML-193 CTRP2 0.0685 5.1638 -0.4191 34.6569
MHH-CALL-4 CTRP2 0.1384 3.8202 -0.032 33.2394
HT CTRP2 0.1422 3.1664 0.0662 32.9098
DoHH2 CTRP2 0.1959 1.0975 0.1085 8.3409
KMS-21-BM CTRP2 0.2088 2.6777 0.1789 32.3149
SET-2 CTRP2 0.2331 1.6951 0.2322 32.0565
HEL CTRP2 0.2525 1.4245 -0.5144 2.5919
KMS-20 CTRP2 0.2833 2.2319 0.2751 31.7465
RPMI-8402 CTRP2 0.285 2.3332 0.2737 31.7455
NOMO-1 CTRP2; CTRP1 0.3024 4.0051 0.113 32.2806
SUP-T1 CTRP2 0.3275 3.0471 0.2739 31.6028
NCI-H929 CTRP2 0.349 4.6033 -0.1442 28.4015
Karpas-299 CTRP2 0.3651 2.991 0.3184 31.3298
KMS-11 CTRP2; CTRP1 0.3706 2.9993 0.324 31.3592
OCI-AML-3 CTRP2; CTRP1 0.4093 1.4939 0.4092 30.9465
TALL-1 [Human adult T-ALL] CTRP2 0.4114 3.3194 0.3339 31.1241
PL21 CTRP2; CTRP1 0.4345 4.5809 0.1342 31.7671
KM-H2 CTRP2 0.4779 4.3748 -1.803 10.0495
RCH-ACV CTRP2 0.4805 3.4432 0.3921 30.7006
EHEB CTRP2 0.4921 4.6945 -1.2436 14.7569
GA-10 CTRP2 0.5016 2.455 0.4909 30.3007
L-428 CTRP2 0.5117 3.2647 0.4461 30.4169
Daudi CTRP2 0.5351 1.7712 0.5348 30.0427
LAMA-84 CTRP2 0.5443 3.0887 -1.1175 5.6397
HH [Human lymphoma] CTRP2 0.553 2.8279 0.5263 30.0114
L-540 CTRP2 0.5756 2.4254 0.5673 29.7991
PF-382 CTRP2 0.5844 3.9819 0.2928 26.0016
DB CTRP2 0.6496 2.9652 0.6175 29.386
F-36P CTRP2 0.65 5.1872 0.209 30.7432
EJM CTRP2; CTRP1 0.7306 3.0054 0.6994 28.9124
MOLP-8 CTRP2 0.7418 2.4058 0.7367 28.6815
Mono-Mac-6 CTRP2 0.7621 11.3733 -2.1405 36.3168
Namalwa CTRP2 0.837 4.6125 0.5631 28.9578
KMS-27 CTRP2 0.8448 2.4605 0.8271 23.1374
MM1.S CTRP2 0.8581 3.5791 0.7766 28.1644
JJN-3 CTRP2 0.866 3.3675 0.8094 28.0275
Kasumi-1 CTRP2 0.8789 1.9722 0.8787 27.7517
NB4 CTRP2 0.8847 1.8221 0.8847 27.7126
U266B1 CTRP2 0.8868 3.9723 0.7484 28.1666
KHM-1B CTRP2 0.8871 3.2722 0.841 27.8515
OCI-Ly3 CTRP2 0.8896 2.0556 0.8892 27.6812
SUP-T11 CTRP2 0.9149 3.0909 0.8847 27.6126
OPM-2 CTRP2 0.9414 3.3731 0.8883 27.5133
P12-Ichikawa CTRP2 0.9616 3.9429 0.8339 27.6328
MOTN-1 CTRP2 0.9719 2.0257 0.9717 27.1323
RPMI-6666 CTRP2 0.9995 2.636 0.993 26.9692
SIG-M5 CTRP2 1.0037 2.1772 1.0031 26.9218
EM-2 CTRP2 1.0064 4.3236 0.8114 27.5654
Granta-519 CTRP2 1.0252 3.7553 0.931 27.0949
Reh CTRP2 1.0552 3.5788 0.986 26.81
KYO-1 CTRP2 1.0612 4.7886 0.7645 27.551
KMS-28BM CTRP2 1.0862 4.4769 0.8654 27.1237
ST486 CTRP2 1.0983 2.7584 1.0902 26.3168
HuNS1 CTRP2 1.1174 2.5573 1.1141 26.173
NCO2 CTRP2 1.1349 4.274 0.9608 26.6389
HPB-ALL CTRP2 1.1455 2.6135 1.1416 25.9878
NU-DHL-1 CTRP2 1.1997 2.976 1.1859 25.6602
MOLM-13 CTRP2 1.2084 4.468 1.0002 26.2687
WSU-DLCL2 CTRP2; CTRP1 1.2215 5.5471 0.7282 27.2404
BV-173 CTRP2 1.2516 3.8501 1.1595 25.5803
KMS-34 CTRP2 1.2609 2.6964 1.2569 25.2198
CA46 CTRP2 1.2861 3.8033 1.203 25.3199
RPMI-8226 CTRP2; CTRP1 1.3144 3.534 1.2659 25.0855
LP-1 CTRP2; CTRP1 1.3178 4.3961 1.1362 25.5205
OCI-AML-2 CTRP2 1.3181 3.438 1.2783 24.959
SUP-HD1 CTRP2 1.3232 3.774 1.2466 25.0504
CMK CTRP2 1.3535 3.7456 1.2825 24.8294
Karpas-422 CTRP2 1.3758 2.1092 1.3758 24.4406
SU-DHL-10 CTRP2 1.4033 2.5544 1.4023 24.2606
HEL 92.1.7 CTRP2 1.4369 3.9639 1.3411 24.359
OCI-M1 CTRP2 1.4513 3.677 1.3946 24.1292
THP-1 CTRP2; CTRP1 1.4908 5.1308 1.1451 24.9475
ME1 CTRP2 1.5026 3.9298 1.4165 23.8879
SUP-B15 CTRP2 1.507 5.1202 1.163 24.7619
KO52 CTRP2 1.5081 4.1522 1.387 23.9726
M-07e CTRP2 1.5435 5.0201 1.2304 24.4107
HL-60 CTRP2 1.6199 5.1066 1.29 23.9634
TF-1 CTRP2 1.625 3.7964 1.5648 22.9842
L-363 CTRP2 1.634 3.2799 1.6184 22.7728
MOLP-2 CTRP2 1.6583 3.9301 1.5829 22.8142
K-562 CTRP2 1.6834 2.941 1.6802 22.4021
MOLM-6 CTRP2 1.6866 4.4035 1.5329 22.8975
U-937 CTRP2; CTRP1 1.6957 4.5067 1.5232 22.977
SU-DHL-4 CTRP2; CTRP1 1.6987 3.438 1.6763 22.4395
SU-DHL-8 CTRP2 1.7087 2.9717 1.7053 22.2344
HD-MY-Z CTRP2 1.7466 4.4126 1.5961 22.4866
DND-41 CTRP2 1.8524 4.5927 1.673 21.884
AMO1 CTRP2; CTRP1 1.9046 2.6999 1.9045 20.9946
RL CTRP2 1.9146 2.9933 1.9129 20.857
JeKo-1 CTRP2 2.0067 4.5327 1.8537 20.7639
SU-DHL-1 CTRP2 2.0321 3.7645 1.9982 20.1825
JURL-MK1 CTRP2 2.139 7.462 0.9962 23.499
MHH-CALL-3 CTRP2 2.2771 8.6288 0.63 24.4172
P3HR-1 CTRP2 2.3431 4.024 2.2996 18.1433
MC116 CTRP2 2.3611 3.2015 2.3604 17.8788
A3/Kawakami CTRP2 2.5467 3.8104 2.532 16.6892
MOLT-3 CTRP2 2.5556 4.4166 2.4704 16.8716
MJ CTRP2 2.5604 5.6851 2.135 18.0701
SUP-M2 CTRP2 2.7275 4.6371 2.6143 15.8248
KMS-18 CTRP2 2.7989 5.9691 2.2911 16.7978
SU-DHL-5 CTRP1 2.8134 3.989 2.7976 32.1912
SK-MM-2 CTRP2 2.8572 4.8553 2.7063 15.0948
L-1236 CTRP2 2.9694 7.8413 1.6853 18.669
CML-T1 CTRP2 3.1664 5.5391 2.8413 13.6756
SR CTRP2 3.535 5.9181 3.0972 11.6603
Ku812 CTRP2 3.5867 7.9751 2.2386 14.9307
Ci-1 CTRP2 3.8693 6.0749 3.3849 9.635
OCI-Ly10 CTRP2; CTRP1 3.8698 7.9147 2.5498 13.0716
Karpas-620 CTRP2 3.9548 6.5934 3.2442 9.9711
Raji CTRP2 4.2549 7.1294 3.2882 9.0616
DEL CTRP2 4.9208 7.7106 3.607 6.2848
KCL-22 CTRP2 5.2836 7.8955 3.0639 2.6356
REC-1 CTRP2 5.3317 10.2142 2.6948 9.3202
KMM-1 CTRP2 5.923 10.4817 2.26 5.0952
OCI-AML-5 CTRP2 6.8266 15.0959 1.4155 11.8512
Toledo CTRP2 7.4215 9.2238 4.4535 0.2932
⏷ Show the Full List of 154 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 24 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE15 CTRP2 -4.7452 6.5019 -6.0702 59.4163
TE8 CTRP2 3.0723 13.8029 -1.0703 27.6008
OE21 CTRP2 -3.5825 2.9612 -3.8944 56.3398
TE-4 CTRP2 -2.7362 5.4111 -3.5497 51.4065
OE19 CTRP2 -2.1722 4.782 -2.7612 48.4066
TE-14 CTRP2 -1.814 8.7248 -3.6901 47.1846
KYSE-410 CTRP2 -1.7101 7.3403 -3.0606 46.396
TE-11 CTRP2 -1.476 4.1503 -1.8488 44.1182
TE-5 CTRP2 -0.6298 6.0017 -1.4337 39.766
KYSE-140 CTRP2 -0.3929 7.9344 -2.2054 37.0184
TE-10 CTRP2 0.374 7.0192 -1.0206 31.2598
EC-GI-10 CTRP2 0.8226 18.1515 -5.291 40.4235
TE-6 CTRP2 1.445 5.924 0.8451 26.0743
KYSE-70 CTRP2 1.6833 6.2279 0.9965 24.8196
TE-1 CTRP2 1.8153 7.5389 0.6254 25.7376
KYSE-450 CTRP2 1.8971 9.9259 -0.3414 28.6196
KYSE-520 CTRP2 2.8035 12.085 -0.482 26.613
KYSE-180 CTRP2 2.8253 13.5702 -1.7428 26.4437
COLO 680N CTRP2 3.0043 14.4439 -1.4477 28.7399
OE33 CTRP2 3.4308 10.5815 0.8381 20.7126
TE-9 CTRP2 3.7329 11.2769 0.1932 17.7807
KYSE-30 CTRP2 5.8594 17.5672 -0.5515 20.2187
KYSE-150 CTRP2 9.2835 18.8979 1.251 9.0237
KYSE-510 CTRP2 12.1757 25.2173 0.0987 9.4604
⏷ Show the Full List of 24 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 36 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
N2a-PK1 CTRP2 2.4545 10.4291 -0.0243 26.1177
HuP-T4 CTRP2 -2.7006 3.1342 -2.9735 51.4192
PaTu 8988s CTRP2 -0.1481 4.7142 -0.5357 35.7674
Panc 05.04 CTRP2 0.087 8.655 -1.6494 37.5484
Hs 766T CTRP2 0.3309 6.8579 -0.6881 34.4772
SNU-213 CTRP2 0.658 10.4111 -3.9479 26.2759
PaTu 8902 CTRP2; CTRP1 0.7814 1.9245 0.7811 28.4706
BxPC-3 CTRP2 0.7842 14.1442 -3.4076 38.3223
HPAC CTRP2 1.0476 4.2977 0.8614 27.2614
MIA PaCa-2 CTRP2 1.3075 3.1204 1.2898 24.9551
PK-59 CTRP2 1.8299 7.7082 0.5701 25.8859
AsPC-1 CTRP2 1.9222 6.4733 1.1626 23.5173
SNU-410 CTRP2 2.0641 4.5962 1.9024 20.4125
L3.3 CTRP2 2.1462 10.4606 -0.3416 27.9269
YAPC CTRP2 2.178 5.7722 1.6911 20.8319
QGP-1 CTRP2 2.375 6.3457 -0.5752 6.4662
PK-45H CTRP2 2.4731 8.0241 1.0989 22.2007
KP-3 CTRP2 2.7503 10.253 -0.17 21.4827
Panc 03.27 CTRP2 2.7655 10.0491 0.4584 23.7092
Capan-1 CTRP2 2.8542 8.181 1.4153 20.0039
HPAF-II CTRP2 2.8644 14.8364 -2.3374 27.9537
DAN-G CTRP2 2.8789 6.229 2.2778 16.6229
TCC-Pan2 CTRP2 2.9427 7.586 1.3118 15.008
SW1990 CTRP2 3.343 20.2754 -4.0317 33.1636
Panc 08.13 CTRP2 3.4222 9.2075 1.4937 18.2739
PSN1 CTRP2 4.3482 7.5098 3.1924 9.241
PaTu 8988t CTRP2 4.6665 10.3763 2.0574 13.2425
CFPAC-1 CTRP2 4.7231 12.2393 1.1758 16.5832
HuP-T3 CTRP2 5.2815 12.1936 1.6654 13.5882
SU.86.86 CTRP2 5.5161 9.3182 3.2867 6.5248
Capan-2 CTRP2 5.8234 12.8741 1.7583 12.2251
Panc 04.03 CTRP2 5.9106 10.3929 3.0532 6.8334
KP-2 CTRP2 6.0707 13.0762 1.8485 11.4397
SUIT-2 CTRP2 6.1536 11.1095 2.8792 7.1587
KP-4 CTRP2 6.9742 12.1891 2.924 5.7912
Panc 02.03 CTRP2 7.6141 13.9353 2.5146 12.6669
⏷ Show the Full List of 36 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 49 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SH4 CTRP2 0.4117 8.8469 -1.3886 35.8989
Hs 852.T CTRP2; CTRP1 -1.0837 3.363 -1.2695 41.3497
Hs 940.T CTRP2 0.3046 9.1138 -1.6126 36.7343
G-361 CTRP2 0.37 3.3858 0.2819 31.4348
RPMI-7951 CTRP2 1.1548 3.3718 1.113 26.0536
K029AX CTRP2 1.3332 3.4813 1.2902 24.8692
COLO 792 CTRP2 1.4468 4.0744 1.3341 24.3514
A-375 CTRP2; CTRP1 1.4974 3.5587 1.4562 23.843
SK-MEL-24 CTRP2 1.5387 3.5433 1.5004 23.4841
WM1799 CTRP2 1.7055 4.6911 1.4906 22.9868
MeWo CTRP2 1.8283 3.7507 1.7851 21.5719
SK-MEL-1 CTRP2; CTRP1 1.9264 6.5576 1.1397 23.6603
HMCB CTRP2 1.9415 4.8437 1.7107 21.4734
Hs 944.T CTRP2 2.0117 7.0762 1.0216 23.7689
IGR-39 CTRP2 2.0669 5.0172 1.8024 20.7596
COLO 800 CTRP2 2.0885 4.609 1.9261 20.2525
IPC-298 CTRP2 2.1216 5.0565 1.8513 20.4168
LOX-IMVI CTRP2 2.2831 6.0448 1.7087 20.4603
WM983B CTRP2 2.3315 4.9317 2.1137 18.8323
IGR-37 CTRP2 2.3842 6.7494 1.5469 20.7772
Mel Ho CTRP2 2.3989 6.7785 1.1648 17.0466
A101D CTRP2 2.4216 5.4279 2.0688 18.7232
HT-144 CTRP2 2.4798 4.9999 2.2575 17.8618
SK-MEL-5 CTRP2; CTRP1 2.5694 4.211 2.5179 16.7437
IGR-1 CTRP2 2.5791 6.12 1.9991 18.5246
WM793 CTRP2 2.6797 6.2715 2.049 18.0515
WM115 CTRP2 2.8999 8.0746 1.5096 19.5256
MDA-MB-435S CTRP2 2.9059 6.4763 2.2081 16.8152
Hs 294T CTRP2 3.0197 8.1486 1.5963 18.8828
SK-MEL-31 CTRP2 3.0536 5.0105 2.8809 13.8661
Mel JuSo CTRP2 3.6449 8.4951 2.0486 15.551
Hs 895.T CTRP2 3.8031 13.1255 -0.0721 22.9485
WM88 CTRP2 3.8385 8.3031 2.3263 13.9721
UACC-257 CTRP2 3.8761 6.1993 3.3386 9.7989
WT2-iPS CTRP2 4.3439 7.4839 3.201 9.2153
COLO 741 CTRP2 4.4524 14.0781 0.0252 21.2024
SK-MEL-3 CTRP2 4.8795 9.5658 2.6449 10.3953
Hs 936.T CTRP2 4.9118 9.0891 2.9106 9.2233
A2058 CTRP2 4.9384 8.7177 3.1187 8.2995
UACC-62 CTRP2 5.1058 8.1759 3.5295 6.2498
SK-MEL-30 CTRP2 5.5647 9.4692 3.2493 6.5971
RVH-421 CTRP2 5.8373 16.6353 -0.1043 18.8711
WM266-4 CTRP2 5.9745 10.8007 2.8998 7.36
CJM [Human melanoma] CTRP2 5.9797 14.6905 0.977 14.9059
COLO 829 CTRP2 5.9916 12.8441 1.9031 11.3608
SK-MEL-28 CTRP2; CTRP1 6.0042 6.8952 4.7586 0.2503
Hs 839.T CTRP2 6.2465 11.5855 2.7135 7.6863
SK-MEL-2 CTRP2 6.5346 7.5687 4.7084 0.1295
Hs 688(A).T CTRP2 7.6827 15.4138 1.8593 8.9152
⏷ Show the Full List of 49 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 CTRP2 2.1749 5.4747 1.7856 20.4946
Cancer Drug Sensitivity Data Curated from 13 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SK-N-BE(2) CTRP2 0.312 5.3727 -0.2134 33.2016
SK-N-FI CTRP2 0.3163 1.9316 0.3139 31.5074
KP-N-SI9s CTRP2 0.5041 3.3351 0.4302 30.4952
NH-6 CTRP2 1.2278 2.3238 1.2273 25.4283
SK-N-AS CTRP2 1.4184 3.6528 1.3624 24.3458
SK-N-DZ CTRP2 1.4309 2.0675 1.4309 24.0736
Kelly CTRP2 1.4411 3.4172 1.409 24.1136
SK-N-SH CTRP2 1.4935 3.765 1.429 23.8747
MHH-NB-11 CTRP2 1.9422 4.734 1.7383 21.3731
CHP-126 CTRP2 1.9989 3.5421 1.9808 20.3501
CHP-212 CTRP2 3.8327 8.4135 2.2677 14.2233
KP-N-YN CTRP2 4.6692 7.9903 3.2481 8.3066
NB1 CTRP2 5.6561 10.9097 2.6046 9.1107
⏷ Show the Full List of 13 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 7 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-1079 CTRP2 -5.7622 -0.2608 -5.8282 69.3628
SNU-478 CTRP2 -1.6921 7.0037 -3.2015 43.7232
SNU-308 CTRP2 -1.3125 8.983 -3.6068 42.6936
HuCC-T1 CTRP2 2.7882 9.738 0.6275 23.0639
SNU-1196 CTRP2 3.0098 12.1748 -0.3318 25.6462
HuH-28 CTRP2 6.2184 13.4307 1.0504 9.6497
SNU-869 CTRP2 10.6122 24.4361 -0.4969 12.9202
⏷ Show the Full List of 7 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 15 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-673 CTRP2 1.0124 3.2101 0.9775 26.9791
SK-N-MC CTRP2 1.2593 2.6335 1.2564 25.2265
Hs 888.T CTRP2 1.5833 15.8448 -3.4554 36.2783
U2OS CTRP2; CTRP1 1.6658 12.6742 -1.8469 33.1606
MHH-ES-1 CTRP2 2.8299 9.8913 0.5957 23.0681
SK-ES-1 CTRP2 2.917 9.303 0.9584 21.5476
SW1353 CTRP2 4.9636 13.0229 0.3273 14.7177
SJSA-1 CTRP2 5.5163 10.6273 2.6358 9.2293
G-292 clone A141B1 CTRP2 5.537 14.0539 0.9433 15.8417
TC71 CTRP2 5.5615 9.7962 3.0845 7.2886
Hs 822.T CTRP2 5.6841 13.2263 1.4735 13.5814
SaOS-2 CTRP2 5.9284 14.372 1.0953 14.564
HOS CTRP2 6.1647 12.441 2.2331 9.7557
CAL-78 CTRP2 6.44 17.7197 -0.1711 18.0004
MG-63 CTRP2 8.9268 21.4635 -0.1983 14.2126
⏷ Show the Full List of 15 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 71 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ZR-75-30 CTRP2 -12.4281 14.3762 -17.1903 68.8569
UACC-812 CTRP2 -9.9089 21.1612 -17.3678 62.5967
HCC2218 CTRP2 -8.8196 1.9415 -9.3656 75.2121
BT-474 CTRP2 -5.3998 9.4267 -7.7918 59.775
HCC1419 CTRP2 -5.3091 7.3035 -6.9435 60.7479
SK-BR-3 CTRP2 -5.2564 5.5495 -6.3391 61.7867
AU565 CTRP2 -4.9056 4.5758 -5.69 61.2669
HCC202 CTRP2 -2.857 9.5071 -5.1053 51.5386
HCC1954 CTRP2 -2.4498 6.0511 -3.6654 47.4935
MDA-MB-468 CTRP2 -0.841 3.6358 -1.0561 39.7915
MDA-MB-157 CTRP2 -0.4734 3.0706 -0.5755 37.0758
CAL-85-1 CTRP2 -0.202 9.8212 -2.4398 39.9322
MDA-MB-453 CTRP2 -0.1886 7.247 -1.3897 37.9968
HDQ-P1 CTRP2 0.7085 7.7863 -0.6414 33.0838
Hs 578T CTRP2 0.8658 3.7584 0.76 28.1954
HCC1143 CTRP2 1.039 6.9678 0.0303 30.0547
DU4475 CTRP2 1.2843 2.3014 1.284 25.0515
CAL-148 CTRP2 1.7747 6.9463 0.4593 21.6688
CAL-51 CTRP2 1.843 4.7264 1.632 22.0583
CAMA-1 CTRP2 1.9934 3.8745 0.3424 2.2718
HCC1806 CTRP2 2.0605 9.6468 -0.05 27.2716
MCF-7 CTRP2; CTRP1 2.1656 5.4688 1.7806 20.6166
HCC1500 CTRP2 2.7142 6.1068 2.1489 17.5757
CAL-120 CTRP2 2.7601 5.7535 2.3273 16.7734
HCC1569 CTRP2 3.0251 13.5562 -1.559 25.4327
KPL-1 CTRP2 3.0963 4.5107 3.0367 13.1818
HCC38 CTRP2 3.2749 6.0136 2.7832 13.5866
BT-549 CTRP2 3.9228 10.8692 1.1515 18.4061
HCC1395 CTRP2 4.1083 13.3204 -0.5116 19.5831
HCC1428 CTRP2 4.5627 9.5939 2.3567 12.2362
HMC-1-8 CTRP2 5.077 6.195 3.6996 0.4841
MDA-MB-361 CTRP2 5.5536 18.6284 -1.3281 23.0009
MDA-MB-231 CTRP2 5.5622 11.982 1.9972 11.748
JIMT-1 CTRP2 5.9689 12.857 1.8793 11.4941
ZR-75-1 CTRP2 6.2462 12.2207 2.4019 8.9453
HCC1937 CTRP2 6.7983 18.2391 -0.8761 15.8264
BT-20 CTRP2 6.9776 15.3382 1.4062 11.6474
T-47D CTRP2 7.0852 16.5731 0.8797 13.3891
BT 416 CTRP2 -0.4287 4.8923 -0.8876 37.7522
BT 239 CTRP2 0.0568 3.4953 -0.0674 33.6328
BT 145 CTRP2 0.8204 5.9937 0.1444 30.3936
BT164 CTRP2 1.2402 5.2241 0.8423 26.7171
BT 330 CTRP2 1.6815 10.1297 -0.6505 30.123
BT 428 CTRP2 2.1321 7.2033 1.0965 23.1542
BT 112 CTRP2 2.1951 6.4168 1.476 21.578
BT 231 CTRP2 2.6845 12.2259 -0.6626 27.4389
BT 139 CTRP2 3.2529 16.4279 -2.2016 29.9214
BT147 CTRP2 3.3398 11.864 0.1273 23.3878
BT 228 CTRP2 3.42 3.9243 3.4196 10.823
BT 286 CTRP2 4.1516 7.083 3.2108 9.6232
BT 172 CTRP2 4.2255 12.2623 0.7322 19.2727
BT 271 CTRP2 4.5286 23.2896 -4.5115 31.6074
BT 131 CTRP2 5.2195 8.6543 3.3832 6.6514
BT 504 CTRP2 5.929 9.1128 3.6919 4.1874
BT 159 CTRP2 5.9609 19.5942 -1.4815 22.6546
BT 359 CTRP2 6.045 12.4217 2.1528 10.2771
BT 245 CTRP2 6.3271 12.4048 2.3708 8.9406
BT 187 CTRP2 6.397 20.3967 -1.5357 22.0195
BT 482 CTRP2 6.4546 7.9689 4.5236 0.5579
BT 320 CTRP2 6.4891 8.1064 4.4843 0.6445
BT 422 CTRP2 6.6124 15.2594 1.1774 13.0817
BT 444 CTRP2 6.6589 12.2222 2.6956 7.1339
BT 232 CTRP2 7.1041 18.2729 0.0583 16.1443
BT 340 CTRP2 7.2597 18.9785 -0.1736 16.6315
BT 216 CTRP2 7.405 14.5475 2.087 8.4418
BT 440 CTRP2 7.6949 14.4432 2.3277 7.1374
BT 328 CTRP2 7.9972 16.9125 1.3542 10.3314
BT 498 CTRP2 8.134 19.5057 0.1987 14.0927
BT 224 CTRP2 8.5934 18.5793 0.957 10.911
BT 179 CTRP2 9.0715 26.1652 -2.3769 19.9254
BT 333 CTRP2 9.1864 20.5666 0.4044 11.9634
⏷ Show the Full List of 71 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Tongue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
YD-38 CTRP2 -3.1499 2.2915 -3.403 51.3337
Cancer Drug Sensitivity Data Curated from 45 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-466 CTRP2 -0.2595 3.5378 -0.5185 31.8436
LN-229 CTRP2; CTRP1 0.5429 7.9793 -0.889 34.3349
SF268 CTRP2 0.7579 2.5044 0.7507 28.5814
SF539 CTRP2 1.3288 2.9051 1.3208 24.7804
GMS-10 CTRP2 1.4203 2.6666 1.4184 24.1507
GB-1 CTRP2 1.5372 8.415 -0.0346 28.7297
KNS-60 CTRP2 1.5388 4.599 1.3304 24.0724
D283 Med CTRP2 1.5782 3.8458 1.5088 23.3274
U-87MG ATCC CTRP2 1.829 3.8191 0.2652 2.9513
CAS-1 CTRP2 1.8757 2.9235 1.8745 21.1144
Hs 683 CTRP2 1.8803 3.8279 1.8317 21.2437
A-172 CTRP2 1.9464 5.7742 1.4393 22.4385
GaMG CTRP2; CTRP1 2.0804 6.4596 1.3416 22.4775
YKG-1 CTRP2 2.4784 6.7569 1.6434 20.1506
DK-MG CTRP2 2.5012 7.5832 1.3206 21.3024
LN-18 CTRP2 2.787 5.1564 2.281 11.2632
U-118MG CTRP2 3.47 5.9537 3.0141 12.1597
U-251MG CTRP2 3.5578 5.4191 3.3061 10.8044
ONS-76 CTRP2 3.6968 9.3417 1.6903 16.8511
SNU-201 CTRP2 3.866 12.3522 0.3673 21.3523
T98G CTRP2 3.9286 8.4702 2.3314 13.7407
KNS-42 CTRP2 4.0225 13.5784 -0.1015 22.5476
M059K CTRP2 4.1653 10.1742 1.7145 15.6878
SNU-626 CTRP2 4.3546 8.7775 2.5758 11.7784
GOS-3 CTRP2 4.4517 13.0532 0.5359 19.4787
TM-31 CTRP2 4.4834 10.6153 1.7786 14.7452
CCF-STTG1 CTRP2 4.549 6.7302 3.7599 6.4379
YH-13 CTRP2 4.6688 13.0572 0.7209 18.3671
KALS-1 CTRP2 4.7558 10.7768 1.9343 13.5563
KG-1-C CTRP2 4.8393 12.1693 1.3096 15.8378
Becker CTRP2 4.8927 9.2617 2.808 9.6896
SW1088 CTRP2 5.1817 11.1881 2.0862 12.1006
NMC-G1 CTRP2 5.245 11.7095 1.8775 12.8183
SNU-489 CTRP2 5.2585 9.1352 3.1745 7.4541
SNU-738 CTRP2 5.3235 10.8972 2.3472 10.7691
SF295 CTRP2 5.3839 8.8717 2.6703 4.133
SNB-75 CTRP2 5.387 10.4664 2.6134 9.5562
SNU-1105 CTRP2 5.4556 14.4856 0.6619 17.0079
SW1783 CTRP2 5.5103 19.2423 -1.6701 23.9768
KNS-81 CTRP2 5.5946 12.6846 1.6726 12.9737
42-MG-BA CTRP2 6.422 12.9556 2.1699 9.5893
DBTRG-05MG CTRP2 7.1623 15.8449 1.2913 11.7843
SF126 CTRP2 7.729 12.6707 3.1681 3.9613
Daoy CTRP2 7.731 16.9149 1.1716 11.3653
8-MG-BA CTRP2 8.2831 15.6599 2.1317 7.1247
⏷ Show the Full List of 45 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 22 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JHUEM-3 CTRP2 -1.1417 13.9281 -5.217 45.6309
HEC-151 CTRP2; CTRP1 -0.1239 1.9423 -0.1315 34.5201
RL95-2 CTRP2 0.3137 9.4917 -1.764 37.0102
HEC-1-B CTRP2 0.7622 5.8512 -1.5815 15.7862
HEC-251 CTRP2 0.9187 6.4181 -1.7309 16.1262
JHUEM-2 CTRP2; CTRP1 1.3786 4.2264 1.2353 24.9838
KLE CTRP2; CTRP1 1.6157 11.4636 -1.3259 32.1139
JHUEM-1 CTRP2 2.0211 6.8424 1.1252 23.3668
ESS-1 CTRP2 2.22 4.7886 2.028 19.4819
HEC-6 CTRP2 2.4686 6.4684 -0.5712 6.2687
HEC-1-A CTRP2 2.5767 5.9956 2.0426 18.3681
EN CTRP2 2.6894 4.9661 2.4953 16.3659
JHUEM-7 CTRP2 3.195 7.1445 2.2256 15.9721
HEC-108 CTRP2; CTRP1 3.4301 10.1227 1.068 19.9406
HEC-50B CTRP2 3.4389 6.1643 2.8968 12.6975
EFE-184 CTRP2 3.4969 12.8431 -0.2094 24.0922
AN3-CA CTRP2 4.4583 9.6831 2.2202 13.0163
HEC-59 CTRP2; CTRP1 4.5971 9.9002 2.2434 12.7061
MFE-319 CTRP2 6.1903 17.1153 -0.0646 18.1019
MFE-296 CTRP2 6.7468 10.0175 3.7926 2.7428
HEC-265 CTRP2 6.8499 7.9395 4.6942 0.0855
Ishikawa (Heraklio) 02 ER- CTRP2; CTRP1 0.4628 2.8288 0.433 30.6895
⏷ Show the Full List of 22 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 21 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
UO-31 CTRP2 -0.5257 1.9211 -0.5406 37.1568
769-P CTRP2 1.0953 9.8383 -1.5475 30.5231
RCC10RGB CTRP2; CTRP1 1.1793 3.8363 1.0853 26.1395
786-O CTRP2 1.288 3.6625 1.2232 25.2445
KMRC-2 CTRP2 1.2987 3.5811 1.2438 25.1396
CAL-54 CTRP2 1.4773 14.9478 -3.1229 36.0239
TUHR14TKB CTRP2 1.5464 2.8666 1.5429 23.3159
VMRC-RCW CTRP2 1.5589 3.6983 1.5061 23.3992
KMRC-3 CTRP2 1.7642 8.5091 0.1589 27.4487
KMRC-1 CTRP2 2.184 6.2828 1.5146 21.4667
OS-RC-2 CTRP2 2.3959 5.5266 2.0093 19.018
ACHN CTRP2 2.5894 14.2622 -1.742 30.4633
BFTC-909 CTRP2 3.1301 5.9134 2.667 14.4357
Caki-2 CTRP2 3.1464 11.7041 0.0254 24.1902
TUHR4TKB CTRP2 3.2129 8.677 1.5424 18.6011
KMRC-20 CTRP2 3.2612 9.3465 1.2724 19.5145
Caki-1 CTRP2 3.7393 16.1065 -1.6087 27.4415
A-498 CTRP2 3.8193 6.5161 3.1415 10.7274
VMRC-RCZ CTRP2 4.5926 11.3577 1.5038 15.5974
TUHR10TKB CTRP2 6.0862 15.3832 0.7155 15.6544
SNU-1272 CTRP2 6.1139 7.8768 3.4999 0.4394
⏷ Show the Full List of 21 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 52 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CCK-81 CTRP2 -4.5984 3.0584 -5.0109 61.1482
HT115 CTRP2; CTRP1 -4.3559 1.7914 -4.5429 60.9426
NCI-H508 CTRP2; CTRP1 -3.9579 5.1229 -4.799 57.1772
SW1116 CTRP2 -2.7475 4.8824 -3.4154 51.5155
CW-2 CTRP2; CTRP1 -2.4627 4.4588 -2.9939 50.0514
HT-55 CTRP2; CTRP1 -2.2847 3.3657 -2.5647 48.9918
GP2d CTRP2 -2.1813 4.7958 -2.7748 48.4593
LS180 CTRP2; CTRP1 -1.1413 2.4285 -1.2113 41.4547
SW948 CTRP2; CTRP1 -0.9024 12.2873 -4.2303 44.2915
LoVo CTRP2; CTRP1 -0.8695 4.7012 -1.3169 40.5517
SNU-C4 CTRP2; CTRP1 -0.8228 3.9908 -1.103 39.8863
COLO 678 CTRP2; CTRP1 -0.7946 10.3007 -3.254 43.0657
NCI-H747 CTRP2 -0.7922 3.4425 -0.9702 39.3813
CL-40 CTRP1 -0.4153 5.2522 -0.9691 66.139
SNU-175 CTRP1 -0.4146 7.0757 -1.5654 63.0401
SNU-61 CTRP2; CTRP1 -0.2365 6.2503 -1.0844 37.5533
LS513 CTRP2 -0.2168 3.2031 -0.3193 35.3781
SW1417 CTRP2 0.3068 5.973 -0.4063 33.7848
SNU-C2A CTRP2 0.6455 10.1708 -1.7182 35.8441
SNU-81 CTRP1 0.6464 7.1933 -0.4707 56.8438
SNU-C5 CTRP2; CTRP1 0.7833 4.2595 0.5843 29.1284
SNU-407 CTRP2 0.7922 7.5053 -0.441 32.2554
T84 CTRP2 0.8749 4.1735 0.6988 28.3743
COLO 320 CTRP1 0.9036 13.1281 -3.3144 50.6816
SW48 CTRP2 0.9375 61.874 -26.8615 46.959
HCT 15 CTRP2 0.9628 4.3387 0.761 27.8782
SNU-1033 CTRP2 1.3677 8.2219 -0.1284 29.528
KM12 CTRP2; CTRP1 1.5264 3.9875 1.4347 23.8224
CL-11 CTRP2 1.7457 5.203 1.3999 23.1853
HCT 116 CTRP2; CTRP1 1.8948 4.6734 1.703 21.721
SW620 CTRP2; CTRP1 1.9115 5.4908 1.4971 22.4075
LS123 CTRP2; CTRP1 2.1193 7.3253 1.0379 23.4749
RCM-1 [Human ESC] CTRP2; CTRP1 2.2314 6.9562 1.3071 22.1737
RKO CTRP2; CTRP1 2.3941 4.233 2.3275 17.9619
SW480 CTRP1 2.5274 5.1037 2.2838 37.6272
SK-CO-1 CTRP2 2.6884 9.0352 0.8577 22.5054
CL-34 CTRP1 2.7957 4.6397 2.6895 33.0718
NCI-H716 CTRP2 2.8736 5.0509 2.6735 15.1622
LS1034 CTRP2 3.206 6.2614 2.6118 14.4362
C2BBe1 CTRP2 3.3033 24.6425 -6.2409 36.2083
SNU-1040 CTRP1 3.3584 7.5775 2.2032 32.0828
SNU-C1 CTRP2 3.4051 7.8879 2.1004 15.9314
LS411N CTRP2 4.1701 7.0174 3.2599 9.3785
MDST8 CTRP2; CTRP1 4.2464 6.7291 3.4777 8.3927
HCC-56 CTRP2 4.3716 10.7944 1.5911 15.7244
SNU-503 CTRP2 4.6645 16.0396 -0.7729 23.2103
DLD-1 CTRP2 4.7172 8.3387 3.1172 8.7537
HCT 8 CTRP2; CTRP1 4.984 9.2468 2.9021 9.1965
HT-29 CTRP2; CTRP1 5.7571 8.4394 3.9092 3.6363
COLO201 CTRP2 6.1305 10.7621 3.0324 6.5705
OUMS-23 CTRP2 6.3373 12.3685 2.396 8.8232
COLO205 CTRP2 6.5967 11.0564 3.2129 5.1637
⏷ Show the Full List of 52 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 22 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-182 CTRP2 -1.5858 4.9004 -2.1525 45.0312
JHH-5 CTRP2 -1.1643 8.3412 -2.8491 43.9768
SNU-398 CTRP2; CTRP1 1.0748 5.1635 0.6819 27.8603
SNU-761 CTRP2 1.29 4.174 1.1477 25.4976
JHH-4 CTRP2 1.6392 4.6188 1.4352 23.3893
HuH-6 CTRP2 1.7821 4.461 1.6248 22.274
Li-7 CTRP2 1.8268 11.9888 -1.3731 31.5862
Hep 3B2.1-7 CTRP2 2.4669 4.333 2.3889 17.4372
SNU-449 CTRP2; CTRP1 2.6276 7.6578 1.4242 20.6448
JHH-6 CTRP2; CTRP1 2.6754 2.9201 2.6754 15.864
SNU-886 CTRP2 2.7108 3.9451 2.6934 15.6051
SK-HEP-1 CTRP2 2.8234 6.2436 2.213 17.0251
HuH-1 CTRP2 3.0009 5.6905 2.6095 15.0214
Hep-G2 CTRP2; CTRP1 3.0566 4.3478 3.0189 13.4542
HLF CTRP2 3.0946 6.4362 2.4232 15.4691
SNU-387 CTRP2 3.2778 7.1283 2.3175 15.395
SNU-423 CTRP2 3.7911 6.3981 3.1646 10.7088
SNU-878 CTRP2 4.4971 9.659 2.2665 12.7445
PLC/PRF/5 CTRP2 6.0146 14.7802 0.9595 14.9069
JHH-2 CTRP2 6.0269 18.5109 -0.8886 20.9031
SNU-475 CTRP2 7.1526 12.7166 2.7909 6.0728
JHH-1 CTRP2 7.3396 8.3772 4.7152 0.0522
⏷ Show the Full List of 22 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 155 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H1975 CTRP2 -5.4404 -2.7954 -5.4408 69.6678
HCC2935 CTRP2; CTRP1 -4.3992 -0.275 -4.4234 62.4033
NCI-H2170 CTRP2 -4.3838 7.2196 -5.9115 57.7748
NCI-H3255 CTRP1 -3.979 3.5345 -4.434 81.9159
EPLC-272H CTRP2 -3.9481 4.3615 -4.5916 57.4732
NCI-H209 CTRP2 -3.8123 19.6556 -10.5136 53.036
HCC827 CTRP2; CTRP1 -3.6941 -0.6201 -3.6995 58.1708
HCC4006 CTRP2; CTRP1 -3.5665 2.2763 -3.7663 56.5581
NCI-H1963 CTRP1 -3.2043 0.6553 -3.2359 90.2669
NCI-H1666 CTRP2 -3.1787 8.5943 -5.0991 52.8894
PC-14 CTRP2 -3.0496 -0.8383 -3.0503 53.9188
NCI-H1435 CTRP2; CTRP1 -2.5347 2.78 -2.7356 50.4941
NCI-H358 CTRP2 -2.503 4.5287 -3.0574 50.2325
SCLC-21H CTRP1 -2.4536 -0.2469 -2.4547 93.262
Calu-3 CTRP2 -2.4044 10.9298 -5.2037 49.7936
CAL-12T CTRP2; CTRP1 -2.257 4.5848 -2.8008 48.9074
COR-L105 CTRP2 -1.9134 4.137 -2.3217 46.8047
NCI-H1623 CTRP2 -1.8935 5.1295 -2.5505 46.8828
COR-L51 CTRP2; CTRP1 -1.582 2.2581 -1.6585 44.3614
NCI-H1568 CTRP2 -1.2073 4.9018 -1.7399 42.7315
NCI-H322 CTRP2 -0.9464 7.0471 -2.1322 42.2316
NCI-H146 CTRP2 -0.8589 3.6183 -1.0723 39.9034
Calu-6 CTRP2 -0.8242 1.0387 -0.8259 39.1028
NCI-H1836 CTRP1 -0.6745 2.343 -0.7161 75.6371
HCC1588 CTRP2 -0.5499 5.3435 -1.3647 35.5547
NCI-H1869 CTRP2 -0.5118 11.3186 -3.4088 42.2325
DV-90 CTRP2 -0.3102 8.3888 -1.9606 39.5327
LXF 289 CTRP2; CTRP1 -0.1672 1.5721 -0.1694 34.7905
NCI-H524 CTRP2 -0.1108 3.1006 -0.1943 34.6152
NCI-H1341 CTRP2 -0.0135 2.9588 -0.0764 33.9025
NCI-H661 CTRP2 -0.0086 9.4867 -2.0966 38.7112
NCI-H2141 CTRP2; CTRP1 0.0243 3.136 -0.0544 33.766
NCI-H1876 CTRP1 0.0478 4.6755 -0.3101 64.3668
NCI-H2286 CTRP2; CTRP1 0.1093 4.8312 -0.2823 34.1743
NCI-H1694 CTRP2; CTRP1 0.1715 2.7431 0.1361 32.6464
NCI-H1563 CTRP2 0.2556 2.6197 0.2308 31.9859
NCI-H292 CTRP2 0.2609 12.1978 -3.4744 37.2821
LUDLU-1 CTRP2 0.2938 16.6372 -5.0673 41.5307
SK-MES-1 CTRP2 0.3107 5.5283 -0.2614 33.3494
DMS 79 CTRP2 0.356 5.1183 -0.3065 28.9576
NCI-H2009 CTRP2; CTRP1 0.3808 4.5943 0.0725 32.1457
NCI-H211 CTRP2 0.4073 3.6806 0.2803 31.3156
LCLC-97TM1 CTRP2 0.4696 6.4504 -0.3923 33.1872
NCI-H1105 CTRP2; CTRP1 0.5179 1.7288 0.5177 30.2242
NCI-H1573 CTRP2 0.5552 9.2747 -1.4207 35.4977
NCI-H1734 CTRP2 0.6359 9.4292 -1.8135 32.6429
NCI-H1915 CTRP2; CTRP1 0.8466 4.422 0.6188 28.8061
NCI-H2087 CTRP2 0.9311 5.4209 0.4473 29.0444
NCI-H810 CTRP2 1.0279 2.3554 1.0263 26.7637
NCI-H522 CTRP2 1.1115 5.85 0.5081 28.2672
NCI-H1184 CTRP2 1.1615 3.4997 1.1075 26.0503
NCI-H1838 CTRP2 1.1754 7.1275 -0.2341 26.0688
NCI-H2081 CTRP2; CTRP1 1.2125 2.3839 1.2117 25.6031
COLO 699 CTRP2; CTRP1 1.228 8.0708 -0.2055 30.25
COLO 668 CTRP2; CTRP1 1.2543 3.9215 1.1529 25.666
NCI-H2171 CTRP2 1.2994 2.2637 1.2992 24.9505
NCI-H1693 CTRP2 1.3447 8.8623 -0.4268 30.4836
NCI-H1755 CTRP2; CTRP1 1.4405 4.8263 1.1711 25.0124
NCI-H889 CTRP2 1.4803 3.1018 1.4686 23.7835
EKVX CTRP2 1.4999 11.4151 -1.4245 32.6261
COR-L23 CTRP1 1.5073 4.9664 1.2078 50.5926
DMS 454 CTRP2 1.5175 2.8167 1.5145 23.5066
COR-L95 CTRP2 1.5657 2.0951 1.5657 23.1753
DMS 53 CTRP2 1.5735 2.3142 1.5735 23.1234
RERF-LC-KJ CTRP1 1.7197 5.0374 1.4206 48.1121
NCI-H446 CTRP2 1.7425 3.3107 1.7286 22.0443
NCI-H2029 CTRP2 1.7784 4.5977 1.5914 22.403
NCI-H23 CTRP2 1.7856 5.3283 1.4066 23.0398
NCI-H1703 CTRP2 1.8233 6.5143 1.0412 24.245
HCC1833 CTRP2; CTRP1 1.8321 7.1337 0.8137 25.1002
NCI-H520 CTRP2 1.8513 3.9215 1.7897 21.4815
EBC-1 CTRP2 1.9041 5.6554 1.4329 22.5876
HCC1359 CTRP1 1.9514 2.5934 1.9514 44.3931
NCI-H441 CTRP2; CTRP1 2.0013 10.4104 -0.4544 28.7185
HCC1171 CTRP2 2.0096 14.7844 -2.5393 33.6143
NCI-H2085 CTRP2 2.046 9.1026 0.1829 26.5676
Sq-1 CTRP2; CTRP1 2.0581 13.5958 -1.9108 32.247
NCI-H650 CTRP2 2.06 6.5593 -0.8994 8.8621
HCC2108 CTRP2; CTRP1 2.094 8.5273 0.495 25.4578
NCI-H2030 CTRP2; CTRP1 2.1642 10.0296 -0.1163 27.253
NCI-H526 CTRP2 2.2082 8.9381 -0.0392 22.3978
NCI-H1930 CTRP1 2.2114 3.7186 2.1902 40.8054
HCC2279 CTRP2 2.2622 10.5112 -0.7486 24.7834
NCI-H69 CTRP2 2.3179 5.2038 1.768 14.7509
SW1271 CTRP2 2.3331 5.2691 2.0212 19.1614
NCI-H1355 CTRP2 2.3453 7.2384 1.3054 21.7878
NCI-H2405 CTRP2 2.367 8.0678 0.5294 19.7562
HCC366 CTRP2 2.371 10.5081 -0.1431 26.7137
LOU-NH91 CTRP2 2.3713 12.5316 -1.1077 29.4605
NCI-H596 CTRP1 2.4739 4.7066 2.3256 37.8393
NCI-H2122 CTRP2; CTRP1 2.5463 5.9803 2.0197 18.6189
NCI-H2106 CTRP2 2.5493 4.6684 2.4141 17.0887
DMS 273 CTRP2 2.6008 5.3146 2.2992 17.3452
VMRC-LCD CTRP2 2.7088 5.9718 2.1933 17.4234
Lu-65 CTRP2 2.7991 11.9469 -0.4193 26.438
RERF-LC-Ad2 CTRP2 2.8265 11.3864 -0.1226 25.4606
NCI-H196 CTRP2 3.0507 10.7744 -0.155 20.6887
NCI-H841 CTRP2; CTRP1 3.1654 9.1493 1.2806 19.7938
HOP-62 CTRP2 3.2273 8.0567 1.8457 17.3836
HCC15 CTRP2; CTRP1 3.2393 9.9162 0.9862 20.7072
NCI-H2342 CTRP2; CTRP1 3.2656 8.6385 1.6193 18.2471
HCC44 CTRP2 3.3289 11.6636 0.2153 23.1233
COR-L88 CTRP2 3.3388 8.5907 1.7063 17.6513
NCI-H2196 CTRP2 3.4243 4.9407 3.3035 11.2132
SK-LU-1 CTRP2; CTRP1 3.475 12.5176 -0.0607 23.7356
IA-LM CTRP2 3.6027 5.5276 3.3169 10.6343
ChaGo-K-1 CTRP2 3.6782 8.473 2.0912 15.3011
NCI-H2110 CTRP2; CTRP1 3.7354 15.4136 -1.2589 26.6087
T3M-10 CTRP2; CTRP1 3.783 11.8457 0.5512 20.9725
NCI-H647 CTRP2 3.9086 10.3397 1.3994 17.4946
SHP-77 CTRP2 3.9686 10.8532 1.2011 18.1157
LK2 CTRP2 4.1518 7.6798 2.9248 10.7946
NCI-H1781 CTRP1 4.189 8.8199 2.412 26.1207
A-549 CTRP2 4.3442 11.0645 1.4326 16.4012
NCI-H2126 CTRP2 4.3921 10.8474 1.5829 15.7129
NCI-H2444 CTRP2 4.4061 6.264 3.8457 6.4231
NCI-H1339 CTRP2 4.5535 6.0496 4.0909 5.0681
NCI-H1373 CTRP2 4.6228 11.0916 1.6626 14.9124
NCI-H1581 CTRP2 4.6274 10.6451 1.8894 14.0007
Lu-99 CTRP2 4.6519 11.8286 1.3199 16.1833
NCI-H838 CTRP2 4.7447 10.495 2.0655 13.0491
NCI-H2228 CTRP2 4.8054 11.4238 1.6534 14.5731
BEN CTRP2 4.8213 5.3795 4.6676 2.0745
NCI-H1395 CTRP2 4.8347 21.259 -3.2383 28.7812
NCI-H1944 CTRP2 4.8634 14.2671 0.2813 19.4948
NCI-H1650 CTRP2 5.0173 16.535 -0.7235 22.3488
LC-1/sq-SF CTRP2 5.0546 16.2797 -0.5648 21.8044
RERF-LC-A1 CTRP2 5.1816 12.7699 1.2953 15.2112
HCC78 CTRP2 5.2374 11.3185 2.0667 12.0729
MOR/CPR CTRP2 5.2418 8.4585 2.7729 3.9031
NCI-H2291 CTRP2 5.2859 10.2607 1.9337 7.4421
NCI-H1792 CTRP2 5.3491 13.5495 1.043 15.8331
NCI-H727 CTRP2 5.351 15.1166 0.2614 18.5918
NCI-H2073 CTRP1 5.4274 15.7296 0.0274 31.2058
HOP-92 CTRP2 5.5394 10.7189 2.6084 9.3011
NCI-H460 CTRP2; CTRP1 5.7706 8.6771 3.8031 4.0489
HCC95 CTRP2 5.8141 18.492 -1.0492 21.7491
NCI-H226 CTRP2 5.8249 10.147 3.1108 6.7356
Calu-1 CTRP2 6.0247 11.8783 2.4061 9.2915
NCI-H1651 CTRP2 6.121 14.3589 1.2511 13.6441
NCI-H1155 CTRP2 6.2851 13.5087 1.7965 11.2809
LCLC-103H CTRP2 6.3271 10.845 3.131 5.8733
SBC-5 CTRP2 6.5207 7.4872 4.7319 0.1004
SW1573 CTRP2 6.5924 20.7443 -1.5557 21.7333
HCC1438 CTRP2 6.9317 10.8653 3.5159 3.565
RERF-LC-Ad1 CTRP2 6.9586 17.1038 -0.2111 13.2913
DMS 114 CTRP2 7.0287 13.3235 2.419 7.6917
RERF-LC-MS CTRP2 7.0603 14.061 2.0855 8.9418
HARA [Human squamous cell lung carcinoma] CTRP2 7.2801 19.3376 -0.3353 17.1018
KNS-62 CTRP2 7.382 14.7758 1.962 8.9498
HCC1195 CTRP2; CTRP1 7.821 16.0054 1.6811 9.4505
NCI-H2023 CTRP2; CTRP1 7.974 14.77 2.3644 6.7116
NCI-H1299 CTRP2 8.7131 16.5023 2.0075 7.0585
NCI-H2172 CTRP2; CTRP1 9.9587 20.7449 0.8259 9.6923
Hs 888.Lu CTRP2 3.25 9.5671 1.1562 19.9795
⏷ Show the Full List of 155 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Clivus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
U-CH1 CTRP2 -0.6669 10.0149 -3.0055 42.3066
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Thigh Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
P-STS CTRP2 1.3104 2.8996 1.3022 24.904
H-STS CTRP2 1.7997 3.1046 1.7947 21.6333
SYO-1 CTRP2 3.7057 6.6687 2.9579 11.7502
Cancer Drug Sensitivity Data Curated from 45 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
2004 CTRP2 2.3997 10.2343 0.0137 26.1434
OVKATE CTRP1 -3.2072 0.2345 -3.2231 91.8672
OVCAR-8 CTRP2; CTRP1 -2.1586 -1.2739 -2.1586 48.0374
COV434 CTRP2; CTRP1 -1.8134 1.649 -1.8531 45.8139
JHOS-4 CTRP1 -1.7823 1.0464 -1.7949 86.1705
OVCAR-4 CTRP2; CTRP1 -1.1027 0.3614 -1.1028 41.0101
IGROV-1 CTRP2; CTRP1 -1.0617 2.7441 -1.16 41.0013
RMG-I CTRP2; CTRP1 -0.5901 5.5429 -1.2447 39.2686
JHOC-5 CTRP2; CTRP1 -0.28 4.8844 -0.7209 36.8183
SNU-119 CTRP2 -0.0102 10.4524 -2.5141 39.4022
FU-OV-1 CTRP2 0.2372 8.1896 -1.3017 36.296
ONCO-DG-1 CTRP2 0.4087 6.3462 -0.4217 33.478
Kuramochi CTRP2 0.4651 8.7731 -1.302 35.5277
OVCAR-5 CTRP2 0.6083 3.4264 0.53 29.8164
RMUG-S CTRP1 0.9525 6.7283 0.0319 55.0286
OVK18 CTRP2; CTRP1 1.0207 2.0645 1.0205 26.8778
TYK-nu CTRP2; CTRP1 1.1251 4.2126 0.9637 26.731
OC 314 CTRP2 1.3627 2.4052 1.3623 24.529
EFO-27 CTRP2; CTRP1 1.3655 10.1134 -0.9546 31.9164
COV362 CTRP2; CTRP1 1.9503 7.6163 0.7398 25.0188
HEY A8 CTRP2 2.0328 6.7893 1.1586 23.2112
SNU-840 CTRP2; CTRP1 2.0392 20.2145 -5.1623 37.5349
A2780 CTRP2; CTRP1 2.1693 5.4346 1.7954 20.5518
OVMANA CTRP1 2.2767 4.9448 2.053 40.8845
Caov-3 CTRP2; CTRP1 3.0304 8.6602 1.3775 19.7672
COV318 CTRP1 3.1767 4.4522 3.1331 27.2026
SNU-8 CTRP2 3.3389 11.4769 0.3157 22.7628
JHOM-1 CTRP2; CTRP1 3.3709 8.2508 1.9045 16.8695
TOV-21G CTRP2 3.4164 6.3705 2.7879 13.1815
ES2 CTRP2 3.4206 8.9268 1.6263 17.7627
OAW28 CTRP2 3.6766 11.5997 0.5671 21.097
COV644 CTRP2; CTRP1 3.8011 15.854 -1.4197 26.8785
OV7 CTRP2; CTRP1 3.9003 11.4256 0.865 19.5865
JHOS-2 CTRP2 4.1382 11.1926 1.1859 17.7941
OVTOKO CTRP2 4.2885 18.1012 -2.1242 27.4959
OAW42 CTRP2; CTRP1 4.3444 4.9218 4.3118 4.8673
SK-OV-3 CTRP2 4.4532 16.5995 -1.2329 24.9321
MCAS CTRP2 5.1896 9.7496 2.8117 9.0991
DOV13 CTRP2 5.2895 9.7944 2.1631 6.4453
OVSAHO CTRP2 5.37 9.6304 2.2983 5.7368
OVISE CTRP2 5.4084 15.1307 -0.3757 16.5139
OV56 CTRP2 5.9088 10.3384 3.0787 6.7314
EFO-21 CTRP2 6.2649 11.8921 2.5767 8.2108
OV-90 CTRP2; CTRP1 6.6773 12.4356 2.6167 7.4929
TOV-112D CTRP2 7.5186 14.5952 2.1402 8.0824
⏷ Show the Full List of 45 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 22 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Aska-SS CTRP2 5.3252 9.0977 3.2467 7.03
Yamato-SS CTRP2 6.8824 12.7119 2.6132 7.1379
TE 617.T CTRP2 -7.4286 0.3877 -7.6359 74.3458
TE 441.T CTRP2 0.2909 2.5899 0.2689 31.7416
Rh41 CTRP2 0.5486 3.9867 0.381 30.5122
GCT CTRP2 0.7765 2.7388 0.7616 28.4834
RKN CTRP2; CTRP1 1.1919 2.1125 1.1918 25.7378
G-401 CTRP2 1.6143 8.3154 0.0879 28.115
RD CTRP2 1.6221 4.4386 1.4558 23.3709
Rh18 CTRP2 1.7543 4.8373 1.5082 22.7727
A-204 CTRP2 2.3222 9.3245 0.3595 25.22
Hs 729.T CTRP2 2.631 7.1804 1.6277 19.7898
G-402 CTRP2 3.4926 8.4864 1.9055 16.4893
SW982 CTRP2 4.0386 13.7648 -0.18 22.7606
BT-16 CTRP2 4.4796 15.3657 -0.5941 23.0725
MES-SA CTRP2 4.6188 8.1481 3.125 8.9275
SK-LMS-1 CTRP2 4.6452 11.2604 1.5978 15.1208
TTC-709 CTRP2 5.0409 11.2713 1.928 13.011
BT-12 CTRP2 5.1597 7.2584 4.032 4.038
Tm87-16 CTRP2 5.2079 10.1152 2.6439 9.7622
HT-1080 CTRP2; CTRP1 5.7424 9.3903 3.4331 5.6163
SK-UT-1 CTRP2 6.7456 14.3295 1.7319 10.7827
⏷ Show the Full List of 22 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MSTO-211H CTRP2 -1.038 3.7992 -1.2997 41.1674
IST-Mes1 CTRP2 1.9182 6.2112 1.2556 23.1909
NCI-H2452 CTRP2 2.1744 6.146 1.555 21.345
NCI-H28 CTRP2 2.3576 6.1856 1.7372 20.1396
MPP 89 CTRP2 2.811 5.8353 2.353 16.5303
NCI-H2052 CTRP2 3.3184 10.1976 0.9183 20.6922
JL-1 CTRP2 4.8546 10.9829 1.9155 13.4315
ACC-MESO-1 CTRP2 6.8952 12.3511 2.7946 6.4058
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
22Rv1 CTRP2 1.587 8.8963 -0.623 26.2147
LNCaP clone FGC CTRP2 1.7551 5.914 1.1846 23.9311
PaCa-3 CTRP2; CTRP1 1.8015 2.594 1.8014 21.6806
VCaP CTRP2 2.18 6.4898 1.432 21.7841
DU145 CTRP2 3.9236 12.926 0.1345 22.0033
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
YD-15 CTRP2 -2.9566 2.6766 -3.2658 50.1092
A-253 CTRP2 2.6492 10.7591 0.0083 25.502
Cancer Drug Sensitivity Data Curated from 34 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-N87 CTRP2 -11.3944 -4.4163 -11.4425 89.0236
NCC-StC-K140 CTRP2 -5.4809 8.4627 -7.5286 60.5382
NUGC-4 CTRP2 -3.481 5.5558 -4.4041 54.8976
ECC10 CTRP2 -1.6692 0.979 -1.6783 44.7492
KE-39 CTRP2 -1.2996 4.7375 -1.7977 43.2339
IM95 CTRP2 -0.6612 6.4316 -1.6097 40.2304
NUGC-3 CTRP2 -0.6521 6.8623 -1.7489 40.4474
SNU-216 CTRP2 -0.5533 6.282 -1.4423 39.483
GSS CTRP2 0.3775 2.4135 0.3655 31.1314
HGC-27 CTRP2 0.9196 6.7185 -0.0041 30.5425
SNU-16 CTRP2 1.0445 2.3519 1.043 26.653
SNU-1 CTRP2 1.0815 3.7037 0.9982 26.6829
MKN74 CTRP2; CTRP1 1.5491 7.3186 0.4402 27.2206
SNU-719 CTRP2 1.5941 9.7235 -2.1599 22.0264
AGS CTRP2; CTRP1 1.8633 3.4819 1.8443 21.3324
MKN7 CTRP2 1.9094 12.126 -1.3578 31.3227
Hs 746.T CTRP2 2.3658 4.8927 2.1611 18.5573
MKN1 CTRP2 3.3109 7.6211 2.1292 16.0541
SNU-620 CTRP2 3.4866 5.5733 3.1754 11.4995
SNU-5 CTRP2 3.7024 10.1904 0.7095 15.7744
GSU CTRP2 3.9374 8.3424 2.4015 13.4353
23132/87 CTRP2 4.3776 8.4472 2.7597 10.9674
HuG1-N CTRP2 4.3922 17.7919 -1.8807 26.7069
KATO III CTRP2 4.7294 8.0655 3.2639 8.1143
Fu97 CTRP2 4.8432 8.7503 3.0212 8.8977
SNU-601 CTRP2 5.9885 15.0325 0.8137 15.4798
MKN45 CTRP2 6.4828 7.7017 4.6395 0.2666
ECC12 CTRP2 6.8295 11.8757 2.9774 5.7763
SNU-668 CTRP2 6.8305 18.2397 -0.8533 15.699
LMSU CTRP2 8.0989 17.1151 1.3256 10.2928
SH-10-TC CTRP2 8.7532 16.0647 2.2325 6.2098
SNG-M CTRP2; CTRP1 0.3611 3.7164 0.2263 31.7138
SNU-685 CTRP2 3.6334 9.1541 1.7211 16.8796
SNU-1077 CTRP2 8.7607 19.0652 0.8367 11.0972
⏷ Show the Full List of 34 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 12 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ML-1 [Human leukemia] CTRP2 -0.2901 4.6834 -0.6828 36.6957
TT CTRP2 0.834 10.4168 -2.0754 32.6927
FTC-238 CTRP2 0.9223 3.0517 0.8952 27.5528
SW579 CTRP2 1.0424 3.0587 1.0193 26.7391
CAL-62 CTRP2 1.1187 2.8395 1.1083 26.1883
8305C CTRP2 1.3136 6.9388 0.3347 28.2187
TT2609-C02 CTRP2 4.8921 9.6682 2.6043 10.5387
B-CPAP CTRP2 4.9527 11.6508 1.6645 14.2335
CGTH-W-1 CTRP2 5.4759 10.1918 2.8209 8.5352
8505C CTRP2 5.5085 10.6994 2.5938 9.4167
BHT-101 CTRP2 5.8302 9.9807 2.4357 4.4955
FTC-133 CTRP2 6.8054 12.3201 2.7489 6.7116
⏷ Show the Full List of 12 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 29 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
YD-10B CTRP2 -5.6335 5.2799 -6.8695 61.4985
SNU-1076 CTRP2 -4.1918 3.3601 -4.6305 59.1272
CAL-27 CTRP2 -3.9661 2.7279 -4.2672 58.4057
BHY CTRP2 -3.4924 2.5433 -3.7276 56.017
SNU-1214 CTRP2 -3.401 5.3694 -4.4677 52.3203
SCC-25 CTRP2 -3.1921 3.213 -3.5187 54.177
PE/CA-PJ34 (clone C12) CTRP2 -2.0991 6.8664 -3.3155 48.2524
PE/CA-PJ15 CTRP2 -1.8994 7.6563 -3.3787 47.3929
HSC-2 CTRP2 -1.3202 5.7551 -2.1078 43.7697
SCC-9 CTRP2; CTRP1 -0.5886 3.9487 -0.8407 38.3069
BICR 56 CTRP2 -0.5465 13.5824 -4.4618 43.3373
HSC-3 CTRP2 0.0624 4.1093 -1.3534 16.6795
CAL-33 CTRP2 0.3955 9.0538 -1.4927 36.1794
SNU-1066 CTRP2 0.3974 9.8516 -1.8328 36.8707
BICR 22 CTRP2 0.3979 7.2227 -0.752 34.4156
FaDu CTRP2 0.4195 10.4219 -2.0602 37.2334
BICR 31 CTRP2 0.5264 14.4648 -3.8105 39.5711
PE/CA-PJ41 (clone D2) CTRP2 0.6222 15.9764 -4.4355 40.044
PE/CA-PJ49 CTRP2 0.6299 8.7565 -1.1229 34.5684
Detroit 562 CTRP2 0.6937 5.2327 0.0181 26.6644
SNU-899 CTRP2 1.1419 5.0086 0.5814 23.0896
HSC-4 CTRP2 1.7625 14.0507 -2.4191 34.0232
BICR 6 CTRP2 1.83 9.5596 -0.2418 28.5118
BICR 16 CTRP2 2.5419 9.3743 0.5552 23.9617
YD-8 CTRP2 2.6923 11.1964 -0.1593 25.9188
BICR 18 CTRP2 2.9983 6.7112 2.2084 16.5623
SNU-1041 CTRP2 3.403 17.3055 -2.5025 30.2289
SCC-4 CTRP2 4.9196 15.2609 -0.1682 20.8529
SNU-46 CTRP2 6.8787 25.7108 -4.4952 25.1508
⏷ Show the Full List of 29 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 23 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
U-BLC1 CTRP2 -6.1654 -4.5568 -6.1654 74.654
5637 CTRP2 -3.4221 2.3208 -3.702 52.9969
SCaBER CTRP2 -1.2585 9.4413 -3.3869 44.8309
647V CTRP2 0.0773 4.3488 -0.2034 33.9865
VM-CUB-1 CTRP2 0.2289 8.2165 -1.3213 36.368
CAL-29 CTRP2 0.7948 5.5069 0.2726 30.0624
BC-3C CTRP2 1.5715 10.5186 -0.9388 31.2173
SW1710 CTRP2 1.6093 5.877 1.0392 24.8899
HT-1197 CTRP2 1.8707 12.297 -7.0231 15.546
JMSU-1 CTRP2 2.0997 8.3192 0.5866 25.0603
BFTC-905 CTRP2 2.4394 4.4497 2.3389 17.6988
253J-BV CTRP2 2.6323 8.1727 1.1949 21.4179
T24 CTRP2 2.7336 5.2085 2.4759 16.3023
RT-4 CTRP2 2.7965 7.503 1.6595 19.2233
HT-1376 CTRP2 2.9386 11.8306 -0.2313 25.5159
UM-UC-1 CTRP2 5.482 12.3258 1.7617 12.8316
KU-19-19 CTRP2 5.6027 11.6601 2.1895 10.9004
J82 CTRP2 5.8037 13.6923 1.3358 13.8892
639V CTRP2 6.3145 9.8121 3.6178 3.9421
TCCSUP CTRP2 7.6156 20.0354 -0.4312 16.8606
RT-112 CTRP2 8.3128 16.8447 1.5951 9.0378
KMBC-2 CTRP2 8.3354 22.8868 -1.3049 18.2689
UM-UC-3 CTRP2 9.1668 17.7126 1.7271 7.5199
⏷ Show the Full List of 23 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HeLa CTRP2 5.2417 8.2938 3.581 5.7805

Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Disease Different from HKI-272 (Comorbidity)
DDI Drug Name DDI Drug ID Severity Mechanism Comorbidity REF
Arn-509 DMT81LZ Major Increased metabolism of HKI-272 caused by Arn-509 mediated induction of CYP450 enzyme. Acute myeloid leukaemia [2A60] [9]
Gilteritinib DMTI0ZO Moderate Decreased clearance of HKI-272 due to the transporter inhibition by Gilteritinib. Acute myeloid leukaemia [2A60] [10]
Troleandomycin DMUZNIG Major Decreased metabolism of HKI-272 caused by Troleandomycin mediated inhibition of CYP450 enzyme. Bacterial infection [1A00-1C4Z] [11]
MK-8228 DMOB58Q Major Decreased metabolism of HKI-272 caused by MK-8228 mediated inhibition of CYP450 enzyme. Cytomegaloviral disease [1D82] [11]
Ripretinib DM958QB Moderate Decreased clearance of HKI-272 due to the transporter inhibition by Ripretinib. Gastrointestinal stromal tumour [2B5B] [9]
Berotralstat DMWA2DZ Major Decreased clearance of HKI-272 due to the transporter inhibition by Berotralstat. Innate/adaptive immunodeficiency [4A00] [12]
PF-06463922 DMKM7EW Major Increased metabolism of HKI-272 caused by PF-06463922 mediated induction of CYP450 enzyme. Lung cancer [2C25] [9]
IPI-145 DMWA24P Major Decreased metabolism of HKI-272 caused by IPI-145 mediated inhibition of CYP450 enzyme. Mature B-cell leukaemia [2A82] [11]
Arry-162 DM1P6FR Moderate Decreased clearance of HKI-272 due to the transporter inhibition by Arry-162. Melanoma [2C30] [9]
Ubrogepant DM749I3 Moderate Decreased clearance of HKI-272 due to the transporter inhibition by Ubrogepant. Migraine [8A80] [13]
Rimegepant DMHOAUG Moderate Decreased clearance of HKI-272 due to the transporter inhibition by Rimegepant. Migraine [8A80] [14]
Fedratinib DM4ZBK6 Major Decreased metabolism of HKI-272 caused by Fedratinib mediated inhibition of CYP450 enzyme. Myeloproliferative neoplasm [2A20] [11]
Lefamulin DME6G97 Moderate Decreased metabolism of HKI-272 caused by Lefamulin mediated inhibition of CYP450 enzyme. Pneumonia [CA40] [15]
Relugolix DMK7IWL Major Decreased clearance of HKI-272 due to the transporter inhibition by Relugolix. Prostate cancer [2C82] [16]
Voxelotor DMCS6M5 Major Decreased metabolism of HKI-272 caused by Voxelotor mediated inhibition of CYP450 enzyme. Sickle-cell disorder [3A51] [11]
Lusutrombopag DMH6IKO Moderate Decreased clearance of HKI-272 due to the transporter inhibition by Lusutrombopag. Thrombocytopenia [3B64] [17]
Betrixaban DM2C4RF Moderate Decreased clearance of HKI-272 due to the transporter inhibition by Betrixaban. Venous thromboembolism [BD72] [18]
⏷ Show the Full List of 17 DDI Information of This Drug

Drug Inactive Ingredient(s) (DIG) and Formulation(s) of This Drug

DIG
DIG Name DIG ID PubChem CID Functional Classification
Mannitol E00103 6251 Diluent; Flavoring agent; Lyophilization aid; Plasticizing agent; Tonicity agent
Crospovidone E00626 Not Available Disintegrant
Eisenoxyd E00585 56841934 Colorant
Magnesium stearate E00208 11177 lubricant
Polyethylene glycol 4000 E00654 Not Available Coating agent; Diluent; Ointment base; Plasticizing agent; Solvent; Suppository base; lubricant
Polyvinyl alcohol E00666 Not Available Coating agent; Emulsion stabilizing agent; Film/Membrane-forming agent
Povidone E00667 Not Available Binding agent; Coating agent; Disintegrant; Film/membrane-forming agent; Solubilizing agent; Suspending agent
Silicon dioxide E00670 Not Available Anticaking agent; Opacifying agent; Viscosity-controlling agent
Talc E00520 16211421 Anticaking agent; Diluent; Glidant; lubricant
Titanium dioxide E00322 26042 Coating agent; Colorant; Opacifying agent
Water E00035 962 Solvent
Haematite red E00236 14833 Colorant
Hydrophobic colloidal silica E00285 24261 Anticaking agent; Emulsion stabilizing agent; Glidant; Suspending agent; Viscosity-controlling agent
Cellulose microcrystalline E00698 Not Available Adsorbent; Suspending agent; Diluent
⏷ Show the Full List of 14 Pharmaceutical Excipients of This Drug
Pharmaceutical Formulation
Formulation Name Drug Dosage Dosage Form Route
Neratinib 40 mg tablet 40 mg Oral Tablet Oral
Neratinib Maleate 40 mg tablet 40 mg Tablet Oral
Jump to Detail Pharmaceutical Formulation Page of This Drug

References

1 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800021154)
2 Dual irreversible kinase inhibitors: quinazoline-based inhibitors incorporating two independent reactive centers with each targeting different cyst... Bioorg Med Chem. 2007 Jun 1;15(11):3635-48.
3 Identification of genotype-correlated sensitivity to selective kinase inhibitors by using high-throughput tumor cell line profiling. Proc Natl Acad Sci U S A. 2007 Dec 11;104(50):19936-41.
4 A comparison of physicochemical property profiles of marketed oral drugs and orally bioavailable anti-cancer protein kinase inhibitors in clinical development. Curr Top Med Chem. 2007;7(14):1408-22.
5 Pharmacodynamics, pharmacokinetics and clinical efficacy of neratinib in HER2-positive breast cancer and breast cancer with HER2 mutations. Expert Opin Drug Metab Toxicol. 2016 Aug;12(8):947-57.
6 A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicol Sci. 2013 Nov;136(1):216-41.
7 Cysteine mapping in conformationally distinct kinase nucleotide binding sites: application to the design of selective covalent inhibitors. J Med Chem. 2011 Mar 10;54(5):1347-55. doi: 10.1021/jm101396q. Epub 2011 Feb 15.
8 Irreversible EGFR inhibitor EKB-569 targets low-LET -radiation-triggered rel orchestration and potentiates cell death in squamous cell carcinoma. PLoS One. 2011;6(12):e29705. doi: 10.1371/journal.pone.0029705. Epub 2011 Dec 29.
9 Cerner Multum, Inc. "Australian Product Information.".
10 Cerner Multum, Inc. "UK Summary of Product Characteristics.".
11 Abbas R, Hug BA, Leister C, Burns J, Sonnichsen D "Pharmacokinetics of oral neratinib during co-administration of ketoconazole in healthy subjects." Br J Clin Pharmacol 71 (2011): 522-7. [PMID: 21395644]
12 Product Information. Orladeyo (berotralstat). BioCryst Pharmaceuticals Inc, Durham, NC.
13 Product Information. Ubrelvy (ubrogepant). Allergan Inc, Irvine, CA.
14 Product Information. Nurtec ODT (rimegepant). Biohaven Pharmaceuticals, New Haven, CT.
15 Product Information. Xenleta (lefamulin). Nabriva Therapeutics US, Inc., King of Prussia, PA.
16 Product Information. Orgovyx (relugolix). Myovant Sciences, Inc., Brisbane, CA.
17 EMA. European Medicines Agency. European Union "EMA - List of medicines under additional monitoring.".
18 Product Information. Bevyxxa (betrixaban). Portola Pharmaceuticals, South San Francisco, CA.