Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM6XJ9S)

Drug Name
SB-743921 Drug Info
Synonyms N-[1-(3-benzyl-7-chloro-4-oxo-quinazolin-2-yl)propyl]-4-bromo-N-(3-dimethylaminopropyl)benzamide
Therapeutic ClassAnticancer Agents
Cross-matching ID
PubChem CID
49867937
CAS Number
CAS 940929-33-9
TTD Drug ID
D0U4EU

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Autoimmune thyroid disease -1.73 3.36e-2 46/53 (86.79%) HLA-DPB1;HLA-DRB1;HLA-G;...
Graft-versus-host disease -1.74 3.56e-2 32/42 (76.19%) HLA-DPB1;HLA-DRB1;HLA-G;...
Antigen processing and presentation -1.79 2.35e-2 60/78 (76.92%) B2M;HLA-DPB1;HLA-DRB1;...
Mismatch repair -1.79 2.49e-2 22/23 (95.65%) RPA2;MSH3;MSH2;...
Folate biosynthesis -1.86 8.39e-3 23/26 (88.46%) GCH1;AKR1B1;DHFR;...
Steroid hormone biosynthesis -1.92 4.79e-3 43/61 (70.49%) SULT1E1;HSD11B1;UGT2B4;...
DNA replication -1.93 3.73e-3 34/36 (94.44%) RPA2;RNASEH2A;POLE2;...
Drug metabolism -1.95 4.47e-3 78/151 (51.66%) GSTM4;GSTA3;GSTM1;...
Pentose and glucuronate interconversions -1.95 5.59e-3 17/34 (50%) UGT2A3;UGDH;GUSB;...
Allograft rejection -1.97 7.46e-3 32/38 (84.21%) HLA-DPB1;HLA-DRB1;HLA-G;...
Glycolysis / Gluconeogenesis -2.00 5.59e-3 56/67 (83.58%) ALDH3A2;LDHB;MINPP1;...
Metabolism of xenobiotics by cytochrome P450 -2.16 0.00e+0 49/77 (63.64%) GSTM4;GSTA3;GSTM1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 3.33uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 3.33uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 0.04uM - 3.33uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.01uM - 3.33uM 24H