Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM7JT24)

Drug Name
Acocantherin Drug Info
Synonyms
Ouabain; Ouabagenin L-Rhamnoside; Ouabagenin L-rhamnoside; Acocantherin; Acocantherine; Acolongifloroside K; Astrobain; G-Strophanthin; G-Strophanthin (JAN); G-Strophicor; Gratibain; Gratus strophanthin; Kombetin; O 3125; OBN; Ouabagenin-L-rhamnosid; Ouabagenin-L-rhamnosid [German]; Ouabain (anhydrous); Ouabain anhydrous; Ouabain octahydrate; Ouabain, Octahydrate; Ouabaine; Oubain; Purostrophan; Quabain; Rectobaina; Solufantina; Strodival; Strophalen; Strophanthin G; Strophanthin-G; Strophoperm; Strophosan; Uabaina; Uabanin
Therapeutic ClassCardiotonic Agents
Cross-matching ID
PubChem CID
439501
ChEBI ID
CHEMBL222863
CAS Number
CAS 630-60-4
TTD Drug ID
D0AR3J
VARIDT Drug ID
DR00155

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Rheumatoid arthritis 2.29 0.00e+0 78/93 (83.87%) FOS;CXCL8;JUN;...
IL-17 signaling pathway 2.25 0.00e+0 84/94 (89.36%) FOS;FOSB;CXCL8;...
TNF signaling pathway 2.23 0.00e+0 103/112 (91.96%) FOS;MMP9;JUNB;...
AGE-RAGE signaling pathway in diabetic complications 2.01 0.00e+0 97/100 (97%) EGR1;CXCL8;JUN;...
Malaria 1.99 2.22e-3 44/50 (88%) CXCL8;THBS1;IL6;...
Colorectal cancer 1.99 1.85e-3 84/86 (97.67%) FOS;GADD45B;EREG;...
NF-kappa B signaling pathway 1.96 1.59e-3 90/104 (86.54%) GADD45B;CXCL8;CXCL1;...
Epithelial cell signaling in Helicobacter pylori infect... 1.95 1.39e-3 62/70 (88.57%) CXCL8;JUN;CXCL1;...
B cell receptor signaling pathway 1.93 1.23e-3 71/81 (87.65%) FOS;JUN;NFKBIB;...
Bladder cancer 1.90 3.33e-3 40/41 (97.56%) CXCL8;MMP9;HBEGF;...
FoxO signaling pathway 1.89 4.04e-3 118/131 (90.08%) GADD45B;IL6;SMAD3;...
Collecting duct acid secretion 1.82 1.11e-2 22/27 (81.48%) ATP6V1D;ATP6V0C;ATP6V1G1;...
Kaposi sarcoma-associated herpesvirus infection 1.78 1.28e-2 172/193 (89.12%) FOS;CXCL8;JUN;...
Hepatitis B 1.77 1.27e-2 151/162 (93.21%) FOS;CXCL8;EGR3;...
Thyroid cancer 1.75 1.48e-2 36/37 (97.3%) GADD45B;TCF7L2;CDKN1A;...
Chronic myeloid leukemia 1.73 1.80e-2 72/76 (94.74%) GADD45B;SMAD3;CDKN1A;...
Osteoclast differentiation 1.71 2.28e-2 117/127 (92.13%) FOS;FOSB;JUNB;...
Transcriptional misregulation in cancer 1.71 2.16e-2 158/192 (82.29%) GADD45B;CXCL8;MMP9;...
Inflammatory bowel disease 1.70 2.39e-2 58/65 (89.23%) JUN;IL6;SMAD3;...
Spliceosome 1.67 3.22e-2 101/150 (67.33%) RBM25;SRSF10;BUD31;...
Protein export 1.67 3.17e-2 17/23 (73.91%) SEC62;SEC61B;SEC61G;...
Renal cell carcinoma 1.66 3.08e-2 68/69 (98.55%) JUN;CDKN1A;CREBBP;...
RIG-I-like receptor signaling pathway 1.65 3.33e-2 64/70 (91.43%) CXCL8;NFKBIB;NFKBIA;...
Phagosome 1.64 3.51e-2 118/152 (77.63%) THBS1;ATP6V1D;RAB7A;...
T cell receptor signaling pathway 1.63 3.61e-2 93/104 (89.42%) FOS;JUN;NFKBIB;...
Toll-like receptor signaling pathway 1.63 3.52e-2 94/104 (90.38%) FOS;CXCL8;JUN;...
Breast cancer 1.62 3.63e-2 119/147 (80.95%) FOS;GADD45B;JUN;...
NOD-like receptor signaling pathway 1.62 3.51e-2 145/181 (80.11%) CXCL8;JUN;CXCL1;...
Cellular senescence 1.62 3.54e-2 139/156 (89.1%) GADD45B;CXCL8;IL6;...
Adherens junction 1.61 3.50e-2 63/71 (88.73%) TCF7L2;SMAD3;CREBBP;...
Mismatch repair -1.62 4.90e-2 22/23 (95.65%) LIG1;MLH3;PCNA;...
Pantothenate and CoA biosynthesis -1.64 4.47e-2 14/21 (66.67%) ENPP1;DPYD;PANK3;...
Phototransduction -1.65 4.41e-2 21/29 (72.41%) CALML3;CALML4;CALML5;...
Fructose and mannose metabolism -1.72 2.17e-2 30/33 (90.91%) FBP1;GMDS;MPI;...
Homologous recombination -1.72 2.20e-2 35/41 (85.37%) POLD3;TOPBP1;RAD51B;...
One carbon pool by folate -1.77 1.76e-2 15/20 (75%) TYMS;DHFR;AMT;...
Glycolysis / Gluconeogenesis -1.77 1.94e-2 56/67 (83.58%) HKDC1;PFKL;G6PC3;...
Ascorbate and aldarate metabolism -1.79 1.96e-2 15/30 (50%) UGDH;ALDH9A1;UGT2B4;...
Amino sugar and nucleotide sugar metabolism -1.79 1.76e-2 38/48 (79.17%) GALE;PGM1;GALK1;...
Histidine metabolism -1.80 1.76e-2 16/22 (72.73%) HNMT;ALDH3B1;ALDH1B1;...
Cysteine and methionine metabolism -1.87 7.35e-3 43/50 (86%) MAT1A;GSS;MAT2B;...
Peroxisome -1.88 5.29e-3 72/82 (87.8%) NOS2;SOD1;SLC25A17;...
Pyruvate metabolism -1.89 6.61e-3 41/47 (87.23%) ACAT2;ALDH9A1;MDH2;...
Pentose and glucuronate interconversions -1.90 2.94e-3 17/34 (50%) UGT2B28;AKR1A1;UGT2A3;...
Porphyrin and chlorophyll metabolism -1.92 4.41e-3 23/43 (53.49%) HMBS;UGT2B4;HEPH;...
Folate biosynthesis -2.00 8.82e-3 23/26 (88.46%) SPR;MOCS2;MOCOS;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 0.12uM - 10uM 6H, 24H, 48H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.12uM - 10uM 6H, 24H, 48H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HuH-7 CVCL_0336 Homo sapiens 6.66uM 72H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.12uM - 10uM 6H, 24H, 48H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 0.37uM - 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H