Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM7L8SG)

Drug Name
AZD8055 Drug Info
Synonyms
AZD8055; 1009298-09-2; AZD-8055; AZD 8055; [5-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[2,3-d]pyrimidin-7-yl]-2-methoxyphenyl]methanol; (5-(2,4-bis((S)-3-methylmorpholino)pyrido[2,3-d]pyrimidin-7-yl)-2-methoxyphenyl)methanol; UNII-970JJ37FPW; 970JJ37FPW; CHEMBL1801204; AK109550; (5-(2,4-Bis((S)-3-methylmorpholino)pyrido-[2,3-d]pyrimidin-7-yl)-2-methoxyphenyl)methanol; (5-(2,4-bis((3S)-3-methylmorpholin-4-yl)pyrido(2,3-d)pyrimidin-7-yl)-2-methoxyphenyl)methanol
Cross-matching ID
PubChem CID
25262965
ChEBI ID
CHEMBL1801204
CAS Number
CAS 1009298-09-2
TTD Drug ID
D0K1VK

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
ECM-receptor interaction 2.33 0.00e+0 80/88 (90.91%) ITGA3;ITGB4;ITGB5;...
Notch signaling pathway 1.91 1.64e-2 49/59 (83.05%) JAG1;TLE1;RFNG;...
Focal adhesion 1.90 1.37e-2 180/201 (89.55%) IGF1R;MET;ERBB2;...
Metabolism of xenobiotics by cytochrome P450 -1.65 2.70e-2 49/77 (63.64%) HPGDS;CBR3;ADH6;...
Butanoate metabolism -1.67 2.34e-2 23/28 (82.14%) OXCT1;BDH1;ECHS1;...
Chemical carcinogenesis -1.68 2.17e-2 186/281 (66.19%) RAF1;UGT2B17;UGT2A3;...
Pentose and glucuronate interconversions -1.69 2.17e-2 17/34 (50%) UGT2B17;UGT2A3;UGDH;...
Ferroptosis -1.70 1.86e-2 36/41 (87.8%) SLC39A14;VDAC3;ACSL4;...
Steroid hormone biosynthesis -1.70 1.88e-2 43/61 (70.49%) CYP19A1;UGT2B28;CYP7B1;...
Pyruvate metabolism -1.72 1.48e-2 41/47 (87.23%) LDHA;ALDH9A1;MDH1;...
Protein export -1.73 1.35e-2 17/23 (73.91%) SRP9;SRP54;SEC61A2;...
Huntington disease -1.74 1.15e-2 233/306 (76.14%) CREB1;CLTC;CASP8;...
Amyotrophic lateral sclerosis -1.74 1.09e-2 267/364 (73.35%) NDUFB2;PPP3CA;NDUFB7;...
Fatty acid elongation -1.75 1.09e-2 19/27 (70.37%) HACD1;HACD2;HSD17B12;...
Valine, leucine and isoleucine degradation -1.77 9.67e-3 42/48 (87.5%) ALDH2;ACAA1;PCCB;...
PPAR signaling pathway -1.78 8.30e-3 66/74 (89.19%) CD36;ACOX3;ACSL4;...
Oxidative phosphorylation -1.79 8.78e-3 93/133 (69.92%) COX6B1;ATP6V1A;NDUFB6;...
Fructose and mannose metabolism -1.80 8.61e-3 30/33 (90.91%) FBP1;PFKFB2;PMM2;...
Prion disease -1.87 1.53e-3 209/273 (76.56%) PIK3CB;SDHC;COX8A;...
Cysteine and methionine metabolism -1.88 1.64e-3 43/50 (86%) GSS;GOT2;ENOPH1;...
Parkinson disease -1.89 8.84e-4 176/249 (70.68%) PSMA1;PARK7;TXN;...
Arginine and proline metabolism -1.90 9.57e-4 39/50 (78%) ALDH2;ALDH18A1;MAOA;...
Citrate cycle (TCA cycle) -1.90 1.04e-3 30/30 (100%) MDH1;SDHC;DLD;...
Glycolysis / Gluconeogenesis -2.02 0.00e+0 56/67 (83.58%) ADPGK;LDHA;ALDH9A1;...
Biosynthesis of unsaturated fatty acids -2.05 0.00e+0 21/27 (77.78%) HACD1;HSD17B4;ACAA1;...
Glycine, serine and threonine metabolism -2.06 0.00e+0 31/40 (77.5%) DLD;GNMT;SRR;...
Glutathione metabolism -2.06 0.00e+0 43/57 (75.44%) GSTM5;GSTP1;ANPEP;...
Terpenoid backbone biosynthesis -2.06 0.00e+0 18/22 (81.82%) ICMT;PDSS1;FDPS;...
Tryptophan metabolism -2.07 0.00e+0 35/42 (83.33%) CYP1A1;HADH;ALDH9A1;...
Folate biosynthesis -2.15 0.00e+0 23/26 (88.46%) GGH;CBR1;QDPR;...
Protein processing in endoplasmic reticulum -2.18 0.00e+0 127/171 (74.27%) SKP1;MAN1A1;CRYAB;...
Proteasome -2.21 0.00e+0 44/46 (95.65%) PSMA7;PSMA6;PSMD8;...
Steroid biosynthesis -2.30 0.00e+0 19/20 (95%) LSS;HSD17B7;FDFT1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-673 CVCL_0080 Homo sapiens 10uM 6H
SK-ES-1 CVCL_0627 Homo sapiens 0.12uM 24H
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 0.12uM - 10uM 6H, 24H, 48H
Brain
Glioblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-251 MG CVCL_0021 Homo sapiens 0.12uM 24H
YH-13 CVCL_1800 Homo sapiens 0.12uM 24H
Glioma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
GI-1 CVCL_1230 Homo sapiens 0.12uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H, 48H
MDA-MB-231 CVCL_0062 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
MDA-MB-468 CVCL_0419 Homo sapiens 0.12uM 24H
SK-BR-3 CVCL_0033 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
Breast carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BT-20 CVCL_0178 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
Hs 578T CVCL_0332 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
Breast ductal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BT-474 CVCL_0179 Homo sapiens 0.12uM 24H
T-47D CVCL_0553 Homo sapiens 0.12uM 24H
ZR-75-1 CVCL_0588 Homo sapiens 0.12uM 24H
Normal (Epithelial)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HME1 CVCL_2950 Homo sapiens 0.04uM - 10uM 3H, 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CL-34 CVCL_1123 Homo sapiens 10uM 6H
GP2d CVCL_1234 Homo sapiens 0.12uM 24H
HT-29 CVCL_0320 Homo sapiens 0.04uM - 10uM 6H, 24H
LoVo CVCL_0399 Homo sapiens 10uM 6H
MDST8 CVCL_1400 Homo sapiens 10uM 6H
NCI-H508 CVCL_1561 Homo sapiens 10uM 6H
SNU-1040 CVCL_5001 Homo sapiens 10uM 6H
SNU-407 CVCL_5004 Homo sapiens 0.12uM 24H
SNU-C4 CVCL_5008 Homo sapiens 10uM 6H
SNU-C5 CVCL_5009 Homo sapiens 10uM 6H
SW480 CVCL_0546 Homo sapiens 10uM 6H
SW620 CVCL_0547 Homo sapiens 10uM 6H
SW948 CVCL_0550 Homo sapiens 10uM 6H
Colorectal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCT 116 CVCL_0291 Homo sapiens 10uM 6H
HT115 CVCL_1294 Homo sapiens 10uM 6H
RKO CVCL_0504 Homo sapiens 10uM 6H
Embryonic stem cell
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
WA09 (H9) Derived CVCL_9773 (WA09) Homo sapiens 0.12uM - 10uM 24H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 0.12uM - 10uM 6H, 24H
HEC-151 CVCL_2927 Homo sapiens 0.12uM 24H
HEC-1-A CVCL_0293 Homo sapiens 0.12uM 24H
HEC-251 CVCL_2928 Homo sapiens 0.12uM 24H
HEC-265 CVCL_2929 Homo sapiens 0.12uM 24H
SNG-M CVCL_1707 Homo sapiens 10uM 6H
Endometrial carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHUEM-2 CVCL_1327 Homo sapiens 10uM 6H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.04uM - 10uM 6H, 24H
Renal cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
RCC10RGB CVCL_1656 Homo sapiens 0.12uM 24H
Rhabdoid tumor
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
G-401 CVCL_0270 Homo sapiens 0.12uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 10uM 6H, 24H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHH-5 CVCL_1320 Homo sapiens 0.12uM 24H
JHH-7 CVCL_1322 Homo sapiens 0.12uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.04uM - 10uM 6H, 24H, 48H
DV-90 CVCL_1184 Homo sapiens 10uM 6H
NCI-H1573 CVCL_1483 Homo sapiens 0.12uM 24H
NCI-H838 CVCL_1594 Homo sapiens 0.12uM 24H
SK-LU-1 CVCL_0624 Homo sapiens 10uM 6H
Lung adenosquamous carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H596 CVCL_1571 Homo sapiens 10uM 6H
Lung large cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COR-L23 CVCL_1133 Homo sapiens 10uM 6H
T3M-10 CVCL_1729 Homo sapiens 10uM 6H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BEN CVCL_1081 Homo sapiens 0.12uM 24H
HCC15 CVCL_1253 Homo sapiens 10uM 6H
HCC95 CVCL_1276 Homo sapiens 0.12uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1299 CVCL_0060 Homo sapiens 10uM 6H
HCC515 CVCL_5134 Homo sapiens 0.04uM - 10uM 6H, 24H
NCI-H2073 CVCL_1523 Homo sapiens 10uM 6H
NCI-H2110 CVCL_1529 Homo sapiens 0.12uM 24H
NCI-H2172 CVCL_1534 Homo sapiens 0.12uM 24H
Small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1694 CVCL_1495 Homo sapiens 10uM 6H
NCI-H1836 CVCL_1502 Homo sapiens 10uM 6H
NCI-H841 CVCL_1595 Homo sapiens 0.12uM 24H
Lymph node
Diffuse large B-cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
WSU-DLCL2 CVCL_1787 Homo sapiens 10uM 6H
Muscle
Rhabdomyosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-204 CVCL_0134 Homo sapiens 0.12uM 24H
Ovary
Ovarian carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
EFO-27 CVCL_1194 Homo sapiens 10uM 6H
OV7 CVCL_1623 Homo sapiens 10uM 6H
OVK18 CVCL_1629 Homo sapiens 0.12uM 24H
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ES-2 CVCL_3509 Homo sapiens 0.12uM 24H
OVTOKO CVCL_3114 Homo sapiens 0.12uM 24H
RMG-I CVCL_1663 Homo sapiens 10uM 6H
Ovarian cystadenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OAW 28 CVCL_1611 Homo sapiens 0.12uM 24H
OC 316 CVCL_1615 Homo sapiens 0.12uM 24H
Ovarian granulosa cell tumor
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COV434 CVCL_2010 Homo sapiens 0.12uM 24H
Ovarian mucinous cystadenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COV644 CVCL_2011 Homo sapiens 10uM 6H
RMUG-S CVCL_1666 Homo sapiens 10uM 6H
Ovarian undifferentiated carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
TYK-nu CVCL_1774 Homo sapiens 10uM 6H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.12uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 10uM 6H
Acute myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NOMO-1 CVCL_1609 Homo sapiens 10uM 6H
PL-21 CVCL_2161 Homo sapiens 10uM 6H
SKM-1 CVCL_0010 Homo sapiens 10uM 6H
Pleural effusion
Histiocytic lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-937 CVCL_0007 Homo sapiens 10uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
22Rv1 CVCL_1045 Homo sapiens 0.12uM 24H
LNCaP CVCL_0395 Homo sapiens 0.04uM - 10uM 3H, 24H
LNCaP clone FGC CVCL_1379 Homo sapiens 0.12uM 24H
PC-3 CVCL_0035 Homo sapiens 0.04uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.04uM - 10uM 6H, 24H
IGR-37 CVCL_1303 Homo sapiens 0.12uM 24H
Mel-HO CVCL_1402 Homo sapiens 0.12uM 24H
SH-4 CVCL_1692 Homo sapiens 0.12uM 24H
SK-MEL-1 CVCL_0523 Homo sapiens 10uM 6H
SK-MEL-28 CVCL_0526 Homo sapiens 10uM 6H
SK-MEL-3 CVCL_0525 Homo sapiens 0.12uM 24H
Stomach
Gastric adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
AGS CVCL_0139 Homo sapiens 0.12uM - 10uM 6H, 24H
MKN45 CVCL_0434 Homo sapiens 0.12uM 24H
Gastric carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
IM95 CVCL_1305 Homo sapiens 0.12uM 24H
Urinary bladder
Bladder transitional cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CAL-29 CVCL_1109 Homo sapiens 0.12uM 24H