Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM7Y1SO)

Drug Name
UNC0642 Drug Info
Synonyms
1481677-78-4; UNC 0642; UNC-0642; CHEMBL2441082; 2-(4,4-Difluoro-1-piperidinyl)-6-methoxy-N-[1-(1-methylethyl)-4-piperidinyl]-7-[3-(1-pyrrolidinyl)propoxy]-4-quinazolinamine; Barrett; GTPL7017; SCHEMBL17372593; AOB2595; MolPort-035-765-953; EX-A2241; BCP08266; ZINC96285772; BDBM50442103; AKOS024458509; SB19046; CS-5269; NCGC00189140-01; NCGC00189140-02; AS-16721; HY-13980; BC600721; AK547424; UNC0642, > KB-146019; J-008448
Cross-matching ID
PubChem CID
53315878
ChEBI ID
CHEMBL2441082
TTD Drug ID
D0BI4T

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Steroid biosynthesis 1.88 3.02e-2 19/20 (95%) LSS;MSMO1;SQLE;...
Terpenoid backbone biosynthesis 1.85 2.52e-2 18/22 (81.82%) HMGCS1;IDI1;ACAT2;...
Biosynthesis of unsaturated fatty acids 1.82 2.01e-2 21/27 (77.78%) SCD;FADS2;SCD5;...
Glutamatergic synapse 1.82 1.51e-2 97/114 (85.09%) GLUL;GNAS;GNG4;...
DNA replication 1.81 1.21e-2 34/36 (94.44%) RFC5;MCM5;RFC4;...
Long-term depression 1.79 1.51e-2 55/60 (91.67%) GUCY1A1;GNAS;PRKCB;...
Synthesis and degradation of ketone bodies 1.78 2.16e-2 9/10 (90%) HMGCS1;ACAT2;HMGCS2
Synaptic vesicle cycle 1.76 2.26e-2 63/78 (80.77%) SNAP25;DNM3;SYT1;...
VEGF signaling pathway 1.72 3.24e-2 50/59 (84.75%) PPP3CA;PRKCB;SPHK2;...
PPAR signaling pathway 1.72 2.92e-2 66/74 (89.19%) SCD;HMGCS1;FADS2;...
Valine, leucine and isoleucine degradation 1.70 2.93e-2 42/48 (87.5%) HMGCS1;ACAT2;ALDH3A2;...
Mineral absorption -2.12 0.00e+0 48/60 (80%) FTL;ATP1B3;HEPH;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 1.11uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 1.11uM - 10uM 24H