Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM83WVF)

Drug Name
Apicidin Drug Info
Synonyms
CHEMBL430060; OSI-2040; (3S,6S,9S,12R)-3-[(2S)-butan-2-yl]-6-[(1-methoxyindol-3-yl)methyl]-9-(6-oxooctyl)-1,4,7,10-tetrazabicyclo[10.4.0]hexadecane-2,5,8,11-tetrone; Acipidin; AC1OCFAM; Apicidin _120249; SCHEMBL147997; ChEMBL_275631; GTPL7495; DTXSID40274182; MolPort-005-944-562; BDBM50238632; ZINC17654900; AKOS030622920; MCULE-8969470747; NCGC00165733-01
Cross-matching ID
PubChem CID
6918328
ChEBI ID
CHEMBL430060
TTD Drug ID
D0W1PV

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Synaptic vesicle cycle 2.20 0.00e+0 63/78 (80.77%) ATP6V1D;ATP6V1E1;ATP6V0D1;...
Oxidative phosphorylation 2.13 0.00e+0 93/133 (69.92%) ATP6V1D;ATP6V1E1;ATP6V0D1;...
Collecting duct acid secretion 2.01 7.71e-3 22/27 (81.48%) ATP6V1D;ATP6V1E1;ATP6V0D1;...
Citrate cycle (TCA cycle) 1.92 1.73e-2 30/30 (100%) IDH3A;DLD;ACLY;...
Steroid biosynthesis 1.80 3.93e-2 19/20 (95%) LIPA;MSMO1;TM7SF2;...
Diabetic cardiomyopathy 1.79 3.85e-2 162/203 (79.8%) MPC1;G6PD;AGT;...
Aldosterone-regulated sodium reabsorption 1.76 4.96e-2 34/37 (91.89%) PDPK1;PRKCB;INSR;...
Vibrio cholerae infection 1.75 4.48e-2 44/50 (88%) ATP6V1D;ADCY9;ATP6V1E1;...
Propanoate metabolism 1.74 4.11e-2 30/34 (88.24%) HIBCH;LDHA;DLD;...
Glycerophospholipid metabolism 1.74 3.93e-2 71/98 (72.45%) PLA2G15;CHKA;LPCAT1;...
Fructose and mannose metabolism 1.72 4.21e-2 30/33 (90.91%) ALDOC;ALDOA;ALDOB;...
HIF-1 signaling pathway 1.71 4.24e-2 105/109 (96.33%) ALDOC;PRKCB;INSR;...
Gastric acid secretion 1.70 4.36e-2 63/76 (82.89%) EZR;GNAI2;ADCY9;...
Lysosome 1.68 4.71e-2 115/128 (89.84%) PLA2G15;LIPA;NEU1;...
mTOR signaling pathway 1.67 4.78e-2 114/154 (74.03%) ATP6V1D;PDPK1;PRKCB;...
Pentose phosphate pathway 1.67 4.48e-2 25/30 (83.33%) ALDOC;TKTL1;G6PD;...
RNA polymerase 1.66 4.56e-2 23/31 (74.19%) POLR1D;POLR2J;POLR2L;...
p53 signaling pathway -1.69 4.92e-2 63/73 (86.3%) CDKN2A;RCHY1;CCNB1;...
Type I diabetes mellitus -1.74 3.73e-2 38/43 (88.37%) IL1A;HLA-DQA1;HLA-DQB1;...
Intestinal immune network for IgA production -1.74 4.13e-2 38/48 (79.17%) TNFSF13;ICOS;HLA-DMB;...
IL-17 signaling pathway -1.82 1.72e-2 84/94 (89.36%) IKBKB;CXCL5;CXCL2;...
One carbon pool by folate -1.83 2.30e-2 15/20 (75%) MTHFD2L;MTR;MTHFS;...
Viral protein interaction with cytokine and cytokine re... -1.90 8.61e-3 84/100 (84%) ACKR4;CCL11;IL10RB;...
ECM-receptor interaction -1.92 8.61e-3 80/88 (90.91%) LAMA3;RELN;THBS3;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.04uM - 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.04uM - 10uM 6H, 24H
Fibroblast
Nasopharyngeal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
FIBRNPC CVCL_UK07 Homo sapiens 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.04uM - 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 10uM 6H, 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.04uM - 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 0.04uM - 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.04uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.04uM - 10uM 6H, 24H