Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM8JWNA)

Drug Name
NVP-LAQ824 Drug Info
Synonyms
Dacinostat; 404951-53-7; LAQ824; LAQ-824; LAQ824 (Dacinostat); UNII-V10P524501; (E)-N-hydroxy-3-[4-[[2-hydroxyethyl-[2-(1H-indol-3-yl)ethyl]amino]methyl]phenyl]prop-2-enamide; CHEMBL356066; V10P524501; (2E)-N-hydroxy-3-[4-({(2-hydroxyethyl)[2-(1H-indol-3-yl)ethyl]amino}methyl)phenyl]prop-2-enamide; Dacinostat [INN]; (E)-N-Hydroxy-3-[4-[[2-hydroxyethyl-[2-(1H-indol-3-yl)ethyl]amino]meth yl]phenyl]prop-2-enamide; (2E)-N-hydroxy-3-(4-{[(2-hydroxyethyl)[2-(1H-indol-3-yl)ethyl]amino]methyl}phenyl)prop-2-enamide; Dacinostat; NVP-LAQ 824; NVP-LAQ824, Dacinostat, LAQ824; LBH539
Cross-matching ID
PubChem CID
6445533
ChEBI ID
CHEMBL356066
CAS Number
CAS 404951-53-7
TTD Drug ID
D0B3FV
VARIDT Drug ID
DR00797

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Bacterial invasion of epithelial cells 2.06 1.15e-2 59/77 (76.62%) CAV2;CAV1;CRK;...
Aldosterone-regulated sodium reabsorption 2.05 5.77e-3 34/37 (91.89%) ATP1A1;PRKCA;ATP1B1;...
Steroid biosynthesis 1.97 7.70e-3 19/20 (95%) LIPA;MSMO1;TM7SF2;...
Glycerolipid metabolism 1.87 2.02e-2 44/61 (72.13%) AKR1B10;LPIN1;AKR1A1;...
Gastric acid secretion 1.84 2.31e-2 63/76 (82.89%) EZR;GNAI2;ATP1A1;...
Cholesterol metabolism 1.84 2.12e-2 44/50 (88%) LIPA;NPC1;NPC2;...
Fructose and mannose metabolism 1.84 1.98e-2 30/33 (90.91%) ALDOC;AKR1B10;ALDOB;...
Synaptic vesicle cycle 1.83 1.73e-2 63/78 (80.77%) SLC1A1;STXBP1;ATP6V1D;...
Collecting duct acid secretion 1.82 1.67e-2 22/27 (81.48%) ATP6V1D;ATP6V1A;CA2;...
Lysosome 1.82 1.50e-2 115/128 (89.84%) LIPA;GM2A;PLA2G15;...
Vibrio cholerae infection 1.81 1.57e-2 44/50 (88%) ATP6V1D;ADCY9;ATP6V1A;...
Porphyrin and chlorophyll metabolism 1.78 1.83e-2 23/43 (53.49%) BLVRA;BLVRB;CP;...
Glycerophospholipid metabolism 1.76 2.04e-2 71/98 (72.45%) PLA2G15;GPD1L;PLAAT3;...
Endocrine and other factor-regulated calcium reabsorpti... 1.76 2.06e-2 49/53 (92.45%) ATP1A1;ADCY9;PRKACA;...
Mineral absorption 1.74 2.54e-2 48/60 (80%) MT1X;ATP1A1;ATOX1;...
Carbohydrate digestion and absorption 1.73 2.45e-2 37/47 (78.72%) ATP1A1;ATP1B1;HK1;...
Glycolysis / Gluconeogenesis 1.69 3.74e-2 56/67 (83.58%) ALDOC;ALDOB;ADH1B;...
Ether lipid metabolism 1.67 4.30e-2 32/49 (65.31%) PLAAT3;LPCAT1;PAFAH1B3;...
Pancreatic secretion 1.67 4.07e-2 87/102 (85.29%) PRSS3;ATP1A1;ADCY9;...
Sulfur metabolism 1.62 4.94e-2 9/10 (90%) PAPSS1;PAPSS2;ETHE1
Type I diabetes mellitus -1.92 2.43e-2 38/43 (88.37%) PTPRN2;CPE;ICA1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 0.12uM - 10uM 6H, 24H, 48H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H, 48H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
1HAEo- CVCL_0128 Homo sapiens 10uM 24H
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
NL20 CVCL_0461 Homo sapiens 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H, 48H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
Normal (Fibroblast)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HFL1 CVCL_4295 Homo sapiens 10uM 24H
IMR-90 CVCL_0347 Homo sapiens 10uM 24H
WI-38 CVCL_0579 Homo sapiens 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.04uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H