Details of the Drug

General Information of Drug (ID: DM8JWNA)

Drug Name
NVP-LAQ824
Synonyms
Dacinostat; 404951-53-7; LAQ824; LAQ-824; LAQ824 (Dacinostat); UNII-V10P524501; (E)-N-hydroxy-3-[4-[[2-hydroxyethyl-[2-(1H-indol-3-yl)ethyl]amino]methyl]phenyl]prop-2-enamide; CHEMBL356066; V10P524501; (2E)-N-hydroxy-3-[4-({(2-hydroxyethyl)[2-(1H-indol-3-yl)ethyl]amino}methyl)phenyl]prop-2-enamide; Dacinostat [INN]; (E)-N-Hydroxy-3-[4-[[2-hydroxyethyl-[2-(1H-indol-3-yl)ethyl]amino]meth yl]phenyl]prop-2-enamide; (2E)-N-hydroxy-3-(4-{[(2-hydroxyethyl)[2-(1H-indol-3-yl)ethyl]amino]methyl}phenyl)prop-2-enamide; Dacinostat; NVP-LAQ 824; NVP-LAQ824, Dacinostat, LAQ824; LBH539
Indication
Disease Entry ICD 11 Status REF
Mood disorder 6A60-6E23 Phase 3 [1]
leukaemia 2A60-2B33 Discontinued in Phase 1/2 [1]
Multiple myeloma 2A83 Investigative [2]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 379.5
Logarithm of the Partition Coefficient (xlogp) 2.6
Rotatable Bond Count (rotbonds) 9
Hydrogen Bond Donor Count (hbonddonor) 4
Hydrogen Bond Acceptor Count (hbondacc) 4
Adverse Drug Reaction (ADR)
ADR Term Variation Related DOT DOT ID REF
Apoptosis Not Available HRAS OTFYE6AJ [3]
Apoptosis Not Available HSP90AA1 OTLG1WPK [3]
Chemical Identifiers
Formula
C22H25N3O3
IUPAC Name
(E)-N-hydroxy-3-[4-[[2-hydroxyethyl-[2-(1H-indol-3-yl)ethyl]amino]methyl]phenyl]prop-2-enamide
Canonical SMILES
C1=CC=C2C(=C1)C(=CN2)CCN(CCO)CC3=CC=C(C=C3)/C=C/C(=O)NO
InChI
InChI=1S/C22H25N3O3/c26-14-13-25(12-11-19-15-23-21-4-2-1-3-20(19)21)16-18-7-5-17(6-8-18)9-10-22(27)24-28/h1-10,15,23,26,28H,11-14,16H2,(H,24,27)/b10-9+
InChIKey
BWDQBBCUWLSASG-MDZDMXLPSA-N
Cross-matching ID
PubChem CID
6445533
ChEBI ID
CHEBI:94063
CAS Number
404951-53-7
UNII
V10P524501
DrugBank ID
DB17034
TTD ID
D0B3FV
VARIDT ID
DR00797
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug
Repurposed Drugs (RPD) Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Histone deacetylase (HDAC) TTBH0VX NOUNIPROTAC Inhibitor [2]
Histone deacetylase 1 (HDAC1) TT6R7JZ HDAC1_HUMAN Inhibitor [4]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Gene/Protein Processing [5]
DNA repair protein RAD50 (RAD50) OTYMU9G1 RAD50_HUMAN Gene/Protein Processing [6]
Heat shock protein HSP 90-alpha (HSP90AA1) OTLG1WPK HS90A_HUMAN Drug Response [3]
Histone H1.2 (H1-2) OT0AVI4M H12_HUMAN Drug Response [6]
Histone H2AX (H2AX) OT18UX57 H2AX_HUMAN Gene/Protein Processing [6]
p21 protein (HRAS) OTFYE6AJ P78460_HUMAN Drug Response [3]
Retinoic acid receptor beta (RARB) OT367U3E RARB_HUMAN Post-Translational Modifications [5]
Superoxide dismutase , mitochondrial (SOD2) OTIWXGZ9 SODM_HUMAN Gene/Protein Processing [6]
Thioredoxin-interacting protein OT46QN4B TXNIP_HUMAN Gene/Protein Processing [6]
Transgelin (TAGLN) OTAEZ0KP TAGL_HUMAN Gene/Protein Processing [5]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Mood disorder
ICD Disease Classification 6A60-6E23
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Histone deacetylase 1 (HDAC1) DTT HDAC1 6.73E-02 0.24 0.59
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 36 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RPMI-3460/CS1 GDSC1 -3.2576 -1.1079 -3.3231 41.4649
EW-13 GDSC1 -6.444 -3.963 -6.4512 77.7628
ES4 GDSC1 -6.2095 -4.6421 -6.2097 77.3177
NOS-1 [Human HNSCC] GDSC1 -6.0563 -4.503 -6.0566 75.5591
ES8 GDSC1 -5.7982 -3.8987 -5.8002 72.0709
NY GDSC1 -5.709 -3.9031 -5.7106 71.1608
EW-16 GDSC1 -5.6966 -3.8969 -5.6981 71.0229
ES6 GDSC1 -5.2643 -4.1754 -5.2643 66.2049
ES1 GDSC1 -5.2543 -4.1429 -5.2543 66.0764
EW-1 GDSC1 -5.236 -3.3764 -5.2394 65.4867
EW-7 GDSC1 -5.1258 -2.8534 -5.1398 63.7837
U2OS GDSC1 -5.0568 -1.3677 -5.2113 61.2084
MHH-ES-1 GDSC1 -5.0147 -3.7659 -5.0149 63.0735
EW-18 GDSC1 -4.9973 -3.1841 -5.001 62.638
SK-ES-1 GDSC1 -4.8387 -2.2986 -4.8724 60.1884
SK-PN-DW GDSC1 -4.4613 -1.8163 -4.5174 55.7516
EW-11 GDSC1 -4.3295 -2.5855 -4.336 54.4865
HOS GDSC1 -4.3073 -3.1953 -4.3075 54.2659
SJSA-1 GDSC1 -4.2266 -0.2008 -4.5537 52.5979
A-673 GDSC1 -4.1344 -2.951 -4.1349 52.1054
SaOS-2 GDSC1 -3.7229 3.3613 -5.2856 48.3268
ES7 GDSC1 -3.5626 0.3785 -3.9903 45.9452
CHSA0108 GDSC1 -3.3365 -1.5052 -3.3652 42.2751
HuO-3N1 GDSC1 -3.1761 0.4928 -3.6044 41.8243
TC-71 GDSC1 -2.601 -1.4927 -2.6064 32.9735
EW-3 GDSC1 -2.435 0.6151 -2.8389 33.2525
MG-63 GDSC1 -2.1979 2.4586 -3.3194 34.1405
CHSA0011 GDSC1 -1.3156 0.8598 -1.7247 19.6769
CAL-72 GDSC1 -1.2846 6.9651 -4.5835 34.1761
H-EMC-SS GDSC1 -1.0923 2.4168 -2.1895 21.8265
EW-24 GDSC1 -0.9959 1.8614 -1.8345 18.8725
ES5 GDSC1 -0.963 7.5138 -4.566 32.7865
CHSA8926 GDSC1 0.3797 3.2332 -1.2873 9.21
G-292 clone A141B1 GDSC1 1.965 8.3319 -2.6366 13.8554
HuO9 GDSC1 2.0807 4.7521 -0.9165 2.5856
CAL-78 GDSC1 4.0057 18.1594 -5.97 23.0909
⏷ Show the Full List of 36 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 146 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JM1 GDSC1 -5.7559 -4.3142 -5.7561 72.1001
RPMI-6666 GDSC1 -7.7008 -3.4278 -7.7723 81.8887
SK-MM-2 GDSC1 -7.4249 -4.9348 -7.428 86.4203
NB4 GDSC1 -7.2096 -5.6364 -7.2097 87.8769
Karpas-231 GDSC1 -7.1608 -5.04 -7.1619 85.5929
RS4;11 GDSC1 -7.1359 -4.7815 -7.1386 84.5658
ALL-PO GDSC1 -7.0942 -5.1589 -7.0947 85.6282
ALL-SIL GDSC1 -7.0839 -6.0911 -7.0839 88.226
KE-37 GDSC1 -6.9895 -5.4933 -6.9895 85.9765
SUP-B15 GDSC1 -6.978 -5.2906 -6.9781 85.3114
SU-DHL-6 GDSC1 -6.9755 -5.6777 -6.9755 86.3554
CA46 GDSC1 -6.9573 -2.9057 -7.0387 77.3832
SR GDSC1 -6.9236 5.9067 -9.6954 61.9629
MOLP-8 GDSC1 -6.8891 -4.2052 -6.8975 81.303
Karpas-45 GDSC1 -6.8264 -5.6422 -6.8264 84.99
ST486 GDSC1 -6.7891 -5.6005 -6.7891 84.564
697 GDSC1 -6.7564 -5.6996 -6.7564 84.415
HH [Human lymphoma] GDSC1 -6.7474 -3.9815 -6.7588 79.775
Loucy GDSC1 -6.7029 -4.7216 -6.7039 81.7373
JSC-1 GDSC1 -6.6824 -4.5204 -6.6846 81.0182
SU-DHL-16 GDSC1 -6.6461 -4.7235 -6.647 81.3228
GDM-1 GDSC1 -6.6375 -1.2353 -6.9436 71.2606
H9 GDSC1 -6.5998 -5.5259 -6.5998 82.563
SU-DHL-5 GDSC1 -6.5974 -4.7084 -6.5982 80.9088
LC4-1 GDSC1 -6.5714 -4.4339 -6.5736 79.9826
NALM-6 GDSC1 -6.5565 -4.6385 -6.5574 80.4091
RPMI-8402 GDSC1 -6.498 -5.6357 -6.498 81.5377
OCI-AML-5 GDSC1 -6.4809 -4.9793 -6.481 80.5187
MY-M12 GDSC1 -6.4618 -4.5048 -6.463 79.3201
HEL GDSC1 -6.4154 -4.6968 -6.4158 79.3606
MV4-11 GDSC1 -6.3773 -5.1581 -6.3774 79.7593
NKM-1 GDSC1 -6.3272 -4.7649 -6.3274 78.6733
CCRF-CEM GDSC1 -6.2879 -4.6637 -6.2882 78.1199
A4/Fukuda GDSC1 -6.2645 -5.4369 -6.2645 78.6828
QIMR-WIL GDSC1 -6.26 -2.9719 -6.304 73.7633
NU-DUL-1 GDSC1 -6.2004 -5.0506 -6.2004 77.7119
DND-41 GDSC1 -6.1901 -4.5051 -6.1906 76.9045
SIG-M5 GDSC1 -6.1654 -5.0859 -6.1654 77.3399
P32/ISH GDSC1 -6.0479 -4.5456 -6.0481 75.5261
P30/OHK GDSC1 -5.9664 -4.5567 -5.9666 74.6611
Ku812 GDSC1 -5.9479 0.7749 -6.7106 63.8985
PF-382 GDSC1 -5.9404 -4.7186 -5.9405 74.5035
BALL-1 GDSC1 -5.9264 -4.6559 -5.9265 74.2989
SU-DHL-8 GDSC1 -5.9262 -4.6454 -5.9262 74.2884
KMS-12-BM GDSC1 -5.9124 -4.7625 -5.9124 74.2045
BL-41 GDSC1 -5.9074 -4.8376 -5.9074 74.1816
SUP-T1 GDSC1 -5.8964 -4.4159 -5.8966 73.7527
Karpas-620 GDSC1 -5.8878 -4.6817 -5.8878 73.8714
YT GDSC1 -5.8873 -2.8104 -5.9275 70.6957
MOLT-16 GDSC1 -5.8584 -5.0904 -5.8584 73.6466
OCI-Ly19 GDSC1 -5.8483 -4.0317 -5.8497 72.7714
AMO1 GDSC1 -5.8318 -2.5093 -5.893 69.587
A3/Kawakami GDSC1 -5.7765 -4.8422 -5.7765 72.6029
ARH-77 GDSC1 -5.7752 -3.114 -5.795 70.4444
MOLM-13 GDSC1 -5.7618 -2.7264 -5.8028 69.5193
P12-Ichikawa GDSC1 -5.7297 -5.0106 -5.7297 72.0445
VL51 GDSC1 -5.7145 -4.6329 -5.7145 71.7962
CESS GDSC1 -5.7143 -4.739 -5.7143 71.8223
EoL-1 GDSC1 -5.7046 -4.1706 -5.705 71.4019
MOLT-4 GDSC1 -5.6855 -2.7959 -5.719 69.0337
L-363 GDSC1 -5.6825 -3.8216 -5.6845 70.78
DB GDSC1 -5.6619 -4.3111 -5.662 71.0231
Reh GDSC1 -5.6467 -4.4211 -5.6467 70.9033
WIL2 NS GDSC1 -5.6184 -3.0004 -5.6389 68.8422
BC-1 GDSC1 -5.5919 -4.5834 -5.5919 70.2937
CTB-1 GDSC1 -5.5833 -2.1505 -5.6668 66.9023
HL-60 GDSC1 -5.5747 -4.7963 -5.5747 70.1059
MHH-PREB-1 GDSC1 -5.5132 -3.3805 -5.5196 68.4496
OCI-AML-2 GDSC1 -5.5042 -4.6084 -5.5042 69.218
BV-173 GDSC1 -5.4982 -4.2278 -5.4983 69.0555
OCI-M1 GDSC1 -5.4504 -4.9321 -5.4504 68.5572
HDLM-2 GDSC1 -5.4499 -1.4955 -5.6132 64.6272
ATN-1 GDSC1 -5.4285 -4.5233 -5.4285 68.2736
TUR GDSC1 -5.4187 -4.2136 -5.4187 68.0958
KOPN-8 GDSC1 -5.3688 -3.5966 -5.3707 67.1546
NK-92MI GDSC1 -5.3659 -3.8857 -5.3663 67.328
Karpas-422 GDSC1 -5.308 -2.5707 -5.3418 65.2474
DEL GDSC1 -5.3019 -3.8325 -5.3023 66.5496
CTV-1 GDSC1 -5.2647 -3.8171 -5.2651 66.1032
EHEB GDSC1 -5.2359 -2.4026 -5.2785 64.3128
DoHH2 GDSC1 -5.228 -4.0024 -5.2281 65.7269
MC116 GDSC1 -5.2279 -4.314 -5.2279 65.7691
Namalwa GDSC1 -5.2032 -3.309 -5.2072 65.0644
BE-13 GDSC1 -5.1961 -3.9673 -5.1962 65.3298
Ramos.2G6.4C10 GDSC1 -5.1761 -3.6977 -5.1766 65.0001
OPM-2 GDSC1 -5.1702 -2.846 -5.1855 64.2419
SUP-HD1 GDSC1 -5.1477 -2.0414 -5.2183 62.9638
KMOE-2 GDSC1 -5.1476 -2.7942 -5.1644 63.9472
HC-1 GDSC1 -5.1363 -3.0875 -5.1435 64.129
MLMA GDSC1 -5.1137 -3.3904 -5.1159 64.1079
MEG-01 GDSC1 -5.1062 -3.4237 -5.1081 64.041
Hs 445 GDSC1 -5.0862 -3.1683 -5.0912 63.6409
KCL-22 GDSC1 -5.0694 -3.5909 -5.0701 63.6864
L-1236 GDSC1 -5.0421 -3.3343 -5.0443 63.2445
ML-2 GDSC1 -5.0117 -3.8382 -5.0118 63.0486
OCI-AML-3 GDSC1 -5.0015 -3.8733 -5.0016 62.927
EB2 GDSC1 -4.9914 -3.109 -4.9962 62.5227
Farage GDSC1 -4.983 -3.2529 -4.9857 62.5115
TK [Human B-cell lymphoma] GDSC1 -4.8789 -2.0714 -4.9324 60.386
Sc-1 GDSC1 -4.8485 -2.0551 -4.902 60.0588
WSU-NHL GDSC1 -4.8256 -3.5522 -4.8259 60.7176
Mono-Mac-6 GDSC1 -4.8164 0.51 -5.3967 57.1674
KG-1 GDSC1 -4.8137 -3.7498 -4.8138 60.5904
JJN-3 GDSC1 -4.7842 -1.8878 -4.8507 59.2389
Daudi GDSC1 -4.7417 -1.4029 -4.8675 58.3519
HT GDSC1 -4.7189 -3.4001 -4.7194 59.3834
U266B1 GDSC1 -4.7 -3.957 -4.7 59.1777
ME1 GDSC1 -4.6453 -1.3871 -4.7665 57.3905
Jiyoye GDSC1 -4.6312 -2.606 -4.6429 58.0859
EJM GDSC1 -4.5939 -3.1046 -4.5953 57.8017
SU-DHL-1 GDSC1 -4.5545 -1.0163 -4.7308 56.2059
RPMI-8226 GDSC1 -4.5383 -3.7511 -4.5383 57.1564
HAL-01 GDSC1 -4.5137 -3.0231 -4.5154 56.8076
LP-1 GDSC1 -4.4262 -2.1903 -4.4513 55.5266
JURL-MK1 GDSC1 -4.3988 -2.9416 -4.4004 55.3848
L-540 GDSC1 -4.3519 -2.9337 -4.3533 54.8053
SU-DHL-4 GDSC1 -4.3516 -3.305 -4.3517 54.8208
BC-3 GDSC1 -4.3512 -2.6706 -4.3561 54.7637
NOMO-1 GDSC1 -4.3349 -2.6471 -4.34 54.5612
Karpas-299 GDSC1 -4.3041 -2.5212 -4.3118 54.1662
K-562 GDSC1 -4.2588 -3.0159 -4.2594 53.6565
GR-ST GDSC1 -4.1845 -0.5278 -4.4294 52.2796
JVM-3 GDSC1 -4.1128 -3.2369 -4.1128 51.837
LAMA-84 GDSC1 -4.0973 -2.9671 -4.0976 51.6421
ROS-50 GDSC1 -4.0891 -1.097 -4.2149 51.3857
PL-21 GDSC1 -3.8398 -0.1926 -4.1339 48.6848
Raji GDSC1 -3.8376 -1.2512 -3.9222 48.5011
L-428 GDSC1 -3.8227 -1.7506 -3.8537 48.262
THP-1 GDSC1 -3.8113 -1.0699 -3.9207 48.2191
SCC-3 GDSC1 -3.747 -2.7343 -3.7473 47.2664
RPMI-8866 GDSC1 -3.7251 -2.5919 -3.7258 46.9936
EM-2 GDSC1 -3.5837 -0.9503 -3.6955 45.557
SUP-M2 GDSC1 -3.5722 -1.3531 -3.6275 45.2683
MN-60 GDSC1 -3.5317 1.6888 -4.4077 46.2788
KM-H2 GDSC1 -3.5107 0.1271 -3.8602 45.2524
Granta-519 GDSC1 -3.5081 -1.1436 -3.5853 44.5577
U-698-M GDSC1 -3.3193 0.0292 -3.6242 43.0377
KY821 GDSC1 -3.2932 -2.6331 -3.2932 41.5929
RC-K8 GDSC1 -3.2323 -1.9383 -3.2369 40.8582
RL GDSC1 -3.2255 -1.4214 -3.2559 40.9068
VAL GDSC1 -2.9997 13.599 -9.4172 46.8795
P31/FUJ GDSC1 -2.9933 -2.1291 -2.9937 37.8467
DG-75 GDSC1 -1.3964 4.8436 -3.6466 31.3128
JVM-2 GDSC1 0.1829 5.731 -2.6913 19.7348
IM-9 GDSC1 0.3951 9.2953 -4.2991 26.8402
WSU-DLCL2 GDSC1 1.8497 3.2753 -0.435 0.4797
⏷ Show the Full List of 146 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 4 Cell Line(s) in Aero Dig Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KYSE-50 GDSC1 -4.8576 -3.4221 -4.8583 61.0825
TE-12 GDSC1 -4.2021 -1.7534 -4.2508 52.7944
KYSE-220 GDSC1 -4.0707 -2.3152 -4.08 51.2937
HCE-4 GDSC1 -3.783 -1.9945 -3.7978 47.7489
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 GDSC1 -4.4616 0.2132 -4.9223 54.5474
Cancer Drug Sensitivity Data Curated from 29 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CHP-212 GDSC1 -6.865 -5.2624 -6.8652 84.4203
SK-N-SH GDSC1 -6.4361 -2.5327 -6.5268 73.6239
SJNB-7 GDSC1 -5.7042 -4.9024 -5.7042 71.7203
CHP-126 GDSC1 -5.6488 -3.2381 -5.6611 69.5479
KP-N-YS GDSC1 -5.5669 -4.1659 -5.5671 69.8326
NB(TU)1 GDSC1 -5.4623 -3.0229 -5.4779 67.4203
NB69 GDSC1 -5.2997 -3.1704 -5.3075 65.9731
SJNB-13 GDSC1 -4.9732 -3.6443 -4.9735 62.5407
GI-ME-N GDSC1 -4.9598 -1.1107 -5.1514 60.0351
SJNB-14 GDSC1 -4.6298 -3.2308 -4.6306 58.2634
SK-N-MC-IXC GDSC1 -4.5722 -3.6929 -4.5722 57.579
SJNB-6 GDSC1 -4.4991 -2.4414 -4.5138 56.473
SK-N-DZ GDSC1 -4.3064 -1.2611 -4.4223 53.8034
SK-N-BE(2)-M17 GDSC1 -4.2619 -2.7532 -4.2645 53.6787
TGW GDSC1 -4.2504 -2.9788 -4.2511 53.5508
NB1 GDSC1 -4.1633 -1.7866 -4.2071 52.3495
Kelly GDSC1 -4.0623 -1.1988 -4.1702 51.0997
NH-12 GDSC1 -4.0601 -2.3232 -4.069 51.1643
IMR-5 GDSC1 -4.0447 -0.8567 -4.2095 50.8687
SJNB-12 GDSC1 -3.7683 -1.49 -3.8199 47.6337
SJNB-5 GDSC1 -3.4943 -1.9798 -3.5025 44.1446
SJNB-10 GDSC1 -3.4151 -1.2686 -3.4707 43.3535
MHH-NB-11 GDSC1 -3.2389 0.8599 -3.7931 42.8535
SiMa GDSC1 -2.8983 0.3789 -3.2665 38.4863
KP-N-YN GDSC1 -2.8263 -0.3707 -2.9871 36.6576
GOTO GDSC1 -2.5697 2.0014 -3.5108 37.2161
SK-N-FI GDSC1 -2.0497 0.1585 -2.2751 27.5016
SK-N-AS GDSC1 -1.4258 0.3876 -1.6679 19.8702
LA-N-6 GDSC1 -0.7901 4.6906 -3.0122 25.4793
⏷ Show the Full List of 29 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuCC-T1 GDSC1 -5.1924 -2.1521 -5.2543 63.5372
Cancer Drug Sensitivity Data Curated from 50 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CAL-85-1 GDSC1 -6.3635 -3.1191 -6.4017 74.8395
HCC1428 GDSC1 -6.271 -4.7359 -6.2711 78.0762
DU4475 GDSC1 -5.9813 -4.3962 -5.9817 74.6379
OCUB-M GDSC1 -5.9419 -4.6761 -5.9419 74.4902
MDA-MB-157 GDSC1 -5.9394 -1.1722 -6.1996 67.3562
HCC2218 GDSC1 -5.8862 -2.5034 -5.9507 69.9795
HCC202 GDSC1 -5.7268 -1.4094 -5.9258 66.4693
MDA-MB-361 GDSC1 -5.6842 -4.3963 -5.6843 71.333
AU565 GDSC1 -5.649 -3.5827 -5.6534 70.1075
HCC1599 GDSC1 -5.6315 -4.8545 -5.6315 70.8153
HCC2157 GDSC1 -5.5869 -3.6854 -5.5895 69.6091
MDA-MB-330 GDSC1 -5.5375 -2.6173 -5.5771 67.4174
HCC38 GDSC1 -5.5014 -0.975 -5.7644 64.0891
EFM-19 GDSC1 -5.4433 1.3485 -6.3479 60.3871
MCF-7 GDSC1 -5.3916 -4.5568 -5.3916 67.8169
EFM-192A GDSC1 -5.0384 -0.7721 -5.3041 60.2708
T-47D GDSC1 -5.0271 -2.3858 -5.0623 62.2378
HCC1419 GDSC1 -4.9919 -3.2938 -4.9942 62.637
ZR-75-30 GDSC1 -4.9644 -3.0409 -4.9702 62.1695
HCC1500 GDSC1 -4.5977 -2.4395 -4.6151 57.6165
CAMA-1 GDSC1 -4.5742 -3.4146 -4.5744 57.5956
MDA-MB-453 GDSC1 -4.5395 -2.9615 -4.542 57.1114
CAL-148 GDSC1 -4.5113 -2.8973 -4.5143 56.7545
HCC1569 GDSC1 -4.506 -2.4159 -4.522 56.5442
JIMT-1 GDSC1 -4.3053 -1.994 -4.3388 54.0557
Evsa-T GDSC1 -4.1632 -2.735 -4.1653 52.4574
HCC70 GDSC1 -4.1134 -3.1734 -4.1135 51.845
BT-474 GDSC1 -3.9611 -1.6118 -4.0109 49.9441
CAL-51 GDSC1 -3.9602 -1.1287 -4.0714 49.9363
MDA-MB-231 GDSC1 -3.7984 -1.0721 -3.9066 48.0686
CAL-120 GDSC1 -3.5116 -1.8734 -3.5243 44.3791
HCC1937 GDSC1 -3.4837 -1.6041 -3.5112 44.0905
HCC1395 GDSC1 -3.4413 1.0334 -4.0719 45.0684
HCC1954 GDSC1 -3.4163 -1.7916 -3.4301 43.1981
HCC1806 GDSC1 -3.3111 -1.4271 -3.3451 41.9836
MRK-nu-1 GDSC1 -3.2933 1.1069 -3.9379 43.6282
UACC-893 GDSC1 -3.253 -1.1878 -3.3083 41.3632
BT-483 GDSC1 -3.1094 -1.2026 -3.1546 39.5414
COLO 824 GDSC1 -3.0625 0.0774 -3.3573 40.0774
MDA-MB-415 GDSC1 -2.9198 -0.6092 -3.0394 37.586
BT-549 GDSC1 -2.8496 -0.5598 -2.973 36.7462
MDA-MB-175-VII GDSC1 -2.6164 -1.0606 -2.6492 33.3351
MDA-MB-468 GDSC1 -2.3178 3.3193 -3.8253 36.8214
MFM-223 GDSC1 -1.7962 0.9914 -2.2872 26.1216
BT-20 GDSC1 -1.5967 2.1923 -2.588 26.9304
MDA-MB-436 GDSC1 -1.4548 0.1659 -1.6285 19.7608
HDQ-P1 GDSC1 -0.8514 2.7543 -2.1196 20.2246
UACC-812 GDSC1 0.3763 3.5975 -1.471 10.6265
HCC1187 GDSC1 1.1054 5.3443 -1.7897 10.72
Hs 578T GDSC1 2.2602 4.2253 -0.6221 0.8913
⏷ Show the Full List of 50 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 52 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
D-566MG GDSC1 -7.5495 3.4218 -9.3631 66.4398
Daoy GDSC1 -6.1314 -3.6873 -6.1401 74.68
GB-1 GDSC1 -5.2644 -2.5391 -5.2986 64.7842
GaMG GDSC1 -5.134 -3.0765 -5.1415 64.0942
KS-1 [Human Krukenberg tumour] GDSC1 -4.7263 0.7511 -5.3732 56.2974
LN-229 GDSC1 -4.6289 -1.6304 -4.7156 57.4213
MOG-G-CCM GDSC1 -4.561 -1.6215 -4.6446 56.7077
SF295 GDSC1 -4.4671 -3.1057 -4.468 56.2448
YKG-1 GDSC1 -4.4285 -2.3891 -4.4435 55.6243
SK-MG-1 GDSC1 -4.3596 -1.9627 -4.3978 54.6722
ONS-76 GDSC1 -4.3006 -1.6672 -4.3634 53.895
SF268 GDSC1 -4.2261 -2.6352 -4.2301 53.2275
GI-1 GDSC1 -4.1402 -2.9224 -4.1407 52.1763
D283 Med GDSC1 -4.1167 -3.2623 -4.1167 51.8867
D-423MG GDSC1 -4.0528 -1.7829 -4.0916 51.043
8-MG-BA GDSC1 -4.0315 -2.3091 -4.0402 50.8111
H4 GDSC1 -3.9999 -2.4694 -4.0041 50.4232
M059J GDSC1 -3.9457 -1.3139 -4.0291 49.7661
SF539 GDSC1 -3.9274 -1.8838 -3.9533 49.5326
SNB-75 GDSC1 -3.7235 0.9955 -4.3643 47.7864
Hs 683 GDSC1 -3.5347 -2.1232 -3.5396 44.6341
AM-38 GDSC1 -3.5112 -2.0634 -3.5173 44.3464
SF126 GDSC1 -3.4557 -0.9248 -3.562 44.0191
SW1783 GDSC1 -3.4434 -1.0887 -3.5238 43.7865
Onda 10 GDSC1 -3.4253 0.0617 -3.7488 44.2648
Becker GDSC1 -3.3964 -0.9907 -3.4879 43.2575
NMC-G1 GDSC1 -3.3893 0.4144 -3.8123 44.1128
KINGS-1 GDSC1 -3.3757 -1.3642 -3.4189 42.8215
U-251MG GDSC1 -3.3592 -1.6386 -3.3795 42.5182
D-542MG GDSC1 -3.2461 1.4912 -4.0275 43.466
KALS-1 GDSC1 -3.2201 -0.0291 -3.5003 41.8358
Onda 11 GDSC1 -3.1811 0.9458 -3.7601 42.3188
DBTRG-05MG GDSC1 -3.0905 -0.8379 -3.1835 39.5439
42-MG-BA GDSC1 -2.9809 1.3427 -3.6875 40.6205
A-172 GDSC1 -2.9662 -1.778 -2.9704 37.531
MOG-G-UVW GDSC1 -2.7746 -1.3252 -2.793 35.2225
LN-18 GDSC1 -2.7406 -0.9983 -2.7871 34.9662
U-118MG GDSC1 -2.577 0.1421 -2.8456 34.2125
LN-405 GDSC1 -2.5477 0.5877 -2.952 34.5831
PFSK-1 GDSC1 -2.1375 -0.6393 -2.1917 27.4898
YH-13 GDSC1 -2.0528 -0.1333 -2.1999 27.0333
CAS-1 GDSC1 -2.0077 1.7006 -2.7972 30.4208
D-263MG GDSC1 -1.8936 -0.3289 -1.9828 24.6704
KNS-42 GDSC1 -1.7601 -0.0112 -1.9118 23.4183
U-87MG ATCC GDSC1 -1.7215 1.2624 -2.3158 25.8935
LNZTA3WT4 GDSC1 -1.6145 -0.2485 -1.6965 21.1383
KNS-81-FD GDSC1 -1.476 0.2353 -1.6729 20.1835
T98G GDSC1 -1.4524 0.8901 -1.8818 21.5055
SW1088 GDSC1 -1.266 1.5885 -1.982 21.2433
DK-MG GDSC1 -1.2155 1.367 -1.8326 19.9321
D-502MG GDSC1 -1.1185 0.023 -1.2208 15.0796
D-392MG GDSC1 -0.7402 3.1782 -2.2221 20.4287
⏷ Show the Full List of 52 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Digestive System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ETK-1 GDSC1 -5.9419 -1.3994 -6.1597 67.8556
TGBC24TKB GDSC1 -4.9881 -3.3661 -4.9897 62.6266
TGBC1TKB GDSC1 -2.6831 -0.4875 -2.8069 34.701
Cancer Drug Sensitivity Data Curated from 7 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ESS-1 GDSC1 -5.4568 -1.4875 -5.6219 64.6659
AN3-CA GDSC1 -4.9561 -2.1707 -5.0047 61.2751
MFE-319 GDSC1 -4.8471 -2.5372 -4.8672 60.4832
MFE-296 GDSC1 -4.5616 0.3117 -5.0598 55.3258
KLE GDSC1 -4.059 -1.8508 -4.0927 51.1228
MFE-280 GDSC1 -3.1146 -0.2863 -3.3202 40.3292
EN GDSC1 -2.2546 1.0383 -2.7951 31.8818
⏷ Show the Full List of 7 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 25 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
786-O GDSC1 -6.5313 -4.086 -6.5374 78.7212
HA7-RCC GDSC1 -5.9474 -1.8102 -6.0983 68.8029
VMRC-RCW GDSC1 -5.2563 -3.1153 -5.2649 65.4525
CAL-54 GDSC1 -5.2436 -1.1328 -5.4541 62.4194
LB1047-RCC GDSC1 -5.0844 -2.4728 -5.116 62.9208
769-P GDSC1 -5.0016 -3.2012 -5.0051 62.6985
OS-RC-2 GDSC1 -4.9026 -2.2258 -4.9442 60.7877
TK-10 GDSC1 -4.8464 -2.2472 -4.884 60.2226
BFTC-909 GDSC1 -4.6591 -1.3447 -4.7878 57.4917
BB65-RCC GDSC1 -4.3924 -1.6371 -4.4638 54.9034
UO-31 GDSC1 -4.323 -0.6662 -4.5497 53.7207
SW13 GDSC1 -4.2431 -2.4329 -4.2522 53.4119
RCC10RGB GDSC1 -4.1303 0.8079 -4.7433 51.4629
LB2241-RCC GDSC1 -4.0222 -1.3037 -4.1121 50.6522
ACHN GDSC1 -4.0045 -1.8497 -4.036 50.4683
RXF 393L GDSC1 -3.8389 -1.042 -3.9549 48.5454
VMRC-RCZ GDSC1 -3.7732 -2.0653 -3.7847 47.6204
SW156 GDSC1 -3.7437 -1.1562 -3.8353 47.4045
A-704 GDSC1 -3.6732 -0.9407 -3.7934 46.6269
LB996-RCC GDSC1 -3.5546 -1.7909 -3.5728 44.9335
Caki-1 GDSC1 -3.3371 0.1197 -3.6687 43.3116
KMRC-20 GDSC1 -2.4018 2.1446 -3.3952 35.6966
SN12C GDSC1 -2.2889 -0.7061 -2.3441 29.3871
KMRC-1 GDSC1 0.2621 8.4541 -3.9874 26.0357
A-498 GDSC1 1.1789 7.9123 -2.9963 18.1711
⏷ Show the Full List of 25 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 37 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO205 GDSC1 -6.0446 -4.9214 -6.0446 75.8375
LS411N GDSC1 -5.6303 -4.3109 -5.6304 70.6554
LoVo GDSC1 -5.4531 -3.3489 -5.4593 67.7922
HT-29 GDSC1 -5.4375 -4.294 -5.4375 68.3465
LS180 GDSC1 -5.3711 -2.8244 -5.3928 66.2353
LS1034 GDSC1 -5.2956 -2.0517 -5.3734 64.315
T84 GDSC1 -5.1123 -2.3488 -5.1536 63.0441
SW837 GDSC1 -4.966 -2.0859 -5.0226 61.2775
SNU-C2B GDSC1 -4.8937 -1.9889 -4.9558 60.4484
SW620 GDSC1 -4.7423 -3.9109 -4.7423 59.705
SW626 GDSC1 -4.7267 -3.0436 -4.7298 59.3926
NCI-H747 GDSC1 -4.6608 -3.133 -4.6624 58.6229
RKO GDSC1 -4.6263 -2.4508 -4.644 57.9507
GP5d GDSC1 -4.5952 -2.9664 -4.5981 57.7882
HCC2998 GDSC1 -4.5791 -3.6944 -4.5791 57.6654
COLO 320HSR GDSC1 -4.5011 -2.931 -4.5036 56.6378
HCT 116 GDSC1 -4.3279 -2.7957 -4.3306 54.4958
KM12 GDSC1 -4.2579 -2.3975 -4.2685 53.5857
CCK-81 GDSC1 -4.1752 -2.6852 -4.1779 52.6026
LS123 GDSC1 -4.1734 -2.3486 -4.1838 52.5531
SW1417 GDSC1 -4.0865 -2.6342 -4.0891 51.5019
SW948 GDSC1 -3.7061 -1.4904 -3.7543 46.8753
SNU-C1 GDSC1 -3.6496 -0.3498 -3.8881 46.5659
C2BBe1 GDSC1 -3.2214 -0.8595 -3.3206 41.1678
RCM-1 [Human ESC] GDSC1 -2.9233 -1.2107 -2.9576 37.1706
HT-55 GDSC1 -2.8818 -0.9438 -2.9442 36.8121
CaR-1 GDSC1 -2.7416 -0.0066 -2.9841 36.0548
SW48 GDSC1 -2.5976 -0.645 -2.6851 33.4316
MDST8 GDSC1 -2.333 -1.1636 -2.3453 29.6672
HT115 GDSC1 -2.1518 -0.5676 -2.2182 27.7467
LS513 GDSC1 -2.027 0.2817 -2.2875 27.4478
HCT 15 GDSC1 -1.589 4.4321 -3.6301 32.1797
SW1463 GDSC1 -1.5622 0.1764 -1.7489 21.1876
CL-11 GDSC1 -0.9445 0.9435 -1.3697 15.2141
COLO 678 GDSC1 -0.8086 2.8017 -2.1022 19.9103
NCI-H716 GDSC1 -0.3367 4.511 -2.5203 20.6762
CW-2 GDSC1 0.7077 2.6322 -0.7555 4.1691
⏷ Show the Full List of 37 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Leukemia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MO-T GDSC1 -0.0187 5.1115 -2.5487 19.6078
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-398 GDSC1 -6.1705 -1.7287 -6.3501 69.9979
JHH-1 GDSC1 -6.0675 -5.0878 -6.0675 76.193
SNU-423 GDSC1 -5.8556 -4.1018 -5.8566 72.9441
Hep 3B2.1-7 GDSC1 -5.321 -4.0717 -5.3211 66.8738
HLE GDSC1 -4.6935 -2.4372 -4.7139 58.7047
Hep-G2/C3A GDSC1 -4.6659 -2.4279 -4.6859 58.3877
JHH-6 GDSC1 -4.3994 -0.4676 -4.6771 54.3655
SK-HEP-1 GDSC1 -4.3874 -1.8075 -4.4406 54.9259
SNU-449 GDSC1 -4.3863 -2.2218 -4.4082 55.0726
JHH-4 GDSC1 -3.9671 -2.5637 -3.9695 50.0162
SNU-387 GDSC1 -3.8077 -1.4717 -3.8635 48.1143
JHH-7 GDSC1 -3.4397 -2.9022 -3.4397 43.4242
SNU-475 GDSC1 -2.367 1.0741 -2.9289 33.2997
HuH-1 GDSC1 -2.272 -1.0252 -2.2911 28.9478
JHH-2 GDSC1 -1.899 -0.2618 -2.0027 24.8329
Huh-7 GDSC1 -1.7668 1.2677 -2.3657 26.4657
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 168 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SBC-3 GDSC1 -7.2556 -5.3775 -7.2559 87.2607
LC-2/ad GDSC1 -6.5704 -4.3777 -6.5731 79.8206
NCI-H1944 GDSC1 -6.5536 -2.1878 -6.6929 73.3076
NCI-H727 GDSC1 -6.4608 -1.9596 -6.626 72.2074
NCI-H211 GDSC1 -6.4077 -4.6934 -6.4081 79.2848
NCI-H522 GDSC1 -6.3881 -3.2875 -6.4175 75.4745
NCI-H1975 GDSC1 -6.3138 -4.4693 -6.3147 77.9834
NCI-H2369 GDSC1 -6.3092 -5.6425 -6.3092 79.2767
NCI-H2122 GDSC1 -6.1694 -3.5719 -6.1817 74.6983
NCI-H810 GDSC1 -6.1547 -4.4148 -6.1553 76.4081
LB647-SCLC GDSC1 -6.0529 -3.7768 -6.0587 74.2283
NCI-H847 GDSC1 -5.9396 -4.1187 -5.9408 73.8185
LK-2 GDSC1 -5.9263 -4.5271 -5.9264 74.1898
NCI-H1437 GDSC1 -5.8679 -1.8233 -6.0113 68.3031
HOP-62 GDSC1 -5.7676 -1.7095 -5.9208 67.3688
HCC44 GDSC1 -5.7273 -3.0147 -5.7503 69.8311
Ms-1 GDSC1 -5.7161 -3.8775 -5.7179 71.2023
COLO 668 GDSC1 -5.6759 -4.5185 -5.6759 71.2915
EBC-1 GDSC1 -5.5853 -3.4069 -5.5921 69.2113
DMS 273 GDSC1 -5.4294 -4.004 -5.4297 68.1366
COR-L88 GDSC1 -5.3385 -4.2247 -5.3385 67.1234
NCI-H64 GDSC1 -5.3162 -4.288 -5.3162 66.8595
NCI-H1568 GDSC1 -5.286 0.1491 -5.8037 60.8932
NCI-H510A GDSC1 -5.274 -3.9714 -5.2741 66.2745
NCI-H2228 GDSC1 -5.2159 -1.4224 -5.3735 62.6385
HCC33 GDSC1 -5.1883 -4.0492 -5.1884 65.2514
Calu-3 GDSC1 -5.1718 -2.8474 -5.1872 64.2612
NCI-H460 GDSC1 -5.1576 -3.7293 -5.1581 64.7934
COR-L23 GDSC1 -5.1546 -2.9794 -5.165 64.2224
NCI-H209 GDSC1 -5.1441 -3.7079 -5.1446 64.6241
HCC78 GDSC1 -5.1414 -2.6689 -5.1638 63.7368
NCI-H748 GDSC1 -5.1287 -3.8028 -5.1289 64.4697
LCLC-103H GDSC1 -5.0868 -2.912 -5.0979 63.4254
LCLC-97TM1 GDSC1 -5.0524 -3.6795 -5.0528 63.5115
ABC-1 GDSC1 -5.0371 -2.0825 -5.0977 61.9708
NCI-H1963 GDSC1 -5.0342 -3.5213 -5.0351 63.2401
HOP-92 GDSC1 -5.0288 -2.8763 -5.0399 62.7609
NCI-H1355 GDSC1 -5.0271 -2.6698 -5.0461 62.5457
Calu-6 GDSC1 -4.9839 -2.5558 -5.0072 61.9733
SBC-5 GDSC1 -4.981 -4.2517 -4.981 62.6894
NCI-H290 GDSC1 -4.9616 -3.8698 -4.9616 62.4329
NCI-H650 GDSC1 -4.954 -0.1105 -5.3708 58.8206
NCI-H526 GDSC1 -4.921 -2.8803 -4.9299 61.5664
LC-1/sq GDSC1 -4.9096 -2.9033 -4.9177 61.4538
NCI-H3122 GDSC1 -4.7853 -2.1328 -4.8291 59.4748
NCI-H2170 GDSC1 -4.7575 -3.8551 -4.7575 59.8946
IST-SL1 GDSC1 -4.7443 -3.4716 -4.7446 59.706
Lu-134-A GDSC1 -4.7401 -3.1966 -4.7416 59.5998
NCI-H520 GDSC1 -4.7399 -3.776 -4.7399 59.6724
Lu-135 GDSC1 -4.7349 -2.9827 -4.7389 59.4669
NCI-H1915 GDSC1 -4.7115 -2.8966 -4.7168 59.1558
NCI-H1651 GDSC1 -4.6953 -2.8084 -4.7022 58.9266
CAL-12T GDSC1 -4.6764 -3.0645 -4.6788 58.7947
CPC-N GDSC1 -4.6571 -3.2927 -4.6577 58.6078
LXF 289 GDSC1 -4.6196 -2.7452 -4.6268 58.0087
NCI-H1836 GDSC1 -4.5796 -3.4664 -4.5797 57.6653
NCI-H2342 GDSC1 -4.5758 -2.1219 -4.6113 57.1937
NCI-H1299 GDSC1 -4.5449 -1.3537 -4.664 56.3535
NCI-H1770 GDSC1 -4.5244 -3.5142 -4.5245 56.98
SK-MES-1 GDSC1 -4.5063 -2.4955 -4.5191 56.5787
IST-SL2 GDSC1 -4.489 -1.3495 -4.6048 55.7764
NCI-H2171 GDSC1 -4.4659 -3.775 -4.4659 56.2515
NCI-H358 GDSC1 -4.4549 -2.3359 -4.473 55.9154
NCI-H661 GDSC1 -4.4468 -3.048 -4.448 55.9886
A-427 GDSC1 -4.444 -2.9642 -4.4458 55.9441
Lu-99A GDSC1 -4.4163 -0.3468 -4.7242 54.4583
NCI-H2030 GDSC1 -4.4053 -2.0587 -4.4382 55.2335
NCI-H2591 GDSC1 -4.3937 2.5182 -5.647 53.0028
PaCa-3 GDSC1 -4.3377 -1.8619 -4.3833 54.3854
NCI-H2405 GDSC1 -4.2688 -3.0684 -4.2692 53.7828
Lu-165 GDSC1 -4.2457 -2.4873 -4.2533 53.4515
NCI-H2595 GDSC1 -4.2205 -1.582 -4.288 52.9622
IA-LM GDSC1 -4.2165 -1.494 -4.2942 52.8937
NCI-H1688 GDSC1 -4.1602 -2.4028 -4.1686 52.3976
NCI-H2085 GDSC1 -4.1387 -0.5438 -4.376 51.8163
NCI-H69 GDSC1 -4.1243 -2.5081 -4.1294 51.9639
NCI-H226 GDSC1 -4.1234 -3.1625 -4.1234 51.9694
NCI-H2081 GDSC1 -4.0949 -2.0095 -4.119 51.5664
NCI-H2804 GDSC1 -4.0845 -1.6173 -4.1404 51.4023
NCI-H2009 GDSC1 -4.0792 -1.7074 -4.1259 51.3493
NCI-H441 GDSC1 -4.0737 -1.697 -4.1211 51.2831
NCI-H1648 GDSC1 -4.0596 -2.3413 -4.0679 51.1583
NCI-H2135 GDSC1 -4.0595 -2.5874 -4.0624 51.1652
NCI-H2461 GDSC1 -4.0537 -1.4455 -4.1272 51.0252
NCI-H2087 GDSC1 -4.0118 -3.0796 -4.0118 50.5745
COR-L105 GDSC1 -3.9703 0.0961 -4.3531 50.0449
NCI-H1694 GDSC1 -3.9608 -2.3283 -3.9676 49.9382
BEN GDSC1 -3.919 -2.0631 -3.9345 49.4255
NCI-H187 GDSC1 -3.9102 -2.7554 -3.9108 49.3061
Lu-139 GDSC1 -3.8972 -2.412 -3.9012 49.1476
NCI-H2196 GDSC1 -3.8224 -2.3931 -3.8259 48.216
NCI-H1092 GDSC1 -3.7185 -1.6507 -3.7528 46.9973
NCI-H1304 GDSC1 -3.7084 -1.9998 -3.721 46.8212
NCI-H2141 GDSC1 -3.6964 -1.661 -3.7288 46.7225
PC-14 GDSC1 -3.6658 -0.5609 -3.8582 46.6703
NCI-H196 GDSC1 -3.6437 -1.86 -3.661 46.033
NCI-H596 GDSC1 -3.6242 -1.9626 -3.6361 45.775
NCI-H1734 GDSC1 -3.622 -1.3311 -3.6828 45.8875
NCI-H82 GDSC1 -3.6199 -2.3289 -3.6222 45.686
NCI-H2347 GDSC1 -3.6111 0.3109 -4.0229 46.4234
NCI-H1993 GDSC1 -3.5576 -0.0721 -3.8572 45.6636
NCI-H1693 GDSC1 -3.5282 1.1172 -4.1951 45.9697
NCI-H1581 GDSC1 -3.5185 -2.4346 -3.5192 44.4128
HCC827 GDSC1 -3.4973 -0.0887 -3.7869 44.9796
NCI-H292 GDSC1 -3.4959 -1.7315 -3.5155 44.2114
SHP-77 GDSC1 -3.4741 -1.3537 -3.5237 44.0541
NCI-H2444 GDSC1 -3.4579 0.8497 -4.027 45.1228
UMC-11 GDSC1 -3.3994 -2.726 -3.3994 42.9197
EPLC-272H GDSC1 -3.3944 -0.2204 -3.6412 43.7195
NCI-H2731 GDSC1 -3.3784 -1.2245 -3.437 42.916
NCI-H1436 GDSC1 -3.354 -0.1099 -3.6251 43.3301
NCI-H3255 GDSC1 -3.3426 0.3547 -3.7433 43.5566
NCI-H2722 GDSC1 -3.3267 -0.5927 -3.4835 42.6531
NCI-H446 GDSC1 -3.3137 -1.7344 -3.3272 41.9203
COR-L95 GDSC1 -3.3038 -0.155 -3.5587 42.7097
HCC15 GDSC1 -3.2921 -0.6836 -3.4281 42.1668
NCI-H2172 GDSC1 -3.2833 11.0669 -8.443 47.4684
NCI-H2110 GDSC1 -3.2286 -0.6637 -3.3632 41.401
DMS 79 GDSC1 -3.2272 -1.4406 -3.2562 40.9206
ChaGo-K-1 GDSC1 -3.2102 -0.8603 -3.3085 41.0284
NCI-H2023 GDSC1 -3.1562 -0.6358 -3.2902 40.5277
NCI-H2869 GDSC1 -3.1079 0.9451 -3.6807 41.5336
NCI-H1650 GDSC1 -3.0627 1.2416 -3.7379 41.367
NCI-H1435 GDSC1 -3.0621 -1.3613 -3.09 38.8628
A-549 GDSC1 -3.0589 -0.0156 -3.3279 39.9326
NCI-H23 GDSC1 -3.0343 -1.5176 -3.0503 38.4504
NCI-H2803 GDSC1 -3.0146 -1.5993 -3.0259 38.1773
NCI-H647 GDSC1 -2.9521 -0.2762 -3.1456 38.34
LOU-NH91 GDSC1 -2.9016 -1.5155 -2.9135 36.7704
SK-LU-1 GDSC1 -2.8919 1.7828 -3.7624 40.2265
NCI-H1623 GDSC1 -2.8875 -0.315 -3.0662 37.4909
NCI-H1869 GDSC1 -2.8572 -0.8168 -2.9363 36.6004
NCI-H2373 GDSC1 -2.8147 -0.7822 -2.8961 36.0872
NCI-H1792 GDSC1 -2.767 -0.3168 -2.9346 35.9708
HARA [Human squamous cell lung carcinoma] GDSC1 -2.7209 1.8088 -3.5917 38.5035
NCI-H2029 GDSC1 -2.6941 -1.4988 -2.7013 34.149
SBC-1 GDSC1 -2.6653 -1.8794 -2.6657 33.7469
Lu-65 GDSC1 -2.5927 0.002 -2.8239 34.197
SW1271 GDSC1 -2.5639 0.5747 -2.9652 34.7577
SW1573 GDSC1 -2.5611 -1.095 -2.5878 32.6077
NCI-H838 GDSC1 -2.5384 0.5293 -2.9226 34.3696
NCI-H524 GDSC1 -2.4744 -1.065 -2.4996 31.5149
NCI-H1755 GDSC1 -2.4292 1.086 -3.0002 34.0596
NCI-H1703 GDSC1 -2.3426 -0.4789 -2.4398 30.3213
RERF-LC-MS GDSC1 -2.216 1.846 -3.0757 33.112
NCI-H841 GDSC1 -2.0901 -0.6263 -2.1429 26.8895
NCI-H1155 GDSC1 -1.9771 -1.0779 -1.983 25.1783
NCI-H1048 GDSC1 -1.9413 0.2836 -2.1946 26.343
NCI-H1573 GDSC1 -1.7346 1.1557 -2.2865 25.7754
NCI-H2795 GDSC1 -1.6448 8.5208 -5.6784 38.3881
NCI-H345 GDSC1 -1.5425 0.1408 -1.7167 20.857
DMS 53 GDSC1 -0.9834 6.6074 -4.1348 31.3864
NCI-H1876 GDSC1 -0.978 0.9419 -1.4038 15.6315
NCI-H513 GDSC1 -0.9482 3.9991 -2.8165 25.093
NCI-H2818 GDSC1 -0.9138 0.567 -1.1826 13.6962
DMS 114 GDSC1 -0.753 1.393 -1.3764 14.3403
NCI-H1781 GDSC1 -0.7222 2.552 -1.8997 18.0888
NCI-H2227 GDSC1 -0.5008 7.0872 -3.9474 28.6903
EKVX GDSC1 -0.3695 7.4983 -4.0394 28.5524
RERF-LC-Sq1 GDSC1 -0.0863 4.0012 -2.0506 16.5497
NCI-H1793 GDSC1 -0.0588 3.495 -1.7742 14.4511
NCI-H1563 GDSC1 0.2076 3.6048 -1.6087 12.2456
NCI-H1666 GDSC1 0.3279 3.6604 -1.5403 11.3145
RERF-LC-KJ GDSC1 0.5144 8.9228 -4.0166 25.2993
NCI-H720 GDSC1 0.9516 3.9256 -1.2102 6.9237
NCI-H2291 GDSC1 1.2186 5.688 -1.8768 11.0079
NCI-H322M GDSC1 1.4646 4.7955 -1.2862 6.1926
NCI-H1838 GDSC1 1.7028 5.6186 -1.5201 7.2714
⏷ Show the Full List of 168 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Lymphoma Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CBTCi002-A GDSC1 -3.1754 -0.1736 -3.414 41.1716
Cancer Drug Sensitivity Data Curated from 23 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE-8 GDSC1 -7.2321 -6.112 -7.2321 89.4728
T.T GDSC1 -5.9779 -3.3935 -5.992 72.7502
TE-1 GDSC1 -5.9423 -4.1241 -5.9435 73.854
KYSE-270 GDSC1 -5.9367 -4.2397 -5.9374 73.9671
COLO 680N GDSC1 -5.4159 -2.9447 -5.4335 66.851
KYSE-510 GDSC1 -5.1117 -3.8754 -5.1119 64.2813
OE19 GDSC1 -5.082 -3.4683 -5.0834 63.7826
KYSE-410 GDSC1 -4.9468 -3.693 -4.947 62.2285
KYSE-70 GDSC1 -4.7871 -3.1989 -4.789 60.1678
TE-15 GDSC1 -4.6421 -3.3247 -4.6426 58.4283
KYSE-180 GDSC1 -4.6133 -2.8269 -4.6187 57.9644
KYSE-140 GDSC1 -4.5769 -0.5213 -4.8579 56.0486
TE-10 GDSC1 -4.5491 -1.5315 -4.6434 56.5206
TE-11 GDSC1 -4.4996 -0.5502 -4.7672 55.3578
KYSE-450 GDSC1 -4.4462 -2.5853 -4.4547 55.8938
OE33 GDSC1 -4.4454 -2.806 -4.4491 55.9353
TE-5 GDSC1 -4.3738 0.6421 -4.9552 53.5882
OE21 GDSC1 -4.2537 1.0114 -4.9445 52.4566
KYSE-150 GDSC1 -4.1123 -2.0626 -4.1339 51.7815
TE-6 GDSC1 -3.6091 -0.4722 -3.8159 46.0566
TE-9 GDSC1 -2.9862 0.6329 -3.443 39.8294
KYSE-520 GDSC1 -2.3571 6.8133 -5.5084 41.1279
EC-GI-10 GDSC1 -1.1095 1.3351 -1.71 18.5205
⏷ Show the Full List of 23 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 25 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
OVCAR-5 GDSC1 -6.3452 -2.9252 -6.3961 74.1804
EFO-27 GDSC1 -6.0176 -3.822 -6.0223 74.0148
OVCAR-8 GDSC1 -5.7941 -3.1094 -5.8147 70.5971
IGROV-1 GDSC1 -5.7893 -3.9434 -5.7909 72.045
SK-OV-3 GDSC1 -5.3207 -2.8642 -5.3391 65.7981
TOV-112D GDSC1 -5.3063 -3.9724 -5.3065 66.6636
FU-OV-1 GDSC1 -5.2587 -3.3895 -5.262 65.7498
OVTOKO GDSC1 -4.9894 -0.4774 -5.3175 59.5156
OVCAR-3 GDSC1 -4.9118 -1.6639 -5.0124 60.2604
OVCAR-4 GDSC1 -4.6973 -1.6713 -4.7833 58.1562
Kuramochi GDSC1 -4.6791 -2.1781 -4.7147 58.3694
OAW42 GDSC1 -4.6297 0.394 -5.1583 55.8202
A2780 GDSC1 -4.5135 -3.0233 -4.5151 56.8047
OV-90 GDSC1 -4.2138 -1.8051 -4.2584 52.942
OVISE GDSC1 -3.8786 -0.8589 -4.0294 49.0224
OC 314 GDSC1 -3.7532 -2.1211 -3.7623 47.3677
OAW28 GDSC1 -3.73 -1.7332 -3.7585 47.1252
EFO-21 GDSC1 -3.17 0.2021 -3.5099 41.4692
Caov-4 GDSC1 -2.9286 1.6738 -3.7584 40.4682
TYK-nu GDSC1 -2.8458 -0.5692 -2.9671 36.6884
RMG-I GDSC1 -2.6449 -1.0047 -2.6851 33.736
ES-2 GDSC1 -2.5414 -1.1509 -2.5627 32.3278
OVKATE GDSC1 -1.1596 4.0391 -3.0332 27.272
TOV-21G GDSC1 -0.8652 1.1072 -1.3595 14.7483
Caov-3 GDSC1 -0.1731 1.636 -0.9454 8.5106
⏷ Show the Full List of 25 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 30 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KP-2 GDSC1 -7.3759 -2.9047 -7.4799 79.0739
HPAC GDSC1 -6.1202 -1.9369 -6.2649 70.198
PSN1 GDSC1 -5.759 -4.6931 -5.759 72.3509
BxPC-3 GDSC1 -5.0156 -2.7215 -5.0321 62.4748
MIA PaCa-2 GDSC1 -4.6523 -3.6088 -4.6523 58.576
Panc 10.05 GDSC1 -4.629 -0.9473 -4.8244 56.8673
SUIT-2 GDSC1 -4.584 -2.9966 -4.5864 57.6597
SU.86.86 GDSC1 -4.5371 0.0425 -4.9569 55.299
Panc 02.03 GDSC1 -4.5237 -1.9679 -4.569 56.5245
MZ-PC-1 GDSC1 -4.3396 -2.1765 -4.3624 54.5106
PaTu 8902 GDSC1 -4.305 -2.7889 -4.3076 54.2137
CFPAC-1 GDSC1 -4.2192 -0.6184 -4.4472 52.6589
AsPC-1 GDSC1 -4.0607 -1.1072 -4.1828 51.0712
KP-3 GDSC1 -4.049 -0.1139 -4.3823 50.8383
PL4 GDSC1 -4.0089 -0.4617 -4.2534 50.4559
KP-1N GDSC1 -3.9705 -1.9222 -3.9956 50.0578
HuP-T4 GDSC1 -3.8936 -2.1078 -3.9065 49.1112
HuP-T3 GDSC1 -3.6553 -0.2546 -3.9172 46.6663
HPAF-II GDSC1 -3.5144 1.3684 -4.2701 45.965
Panc 03.27 GDSC1 -3.3237 -1.3784 -3.3627 42.162
PaTu 8988t GDSC1 -3.3071 -0.3885 -3.5062 42.5669
DAN-G GDSC1 -3.1896 -1.9492 -3.1933 40.3189
Panc 08.13 GDSC1 -3.1257 -1.5278 -3.1443 39.6046
SW1990 GDSC1 -3.0603 1.8801 -3.9795 42.0041
KP-4 GDSC1 -2.9727 -0.0269 -3.2309 38.8782
Hs 766T GDSC1 -2.9342 -0.5783 -3.061 37.799
Capan-1 GDSC1 -2.7194 -0.8929 -2.7778 34.7728
Panc 04.03 GDSC1 -2.6697 1.6675 -3.481 37.7556
Capan-2 GDSC1 -2.4014 3.7174 -4.0905 38.1526
YAPC GDSC1 0.5659 3.9567 -1.5034 10.2559
⏷ Show the Full List of 30 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H28 GDSC1 -3.9059 -1.0175 -4.031 49.3194
NCI-H2052 GDSC1 -3.7703 -1.0327 -3.8826 47.7464
IST-Mes1 GDSC1 -3.3289 -0.1326 -3.5919 43.0213
MPP 89 GDSC1 -2.4642 -0.9091 -2.5045 31.4821
NCI-H2452 GDSC1 -1.4661 11.3818 -6.9337 39.8483
MSTO-211H GDSC1 1.5439 3.3315 -0.591 1.4773
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
22Rv1 GDSC1 -5.46 -3.7134 -5.4616 68.2715
VCaP GDSC1 -5.117 -2.208 -5.17 62.9042
DU145 GDSC1 -4.8504 -3.2529 -4.8521 60.9439
LNCaP clone FGC GDSC1 -4.2702 -1.938 -4.3063 53.6309
PC-3 GDSC1 -3.5924 -1.058 -3.6878 45.62
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 GDSC1 -2.0333 0.0091 -2.2153 27.0179
Cancer Drug Sensitivity Data Curated from 56 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
LOX-IMVI GDSC1 -7.0062 -1.894 -7.2217 74.6074
CHL-1 GDSC1 -6.5828 -5.482 -6.5828 82.329
G-361 GDSC1 -6.5308 -4.227 -6.5347 79.1161
COLO 679 GDSC1 -6.3592 -3.0194 -6.4039 74.5318
HT-144 GDSC1 -6.3588 -3.4022 -6.3819 75.6067
WM35 GDSC1 -6.2656 -3.7208 -6.2756 75.8088
Mel Ho GDSC1 -6.2222 -3.8225 -6.2293 75.7311
451Lu GDSC1 -5.4284 -3.0541 -5.4421 67.1359
A-431 GDSC1 -5.2202 -3.828 -5.2205 65.5783
MZ-MEL-7 GDSC1 -5.2031 -3.5727 -5.2043 65.2526
SH-4 GDSC1 -5.0314 -2.4855 -5.0603 62.3944
IGR-1 GDSC1 -4.9777 -3.8935 -4.9777 62.6347
IST-MEL1 GDSC1 -4.9566 -2.4992 -4.9822 61.6284
IGR-37 GDSC1 -4.7577 -2.6962 -4.7689 59.5915
A101D GDSC1 -4.6835 -2.3914 -4.7059 58.5636
Hs 940.T GDSC1 -4.5769 -3.1664 -4.5779 57.6047
WM278 GDSC1 -4.5395 -2.7269 -4.5459 57.051
IPC-298 GDSC1 -4.4936 -1.473 -4.5921 55.9015
WM793 GDSC1 -4.4501 0.0866 -4.8741 54.5198
Mel JuSo GDSC1 -4.4471 -2.3203 -4.4658 55.819
RPMI-7951 GDSC1 -4.4046 -2.9465 -4.4062 55.4563
UACC-257 GDSC1 -4.3727 -1.4465 -4.4667 54.5997
SK-MEL-5 GDSC1 -4.3643 -3.0832 -4.3649 54.97
RVH-421 GDSC1 -4.3454 -1.8835 -4.3895 54.4809
SK-MEL-3 GDSC1 -4.2004 -1.5313 -4.2726 52.7217
MZ-MEL-2 GDSC1 -4.1907 -2.0594 -4.2153 52.7209
A2058 GDSC1 -4.1389 -1.5536 -4.2048 52.0233
A-375 GDSC1 -4.0855 -2.5644 -4.0891 51.4874
MMAc-SF GDSC1 -4.0473 -2.0773 -4.066 50.9951
SK-MEL-30 GDSC1 -4.016 -1.6031 -4.0696 50.5953
CP66-MEL GDSC1 -3.9455 -1.8552 -3.974 49.7534
GAK GDSC1 -3.9048 -2.0071 -3.9227 49.2528
A-388 GDSC1 -3.8402 -1.2748 -3.9218 48.5293
Hs 938.T GDSC1 -3.7813 -1.5841 -3.8244 47.7776
LB2518-MEL GDSC1 -3.6732 -1.3436 -3.7356 46.5091
LB373-MEL-D GDSC1 -3.6196 -1.747 -3.6427 45.7536
UACC-62 GDSC1 -3.5472 -1.9667 -3.557 44.8097
COLO 800 GDSC1 -3.519 -2.126 -3.5237 44.4373
SK-MEL-2 GDSC1 -3.5146 0.4854 -3.9708 45.497
WM1552C GDSC1 -3.4172 -0.7186 -3.5568 43.6664
VMRC-MELG GDSC1 -3.3908 -1.466 -3.4252 42.9713
HMV-II GDSC1 -3.3567 -0.7678 -3.4823 42.9005
G-mel GDSC1 -3.2968 -1.9143 -3.3031 41.6728
CP50-MEL-B GDSC1 -2.9206 0.7906 -3.4246 39.2807
SK-MEL-24 GDSC1 -2.3288 2.7853 -3.5973 36.0587
DJM-1 GDSC1 -2.0408 1.0304 -2.5633 29.2561
SK-MEL-28 GDSC1 -1.8015 -0.8616 -1.8131 23.0193
COLO 829 GDSC1 -1.7542 0.8898 -2.2033 25.3363
M14 GDSC1 -1.7292 1.8774 -2.5838 27.6172
COLO 783 GDSC1 -1.4233 0.5292 -1.7146 20.1816
COLO 792 GDSC1 -1.2209 -0.2118 -1.2771 16.0511
SK-MEL-1 GDSC1 -1.0556 1.5182 -1.7368 18.4508
WT2-iPS GDSC1 -0.3989 0.8033 -0.7519 7.9699
WM115 GDSC1 -0.2237 4.1838 -2.2593 18.521
MeWo GDSC1 0.1717 4.4529 -2.0616 15.6664
EquiPSC Line K2 GDSC1 -2.228 2.0382 -3.1692 33.6339
⏷ Show the Full List of 56 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Small Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuTu 80 GDSC1 -5.341 -4.0791 -5.3411 67.1164
Cancer Drug Sensitivity Data Curated from 22 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
G-401 GDSC1 -5.8248 1.1966 -6.7114 62.6545
A-204 GDSC1 -5.3338 -1.3998 -5.5041 63.558
G-402 GDSC1 -5.3037 3.3204 -6.9299 57.7949
Rh30 GDSC1 -5.279 -4.3303 -5.279 66.4048
MFH-ino GDSC1 -4.9263 -3.1803 -4.9294 61.811
STS-0421 GDSC1 -4.8792 -2.2036 -4.9215 60.5233
EW-8 GDSC1 -4.6438 -3.3504 -4.6442 58.4512
Hs 633.T GDSC1 -4.5082 -3.0253 -4.5098 56.74
RD GDSC1 -4.4434 -2.3186 -4.462 55.7746
SK-LMS-1 GDSC1 -4.372 -2.2157 -4.3938 54.9035
SW982 GDSC1 -4.223 -1.979 -4.2541 53.0879
Rh41 GDSC1 -4.2107 -2.4407 -4.219 53.0185
VA-ES-BJ GDSC1 -3.9835 -1.1343 -4.0955 50.2018
KYM-1 GDSC1 -3.9337 -1.8643 -3.9612 49.6108
SW872 GDSC1 -3.8774 -2.9786 -3.8775 48.8955
SK-UT-1 GDSC1 -3.6256 -1.286 -3.692 45.9449
HT-1080 GDSC1 -3.599 -2.1041 -3.6055 45.4416
MES-SA GDSC1 -3.3841 -1.9183 -3.392 42.7701
RKN GDSC1 -3.3507 -0.002 -3.65 43.3737
GCT GDSC1 -2.1695 0.1712 -2.4095 29.0733
TE 441.T GDSC1 -1.8243 1.447 -2.4997 27.6293
SW684 GDSC1 -0.9227 -0.1065 -0.9753 12.3024
⏷ Show the Full List of 22 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 25 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
IM95 GDSC1 -6.1737 -3.9824 -6.1776 75.7112
RF-48 GDSC1 -6.1447 -3.1533 -6.1735 73.4508
HGC-27 GDSC1 -6.1295 -5.1971 -6.1295 76.9766
ECC10 GDSC1 -5.5226 -4.2858 -5.5227 69.3694
AGS GDSC1 -5.4966 -3.6832 -5.4987 68.6429
RERF-GC-1B GDSC1 -5.1738 -1.2659 -5.3546 62.0563
Fu97 GDSC1 -4.9738 -3.025 -4.98 62.2653
GCIY GDSC1 -4.9619 -2.4453 -4.9908 61.6296
MKN28 GDSC1 -4.7614 -2.5398 -4.7788 59.5341
TMK-1 GDSC1 -4.711 -2.1649 -4.749 58.7067
NCI-N87 GDSC1 -4.6359 -2.0999 -4.6756 57.8429
23132/87 GDSC1 -4.3899 -3.1054 -4.3905 55.2889
NUGC-3 GDSC1 -4.2625 -1.9373 -4.2984 53.5412
OCUM-1 GDSC1 -4.1333 -0.9334 -4.291 51.841
MKN1 GDSC1 -3.7874 -1.5224 -3.8368 47.8611
NUGC-4 GDSC1 -3.723 -1.7605 -3.7492 47.0345
SNU-1 GDSC1 -3.6329 -1.0701 -3.7293 46.1032
MKN45 GDSC1 -3.3512 -0.7786 -3.4745 42.8269
TGBC11TKB GDSC1 -3.2913 -1.0574 -3.3657 41.9148
MKN7 GDSC1 -2.7504 -0.3304 -2.9135 35.7449
HSC-39 GDSC1 -2.3211 -0.5049 -2.4117 30.012
SNU-5 GDSC1 -1.9604 -0.2963 -2.062 25.5854
SNU-16 GDSC1 -1.6574 -0.2041 -1.7527 21.7612
SCH GDSC1 -1.3636 -0.8438 -1.3649 17.4806
SNG-M GDSC1 -4.9932 -3.5666 -4.9937 62.763
⏷ Show the Full List of 25 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TT2609-C02 GDSC1 -6.5673 -2.3975 -6.681 73.9626
CGTH-W-1 GDSC1 -6.0405 -3.3438 -6.0578 73.1393
8505C GDSC1 -5.5989 -3.6055 -5.6026 69.6316
KMH-2 GDSC1 -5.3178 -3.9882 -5.3179 66.8063
ML-1 [Human leukemia] GDSC1 -5.3164 -2.9609 -5.3309 65.8872
8305C GDSC1 -5.2184 -2.7302 -5.2401 64.5949
B-CPAP GDSC1 -5.144 -3.7649 -5.1444 64.643
IHH-4 GDSC1 -4.584 -3.5505 -4.584 57.723
K5 GDSC1 -4.434 -2.2484 -4.456 55.6394
BHT-101 GDSC1 -4.3952 -0.5774 -4.6475 54.384
CAL-62 GDSC1 -4.2485 -2.4652 -4.2567 53.482
HTC-C3 GDSC1 -4.0584 -0.4767 -4.3038 50.9745
FTC-133 GDSC1 -3.5664 -0.5658 -3.7492 45.5207
ASH-3 GDSC1 -3.4135 -1.1621 -3.482 43.3822
WRO GDSC1 -2.9286 3.1459 -4.3709 42.0322
TT GDSC1 -2.416 0.0639 -2.648 32.0492
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 41 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H3118 GDSC1 -7.062 -3.7991 -7.0868 80.7937
JHU-011 GDSC1 -6.856 -3.3904 -6.8955 78.4505
PCI-06A GDSC1 -6.6508 -5.3251 -6.6508 82.7548
JHU-029 GDSC1 -6.5134 -3.8046 -6.5255 77.7851
Ca9-22 GDSC1 -6.4803 -4.3896 -6.4823 79.1776
KOSC-2 GDSC1 -5.6425 -2.7871 -5.675 68.6502
HSC-3 GDSC1 -5.3548 -2.1023 -5.4305 64.9147
BHY GDSC1 -5.1123 -2.857 -5.1258 63.6438
PCI-04B GDSC1 -5.087 -3.0975 -5.0933 63.5934
SCC-4 GDSC1 -4.8839 -1.1121 -5.0691 59.3687
KON GDSC1 -4.8265 -2.3066 -4.8591 60.0649
BB30-HNC GDSC1 -4.7299 -1.1978 -4.8879 58.0432
OSC-20 GDSC1 -4.6271 -1.5138 -4.729 57.3109
HO-1-N-1 GDSC1 -4.5984 -1.1492 -4.7545 56.7353
PCI-15A GDSC1 -4.5678 -2.1855 -4.5985 57.141
HSC-2 GDSC1 -4.3936 -2.4306 -4.406 55.2225
OSC-19 GDSC1 -4.2757 -2.2721 -4.2918 53.7775
BICR 31 GDSC1 -4.1837 -1.8324 -4.2245 52.5964
CAL-27 GDSC1 -4.0766 -3.2237 -4.0766 51.3853
SCC-25 GDSC1 -3.911 -1.1929 -4.009 49.3675
BICR 78 GDSC1 -3.7605 -2.1234 -3.7696 47.458
HO-1-u-1 GDSC1 -3.6749 -1.3807 -3.7331 46.52
SKN-3 GDSC1 -3.6686 1.6167 -4.5274 47.471
PE/CA-PJ15 GDSC1 -3.6554 -0.3243 -3.9004 46.6402
Detroit 562 GDSC1 -3.655 -1.7637 -3.6783 46.1902
SAT [Human HNSCC] GDSC1 -3.3614 -0.8192 -3.4783 42.9266
CAL-33 GDSC1 -3.3129 -0.3034 -3.5323 42.7013
SCC-15 GDSC1 -3.1207 -0.8517 -3.2137 39.9125
SAS GDSC1 -3.0523 2.3942 -4.1796 42.4221
FaDu GDSC1 -2.9379 -0.9266 -3.0064 37.5404
LB771-HNC GDSC1 -2.8803 -1.4176 -2.8969 36.5318
UPCI-SCC-090 GDSC1 -2.7003 2.8489 -4.0065 39.6897
HSC-4 GDSC1 -2.6666 2.0531 -3.6339 38.2941
SCC-9 GDSC1 -2.6571 0.4352 -3.0215 35.666
PCI-30 GDSC1 -2.6235 -0.9007 -2.6746 33.5353
JHU-022 GDSC1 -2.5333 -0.5688 -2.6292 32.6835
DOK GDSC1 -2.3354 1.8896 -3.2189 34.5182
BICR 22 GDSC1 -1.7463 0.2863 -1.9832 23.8173
PCI-38 GDSC1 -1.743 2.5231 -2.8851 29.4233
BB49-HNC GDSC1 -1.6869 8.1703 -5.5443 38.2877
BICR 10 GDSC1 -1.4962 5.7857 -4.1989 33.8746
⏷ Show the Full List of 41 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SW1710 GDSC1 -6.5864 -3.5417 -6.6095 77.4554
RT-112 GDSC1 -6.5469 -3.0378 -6.5979 75.7077
5637 GDSC1 -5.1754 -3.4997 -5.177 64.8879
HT-1197 GDSC1 -4.9837 -2.4113 -5.0154 61.8202
BFTC-905 GDSC1 -4.8761 -3.2743 -4.8778 61.2591
639V GDSC1 -4.8408 -1.8414 -4.9155 59.7637
647V GDSC1 -4.0712 -2.4524 -4.0768 51.3064
TCCSUP GDSC1 -3.9918 -1.294 -4.0809 50.3006
CAL-29 GDSC1 -3.9749 -1.9308 -3.9996 50.1112
KU-19-19 GDSC1 -3.9197 -1.1693 -4.0218 49.4693
J82 GDSC1 -3.4995 -0.289 -3.739 44.8897
UM-UC-3 GDSC1 -2.8706 0.8923 -3.4057 38.8493
HT-1376 GDSC1 -2.7681 -0.3364 -2.9314 35.9615
RT-4 GDSC1 -2.6918 -1.0152 -2.7336 34.3305
T24 GDSC1 -2.661 4.1093 -4.5298 40.7793
SW780 GDSC1 -0.6918 1.5008 -1.3665 13.9828
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 29 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NEC8 GDSC1 -5.992 -4.6574 -5.992 75.0389
SW954 GDSC1 -5.9617 -3.2287 -5.9816 72.2436
CAL-39 GDSC1 -5.9472 -1.4054 -6.1643 67.9016
DoTc2 4510 GDSC1 -5.8156 -2.4267 -5.8836 69.2806
PA-1 GDSC1 -5.6637 -4.7163 -5.6637 71.1983
NT2-D1 GDSC1 -5.6583 -3.7306 -5.661 70.4102
NCC-IT GDSC1 -5.5468 -4.3396 -5.5469 69.6799
BPH-1 GDSC1 -5.4643 -3.437 -5.469 68.0188
JEG-3 GDSC1 -5.2177 -3.4489 -5.2201 65.3381
DSH1 GDSC1 -4.7273 -2.8945 -4.7328 59.341
C-33 A GDSC1 -4.6463 -3.481 -4.6464 58.4945
KGN GDSC1 -4.6017 -1.9995 -4.648 57.4011
OVMIU GDSC1 -4.4996 -1.6403 -4.5772 56.0688
HEC-1 GDSC1 -4.4989 -3.5712 -4.4989 56.6624
SW962 GDSC1 -4.4846 -1.0555 -4.6483 55.5439
Ca Ski GDSC1 -4.3825 -1.6016 -4.4575 54.7789
SKG-IIIa GDSC1 -4.3407 -1.7274 -4.3993 54.3677
OMC-1 [Human cervical carcinoma] GDSC1 -4.1881 -1.1186 -4.3179 52.478
SiSo GDSC1 -3.8957 -1.7208 -3.9324 49.1543
C-4-I GDSC1 -3.5111 -1.353 -3.5629 44.5133
ME-180 GDSC1 -3.4743 -1.5104 -3.5089 44.0011
JAR GDSC1 -3.4477 -2.6071 -3.4478 43.5246
MS751 GDSC1 -3.3685 1.2598 -4.0736 44.4949
HeLa GDSC1 -3.2309 0.347 -3.6191 42.3026
LB831-BLC GDSC1 -3.184 -0.824 -3.2863 40.7263
SKN GDSC1 -2.9467 -0.7872 -3.0371 37.7656
HT-3 GDSC1 -2.6735 -0.5119 -2.7916 34.5506
SW756 GDSC1 -1.8152 0.9331 -2.285 26.2141
SiHa GDSC1 0.7501 4.0124 -1.3944 8.8716
⏷ Show the Full List of 29 Cancer Drug Sensitivity Data of This Drug

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