Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM8SU6N)

Drug Name
LY-2183240 Drug Info
Synonyms
LY2183240; 874902-19-9; LY 2183240; UNII-2WBU91OKM7; 2WBU91OKM7; CHEMBL509860; LY-2183240; 5-Biphenyl-4-ylmethyl-tetrazole-1-carboxylic acid dimethylamide; LY2183240/LY-2183240; 1H-Tetrazole-1-carboxamide, 5-([1,1'-biphenyl]-4-ylmethyl)-N,N-dimethyl-; 1H-Tetrazole-1-carboxamide, 5-((1,1'-biphenyl)-4-ylmethyl)-N,N-dimethyl-; SCHEMBL2184828; CTK8E8366; CHEBI:92670; KS-00001CUG; BDBM26736; AOB2582; MolPort-023-219-146; HMS3269E15; BCP22610; ZINC13813297; MFCD08703123; 3796AH; AKOS024457108; CS-0913; BCP9000870; LP01268; NCGC00159571-01
Cross-matching ID
PubChem CID
11507802
ChEBI ID
CHEMBL509860
CAS Number
CAS 874902-19-9
TTD Drug ID
D0W7XR

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Focal adhesion 2.36 0.00e+0 180/201 (89.55%) FLNA;ACTN1;THBS1;...
Regulation of actin cytoskeleton 2.32 0.00e+0 185/218 (84.86%) ACTN1;ITGA6;ACTN4;...
Salmonella infection 2.18 0.00e+0 198/249 (79.52%) FLNA;HSP90AA1;TUBB2A;...
Renal cell carcinoma 2.12 0.00e+0 68/69 (98.55%) TGFB1;CDC42;PIK3CD;...
Proteoglycans in cancer 2.08 0.00e+0 172/205 (83.9%) FLNA;THBS1;TGFB1;...
Estrogen signaling pathway 2.05 0.00e+0 119/137 (86.86%) KRT14;HSPA1A;HSPA8;...
Hippo signaling pathway 2.02 1.75e-3 120/186 (64.52%) TGFB1;BMP2;CCND3;...
Bacterial invasion of epithelial cells 2.01 1.53e-3 59/77 (76.62%) CLTB;ILK;ITGA5;...
HIF-1 signaling pathway 1.91 2.72e-3 105/109 (96.33%) HMOX1;PFKP;PRKCA;...
Yersinia infection 1.91 2.45e-3 120/137 (87.59%) ITGA5;IRAK1;CDC42;...
Leukocyte transendothelial migration 1.91 2.23e-3 90/114 (78.95%) ACTN1;ACTN4;PRKCA;...
Tight junction 1.91 2.04e-3 130/169 (76.92%) ACTN1;ACTN4;MYH9;...
Dilated cardiomyopathy 1.88 4.71e-3 86/96 (89.58%) TPM4;TGFB1;ITGA6;...
GnRH signaling pathway 1.88 4.37e-3 80/93 (86.02%) CALML5;PRKCA;CDC42;...
Endocytosis 1.88 4.08e-3 198/252 (78.57%) HSPA1A;CLTB;HSPA8;...
Mineral absorption 1.84 7.65e-3 48/60 (80%) HMOX1;MT1H;MT1HL1;...
Vasopressin-regulated water reabsorption 1.80 1.01e-2 40/44 (90.91%) ARHGDIA;RAB5C;GNAS;...
Gap junction 1.79 1.22e-2 72/88 (81.82%) TUBB2A;PRKCA;PDGFC;...
B cell receptor signaling pathway 1.79 1.16e-2 71/81 (87.65%) PPP3CA;PIK3CD;NFATC3;...
Prostate cancer 1.78 1.41e-2 93/97 (95.88%) HSP90AA1;MMP9;PDGFC;...
Sphingolipid signaling pathway 1.77 1.34e-2 106/119 (89.08%) SPHK1;PRKCA;PPP2CB;...
Ras signaling pathway 1.76 1.67e-2 201/232 (86.64%) CALML5;PRKCA;CDC42;...
Neurotrophin signaling pathway 1.73 1.94e-2 107/119 (89.92%) ARHGDIA;CALML5;IRAK1;...
Shigellosis 1.73 1.91e-2 180/246 (73.17%) ACTN1;CAPN2;ILK;...
MAPK signaling pathway 1.73 1.84e-2 272/294 (92.52%) FLNA;TGFB1;HSPA1A;...
Pathogenic Escherichia coli infection 1.72 1.81e-2 152/197 (77.16%) MYH9;TUBB2A;IRAK1;...
VEGF signaling pathway 1.72 1.84e-2 50/59 (84.75%) SPHK1;PRKCA;CDC42;...
Fc gamma R-mediated phagocytosis 1.71 1.88e-2 79/97 (81.44%) SPHK1;PRKCA;CDC42;...
Hedgehog signaling pathway 1.70 1.90e-2 43/56 (76.79%) SMURF2;CCND1;CSNK1D;...
Arrhythmogenic right ventricular cardiomyopathy 1.70 1.84e-2 70/77 (90.91%) ITGA6;ITGA5;LMNA;...
Sulfur relay system -1.57 4.12e-2 5/8 (62.5%) TST;NFS1
Mismatch repair -1.57 4.13e-2 22/23 (95.65%) MSH2;POLD3;SSBP1;...
Ribosome -1.58 3.90e-2 113/158 (71.52%) RPL30;RPL14;RPS4X;...
Fanconi anemia pathway -1.61 3.02e-2 36/54 (66.67%) REV1;ATR;USP1;...
beta-Alanine metabolism -1.63 2.64e-2 25/30 (83.33%) ALDH2;EHHADH;GAD2;...
Glutathione metabolism -1.64 2.62e-2 43/57 (75.44%) GPX1;GSS;IDH2;...
Nitrogen metabolism -1.65 2.61e-2 16/17 (94.12%) CA8;CA2;CA9;...
Butanoate metabolism -1.65 2.72e-2 23/28 (82.14%) ACSM5;GAD1;HMGCL;...
DNA replication -1.68 2.12e-2 34/36 (94.44%) POLD3;MCM4;DNA2;...
Drug metabolism -1.69 2.03e-2 78/151 (51.66%) ADH6;FMO1;GSTA3;...
Glyoxylate and dicarboxylate metabolism -1.70 1.95e-2 23/30 (76.67%) AGXT;MDH1;HAO1;...
Alanine, aspartate and glutamate metabolism -1.71 1.65e-2 27/37 (72.97%) GAD2;NIT2;ABAT;...
Pentose and glucuronate interconversions -1.74 1.23e-2 17/34 (50%) UGT2A3;GUSB;SORD;...
Taurine and hypotaurine metabolism -1.76 8.97e-3 8/11 (72.73%) GAD1;GGT1;CDO1;...
Sulfur metabolism -1.78 7.15e-3 9/10 (90%) PAPSS1;TST;SUOX;...
Primary bile acid biosynthesis -1.79 5.59e-3 15/17 (88.24%) ACOT8;CYP46A1;CYP27A1;...
Other glycan degradation -1.82 5.45e-3 13/18 (72.22%) MANBA;MAN2C1;HEXA;...
Tyrosine metabolism -1.85 2.93e-3 30/36 (83.33%) TYR;GSTZ1;ADH6;...
Fatty acid degradation -1.86 3.18e-3 40/43 (93.02%) ACADVL;ECI2;CPT2;...
Valine, leucine and isoleucine degradation -1.87 3.47e-3 42/48 (87.5%) MCCC2;HADHB;BCKDHA;...
Peroxisome -1.93 2.29e-3 72/82 (87.8%) PECR;AGXT;HAO1;...
Retinol metabolism -1.94 2.54e-3 41/68 (60.29%) RDH16;ADH6;UGT2B15;...
Metabolism of xenobiotics by cytochrome P450 -1.94 2.86e-3 49/77 (63.64%) ADH6;GSTA3;UGT2B15;...
Glycine, serine and threonine metabolism -1.95 3.27e-3 31/40 (77.5%) GCAT;GAMT;CTH;...
Histidine metabolism -1.98 2.54e-3 16/22 (72.73%) ASPA;ALDH9A1;ALDH3A1;...
Complement and coagulation cascades -2.00 3.05e-3 76/85 (89.41%) C8B;F7;TFPI;...
Linoleic acid metabolism -2.00 3.81e-3 21/29 (72.41%) PLA2G12A;PLA2G5;CYP2C8;...
Steroid hormone biosynthesis -2.17 0.00e+0 43/61 (70.49%) CYP1A2;UGT2A3;CYP3A4;...
Tryptophan metabolism -2.19 0.00e+0 35/42 (83.33%) ALDH2;CYP1A2;EHHADH;...
Arachidonic acid metabolism -2.22 0.00e+0 48/61 (78.69%) GGT1;PLA2G12A;CYP4F2;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-673 CVCL_0080 Homo sapiens 10uM 6H
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.04uM - 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CL-34 CVCL_1123 Homo sapiens 10uM 6H
HT-29 CVCL_0320 Homo sapiens 0.04uM - 10uM 6H, 24H
LoVo CVCL_0399 Homo sapiens 10uM 6H
MDST8 CVCL_1400 Homo sapiens 10uM 6H
NCI-H508 CVCL_1561 Homo sapiens 10uM 6H
SNU-1040 CVCL_5001 Homo sapiens 10uM 6H
SNU-C4 CVCL_5008 Homo sapiens 10uM 6H
SNU-C5 CVCL_5009 Homo sapiens 10uM 6H
SW480 CVCL_0546 Homo sapiens 10uM 6H
SW620 CVCL_0547 Homo sapiens 10uM 6H
SW948 CVCL_0550 Homo sapiens 10uM 6H
Colorectal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCT 116 CVCL_0291 Homo sapiens 10uM 6H
HT115 CVCL_1294 Homo sapiens 10uM 6H
RKO CVCL_0504 Homo sapiens 10uM 6H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 10uM 6H
SNG-M CVCL_1707 Homo sapiens 10uM 6H
Endometrial carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHUEM-2 CVCL_1327 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.04uM - 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 10uM 6H, 24H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HuH-7 CVCL_0336 Homo sapiens 2.5uM - 10uM 6H, 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.04uM - 10uM 6H, 24H
DV-90 CVCL_1184 Homo sapiens 10uM 6H
SK-LU-1 CVCL_0624 Homo sapiens 10uM 6H
Lung adenosquamous carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H596 CVCL_1571 Homo sapiens 10uM 6H
Lung large cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COR-L23 CVCL_1133 Homo sapiens 10uM 6H
T3M-10 CVCL_1729 Homo sapiens 10uM 6H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC15 CVCL_1253 Homo sapiens 10uM 6H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1299 CVCL_0060 Homo sapiens 10uM 6H
HCC515 CVCL_5134 Homo sapiens 0.04uM - 10uM 6H, 24H
NCI-H2073 CVCL_1523 Homo sapiens 10uM 6H
Small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1694 CVCL_1495 Homo sapiens 10uM 6H
NCI-H1836 CVCL_1502 Homo sapiens 10uM 6H
Lymph node
Diffuse large B-cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
WSU-DLCL2 CVCL_1787 Homo sapiens 10uM 6H
Ovary
Ovarian carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
EFO-27 CVCL_1194 Homo sapiens 10uM 6H
OV7 CVCL_1623 Homo sapiens 10uM 6H
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
RMG-I CVCL_1663 Homo sapiens 10uM 6H
Ovarian mucinous cystadenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COV644 CVCL_2011 Homo sapiens 10uM 6H
RMUG-S CVCL_1666 Homo sapiens 10uM 6H
Ovarian undifferentiated carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
TYK-nu CVCL_1774 Homo sapiens 10uM 6H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 10uM 6H
Acute myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NOMO-1 CVCL_1609 Homo sapiens 10uM 6H
PL-21 CVCL_2161 Homo sapiens 10uM 6H
SKM-1 CVCL_0010 Homo sapiens 10uM 6H
Pleural effusion
Histiocytic lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-937 CVCL_0007 Homo sapiens 10uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.04uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.04uM - 10uM 6H, 24H
SK-MEL-1 CVCL_0523 Homo sapiens 10uM 6H
SK-MEL-28 CVCL_0526 Homo sapiens 10uM 6H
Stomach
Gastric adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
AGS CVCL_0139 Homo sapiens 10uM 6H