Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM8TAI9)

• Drug Name: BMS-986202 Drug Info
• Synonyms: AM-095; AM-966; LPA1 antagonists (fibrotic disease), Amira; Lysophosphatidic acid antagonists (fibrotic disease), Amira
• Cross-matching ID:
  PubChem CID: 49838688
  TTD Drug ID: D06XGC

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Ribosome biogenesis in eukaryotes	1.91	8.89e-3	52/108 (48.15%)	REXO2;GAR1;RPP40;...
Amino sugar and nucleotide sugar metabolism	1.87	1.78e-2	38/48 (79.17%)	GALE;HK1;UGDH;...
Protein digestion and absorption	-1.83	2.65e-2	78/103 (75.73%)	COL1A1;ATP1B1;SLC9A3;...
Other glycan degradation	-1.83	3.31e-2	13/18 (72.22%)	GLB1;HEXB;MAN2B2;...
Steroid biosynthesis	-1.89	2.57e-2	19/20 (95%)	DHCR7;LSS;FDFT1;...
Cholesterol metabolism	-1.96	5.51e-3	44/50 (88%)	NPC2;LDLR;LIPG;...
PPAR signaling pathway	-2.04	1.10e-2	66/74 (89.19%)	ACADM;ACSL4;ACOX1;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Liver

Hepatocellular carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Huh7.5.1	CVCL_7927	Homo sapiens	1.11uM	24H	Hide ▲